CN106659834B - 用于去除血液中的促炎介质以及粒细胞和单核细胞的系统 - Google Patents

用于去除血液中的促炎介质以及粒细胞和单核细胞的系统 Download PDF

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Publication number
CN106659834B
CN106659834B CN201580045367.8A CN201580045367A CN106659834B CN 106659834 B CN106659834 B CN 106659834B CN 201580045367 A CN201580045367 A CN 201580045367A CN 106659834 B CN106659834 B CN 106659834B
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blood
membrane
filter
line
shell
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Expired - Fee Related
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CN201580045367.8A
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English (en)
Chinese (zh)
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CN106659834A (zh
Inventor
博多·冯·哈尔滕
德特勒夫·克里特
霍斯特·迪特尔·莱姆克
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3M Innovative Properties Co
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3M Innovative Properties Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/3406—Physical characteristics of the filtrate, e.g. urea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/341—Regulation parameters by measuring the filtrate rate or volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0014—Special media to be introduced, removed or treated removed from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • A61M2202/0441—Granulocytes, i.e. leucocytes containing many granules in their cytoplasm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • A61M2202/0443—Macrophages, e.g. monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0445—Proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • External Artificial Organs (AREA)
CN201580045367.8A 2014-08-26 2015-08-25 用于去除血液中的促炎介质以及粒细胞和单核细胞的系统 Expired - Fee Related CN106659834B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14182261.9 2014-08-26
EP14182261 2014-08-26
PCT/EP2015/069415 WO2016030357A1 (de) 2014-08-26 2015-08-25 System zur entfernung von proinflammatorischen mediatoren sowie von granulozyten und monozyten aus blut

Publications (2)

Publication Number Publication Date
CN106659834A CN106659834A (zh) 2017-05-10
CN106659834B true CN106659834B (zh) 2019-06-18

Family

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CN201580045367.8A Expired - Fee Related CN106659834B (zh) 2014-08-26 2015-08-25 用于去除血液中的促炎介质以及粒细胞和单核细胞的系统

Country Status (5)

Country Link
US (1) US20170266362A1 (enExample)
EP (1) EP3185926B1 (enExample)
JP (1) JP2017525489A (enExample)
CN (1) CN106659834B (enExample)
WO (1) WO2016030357A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3473327A1 (en) 2017-10-19 2019-04-24 3M Innovative Properties Company Integrated fluid treatment device, and process using such device
US20220273855A1 (en) * 2019-08-01 2022-09-01 Seastar Medical, Inc. Device and method for preparing a donor organ for transplantation
CN112511569B (zh) * 2021-02-07 2021-05-11 杭州筋斗腾云科技有限公司 网络资源访问请求的处理方法、系统及计算机设备

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060144782A1 (en) * 2002-12-20 2006-07-06 Reinhold Buck Perm selective asymmetric hollow fibre membrane for the separation of toxic mediators from blood
CN101057141A (zh) * 2004-07-30 2007-10-17 汉斯-维尔纳·海因里希 一种从流体中分离细胞、生物颗粒和/或分子以应用于动物、生物技术(包括生物学研究)和医疗诊断的方法和仪器
WO2008083965A2 (de) * 2007-01-13 2008-07-17 Membrana Gmbh Vorrichtung zur entfernung von leukozyten aus blut
US20130161247A1 (en) * 2011-12-21 2013-06-27 Infomed Sa Apparatus for Blood Purification by Extracorporeal Circulation

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2077137B (en) 1980-03-12 1983-09-07 Asahi Chemical Ind Granulocyte-separating material and granulocyte separator
DE3578502D1 (de) 1984-03-15 1990-08-09 Asahi Medical Co Filtereinheit zum abtrennen von leukozyten.
JP2673567B2 (ja) 1987-12-10 1997-11-05 株式会社日本抗体研究所 血液中の顆粒球除去方法及びこれに用いる顆粒球除去装置
DE69119683T2 (de) 1990-07-27 1996-10-02 Pall Corp Filtereinrichtung zur Entfernung von Leukozyten und Methode zur Verwendung
ATE197547T1 (de) 1991-08-22 2000-12-15 Asahi Medical Co Filtermedium zur selektiven entfernung von leukozyten und entsprechende vorrichtung
DE69314154T2 (de) 1992-12-28 1998-04-30 Asahi Medical Co Filtermaterial, Vorrichtung und Verfahren zum Abtrennen von Leukozyten
US5571418A (en) 1993-08-20 1996-11-05 Lee; Patrice A. Hemofiltration of toxic mediator-related disease
ES2234183T3 (es) 1996-02-06 2005-06-16 Bellco S.P.A. Separacion por absorcion de citoquinas de un paciente afectado por el fallo agudo de un organo.
KR100343092B1 (ko) 1997-08-28 2002-07-05 추후보충 백혈구-제거용 여과재
US6287516B1 (en) 1998-07-10 2001-09-11 Immunocept, L.L.C. Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease
JP4643830B2 (ja) 1999-03-17 2011-03-02 株式会社Jimro 疾患の処置
DE19913707A1 (de) 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
EP1409041A4 (en) 2001-07-25 2007-05-16 Immunocept L L C HEMOFILTRATION SYSTEMS, METHODS AND DEVICES FOR THE TREATMENT OF DISEASES RELATED TO INFLAMMATION MEDIATORS
WO2003033053A1 (en) 2001-10-16 2003-04-24 Asahi Medical Co., Ltd. Method of selectively eliminating virus and leukocytes, eliminating material and eliminating apparatus
ATE414724T1 (de) 2002-06-17 2008-12-15 Asahi Kasei Kuraray Medical Co Biokompatibles polymer und filter zur selektiven eliminierung von leukozyten mit dem polymer
ITTO20020736A1 (it) 2002-08-21 2004-02-22 Fresenius Hemocare Italia Srl Filtro per leucociti e suo impiego per l'impoverimento di prodotti del sangue da leucociti.
JP2006503670A (ja) 2002-10-25 2006-02-02 ポール コーポレイション 生物学的流体フィルタ
EP1582228B2 (en) 2002-12-02 2019-03-13 Asahi Kasei Medical Co., Ltd. Method of removing leukocytes, leukocyte-removing filter and utilization thereof
ITTO20030039A1 (it) 2003-01-24 2004-07-25 Fresenius Hemocare Italia Srl Filtro per separare leucociti da sangue intero e/o da preparati derivati dal sangue, procedimento per la fabbricazione del filtro, dispositivo e utilizzazione.
DE60311240T2 (de) 2003-07-03 2007-07-05 Fresenius Hemocare Italia S.R.L., Cavezzo Filter zur Entfernung von Substanzen aus Blutprodukten
US8999167B2 (en) 2003-08-07 2015-04-07 Asahi Kasei Medical Co., Ltd. Composite porous membrane and process for producing the same
ES2562354T3 (es) 2004-06-09 2016-03-03 Asahi Kasei Medical Co., Ltd. Procedimiento para eliminar leucocitos y filtro para su utilización en el mismo
JP4787842B2 (ja) 2004-12-10 2011-10-05 フレゼニウス・ヘモケア・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ とくに生体液を濾過するための多孔性ウェブ
US20090311770A1 (en) 2005-05-20 2009-12-17 Arkray, Inc. Method of collecting microorganisms using fine particles, method of collecting nucleic acids using fine particles, and kits for use in the these methods
EP1931445B1 (en) 2005-08-31 2018-08-01 Gambro Lundia AB Cyclic olefin copolymer as a leukoreduction material
KR101256363B1 (ko) 2005-09-09 2013-04-25 멤브라나 게엠베하 혈액으로부터 백혈구의 제거방법
EP1897571A1 (en) 2006-09-06 2008-03-12 Fresenius Hemocare Italia S.r.l. A filter for the removal of substances from blood products
EP1944046B1 (en) 2007-01-12 2010-08-11 Bellco S.r.l. Kit for treating a systematic inflammation related diseases
ES3033913T3 (en) * 2007-08-31 2025-08-11 Seastar Medical Inc Selective cytopheresis devices
TWI446939B (zh) 2008-04-14 2014-08-01 Asahi Kasei Medical Co Ltd The filter method for removing the filter material and the blood preparation
EP2380610B1 (en) * 2010-04-20 2014-05-07 Gambro Lundia AB High cut-off hemodialysis membrane for use in liver dialysis
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
CA2844688C (en) 2011-08-12 2021-10-19 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
EP2735359B1 (en) * 2012-11-26 2017-02-08 Gambro Lundia AB Integrated device for liver support systems

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060144782A1 (en) * 2002-12-20 2006-07-06 Reinhold Buck Perm selective asymmetric hollow fibre membrane for the separation of toxic mediators from blood
CN101057141A (zh) * 2004-07-30 2007-10-17 汉斯-维尔纳·海因里希 一种从流体中分离细胞、生物颗粒和/或分子以应用于动物、生物技术(包括生物学研究)和医疗诊断的方法和仪器
WO2008083965A2 (de) * 2007-01-13 2008-07-17 Membrana Gmbh Vorrichtung zur entfernung von leukozyten aus blut
US20130161247A1 (en) * 2011-12-21 2013-06-27 Infomed Sa Apparatus for Blood Purification by Extracorporeal Circulation

Also Published As

Publication number Publication date
EP3185926A1 (de) 2017-07-05
US20170266362A1 (en) 2017-09-21
CN106659834A (zh) 2017-05-10
WO2016030357A1 (de) 2016-03-03
JP2017525489A (ja) 2017-09-07
EP3185926B1 (de) 2018-11-28

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