CN106661031B - 吡咯并嘧啶化合物或其盐、含有其的药物组合物及应用 - Google Patents

吡咯并嘧啶化合物或其盐、含有其的药物组合物及应用 Download PDF

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Publication number
CN106661031B
CN106661031B CN201580034466.6A CN201580034466A CN106661031B CN 106661031 B CN106661031 B CN 106661031B CN 201580034466 A CN201580034466 A CN 201580034466A CN 106661031 B CN106661031 B CN 106661031B
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China
Prior art keywords
amino
ethynyl
methyl
base
pyrrolo
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Expired - Fee Related
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CN201580034466.6A
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English (en)
Chinese (zh)
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CN106661031A (zh
Inventor
水谷尊志
吉村千穗子
近藤瞳
北出诚
大久保秀一
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Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580034466.6A 2014-06-24 2015-06-24 吡咯并嘧啶化合物或其盐、含有其的药物组合物及应用 Expired - Fee Related CN106661031B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2014129740 2014-06-24
JP2014-129740 2014-06-24
JP2015024785 2015-02-10
JP2015-024785 2015-02-10
PCT/JP2015/068218 WO2015199136A1 (ja) 2014-06-24 2015-06-24 新規ピロロピリミジン化合物又はその塩、及びこれを含有する医薬組成物、特にｎａｅ阻害作用に基づく腫瘍等の予防剤及び／又は治療剤

Publications (2)

Publication Number Publication Date
CN106661031A CN106661031A (zh) 2017-05-10
CN106661031B true CN106661031B (zh) 2019-07-23

Family

ID=54938214

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580034466.6A Expired - Fee Related CN106661031B (zh) 2014-06-24 2015-06-24 吡咯并嘧啶化合物或其盐、含有其的药物组合物及应用

Country Status (21)

Country Link
US (2) US9963456B2 (https=)
EP (1) EP3103802B1 (https=)
JP (1) JP6192741B2 (https=)
KR (1) KR101947289B1 (https=)
CN (1) CN106661031B (https=)
AU (1) AU2015281155B9 (https=)
BR (1) BR112016025835B1 (https=)
CA (1) CA2946833C (https=)
DK (1) DK3103802T3 (https=)
ES (1) ES2656772T3 (https=)
HU (1) HUE037266T2 (https=)
MX (1) MX2016015015A (https=)
MY (1) MY183327A (https=)
NO (1) NO3103802T3 (https=)
PH (1) PH12016502130A1 (https=)
PL (1) PL3103802T3 (https=)
PT (1) PT3103802T (https=)
RU (1) RU2658008C2 (https=)
SG (1) SG11201608441YA (https=)
TW (1) TWI605048B (https=)
WO (1) WO2015199136A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI623316B (zh) * 2015-12-22 2018-05-11 Taiho Pharmaceutical Co Ltd Antitumor effect enhancer derived from pyrrolopyrimidine compound
WO2018085818A1 (en) * 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
WO2018085833A2 (en) * 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyl transferase 5 (prmt5)
WO2018089786A1 (en) * 2016-11-11 2018-05-17 Millennium Pharmaceuticals, Inc. Atg7 inhibitors and the uses thereof
WO2018110591A1 (ja) * 2016-12-13 2018-06-21 ヤマサ醤油株式会社 抗ウイルス活性を有する２'－デオキシ－７－デアザプリンヌクレオシド誘導体
JP7060694B2 (ja) * 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
CN108822145B (zh) * 2018-06-11 2020-10-23 广东工业大学 一种磺酰胺类化合物及其制备方法和应用
CN108640945B (zh) * 2018-06-11 2020-10-23 广东工业大学 一种酰胺类化合物及其制备方法与应用
AU2019301697A1 (en) * 2018-07-13 2021-01-07 Il-2Rx, Inc. Compounds, compositions, methods, and uses for treating cancer and immunological disorders

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084281A1 (en) * 2005-02-04 2006-08-10 Millennium Pharmaceuticals, Inc. Inhibitors of e1 activating enzymes
WO2007067559A2 (en) * 2005-12-06 2007-06-14 Regents Of The University Of Minnesota Antibacterial agents
WO2012061551A1 (en) * 2010-11-05 2012-05-10 Millennium Pharmaceuticals, Inc. Administration of nedd8-activating enzyme inhibitor
WO2013108809A1 (ja) * 2012-01-19 2013-07-25 大鵬薬品工業株式会社 ３，５－二置換ベンゼンアルキニル化合物及びその塩

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101450535B1 (ko) 2006-02-02 2014-10-14 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ１ 활성화 효소의 억제제
US9233964B2 (en) 2011-01-07 2016-01-12 Leo Pharma A/S Sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use therof
EP2738873A4 (en) * 2011-07-29 2015-04-01 Kuang Chi Innovative Tech Ltd ARTIFICIAL COMPOSITE MATERIAL AND ANTENNA PRODUCED FROM ARTIFICIAL COMPOSITE MATERIAL

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084281A1 (en) * 2005-02-04 2006-08-10 Millennium Pharmaceuticals, Inc. Inhibitors of e1 activating enzymes
WO2007067559A2 (en) * 2005-12-06 2007-06-14 Regents Of The University Of Minnesota Antibacterial agents
WO2012061551A1 (en) * 2010-11-05 2012-05-10 Millennium Pharmaceuticals, Inc. Administration of nedd8-activating enzyme inhibitor
WO2013108809A1 (ja) * 2012-01-19 2013-07-25 大鵬薬品工業株式会社 ３，５－二置換ベンゼンアルキニル化合物及びその塩

Also Published As

Publication number Publication date
KR20170016510A (ko) 2017-02-13
US9963456B2 (en) 2018-05-08
US20180162864A1 (en) 2018-06-14
US10174040B2 (en) 2019-01-08
RU2658008C2 (ru) 2018-06-19
JP6192741B2 (ja) 2017-09-06
TW201625629A (zh) 2016-07-16
PH12016502130B1 (en) 2016-12-19
KR101947289B1 (ko) 2019-02-12
EP3103802B1 (en) 2017-11-08
PL3103802T3 (pl) 2018-02-28
PT3103802T (pt) 2017-12-11
AU2015281155A1 (en) 2016-11-03
HUE037266T2 (hu) 2018-08-28
WO2015199136A1 (ja) 2015-12-30
AU2015281155B9 (en) 2017-11-16
PH12016502130A1 (en) 2016-12-19
NO3103802T3 (https=) 2018-04-07
RU2016149319A3 (https=) 2018-06-18
CA2946833A1 (en) 2015-12-30
EP3103802A1 (en) 2016-12-14
JPWO2015199136A1 (ja) 2017-04-27
EP3103802A4 (en) 2017-03-08
BR112016025835A2 (https=) 2017-08-15
CN106661031A (zh) 2017-05-10
BR112016025835B1 (pt) 2022-09-20
SG11201608441YA (en) 2016-11-29
MY183327A (en) 2021-02-18
TWI605048B (zh) 2017-11-11
US20170066772A1 (en) 2017-03-09
RU2016149319A (ru) 2018-06-18
MX2016015015A (es) 2017-02-27
CA2946833C (en) 2019-03-05
AU2015281155B2 (en) 2017-07-13
ES2656772T3 (es) 2018-02-28
DK3103802T3 (en) 2017-12-11

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