CN106665623A - Sterilization composition containing picarbutrazox and application thereof - Google Patents

Sterilization composition containing picarbutrazox and application thereof Download PDF

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Publication number
CN106665623A
CN106665623A CN201611177883.9A CN201611177883A CN106665623A CN 106665623 A CN106665623 A CN 106665623A CN 201611177883 A CN201611177883 A CN 201611177883A CN 106665623 A CN106665623 A CN 106665623A
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China
Prior art keywords
picarbutrazox
amisulbrom
cyazofamid
agent
ingredient
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CN201611177883.9A
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Chinese (zh)
Inventor
张承来
吴成林
戴兰芳
蒋卫国
彭勇
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DONGGUAN RUIDEFENG BIOLOGICAL SCIENCE AND TECHNOLOGY Co Ltd
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DONGGUAN RUIDEFENG BIOLOGICAL SCIENCE AND TECHNOLOGY Co Ltd
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Priority to CN201611177883.9A priority Critical patent/CN106665623A/en
Publication of CN106665623A publication Critical patent/CN106665623A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

The invention relates to a sterilization composition containing picarbutrazox. The sterilization composition is prepared from effective ingredients of A and B, wherein the ingredient A is picarbutrazox, the ingredient B is chosen from any of cyazofamid and amisulbrom, the weight ratio of the ingredient A to the ingredient B is (50 to 1) to (1 to 50), and the mass percent content of an active ingredient in the composition is 5% to 80%. The composition can be prepared into dosage forms like a suspending agent, wettable powder, water dispersible granule and the like. Application places of the sterilization composition are farmland, orchards and the like, the sterilization composition can be used to prevent and treat varieties of oomycete diseases like late blight, downy mildew, epidemic diseases and like of crops including vegetables, fruit trees, flowers and the like.

Description

A kind of bactericidal composition containing picarbutrazox and its application
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of bactericidal composition containing picarbutrazox and its The application of preventing and treating corps diseases, belongs to disinfectant use in agriculture field.
Background technology
The late blight of potato (Potato Late Blight) is caused by phytophthora infestans, causes potato haulm dead and block The rotten a kind of crushing oomycetes disease of stem rot.Cardinal symptom：Blade is caught an illness first in blade tip or the green brown spot of leaf margin life water soaking mode, Has light green color haloing around scab, scab expands rapidly during high humidity, brown, and produces a circle white mould, i.e. sporangiophore and spore Ascus, it is especially obvious with blade back；Scab browning dries up when being dried, and matter is crisp easily to be split, and loses white mould, and expansion rate slows down.Stem Portion or petiole are caught an illness existing brown streak.The serious blade of morbidity wither it is vertical, crispatura, the black corruption of Herb is caused eventually, full field is a piece of dried-up, distributes Go out corrupt smell.Tuber is caught an illness nascent brown or puce bulk scab, slightly concave to fall into, and the subcutaneous potato meat in sick portion is also brown, slowly Expand or rot to surrounding.
The late blight of potato in the rainy time, there was dampness in the air or it is warm it is foggy under the conditions of morbidity weight.Plantation susceptible variety, plants Strain is in the flowering phase again, as long as there is 22 DEG C or so of daytime, relative humidity continues more than 8 hours higher than 95%, and night 10~ 13 DEG C, there are the super-humid conditions that water droplet continues 11~14 hours on leaf, primary disease can occur, and 10~14 days diseases spread entirely after morbidity Field or cause is very popular.
All over the world, there is a generation in Rhizoma Solani tuber osi producing region to the late blight of potato, the general underproduction 30% of popular year.19th century 40 Age Irish potato dies of hunger more than 100 ten thousand people, 2,000,000 people's resettlements because of late blight Large Scale Death, underproduction half.
Cucumber downy mildew, is commonly called as " horse race is dry ", " dry leaves ", and seedling stage strain all can be aggrieved, mainly cause harm blade and stem, volume Palpus and bennet are aggrieved less.Cucumber downy mildew cause of disease is Mastigomycotina Pseudoperonospora Cuba artificial downy mildew (Pseudoperonospora cubensis), the Sporangium of the pathogenic bacteria is propagated by air-flow and rainwater.Cucumber downy mildew is Fructus Cucumidis sativi There is the most universal, disease of the most serious that cause harm in cultivation.The state of an illness oncoming force is violent, morbidity weight, propagates fast, such as prevents and treats not in time, will give Fructus Cucumidis sativi causes destructive loss.
In the preventing and treating of the late blight of potato and cucumber downy mildew, metalaxyl, dimethomorph and some protections are relied primarily on Property medicament.Because life-time service has generated different degrees of Drug resistance, prevention effect is reduced these medicaments.Simultaneously medicament is big Amount endangers food safety using increased pesticide residues, has increased environmental pollution.
Picarbutrazox, is new oximino ether bactericide, molecular formula:C20H23N7O3, molecular weight 409.4.Medicament master It is effective to oomycetes.The antibacterial structure is special, with other antibacterial no interactions resistances.
By picarbutrazox and the pesticide active ingredient combination application of other structures type, there is the combination of potentiation Thing can not only significantly improve actual preventive effect, reduce dosage and cost, additionally aid the generation that avoids pathogenic bacteria resistance and delay Drug-fast generation speed, the problems such as the resistance and cost in current pesticide single dose application process can be solved.
The content of the invention
It is an object of the invention to provide a kind of resistance risk is little, low cost, good drug efficacy, the Bactericidal composite of lasting period length Thing.
Inventor is found surprisingly that picarbutrazox and cyanogen frost by substantial amounts of indoor biometricses and field control effectiveness test Any one in azoles, amisulbrom be in certain proportion after mixture, to diseases such as the late blight of potato and cucumber downy mildews There is significant potentiation.
The cyazofamid (cyazofamid), molecular formula C13H13ClN4O2S.Cyazofamid is a kind of novel low-toxicity antibacterial, With good protection activity and certain interior suction therapeutic activity, the lasting period is long, resistance of rainwater washing against, using conveniently, safely.The medicine Category mitochondrial respiratory inhibitor, its bactericidal mechanism be by suppressing pathogenic bacteria metabolic process in Qi in cytochrome b cl, and cause Pathogenic bacteria is dead, different from methoxy acrylic medicament (being Q0 inhibitor in cytochrome b cl).All growths to oomycetes There is effect in stage, and the pathogenic bacteria for producing resistance or sensitivity to metalaxyl is active.
The amisulbrom (amisulbrom), molecular formula C13H13BrFN5O4S2.Amisulbrom belongs to triazolylsulfonamide Series bactericidal agent, the medicament is mainly used in the fungal disease that prevention and control are caused by Oomycete. to Fructus Cucumidis sativi, Fructus Vitis viniferae downy mildew, Rhizoma Solani tuber osi, Fructus Lycopersici esculenti Late blight and capsicum epidemic disease etc. are respectively provided with preferable prevention effect amisulbrom and have lasting effect strong. and resistance to rainwater shower is right The features such as disease effect stability.
Inventor, through carrying out symphyogenetic quantitative analyses to compositionss, defines this on the basis of above-mentioned discovery The technical scheme of invention, i.e.,：A kind of bactericidal composition containing picarbutrazox, be containing effective constituents A and B, A Picarbutrazox, B be in cyazofamid, amisulbrom any one, both mass ratioes be the ︰ 50 of 50 ︰ 1~1, preferably Mass ratio is the ︰ 30 of 30 ︰ 1~1.Active component gross mass percentage composition is 5~80% in compositionss.
The present composition can be prepared into any one dosage form of suitable agricultural use, preferable agent with known method Type has suspending agent, wettable powder, water dispersible granules etc..These preparations can be prepared by general method, for example, by active substance Mix with liquid flux and/or solid carrier, while surfactant such as emulsifying agent, dispersant, stabilizer, wetting agent are added, Binding agent, defoamer, oxidant, dyestuff etc. can also be added.
For suspending agent, the dispersant that can be used such as polycarboxylate, lignosulfonates such as lignin sulfonic acid sodium salt, alkyl One or more in naphthalene sulfonate；Emulsifying agent such as Nongru-700 # (common name alkyl phenol formaldehyde resin polyoxyethylene ether), two fourths Base naphthalenesulfonic acid-formaldehyde condensate, agriculture breast 2201#, this disk -60# (common name sorbitol anhydride monostearate), agriculture breast 1601# One kind in (common name triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer), TERSPERSE 4894 (2500) or It is various；Wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products phosphate, tea seed cake powder, alkylphenol-polyethenoxy base ether phosphoric acid One or more in ester, phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Increase One or more in thick dose such as xanthan gum, polyvinyl alcohol, bentonite；In preservative such as formaldehyde, benzoic acid, sodium benzoate one Plant or various；Defoamer such as silicone defoamer；Antifreezing agent such as ethylene glycol, Propylene Glycol, glycerol, carbamide, inorganic salts such as chlorine Change one or more in sodium.
For water dispersible granules, the dispersant that can be used such as polycarboxylate, lignosulfonates, NNO4, alkyl naphthalene sulfonic acid One or more in salt；Wetting agent such as NPE, polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate, naphthalene One or more in sulfonate；One or more in disintegrating agent such as ammonium sulfate, carbamide, sucrose, glucose；Binding agent such as diatom One or more in soil, corn starch, PVA, carboxymethyl (ethyl) cellulose；Filler such as kieselguhr, calcium bicarbonate, kaolinite One or more in soil, white carbon, Pulvis Talci, potter's clay.
For wettable powder, one in the dispersant that can be used such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate Plant or various；One or more in wetting agent such as alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Filler such as ammonium sulfate, urine One or more in element, sucrose, glucose, kieselguhr, Kaolin, white carbon, fine particle calcium carbonate, Pulvis Talci, attapulgite, potter's clay.
The present composition can be provided in finished product preparation form, i.e., each material is blended in compositionss；Compositionss Composition can also be provided with unit dose preparation, be mixed in proportion in bucket (tank) using front.The concentrate of the present invention is generally mixed with water Conjunction obtains the concentration of required active substance.
The compositionss of the present invention can be used to prevent and treat the important disease caused by ascomycetess, oomycetes etc., be particularly suitable for preventing and treating Late blight.It is farmland, orchard etc. that the compositionss of the present invention apply place.
The compound that the compositionss of the present invention can also have weeding, parasite killing or bactericidal property with other is particularly protectiveness Antibacterial is used in mixed way, it is also possible to mix with nematicide, protective agent, growth regulator, nutrient for plants or soil conditioner Use.
Present invention additionally comprises a kind of method that funguses are killed at scene, before or after crop and/or fruit are susceptible, to work The compositionss of the present invention are applied in thing and/or fruit and its growth or the place for storing.Can apply by common method, such as pour Note, injection, spraying, dusting, distribution.The amount of application of the present invention changes with weather condition or crop condition.Protective effect continues Time is generally relevant with the content of single compound in compositionss, related to extraneous factor, for example weather, but by using appropriate Dosage form can slow down the impact of weather.
The compositionss of the present invention possess advantages below：One is that compositionss potentiation is obvious, and drug effect is greatly improved；Two is group Compound drug effect is improved, and field rate declines, and reduces production and use cost, reduces pesticide residues and environmental pollution；Three is group Compound is made up of the effective ingredient of different mechanism of action, and action site increases, and is conducive to overcoming and delaying the drug-fast product of pathogenic bacteria It is raw.
Specific embodiment
After different pesticide active ingredient mixing, three kinds of type of action are typically exhibited：Summation action, potentiation and short of money Anti- effect.But which kind of effect be specially, it is impossible to predict, only just can know that by lot of experiments.The good formula of compound synergic, Due to significantly improving actual prevention effect, the usage amount of pesticide is reduced, so as to greatly delay the drug-fast product of pathogenic bacteria Raw speed, is the important means of scientific prevention and cure disease.
Inventor has carried out the test of substantial amounts of indoor bioassay and field control effectiveness test, find picarbutrazox with Any one combination Phytophthora infestans and bacterium of downy mildew of cucumber etc. have significant collaboration in cyazofamid, amisulbrom Potentiation, and the simple addition (referring to bioassay example 1) of not exclusively two kinds medicaments.
Assays Example 1：Picarbutrazox and cyazofamid, amisulbrom compounding Phytophthora infestans The Toxicity Determination test of (Phytophthora infestans)
Test adopts mycelial growth rate method.Take the experiment medicinal liquid that 5ml prepares to be added to equipped with the hot culture medium (rye (Secale cereale L.)s of 45ml Culture medium, 45-50 DEG C) conical flask in, after shaking up, pour diameter 90mm glass culture dishs into rapidly, each culture dish pours band into Medicine culture medium 12ml, each process 4 repetitions, horizontal rest, after cooling flat board.With diameter 5mm card punch from culture 5d Cut bacteria cake for examination bacterium edge, the one side with mycelia is connected in the malicious culture medium of band with hordeolum, all operations are ultra-clean Workbench carries out sterile working.Flat board is placed in 25 DEG C of constant temperature aseptic culture case after process is cultivated, handed over using cross after 10d Fork method measures respectively the colony diameter of each process, calculates each meansigma methodss, average net growth of colony diameter for processing colony diameter Amount and mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate (%)=[(matched group net growth-treatment group net growth)/matched group net growth] ×100
Mycelial growth inhibition rate is converted into into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm value (x), with minimum Square law calculates concentration EC in virulence equation and suppression50, according to the abundant methods of Sun Yun the toxicity index and co-toxicity coefficient of medicament are calculated (CTC)。
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100.
CTC≤80 are antagonism, and 80 ＜ CTC ＜ 120 are summation action, and CTC >=120 are potentiation.
Knowable to table 1,2 results, any one compounding in picarbutrazox and cyazofamid, amisulbrom, in proportioning For 50:1~1:When between 50, all more than 120, Phytophthora infestans has potentiation to co-toxicity coefficient, especially 30: 1~1:When between 30, co-toxicity coefficient is all more than 170.
The picarbutrazox of table 1 compounds the isolated test result of Phytophthora infestans with cyazofamid
The picarbutrazox of table 2 compounds the isolated test result of Phytophthora infestans with amisulbrom
Assays Example 2：Picarbutrazox is compounded to bacterium of downy mildew of cucumber with cyazofamid, amisulbrom The Toxicity Determination test of (Pseudoperonospora cubensis)
This test adopts pot-culture method.The consistent two panels leaf period cucumber seedling of growing way is chosen, each is processed from 5 basins for examination melon Seedling, numbers standby.Sprayed under 50PSI pressure with Potter spray towers, per basin 5mL.Each medicament arranges 5 Concentraton gradient, With spray equivalent clear water as blank.Spray inoculation bacterium of downy mildew of cucumber sporangia suspension, spore after chemicals treatment 24h The configuration process of capsule suspension is as follows：The cucumber leaves with Pseudoperonospora cubensis for picking up from field are taken, with brush pen 10 DEG C or so are dipped Distillation washing lower back face Sporangium, be made into concentration for 3 × 105The sporangia suspension of individual/mL.Cucumber seedling is put after inoculation (relative humidity 100%, temperature 15-20 DEG C) culture, keeping temperature 15-24 DEG C, relative humidity after 24h in growth cabinet 90% or so moisturizing induces, and incidence is recorded in investigation after 10d, calculates disease index and prevention effect.
Cucumber downy mildew grade scale:
0 grade：Blade disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole blade area；
3 grades：Lesion area accounts for the 6-10% of whole blade area；
5 grades：Lesion area accounts for the 11-25% of whole blade area；
7 grades：Lesion area accounts for the 26-50% of whole blade area；
9 grades：Lesion area accounts for more than the 50% of whole blade area.
Concentration EC in suppressing is calculated with method of least square50, then calculate co-toxicity coefficient (CTC) according to the abundant methods of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100.
CTC≤80 are antagonism, and 80 ＜ CTC ＜ 120 are summation action, and CTC >=120 are potentiation.
Knowable to table 3, the result of table 4, picarbutrazox is compounded with cyazofamid or amisulbrom, is 50 in proportioning:1 ~1:When between 50, co-toxicity coefficient has potentiation to bacterium of downy mildew of cucumber, especially 30 all more than 120:1~1:30 Between when, co-toxicity coefficient is all more than 170.
The picarbutrazox of table 3 compounds the results from pot experiment test to bacterium of downy mildew of cucumber with cyazofamid
The picarbutrazox of table 4 compounds the results from pot experiment test to bacterium of downy mildew of cucumber with amisulbrom
Hereinafter the present invention is further illustrated with specific embodiment, but the present invention is limited to absolutely not these examples.Described below is only For preferably embodiment of the invention, only to explain the present invention, therefore can not be interpreted as to the scope of the claims of the present invention Limit.It should be pointed out that all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., Should be included within the scope of the present invention.Therefore, the protection domain of patent of the present invention should be defined by claims.
Percentage composition is mass percent in all formulations proportioning.
Suspending agents
By formula proportion, each components such as active component, dispersant, wetting agent, thickening agent, antifreeze and water are pressed into formula Ratio mix homogeneously, after ground or high speed shear suspending agent is made.
Embodiment 1：31%picarbutrazox cyazofamid suspending agents
Picarbutrazox 30%, cyazofamid 1%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, 12 Alkyl sodium sulfate (wetting agent) 3%, xanthan gum (thickening agent) 2%, bentonite (thickening agent) 1%, glycerol (antifreeze) 5%, water Complement to 100%.
Embodiment 2：31%picarbutrazox amisulbrom suspending agents
Picarbutrazox 30%, amisulbrom 1%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, Sodium lauryl sulphate (wetting agent) 3%, xanthan gum (thickening agent) 2%, bentonite (thickening agent) 1%, glycerol (antifreeze) 5%, water complements to 100%.
Embodiment 3：31%picarbutrazox cyazofamid suspending agents
Picarbutrazox1%, cyazofamid 30% is polycarboxylate (dispersant) 10%, tea seed cake powder (wetting agent) 3%, poly- Vinyl alcohol (thickening agent) 2%, bentonite (thickening agent) 1%, ethylene glycol (antifreeze) 5%, water complements to 100%.
Embodiment 4：31%picarbutrazox amisulbrom suspending agents
Picarbutrazox1%, amisulbrom 30%, polycarboxylate (dispersant) 10%, tea seed cake powder (wetting agent) 3%th, polyvinyl alcohol (thickening agent) 2%, bentonite (thickening agent) 1%, ethylene glycol (antifreeze) 5%, water complements to 100%.
Embodiment 5：5%picarbutrazox cyazofamid suspending agents
Picarbutrazox 3%, cyazofamid 2%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, dodecane Base sodium sulfate (wetting agent) 3%, xanthan gum (thickening agent) 2%, bentonite (thickening agent) 1%, carbamide (antifreeze) 5%, water is mended Enough to 100%.
Embodiment 6：5%picarbutrazox amisulbrom suspending agents
Picarbutrazox 2%, amisulbrom 3%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, ten Sodium dialkyl sulfate (wetting agent) 3%, xanthan gum (thickening agent) 2%, bentonite (thickening agent) 1%, carbamide (antifreeze) 5%, Water complements to 100%.
Embodiment 7：16%picarbutrazox cyazofamid suspending agents
Picarbutrazox15%, cyazofamid 1% is polycarboxylate (dispersant) 10%, tea seed cake powder (wetting agent) 3%, poly- Vinyl alcohol (thickening agent) 2%, bentonite (thickening agent) 1%, Propylene Glycol (antifreeze) 5%, water complements to 100%.
Embodiment 8：16%picarbutrazox amisulbrom suspending agents
Picarbutrazox15%, amisulbrom 1%, polycarboxylate (dispersant) 10%, tea seed cake powder (wetting agent) 3%th, polyvinyl alcohol (thickening agent) 2%, bentonite (thickening agent) 1%, Propylene Glycol (antifreeze) 5%, water complements to 100%.
Wettable powder example
Pesticide activity component, auxiliary agent, filler are mixed in proportion Jing after comminution by gas stream and remix prepared wettable powder.It is main Want equipment：Mixer, jet mill.
Embodiment 9：80%picarbutrazox cyazofamid wettable powders
Picarbutrazox50%, cyazofamid 30%, sodium lauryl sulphate (wetting agent) 2%, sodium lignin sulfonate (dispersant) 3%, White Carbon black 10% (filler), Kaolin complements to 100%.
Embodiment 10：80%picarbutrazox amisulbrom wettable powders
Picarbutrazox30%, amisulbrom 50%, sodium lauryl sulphate (wetting agent) 2%, lignin sulfonic acid Sodium (dispersant) 3%, White Carbon black 10% (filler), Kaolin complements to 100%.
Embodiment 11：51%picarbutrazox cyazofamid wettable powders
Picarbutrazox50%, cyazofamid 1%, alkyl sulfate (wetting agent) 3%, polycarboxylate (dispersant) 3%, White Carbon black (filler) 11%, bentonite complements to 100%.
Embodiment 12：51%picarbutrazox amisulbrom wettable powders
Picarbutrazox50%, amisulbrom 1%, alkyl sulfate (wetting agent) 3%, polycarboxylate (dispersion Agent) 3%, White Carbon black (filler) 11%, bentonite complements to 100%.
Embodiment 13：16%picarbutrazox cyazofamid wettable powders
Picarbutrazox1%, cyazofamid 15%, alkylsulfonate (wetting agent) 3%, sodium lignin sulfonate (dispersion Agent) 3%, White Carbon black (filler) 11%, potter's clay complements to 100%.
Embodiment 14：16%picarbutrazox amisulbrom wettable powders
Picarbutrazox1%, amisulbrom 15%, alkylsulfonate (wetting agent) 3%, sodium lignin sulfonate (point Powder) 3%, White Carbon black (filler) 11%, potter's clay complements to 100%.
Water dispersible granules example
By formula proportion, active compound and powder carrier, moistening spreader-sticker and binding agent etc. are carried out into co-grinding, add water and pinch After conjunction, adding in the comminutor equipped with certain specification screen cloth carries out pelletize.Then again drying, screening are obtained final product (by screen cloth scope) Granular product.
Embodiment 15：51%picarbutrazox cyazofamid water dispersible granules
Picarbutrazox1%, cyazofamid 50%, polycarboxylate (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, sodium lauryl sulphate (wetting agent) 2%, ammonium sulfate (disintegrating agent) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 16：51%picarbutrazox amisulbrom water dispersible granules
Picarbutrazox1%, amisulbrom 50%, polycarboxylate (dispersant) 5%, sodium lignin sulfonate (dispersion Agent) 7%, sodium lauryl sulphate (wetting agent) 2%, ammonium sulfate (disintegrating agent) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 17：40%picarbutrazox cyazofamid water dispersible granules
Picarbutrazox20%, cyazofamid 20%, Negel (dispersant) 5%, sodium lignin sulfonate (point Powder) 7%, sodium lauryl sulphate (wetting agent) 2%, carbamide (disintegrating agent) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 18：40%picarbutrazox amisulbrom water dispersible granules
Picarbutrazox20%, amisulbrom 20%, Negel (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, sodium lauryl sulphate (wetting agent) 2%, carbamide (disintegrating agent) 5%, precipitated calcium carbonate complements to 100%.
Field information example 1：Picarbutrazox compounds the field control effectiveness test to the late blight of potato with cyazofamid
Test site Gansu Lanzhou.Choose the late blight of potato to fall ill throughout the year heavier plot.Test medicine and consumption are shown in Table 5, often processes 4 cells and repeats, 20 square metres of each plot area.First time dispenser, Herb are carried out in disease early period of origination Even spraying, is sprayed onto till blade drips, and with clear water blank is processed as.Second medicine is applied after 7 days.Before first time medicine and The incidence of 7 days investigation late blights of potato after second medicine.Per cell using 5 points of samplings, per is investigated 5 plants, per plant of tune All blades are looked into, accounts for the percentage rate of whole leaf area to be classified record with lesion area.Calculate each process disease index and preventing and treating Effect.
Grade scale：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6%-15% of whole leaf area；
5 grades：Lesion area accounts for the 16%-25% of whole leaf area；
7 grades：Lesion area accounts for the 26%-50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area.
Drug effect computational methods：
As can be seen from Table 5：The each single dose of picarbutrazox, cyazofamid is respectively to the preventive effect of the late blight of potato 79.6% and 74.8%, and embodiment of the present invention bactericidal composition is significantly increased in preventive effect, minimum preventive effect is 87.1%, it has been up to 94.1%.The result of field test fully shows that picarbutrazox is right after compounding with cyazofamid The late blight of potato has significant synergistic function, and in the case where effective ingredient consumption is reduced, prevention effect is significantly carried It is high.Therefore, the beneficial effect that the present composition has reduces cost, delaying drug resistance, reduces spraying times and pesticide residues.
The picarbutrazox of table 5 compounds the field test results to the late blight of potato with cyazofamid
Field information example 2：Picarbutrazox compounds the field control effectiveness test to the late blight of potato with amisulbrom
Test site Weichang.Test method and investigation method are with Field information example 1.
As can be seen from Table 6：The each single dose of picarbutrazox, amisulbrom is distinguished the preventive effect of the late blight of potato For 78.2% and 72.4%, and embodiment of the present invention bactericidal composition is significantly increased in preventive effect, and minimum preventive effect is 89.4%, it has been up to 94.8%.The result of field test fully shows that picarbutrazox is compounded with amisulbrom There is afterwards significant synergistic function to the late blight of potato, in the case where effective ingredient consumption is reduced, prevention effect is big Width is improved.Therefore, the beneficial work that the present composition has reduces cost, delaying drug resistance, reduces spraying times and pesticide residues With.
The picarbutrazox of table 6 compounds the field test results to the late blight of potato with amisulbrom
Field information example 3：Picarbutrazox compounds the field control effectiveness test to cucumber downy mildew with cyazofamid
Test site Shandong Shouguang.Test method and investigation method are with Field information example 1.
As can be seen from Table 7：The each single dose of picarbutrazox, cyazofamid is respectively to the preventive effect of cucumber downy mildew 79.5% and 73.1%, and embodiment of the present invention bactericidal composition is significantly increased in preventive effect, minimum preventive effect is 89.0%, it has been up to 93.8%.The result of field test fully shows that picarbutrazox is right after compounding with cyazofamid Cucumber downy mildew has significant synergistic function, and in the case where effective ingredient consumption is reduced, prevention effect is greatly improved. Therefore, the beneficial effect that the present composition has reduces cost, delaying drug resistance, reduces spraying times and pesticide residues.
The picarbutrazox of table 7 compounds the field test results to cucumber downy mildew with cyazofamid
Field information example 4：Picarbutrazox compounds the field control effectiveness test to cucumber downy mildew with amisulbrom
Test site Shandong Anqiu.Test method and investigation method are with Field information example 1.
As can be seen from Table 8：The each single dose of picarbutrazox, amisulbrom is respectively to the preventive effect of cucumber downy mildew 79.8% and 71.9%, and embodiment of the present invention bactericidal composition is significantly increased in preventive effect, minimum preventive effect is 89.4%, It has been up to 94.7%.The result of field test fully shows, to Fructus Cucumidis sativi after picarbutrazox and amisulbrom compounding Downy mildew has significant synergistic function, and in the case where effective ingredient consumption is reduced, prevention effect is greatly improved.Cause This, the beneficial effect that the present composition has reduces cost, delaying drug resistance, reduces spraying times and pesticide residues.
The picarbutrazox of table 8 compounds the field test results to cucumber downy mildew with amisulbrom

Claims (6)

1. a kind of bactericidal composition containing picarbutrazox, it is characterised in that：Effective ingredient is A and B, A are Picarbutrazox, B are any one in cyazofamid and amisulbrom, and the mass ratio of A and B is the ︰ 50 of 50 ︰ 1~1.
2. bactericidal composition according to claim 1, it is characterised in that：Effective constituents A is the ︰ of 30 ︰ 1~1 with the mass ratio of B 30。
3. bactericidal composition according to claim 2, it is characterised in that：Effective constituents A is the ︰ of 15 ︰ 1~1 with the mass ratio of B 15。
4. the bactericidal composition according to any one of claim 1-3, it is characterised in that：Active component accumulation matter in compositionss Amount percentage composition is 5%~80%.
5. bactericidal composition according to claim 4, it is characterised in that：Said composition can prepare any dosage form, preferably Dosage form have suspending agent, wettable powder or water dispersible granules.
6. the bactericidal composition described in claim 1 is used to prevent and treat the purposes of the late blight of potato and cucumber downy mildew.
CN201611177883.9A 2016-12-20 2016-12-20 Sterilization composition containing picarbutrazox and application thereof Pending CN106665623A (en)

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CN107372532A (en) * 2017-08-11 2017-11-24 北京科发伟业农药技术中心 The bactericidal composition of the urethane of pyrrole containing tetrazolium
CN109221205A (en) * 2017-07-10 2019-01-18 江苏龙灯化学有限公司 A kind of bactericidal composition
WO2021129187A1 (en) * 2019-12-26 2021-07-01 江苏龙灯化学有限公司 Stable liquid suspension composition containing picarbutrazox and cyazofamid, and application thereof

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CN1553907A (en) * 2001-08-20 2004-12-08 ���ձ���ī��ѧ��ҵ��ʽ���� Tetrazoyl oxime derivative and agrochemical containing the same as active ingredient
US20110159110A1 (en) * 2008-03-24 2011-06-30 Nippon Soda Co., Ltd. Plant disease control agent
CN106922710A (en) * 2015-12-29 2017-07-07 浙江新农化工股份有限公司 Compositions of the picarbutrazox with mitochondrial cytochrome enzyme inhibitor series bactericidal agent and its preparation and application

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CN1553907A (en) * 2001-08-20 2004-12-08 ���ձ���ī��ѧ��ҵ��ʽ���� Tetrazoyl oxime derivative and agrochemical containing the same as active ingredient
US20110159110A1 (en) * 2008-03-24 2011-06-30 Nippon Soda Co., Ltd. Plant disease control agent
CN106922710A (en) * 2015-12-29 2017-07-07 浙江新农化工股份有限公司 Compositions of the picarbutrazox with mitochondrial cytochrome enzyme inhibitor series bactericidal agent and its preparation and application

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CN109221205A (en) * 2017-07-10 2019-01-18 江苏龙灯化学有限公司 A kind of bactericidal composition
CN107372532A (en) * 2017-08-11 2017-11-24 北京科发伟业农药技术中心 The bactericidal composition of the urethane of pyrrole containing tetrazolium
WO2021129187A1 (en) * 2019-12-26 2021-07-01 江苏龙灯化学有限公司 Stable liquid suspension composition containing picarbutrazox and cyazofamid, and application thereof

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Application publication date: 20170517