CN106668004A - 依达拉奉和(+)2-莰醇搽剂及其制备方法 - Google Patents
依达拉奉和(+)2-莰醇搽剂及其制备方法 Download PDFInfo
- Publication number
- CN106668004A CN106668004A CN201510751056.5A CN201510751056A CN106668004A CN 106668004 A CN106668004 A CN 106668004A CN 201510751056 A CN201510751056 A CN 201510751056A CN 106668004 A CN106668004 A CN 106668004A
- Authority
- CN
- China
- Prior art keywords
- edaravone
- baras
- liniments
- mesh sieves
- liniment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 乙醇 | 40 |
4 | 亚硫酸钠 | 1800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 800 |
2 | (+)2-莰醇 | 200 |
3 | 乙醇 | 200 |
4 | 亚硫酸钠 | 2000 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 20 |
2 | (+)2-莰醇 | 5 |
3 | 乙醇 | 20 |
4 | 亚硫酸钠 | 800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 丙二醇 | 40 |
4 | 焦亚硫酸钠 | 1800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 甘油 | 40 |
4 | 抗坏血酸 | 1800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 甘油 | 40 |
4 | 焦亚硫酸钠 | 1800 |
5 | 水 | 定容至20ml |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510751056.5A CN106668004B (zh) | 2015-11-06 | 2015-11-06 | 依达拉奉和(+)2-莰醇搽剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510751056.5A CN106668004B (zh) | 2015-11-06 | 2015-11-06 | 依达拉奉和(+)2-莰醇搽剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106668004A true CN106668004A (zh) | 2017-05-17 |
CN106668004B CN106668004B (zh) | 2020-09-04 |
Family
ID=58858802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510751056.5A Active CN106668004B (zh) | 2015-11-06 | 2015-11-06 | 依达拉奉和(+)2-莰醇搽剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106668004B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022007833A1 (zh) * | 2020-07-08 | 2022-01-13 | 先声药业有限公司 | 一种组合物在治疗脑卒中的用途 |
WO2022007832A1 (zh) * | 2020-07-08 | 2022-01-13 | 先声药业有限公司 | 组合物在治疗脑卒中的用途 |
WO2022037537A1 (zh) * | 2020-08-17 | 2022-02-24 | 先声药业有限公司 | 一种稳定的药物组合物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101732247A (zh) * | 2010-01-06 | 2010-06-16 | 长沙易睿医药科技有限公司 | 一种含有依达拉奉的注射液 |
CN102579432A (zh) * | 2011-01-12 | 2012-07-18 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与2-莰醇组合物的新应用 |
CN102648908A (zh) * | 2011-02-26 | 2012-08-29 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与龙脑组合物的新应用 |
CN102920697A (zh) * | 2011-08-12 | 2013-02-13 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与2-莰醇组合物的新用途 |
-
2015
- 2015-11-06 CN CN201510751056.5A patent/CN106668004B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101732247A (zh) * | 2010-01-06 | 2010-06-16 | 长沙易睿医药科技有限公司 | 一种含有依达拉奉的注射液 |
CN102579432A (zh) * | 2011-01-12 | 2012-07-18 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与2-莰醇组合物的新应用 |
CN102648908A (zh) * | 2011-02-26 | 2012-08-29 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与龙脑组合物的新应用 |
CN102920697A (zh) * | 2011-08-12 | 2013-02-13 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与2-莰醇组合物的新用途 |
Non-Patent Citations (2)
Title |
---|
HAI-YINWU, ET AL.: "The synergetic effect of edaravone and borneol in the rat model of ischemic stroke", 《EUROPEAN JOURNAL OF PHARMACOLOGY》 * |
毕殿洲主编: "《药剂学》", 30 April 2001, 人民卫生出版社 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022007833A1 (zh) * | 2020-07-08 | 2022-01-13 | 先声药业有限公司 | 一种组合物在治疗脑卒中的用途 |
WO2022007832A1 (zh) * | 2020-07-08 | 2022-01-13 | 先声药业有限公司 | 组合物在治疗脑卒中的用途 |
WO2022037537A1 (zh) * | 2020-08-17 | 2022-02-24 | 先声药业有限公司 | 一种稳定的药物组合物 |
CN116472035A (zh) * | 2020-08-17 | 2023-07-21 | 先声药业有限公司 | 一种稳定的药物组合物 |
Also Published As
Publication number | Publication date |
---|---|
CN106668004B (zh) | 2020-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7012089B2 (ja) | 皮膚炎および炎症性皮膚疾患の処置のためのカンナビノイドの製剤 | |
Hasnain et al. | Use of cashew bark exudate gum in the preparation of 4% lidocaine HCL topical gels | |
WO2019183142A1 (en) | Ionic liquid compositions for treatment of rosacea | |
CN108057018B (zh) | 秋水仙碱外用组合物及其制备方法 | |
CN106668004A (zh) | 依达拉奉和(+)2-莰醇搽剂及其制备方法 | |
CN101601650A (zh) | 丙酸氟替卡松脂质体乳膏 | |
Wu et al. | Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen | |
WO2021023099A1 (zh) | 一种马钱子碱凝胶制剂及其制备方法 | |
JP7175038B2 (ja) | イソトレチノイン製剤ならびにその使用および方法 | |
Sampaopan et al. | Formulation development and pharmaceutical evaluation of Lysiphyllum strychnifolium topical patches for their anti-inflammatory potential | |
CN102657602B (zh) | 3,5-二羟基-4-异丙基二苯乙烯壳聚糖凝胶剂及其制备方法 | |
CN101601652B (zh) | 糠酸莫米松脂质体乳膏 | |
CN105395562A (zh) | 一种以硝酸益康唑、曲安奈德为活性成分的皮肤病外用乳膏及制备方法 | |
Sumner et al. | Development and evaluation of a novel topically applied sildenafil citrate hydrogel and its influence on wound healing in dogs | |
TW201513894A (zh) | 含埃克替尼的皮膚外用藥物組合物及其應用 | |
CN109172518B (zh) | 一种含维生素k1的外用制剂及其制备方法 | |
CN112370420A (zh) | 一种药物凝胶剂及其制备方法和应用 | |
CN103877117A (zh) | 一种丁酸氢化可的松氧化锌药物组合物 | |
CN103877118A (zh) | 一种由醋丙甲泼尼龙、氧化锌组成的药物组合物 | |
CN105687207A (zh) | 一种用于皮炎、湿疹的膏剂及其制备方法 | |
Tatu et al. | Formulation, preparation, physico-chemical, microbiological analysis and clinical uses of capsaicin microemulsions | |
WO2023187116A1 (en) | Mirabegron formulation | |
CN105456182A (zh) | 一种治疗真菌感染的外用乳膏及其生产方法 | |
CN109528693B (zh) | 一种雷帕霉素巴布剂及其制备方法 | |
CN109091482B (zh) | 一种用于丘疹性荨麻疹的膏剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20180525 Address after: 211800 8 Xing Long Road, Pukou Economic Development Zone, Nanjing, Jiangsu. Applicant after: Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd. Applicant after: Jiangsu Simcere Pharmaceutical Co., Ltd. Address before: 210042 699 Xuanwu Road, Xuanwu District, Nanjing, Jiangsu -18 Applicant before: Jiangsu Simcere Pharmaceutical Co., Ltd. |
|
TA01 | Transfer of patent application right | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: No.99, Huakang Road, Jiangbei new district, Nanjing, Jiangsu Province, 210032 Patentee after: SIMCERE PHARMACEUTICAL Group Patentee after: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. Address before: 211800 Nanjing, Pukou Economic Development Zone, Jiangsu Road, No. 8 Patentee before: NANJING SIMCERE DONGYUAN PHARMACEUTICA Co.,Ltd. Patentee before: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. |
|
CP03 | Change of name, title or address |