JP7359550B2 - 血液から病原性毒素を除去するための装置、該装置を備える体外潅流システム、および該装置を製造する方法 - Google Patents
血液から病原性毒素を除去するための装置、該装置を備える体外潅流システム、および該装置を製造する方法 Download PDFInfo
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- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
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- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
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- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
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- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
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- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
- B01D39/02—Loose filtering material, e.g. loose fibres
- B01D39/04—Organic material, e.g. cellulose, cotton
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
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- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/20—Pathogenic agents
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
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- A61M2207/00—Methods of manufacture, assembly or production
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/04—Additives and treatments of the filtering material
- B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/04—Additives and treatments of the filtering material
- B01D2239/0471—Surface coating material
- B01D2239/0492—Surface coating material on fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/46—Impregnation
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- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Description
4 装置
6 ヒト
8 第1ライン
10 第1ポンプ
12 ハウジング
14 中空ファイバ
16 第2ポンプ
18 第2ライン
20 第3ライン
22 第4ライン
24 遮断バルブ
26 第1ポート
28 第2ポート
30 第1カバーキャップ
32 第2カバーキャップ
34 細孔
36 機能化表面
38 病原性毒素
40 内表面
42 外表面
44 血液
46 血漿
48 血液細胞
50 (血液適合性で抗凝固性の)コーティング
Claims (6)
- 体外潅流システム(2)において血漿(46)と細胞成分(48)とを含む血液(44)から負荷電の病原性毒素(38)を除去する装置(4)であって、
ハウジング(12)と、
前記ハウジング(12)内に設けられるとともに、前記血液(44)によって潅流されるように構成された複数の中空ファイバ(14)とを有し、
前記中空ファイバ(14)は、複数の細孔(34)を有し、前記細孔(34)は、前記血液(44)の前記血漿(46)が、前記中空ファイバ(14)の内側から当該中空ファイバ(14)の外側へと当該細孔(34)を通って流れることができるように構成され、
前記中空ファイバ(14)は、前記負荷電の病原性毒素をそれ自体に結合して前記血液から除去する正電荷の機能化表面(36)を備えるように、化学的に改変又は化学的に前処理されている装置において、
前記中空ファイバの内表面(40)のみが、前記血液(44)が前記中空ファイバ(14)を通って流れる時に、当該血液(44)の前記細胞成分(48)のダメージを防止するための血液適合性かつ抗凝固性のコーティング(50)を更に備え、
前記中空ファイバ(14)の前記細孔(34)及び外表面(42)のみが前記機能化表面(36)を備え、前記中空ファイバ(14)の前記内表面(40)は前記機能化表面(36)が存在しない、装置(4)。 - 前記中空ファイバ(14)の前記内表面(40)上の前記コーティング(50)は、それ自体に前記病原性毒素(38)を結合して前記血液から除去する前記中空ファイバ(14)の前記機能化表面(36)に対して適合性であり、前記機能化表面(36)に対して前記コーティング(50)が前記中空ファイバ(14)の内側において施されている、請求項1に記載の装置(4)。
- 請求項1に記載の、血液(44)から病原性病毒(38)を除去するための装置(4)と、
前記血液(44)の前記血漿(46)を、前記中空ファイバ(14)から前記細孔(34)を介して搬出すると共に、前記装置(4)の下流側において、前記装置(4)を通って流れた前記血液(44)に戻し供給するポンプ(16)とを有する、体外潅流システム(2)。 - 血液(44)から負荷電の病原性毒素(38)を除去するための装置(4)を製造する方法であって、
複数の多孔性中空ファイバ(14)を作る工程(a)と、
前記負荷電の病原性毒素(38)をそれ自体に結合して前記血液(44)から除去する正電荷の機能化表面(36)を備えるように、前記中空ファイバ(14)を化学的に改変又は化学的に前処理する工程(b)と、
前記複数の多孔性中空ファイバ(14)をハウジング(12)に挿入する工程(c)と、
前記中空ファイバ(14)の細孔(34)及び外表面(42)のみが前記機能化表面(36)を備え、前記中空ファイバ(14)の内表面(40)は前記機能化表面(36)が存在しないようにするため、負荷電陰イオン溶液を、前記ハウジング(12)内に配置された前記複数の多孔性中空ファイバ(14)の内側に通して流す工程(d)とを含み、
前記工程(a)から(d)は時系列的に行われる、方法。 - 前記溶液の量と流速とを調節する工程(e)を更に含み、前記工程(e)は前記工程(d)の前に行われる、請求項4に記載の方法。
- 前記溶液が前記中空ファイバ(14)に導入される前に、前記ハウジング(12)を出口側で閉じる工程(f)を更に含む、請求項4に記載の方法。
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DE102018104177.2A DE102018104177A1 (de) | 2018-02-23 | 2018-02-23 | Vorrichtung zur Entfernung von Noxen aus Blut, extrakorporales Perfusionssystem mit einer solchen Vorrichtung sowie Verfahren zur Herstellung einer solchen Vorrichtung |
DE102018104177.2 | 2018-02-23 |
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US (1) | US20190262528A1 (ja) |
EP (1) | EP3530302A1 (ja) |
JP (1) | JP7359550B2 (ja) |
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AU2019474912B2 (en) * | 2019-11-19 | 2022-02-17 | Immunicom, Inc. | System and method for removal of immune inhibitors from biological fluids |
US20210146029A1 (en) | 2019-11-19 | 2021-05-20 | Immunicom, Inc. | System and method for removal of immune inhibitors from biological fluids |
TWI762833B (zh) * | 2019-11-19 | 2022-05-01 | 美商英謬免疫股份有限公司 | 自生物流體中移除免疫抑制劑之系統及方法 |
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US20050045554A1 (en) * | 2003-08-28 | 2005-03-03 | Gambro Lundia Ab | Membrane unit element, semipermeable membrane, filtration device, and processes for manufacturing the same |
DE502004003217D1 (de) * | 2004-06-03 | 2007-04-26 | Braun Medizintechnologie Gmbh | Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie Verwendung zur Herstellung eines Mittels zur Entfernung dieser Stoffe |
SE0401834D0 (sv) * | 2004-07-09 | 2004-07-09 | Gambro Lundia Ab | A continuous method for production of a regioselective porous hollow fibre membrane |
AT507847B1 (de) * | 2009-01-22 | 2011-12-15 | Fresenius Medical Care De Gmbh | Sorptionsmittel zum entfernen proteingebundener substanzen |
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2018
- 2018-02-23 DE DE102018104177.2A patent/DE102018104177A1/de active Pending
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- 2019-02-07 EP EP19155913.7A patent/EP3530302A1/de active Pending
- 2019-02-15 US US16/277,187 patent/US20190262528A1/en not_active Abandoned
- 2019-02-21 CN CN201910129356.8A patent/CN110180046A/zh active Pending
- 2019-02-21 CN CN201920219735.1U patent/CN211410390U/zh active Active
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Patent Citations (6)
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US20040228829A1 (en) | 2003-03-11 | 2004-11-18 | Roberts Craig P. | Plasma detoxification system and methods of use |
US20060264355A1 (en) | 2003-09-17 | 2006-11-23 | Markus Storr | Separating material |
JP2006288866A (ja) | 2005-04-13 | 2006-10-26 | Toyobo Co Ltd | 中空糸型血液浄化膜への表面改質剤コーティング方法、表面改質剤コート中空糸型血液浄化膜および表面改質剤コート中空糸型血液浄化器 |
US20120226258A1 (en) | 2009-08-07 | 2012-09-06 | Veit Otto | Device and method for eliminating biologically harmful substances from bodily fluids |
JP2013500797A (ja) | 2009-08-07 | 2013-01-10 | ヘモテック アーゲー | 体液から生物学的に有害な物質を除去するための装置及び方法 |
US20160074569A1 (en) | 2013-06-27 | 2016-03-17 | Mann+Hummel Gmbh | Polymeric Whole Blood Hollow Fiber Membrane Filter Medium and Use Thereof For Separating Blood Plasma/Serum From Whole Blood |
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DE102018104177A1 (de) | 2019-08-29 |
US20190262528A1 (en) | 2019-08-29 |
CN211410390U (zh) | 2020-09-04 |
EP3530302A1 (de) | 2019-08-28 |
CN110180046A (zh) | 2019-08-30 |
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