CN104365611B - A kind of bactericidal composition and application containing amisulbrom and mandipropamid - Google Patents
A kind of bactericidal composition and application containing amisulbrom and mandipropamid Download PDFInfo
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Abstract
The present invention relates to technical field of pesticide combination, be specifically related to a kind of bactericidal composition containing amisulbrom and mandipropamid, also relate to the application of this bactericidal composition.The active ingredient of this bactericidal composition is amisulbrom and mandipropamid, the mass ratio of two kinds of active ingredient amisulbroms and mandipropamid is 1:10 ~ 10:1, in preparation, active ingredient amisulbrom is 1% ~ 60% with the mass fraction ratio of mandipropamid, all the other are for allowing the auxiliary element using and accept in agricultural chemicals, the formulation of bactericidal composition of the present invention is wetting powder, suspending agent, aqueous emulsion, water dispersible granules, microemulsion, effectively can prevent and treat the diseases such as vegetables, grape, lichee, melon downy mildew and epidemic disease.
Description
Technical field
The present invention relates to technical field of pesticide combination, be specifically related to a kind of bactericidal composition containing amisulbrom and mandipropamid, also relate to the application of this bactericidal composition.
Background technology
Downy mildew and epidemic disease are the Common Diseases in the proportion of crop planting processes such as vegetable and fruit, Pseudoperonospora cubensis and the destructiveness of phytophthora root rot bacterium to host plant strong, harmfulness is large, after crop is infected, often significantly the underproduction is even had no harvest, have a strong impact on vegetables and fruit quality and household economy benefit, developed its relevant control product and there is the great market space.According to the literature, due to single agricultural chemicals and other unscientific application methods, downy mildew and epidemic disease has been caused to create pesticide resistance to a lot of common pesticides, after resistance produces, the increase of formulation rate and spraying times causes again peasant burden to increase the weight of and increasing environmental pollution, therefore, one of the mixture common methods becoming control of agricultural pest of different pesticide species.
Amisulbrom (Amisulbrom) is the new type bactericide of Japanese Nissan chemical company initiative, chemical name is 3-(the fluoro-2 methyl indole of the bromo-6-of 3--1-base sulphonyl)-N, N-dimethyl-1,2,4-triazole-1-sulfonamide, belongs to triazolylsulfonamide series bactericidal agent.This bactericide mode of action is novel unique, to epidemic disease, mould and Pseudoperonospora cubensis spore activity of dissociating is very high, carry out control by indirectly suppressing free spore-germination to epidemic disease and downy mildew germ to prevent, there is very strong prevention, treatment, osmotically active, and have good lasting effect and rain wash resistance, good control efficiency can be reached under low usage amount.Nearest research finds, after bacteria infection, spray amisulbrom, and the blade that can make to fall ill can not be formed and perfect spore, thus suppresses other positions to be caused a disease, and avoids crop superinfection germ.Now be mainly used in preventing and treating grape, cucumber downy mildew, potato and tomato blight etc.Its chemical structural formula is:
Mandipropamid (Benthiavalicarb-isopropyl) is the novel almond acid amide fungicides developed by delisting Syngenta Co., Ltd, most of oomycetes diseases control efficiency is stablized, and there is good activity, simultaneously to crop safety, to people, wildlife and Environmental security.Its mechanism of action is suppress the biosynthesis of phosphatide, all has good preventive effect, has higher activity to the spore being in the sprouting stage, and mycelia can be suppressed to grow up and sporulation to large absolutely number by ovum microbial leaf portion and fruit disease.The wax coat of mandipropamid to plant surface has very high affinity, when be sprayed onto fabric face and precipitation drying after, most of active component is adsorbed by wax coat, and be difficult to fallen by rain drop erosion, sub-fraction active component penetrates in plant tissue.Because medicament itself is active high, this part being absorbed in plant tissue is enough to suppress mycelial growth, thus protection blade is not by disease infestation.These characteristics ensure its stability and high efficiency, and the lasting period is long.Existing to register control capsicum epidemic disease, litchi two phytophthora root rot, potato late blight and watermelon epidemic disease in China.Its chemical structural formula is:
Although amisulbrom and mandipropamid have higher bactericidal activity to epidemic disease and downy mildew germ, if be used alone for a long time, easily make plant germ develop immunity to drugs to it, then produce the problems such as dosage increasing, preventive effect reduction, lasting period shortening.Being carried out by the medicament of the different mechanism of action rationally composite, is delay disease to develop immunity to drugs very effective common method, and can according to the effect in production application, judge this composite be synergistic effect or antagonism.The formula that two kinds of agriculture chemical compounding compatibilities are good, can significantly improve preventive effect, greatly reduce the dosage of agricultural chemicals, can also expand fungicidal spectrum, improves germicidal efficiency.
In the present composition, two kinds of active component mechanisms of action are different, and the present inventor, through lot of experiments recipe determination, proposes a kind of Compositional type bactericidal composition, namely with two yuan of combination sterilization compositions that amisulbrom and mandipropamid carry out for active ingredient.The experiment of actual indoor virulence and field efficacy experiment show, by amisulbrom and mandipropamid composite in certain proportion, there is good synergy and act synergistically, substantially increase germicidal efficiency.Meanwhile, well can delay the generation of Disease Resistance, reduce drug cost, improve actual preventive effect, can be used for preventing and treating vegetables, fruit tree, the downy mildew of the crop such as melon and epidemic disease.Composite about amisulbrom and mandipropamid, there is not yet relevant report at home and abroad at present.
Summary of the invention
The object of the invention is to propose that one has synergistic function, use cost is low, to veterinary antibiotics and the crop downy mildew such as melon and the good bactericidal composition of epidemic disease preventive effect.
For realizing above object, the technical solution adopted in the present invention is: a kind of bactericidal composition and application containing amisulbrom and mandipropamid, comprises following content:
The active ingredient of this bactericidal composition is amisulbrom and mandipropamid binary built, and all the other are auxiliary element.
In described bactericidal composition, amisulbrom and the mass fraction of mandipropamid are than being 60:1 ~ 1:60, and when the mass ratio of amisulbrom and mandipropamid is 1:10 ~ 10:1, synergistic effect is optimum.
Its formulation of described bactericidal composition is any one in wetting powder, suspending agent, aqueous emulsion, water dispersible granules, microemulsion.
When bactericidal composition is wetting powder, the percentage by weight of each component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, dispersant 1% ~ 20%, wetting agent 1% ~ 10%, filler 1% ~ 70%, by above-mentioned weight proportion, amisulbrom is mixed with mandipropamid and dispersant, wetting agent and filler, uniform stirring in stirred tank, mix again after airslide disintegrating mill is pulverized, obtain wetting powder bactericidal composition.
When bactericidal composition is suspending agent, the percentage by weight of each component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, dispersant 5% ~ 20%, antifreezing agent 1% ~ 5%, thickener 0.1% ~ 2%, defoamer 0.1% ~ 0.8%, surplus is water, the concrete production stage of this suspending agent is: first mixed by above-mentioned proportioning by auxiliary agent, mix through high speed shear, add amisulbrom and mandipropamid, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all at below 5mm, obtain the bactericidal composition of aqueous suspension formulations.
When bactericidal composition is aqueous emulsion, the percentage by weight of each component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, emulsifier 3% ~ 30%, solvent 5% ~ 15%, stabilizing agent 0.2% ~ 15%, antifreezing agent 0.1% ~ 5%, defoamer 0.1% ~ 8%, thickener 0.1% ~ 2%, surplus are water; The concrete production stage of this aqueous emulsion is: amisulbrom and mandipropamid, solvent and emulsifier are mixed, and makes it to be dissolved into uniform oil phase; Water, antifreezing agent, stabilizing agent, thickener and defoamer are mixed uniformly aqueous phase; While high-speed stirred, oil phase is added aqueous phase in a kettle., slowly add water until reach phase inversion point, open clipper and carry out high speed shear, shear 20 minutes to 1 hour, form the aqueous emulsion of oil-in-water type, obtain the bactericidal composition of aqueous emulsion.
When bactericidal composition is water dispersible granules, the mass percent of component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, dispersant 3% ~ 20%, wetting agent 3% ~ 10%, disintegrant 1% ~ 5%, filler 1% ~ 70%, the concrete production stage of this aqueous emulsion is: amisulbrom, mandipropamid and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then add in fluidized-bed granulation dryer and carry out granulation, drying, screening, obtain the bactericidal composition of water dispersant.
When bactericidal composition is microemulsion, the mass percent of component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, emulsifier 10% ~ 30%, antifreezing agent 1% ~ 8%, stabilizing agent 0.5% ~ 10%, Conventional solvents cosolvent 20% ~ 60%, surplus is supplied with water, the concrete production stage of this microemulsion is: amisulbrom and mandipropamid cosolvent are dissolved completely, add other compositions such as emulsifier, antifreezing agent, stabilizing agent again, Homogeneous phase mixing, finally adds after water fully stirs and can be made into microemulsion.
Described dispersant is: one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Described wetting agent is: one or more in lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX, wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene tri-styryl phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium bicarbonate.
Described emulsifier is: the mixture that one or more and calcium dodecyl benzene sulfonate in aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether form.
Described solvent is any one or more mixed solvents formed with arbitrary proportion in dimethylbenzene, biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), aqueous solvent; Described filler is: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Described thickener is: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol.
Described antifreezing agent is: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described stabilizing agent is: at least one in sodium citrate, resorcinol.
Described defoamer is: silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more in aliphatic alcohols compound.
Bactericidal composition of the present invention has excellent preventive effect to the downy mildew on veterinary antibiotics, the crop such as melon, epidemic disease, and the application of this bactericidal composition in the above-mentioned disease of control is also the scope that will protect.
Beneficial effect of the present invention is:
(1) bactericidal composition provided by the invention, in certain ratio range, obvious synergistic effect is shown to cucumber downy mildew, capsicum epidemic disease, the control efficiency of composition is significantly improved than single dose, reduce the using dosage of agricultural chemicals, reduce drug cost, decrease the adverse effect of agricultural chemicals to ecotope;
(2) two kinds of active ingredient mechanism of action of bactericidal composition provided by the invention are different, can overcome the single shortcoming making with medicament easily produce resistance for a long time, can extend the service life of medicament, significant to the comprehensive regulation of disease;
(3) composition pesticide of the present invention is to crop safety.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
The method that the present invention adopts indoor bioassay and field trial to combine.If no special instructions, the ratio (comprising percentage) below mentioned is all mass ratio.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Test example
After the pestsides synthesis of different cultivars, usually show three kinds of type of action, i.e. summation action, synergistic effect and antagonism, but be specially which kind of effect, unpredictable.Bactericidal composition that the present invention tells for active ingredient, adopts biologicall test example to be illustrated with amisulbrom and mandipropamid.
Test example 1: amisulbrom and the composite toxicity test to cucumber downy mildew of mandipropamid
Subjects: bacterium of downy mildew of cucumber
Test target: the cucumber of never executing amisulbrom and mandipropamid and medicament of the same type from Shouguang, Shandong gathers potted plantly and is separated, for examination cucumber variety: Chang Chun Mi Ci.
Test method:
First use the former medicine of acetone solution, appropriate two former medicines are made into several different ratio by the result according to preliminary experiment, then it is stand-by with acetone, each process to be diluted to several concentration gradients respectively.
By susceptible cucumber variety Chang Chun Mi Ci cultivation in pot for growing seedlings, be placed in greenhouse and cultivate, plant to be planted grows to three to four leaf after dates, gathers the blade of identical leaf age, for cultivation and the mensuration of cucumber downy mildew germ.
Cucumber downy mildew germ adopt plants method 20 DEG C, cultivate under the condition of 12h alternation of light and darkness, every 30d turns culture 1 time.With the conidium on sterile water wash-out incidence of leaf during inoculation, being mixed with spore concentration is 1 × 10
6the spore suspension of individual/mL.
Leaf dish moisturizing method is adopted to carry out toxicity test.First the blade of collection is prepared into the leaf dish that diameter is 1.5cm, random mixing, be placed in the series concentration liquid configured respectively and soak 1h, each concentration 50 leaf dishes, test with the process of not adding medicine as blank, after immersion terminates, leaf faces up and puts on the blotting paper that identical liquor strength is wetting, liquid on leaf dish is blotted, the spore suspension prepared is inoculated in leaf dish central authorities, after room temperature places 5min, be placed in 20 DEG C, cultivate under the condition of 12h alternation of light and darkness, the onset area on leaf dish is measured after 10d, calculate disease index and control efficiency.
The percentage accounting for leaf disc area according to lesion area divides disease level
0 grade: anosis;
1 grade: sorus area accounts for less than 5% of whole leaf area;
3 grades: sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: sorus area accounts for below the 21%-60% of whole leaf area;
9 grades: sorus area accounts for more than 60% of whole leaf area.
Drug effect computational methods:
Control efficiency is converted into probability value (y), and drug concentration (mg/L) converts logarithm value (x) to, calculates virulence equation and concentration EC in suppressing with method of least squares
50.
Carry out the toxicity test of mixture according to mixed ratio by single dose toxicity test method.
Co-toxicity coefficient (CTC) is calculated, co-toxicity coefficient CTC computing formula following (take amisulbrom as standard agent, its toxicity index is 100) according to the abundant method of Sun Yun:
TI × P mandipropamid of TI × P amisulbrom+mandipropamid of theoretical toxicity index (the TTI)=amisulbrom of M
In formula:
M is the mixture of amisulbrom and mandipropamid different ratio
P amisulbrom is the ratio of amisulbrom shared by mixture
P mandipropamid is the ratio ratio of mandipropamid shared by mixture.
If co-toxicity coefficient CTC≤80, then composition shows as antagonism; If 80 < CTC < 120, then composition shows as summation action; If CTC >=120, then composition shows as synergistic effect.
Amisulbrom and the toxicity test of mandipropamid to cucumber downy mildew of different quality mark ratio the results are shown in Table 1:
Table 1 amisulbrom and mandipropamid are to the toxicity test result of cucumber downy mildew
| Treatment agent and mass ratio | EC 50Value (mg/L) | ATI | TTI | Co-toxicity coefficient CTC |
| Amisulbrom (A) | 0.145 | 100 | / | / |
| Mandipropamid (B) | 0.039 | 371.8 | / | / |
| A:B is 20:1 | 0.096 | 151.0 | 112.9 | 133.7 |
| A:B is 10:1 | 0.078 | 185.9 | 124.7 | 149.1 |
| A:B is 5:1 | 0.062 | 233.9 | 145.3 | 161.0 |
| A:B is 3:1 | 0.048 | 302.1 | 168.0 | 179.9 |
| A:B is 2:1 | 0.039 | 371.8 | 190.6 | 195.1 |
| A:B is 1:1 | 0.026 | 557.7 | 235.9 | 236.4 |
| A:B is 1:2 | 0.030 | 483.3 | 281.2 | 171.9 |
| A:B is 1:3 | 0.033 | 439.4 | 303.9 | 144.6 |
| A:B is 1:5 | 0.028 | 517.9 | 326.5 | 158.6 |
| A:B is 1:10 | 0.029 | 500.0 | 347.1 | 144.1 |
| A:B is 1:20 | 0.031 | 467.7 | 358.9 | 130.3 |
As can be seen from the table, with amisulbrom and mandipropamid for active ingredient carries out composite control cucumber downy mildew, when mass ratio is between 20:1 ~ 1:20, co-toxicity coefficient, more than 130.3, has synergistic effect; When mass ratio is between 10:1 ~ 1:10, co-toxicity coefficient is all higher than 144.1, and synergistic effect is obvious.Suggestion carries out further field control effectiveness test to the mixture preparation of suitable proportion about 10:1 ~ 1:10 scope, to evaluate its field practical application effect.
Test example 2: the field control effectiveness test of control cucumber downy mildew
Test method
Test on Shandong Pingdu City cucumber ground, test dispenser twice altogether, check plot spray equivalent clear water.When making up a prescription, after first medicament fully being dissolved with a small amount of water, then add suitable quantity of water carry out complete stool spraying process, even spraying.All adopt power driven sprayer during spray medicine, operating pressure is 0.3 ~ 0.4MPa, shower nozzle aperture 1.3mm.Community spouting liquid is 30 ~ 40kg/667m
2, continuous dispenser 2 times, 7 days intervals, sprays application to crop complete stool uniformly by liquid.
Investigation method
The cucumber booth selecting occurring degree medium is that experimental field soil fertility is medium, and irrigation and drainage are convenient.Each community double diagonal line investigates 5 points, and often some investigation 3 strain cucumber, record occurring degree by staging.
Grade scale is as follows:
0 grade: anosis;
1 grade: sorus area accounts for less than 5% of whole leaf area;
3 grades: sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: sorus area accounts for below the 21%-60% of whole leaf area;
9 grades: sorus area accounts for more than 60% of whole leaf area.
Test is investigated 4 times altogether, and before medicine, radix investigation, investigates after 7 days, the 2nd time medicine after the 1st medicine for 7 days and 14 days.
Drug effect computational methods
Poisoning is investigated: whether after dispenser, continuous 7d estimates medicament has poisoning to crop.
Result of the test and analysis
Each group of experimental pharmacy process to the control efficiency of cucumber downy mildew in table 2
The effect of cucumber downy mildew prevented and treated by table 2 respectively process
As can be seen from Table 2, amisulbrom and mandipropamid bactericidal composition, with the ratio of 2:1, are tested by different amounts, and complex preparation dosage is lower than single dose dosage, after dispenser, it is all better than contrasting medicament to the preventive effect of cucumber downy mildew, and bactericidal effect increases progressively with the increase of dosage.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to cucumber does not all appear in each treatment agent, illustrates that it is safe to cucumber.Prevent at the initial stage of a disease or in advance, preventive effect effect is by even more ideal.Advise that the bactericide different from the mechanism of action is used in combination to delay the drug-fast generation of germ.
Test example 3: the field control effectiveness test of control capsicum epidemic disease
Test method
Test is located at Pingdu pepper planting district, Shandong, and capsicum epidemic disease occurs seriously over the years.Field soil is fertile, and other conditions are moderate.Test is total to dispenser 2 times, check plot spray equivalent clear water.Continuous dispenser twice, 7 days intervals, sprays application to crop complete stool uniformly by liquid.
Investigation method
Each community random searching 5 point, often some investigation 3 strains, record occurring degree by staging, record diseased plant number, dead strain number or obviously withered plant number.
Stage division (by symptom type classification):
0 grade: healthy without disease;
1 grade: overground part only leaf, fruit has scab;
3 grades: terrestrial stem, branch have brown rot spot;
5 grades: basal part of stem has brown rot spot;
7 grades: terrestrial stem, branch and stem rot all have brown rot spot, and part branch is withered;
9 grades: complete stool is withered.
Test is investigated 4 times altogether, and before medicine, radix investigation, investigates after 7 days, the 2nd time medicine after the 1st medicine for 7 days and 14 days.
Drug effect computational methods
Poisoning is investigated: whether after dispenser, continuous 7d estimates medicament has poisoning to crop.
Result of the test and analysis
Each group of experimental pharmacy process to the control efficiency of capsicum epidemic disease in table 3
The effect of capsicum epidemic disease prevented and treated by table 3 respectively process
As known from Table 3, amisulbrom and mandipropamid bactericidal composition are with the ratio of 2:1, test by different amounts, complex preparation dosage is lower than single dose dosage, after dispenser, it is to the effect of the control efficiency of capsicum epidemic disease apparently higher than amisulbrom and mandipropamid single dose, and the lasting period is also better, is the desirable medicament preventing and treating epidemic disease, and to capsicum safety, the drug-fast generation of germ effectively can be delayed.
Example of formulations 1:
When preparing wetting powder bactericidal composition, the mass percent of each component is: amisulbrom 10%, mandipropamid 10%, dispersant 10%, wetting agent 8%, filler 62%;
Above dispersant is: polycarboxylate;
Wetting agent is: lauryl sodium sulfate;
Filler is: kaolin.
By above-mentioned weight proportion by amisulbrom and mandipropamid and the mixing of dispersant, wetting agent and filler, uniform stirring in stirred tank, mixes again, obtains wetting powder bactericidal composition after airslide disintegrating mill is pulverized.
Example of formulations 2:
When preparing wetting powder bactericidal composition, the mass percent of each component is: amisulbrom 10%, mandipropamid 20%, dispersant 8%, wetting agent 6%, filler 56%;
Above dispersant is: sodium lignin sulfonate;
Wetting agent is: lauryl sodium sulfate;
Filler is: kaolin
By above-mentioned weight proportion by amisulbrom and mandipropamid and the mixing of dispersant, wetting agent and filler, uniform stirring in stirred tank, mixes again, obtains wetting powder bactericidal composition after airslide disintegrating mill is pulverized.
Example of formulations 3:
When preparing the bactericidal composition of suspending agent, the percentage by weight of each component is: amisulbrom 12.5%, mandipropamid 12.5%, dispersant 10%, antifreezing agent 4%, thickener 1%, defoamer 0.4%, and surplus is water;
Dispersant is: alkylphenol polyoxyethylene;
Antifreezing agent is: ethylene glycol;
Thickener is: xanthans;
Defoamer is: silicone oil;
The concrete production stage of this suspending agent is: first mixed by above-mentioned proportioning by auxiliary agent, mix through high speed shear, add amisulbrom and mandipropamid, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all at below 5mm, obtain the bactericidal composition of aqueous suspension formulations.
Example of formulations 4:
When preparing the bactericidal composition of suspending agent, the percentage by weight of each component is: amisulbrom 5%, mandipropamid 15%, dispersant 15%, antifreezing agent 5%, thickener 2%, defoamer 0.6%, and surplus is water;
Dispersant is: lignosulfonates;
Antifreezing agent is: propane diols;
Thickener is: xanthans;
Defoamer is: silicone oil;
The concrete production stage of this suspending agent is: first mixed by above-mentioned proportioning by auxiliary agent, mix through high speed shear, add amisulbrom and mandipropamid, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all at below 5mm, obtain the bactericidal composition of aqueous suspension formulations.
Example of formulations 5:
When preparing the bactericidal composition of aqueous emulsion, the percentage by weight of each component is: amisulbrom 10%, mandipropamid 10%, emulsifier 10%, solvent 10%, stabilizing agent 3%, antifreezing agent 3%, defoamer 2%, thickener 1%, surplus are water;
Emulsifier is: calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether;
Solvent is: dimethylbenzene;
Stabilizing agent is: sodium citrate;
Antifreezing agent is: ethylene glycol;
Defoamer is: silicone oil;
Thickener is: xanthans;
The concrete production stage of this aqueous emulsion is: amisulbrom, mandipropamid, dimethylbenzene and emulsifier are mixed, and makes it to be dissolved into uniform oil phase; Water, antifreezing agent, stabilizing agent, thickener and defoamer are mixed uniformly aqueous phase; While high-speed stirred, oil phase is added aqueous phase in a kettle., slowly add water until reach phase inversion point, open clipper and carry out high speed shear, shear 20 minutes to 1 hour, form the aqueous emulsion of oil-in-water type, obtain the bactericidal composition of aqueous emulsion.
Example of formulations 6:
When preparing the bactericidal composition of water dispersible granules, the mass percent of each component is: amisulbrom 10%, mandipropamid 5%, dispersant 10%, wetting agent 8%, disintegrant 3%, filler 64%;
Dispersant is: fatty acid glyceride APEO;
Wetting agent: polyoxyethylene tri-styryl phosphenylic acid salt;
Disintegrant is: citric acid;
Filler is: bentonite;
The concrete production stage of this aqueous emulsion is: amisulbrom, mandipropamid and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then add in fluidized-bed granulation dryer and carry out granulation, drying, screening, obtain the bactericidal composition of water dispersant.
In sum, of the present invention with amisulbrom and mandipropamid for the composite bactericidal composition preparation of active ingredient, have good control efficiency to cucumber downy mildew and capsicum epidemic disease, and to crop safety.Complex preparation not only increases preventive effect, and has delayed germ to the drug-fast generation of medicament, and reduce peasant drug cost, so this compounded combination tool in production practices is of great significance.
Claims (3)
1. contain a preparation method for the bactericidal composition of amisulbrom and mandipropamid, it is characterized in that,
The active ingredient of this bactericidal composition is amisulbrom and mandipropamid binary built, and all the other are auxiliary element, and wherein, the mass ratio of amisulbrom and mandipropamid is 1:10 ~ 10:1;
Its formulation of described bactericidal composition is any one in wetting powder, suspending agent, aqueous emulsion, water dispersible granules, microemulsion;
When bactericidal composition is wetting powder, the percentage by weight of each component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, dispersant 1% ~ 20%, wetting agent 1% ~ 10%, filler 1% ~ 70%, by above-mentioned weight proportion, amisulbrom is mixed with mandipropamid and dispersant, wetting agent and filler, uniform stirring in stirred tank, mix again after airslide disintegrating mill is pulverized, obtain wetting powder bactericidal composition;
When bactericidal composition is suspending agent, the percentage by weight of each component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, dispersant 5% ~ 20%, antifreezing agent 1% ~ 5%, thickener 0.1% ~ 2%, defoamer 0.1% ~ 0.8%, surplus is water, the concrete production stage of this suspending agent is: first mixed by above-mentioned proportioning by auxiliary agent, mix through high speed shear, add amisulbrom and mandipropamid, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all at below 5mm, obtain the bactericidal composition of aqueous suspension formulations;
When bactericidal composition is aqueous emulsion, the percentage by weight of each component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, emulsifier 3% ~ 30%, solvent 5% ~ 15%, stabilizing agent 0.2% ~ 15%, antifreezing agent 0.1% ~ 5%, defoamer 0.1% ~ 8%, thickener 0.1% ~ 2%, surplus are water; The concrete production stage of this aqueous emulsion is: amisulbrom and mandipropamid, solvent and emulsifier are mixed, and makes it to be dissolved into uniform oil phase; Water, antifreezing agent, stabilizing agent, thickener and defoamer are mixed uniformly aqueous phase; While high-speed stirred, oil phase is added aqueous phase in a kettle., slowly add water until reach phase inversion point, open clipper and carry out high speed shear, shear 20 minutes to 1 hour, form the aqueous emulsion of oil-in-water type, obtain the bactericidal composition of aqueous emulsion;
When bactericidal composition is water dispersible granules, the mass percent of component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, dispersant 3% ~ 20%, wetting agent 3% ~ 10%, disintegrant 1% ~ 5%, filler 1% ~ 70%, the concrete production stage of this aqueous emulsion is: amisulbrom, mandipropamid and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then add in fluidized-bed granulation dryer and carry out granulation, drying, screening, obtain the bactericidal composition of water dispersant;
When bactericidal composition is microemulsion, the mass percent of component is: amisulbrom 1% ~ 60%, mandipropamid 1% ~ 60%, emulsifier 10% ~ 30%, antifreezing agent 1% ~ 8%, stabilizing agent 0.5% ~ 10%, Conventional solvents cosolvent 20% ~ 60%, surplus is supplied with water, the concrete production stage of this microemulsion is: amisulbrom and mandipropamid cosolvent are dissolved completely, add other compositions such as emulsifier, antifreezing agent, stabilizing agent again, Homogeneous phase mixing, finally adds after water fully stirs and can be made into microemulsion.
2. the preparation method of bactericidal composition according to claim 1, is characterized in that:
Described dispersant is: one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO;
Described wetting agent is: one or more in lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX, wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene tri-styryl phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder;
Described disintegrant is: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium bicarbonate;
Described emulsifier is: the mixture that one or more and calcium dodecyl benzene sulfonate in aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether form;
Described solvent is any one or more mixed solvents formed with arbitrary proportion in dimethylbenzene, biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), aqueous solvent;
Described filler is: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate;
Described thickener is: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol;
Described antifreezing agent is: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol;
Described stabilizing agent is: at least one in sodium citrate, resorcinol;
Described defoamer is: silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more in aliphatic alcohols compound.
3. bactericidal composition according to claim 1 is for preventing and treating the application in vegetables, grape, lichee, melon downy mildew and epidemic disease.
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| CN115039776B (en) * | 2021-03-08 | 2023-12-08 | 东莞市东阳光农药研发有限公司 | Composition containing mandipropamid and preparation method and application thereof |
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