CN106668004B - 依达拉奉和(+)2-莰醇搽剂及其制备方法 - Google Patents
依达拉奉和(+)2-莰醇搽剂及其制备方法 Download PDFInfo
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- CN106668004B CN106668004B CN201510751056.5A CN201510751056A CN106668004B CN 106668004 B CN106668004 B CN 106668004B CN 201510751056 A CN201510751056 A CN 201510751056A CN 106668004 B CN106668004 B CN 106668004B
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- Prior art keywords
- edaravone
- borneol
- liniment
- antioxidant
- mesh sieve
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 乙醇 | 40 |
4 | 亚硫酸钠 | 1800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 800 |
2 | (+)2-莰醇 | 200 |
3 | 乙醇 | 200 |
4 | 亚硫酸钠 | 2000 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 20 |
2 | (+)2-莰醇 | 5 |
3 | 乙醇 | 20 |
4 | 亚硫酸钠 | 800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 丙二醇 | 40 |
4 | 焦亚硫酸钠 | 1800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 甘油 | 40 |
4 | 抗坏血酸 | 1800 |
5 | 水 | 定容至20ml |
序号 | 成分 | 毫克/单位 |
1 | 依达拉奉 | 80 |
2 | (+)2-莰醇 | 20 |
3 | 甘油 | 40 |
4 | 焦亚硫酸钠 | 1800 |
5 | 水 | 定容至20ml |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510751056.5A CN106668004B (zh) | 2015-11-06 | 2015-11-06 | 依达拉奉和(+)2-莰醇搽剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510751056.5A CN106668004B (zh) | 2015-11-06 | 2015-11-06 | 依达拉奉和(+)2-莰醇搽剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106668004A CN106668004A (zh) | 2017-05-17 |
CN106668004B true CN106668004B (zh) | 2020-09-04 |
Family
ID=58858802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510751056.5A Active CN106668004B (zh) | 2015-11-06 | 2015-11-06 | 依达拉奉和(+)2-莰醇搽剂及其制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN106668004B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023533443A (ja) * | 2020-07-08 | 2023-08-03 | シムサー ファーマシューティカル カンパニー リミテッド | 脳卒中の治療における組成物の使用 |
WO2022007833A1 (zh) * | 2020-07-08 | 2022-01-13 | 先声药业有限公司 | 一种组合物在治疗脑卒中的用途 |
CN116472035A (zh) * | 2020-08-17 | 2023-07-21 | 先声药业有限公司 | 一种稳定的药物组合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101732247B (zh) * | 2010-01-06 | 2012-04-25 | 长沙易睿医药科技有限公司 | 一种含有依达拉奉的注射液 |
CN102579432B (zh) * | 2011-01-12 | 2016-05-11 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与2-莰醇组合物的应用 |
CN102648908B (zh) * | 2011-02-26 | 2015-05-20 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与龙脑组合物的应用 |
CN102920697B (zh) * | 2011-08-12 | 2015-08-19 | 江苏先声药物研究有限公司 | 3-甲基-1-苯基-2-吡唑啉-5-酮与2-莰醇组合物的新用途 |
-
2015
- 2015-11-06 CN CN201510751056.5A patent/CN106668004B/zh active Active
Non-Patent Citations (1)
Title |
---|
The synergetic effect of edaravone and borneol in the rat model of ischemic stroke;Hai-YinWu, et al.;《European Journal of Pharmacology》;20140627;第740卷;522–531 * |
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Publication number | Publication date |
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CN106668004A (zh) | 2017-05-17 |
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Effective date of registration: 20180525 Address after: 211800 8 Xing Long Road, Pukou Economic Development Zone, Nanjing, Jiangsu. Applicant after: Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd. Applicant after: Jiangsu Simcere Pharmaceutical Co., Ltd. Address before: 210042 699 Xuanwu Road, Xuanwu District, Nanjing, Jiangsu -18 Applicant before: Jiangsu Simcere Pharmaceutical Co., Ltd. |
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CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: No.99, Huakang Road, Jiangbei new district, Nanjing, Jiangsu Province, 210032 Patentee after: SIMCERE PHARMACEUTICAL Group Patentee after: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. Address before: 211800 Nanjing, Pukou Economic Development Zone, Jiangsu Road, No. 8 Patentee before: NANJING SIMCERE DONGYUAN PHARMACEUTICA Co.,Ltd. Patentee before: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. |