CN106620811A - 一种采用静电纺丝法制备纳米纤维敷料的方法 - Google Patents

一种采用静电纺丝法制备纳米纤维敷料的方法 Download PDF

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CN106620811A
CN106620811A CN201611008759.XA CN201611008759A CN106620811A CN 106620811 A CN106620811 A CN 106620811A CN 201611008759 A CN201611008759 A CN 201611008759A CN 106620811 A CN106620811 A CN 106620811A
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李长英
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Shaanxi Yipinda Petrochemical Co Ltd
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Abstract

本发明公开了一种采用静电纺丝法制备纳米纤维敷料的方法，以六氟异丙醇为溶剂配制0.1g/mL的I型胶原蛋白溶液，加入利多卡因，得到外层纺丝液；以二氯甲烷为溶剂配制0.2 g/mL的聚己内酯溶液，并加入莫匹罗星，得到内层纺丝液；将外层纺丝液和内层纺丝液分别加入2个注射器中，由同轴针头连接形成同轴结构进行高压静电纺丝，将得到的敷料真空干燥后浸泡在京尼平的乙醇溶液中，用乙醇洗涤后干燥，得到纳米纤维敷料。制备的纳米纤维敷料具有更高溶胀率和力学强度，更适合作为湿性敷料使用并在吸收伤口渗出液，在耐长期使用性和抗菌性等方面具有优势。

Description

一种采用静电纺丝法制备纳米纤维敷料的方法
技术领域
本发明属于医用敷料的制备领域，具体涉及一种采用静电纺丝法制备纳米纤维敷料的方法。
背景技术
医用敷料是重要的辅助医疗用品，主要用于外科创伤、烧伤和各种慢性病引起的皮肤溃烂的治疗。早期的敷料仅具有简单保护和防止感染的单一功能。随着医疗技术的不断发展，具有减轻患者痛苦、可吸收渗出液和抗菌以防止感染、减少疤痕与收缩、促使愈合等作用的功能性敷料应运而生，并在临床上承担起越来越重要的作用。
电纺丝技术在敷料制备中具有出色的可调控性，通过电纺丝技术制备的敷料也具有透气及比表面积大等优点，已逐渐成为医用敷料制备的主流技术之一。目前，现有的医用敷料在作为湿性敷料时，强度较弱，抗菌效果不佳。
发明内容
本发明提供一种采用静电纺丝法制备纳米纤维敷料的方法，制备的敷料具有核壳结构，作为湿性敷料时仍然具有较好的效果。
一种采用静电纺丝法制备纳米纤维敷料的方法，包括以下步骤：
（1）以六氟异丙醇为溶剂配制0.1g/mL的I型胶原蛋白溶液，加入利多卡因，得到外层纺丝液；
（2）以二氯甲烷为溶剂配制0.2 g/mL的聚己内酯溶液，并加入莫匹罗星，得到内层纺丝液；
（3）将步骤（1）和步骤（2）得到的外层纺丝液和内层纺丝液分别加入2个注射器中，由同轴针头连接形成同轴结构进行高压静电纺丝，纺丝参数：正电压17kV，负电压-3 kV，内层PCL流速为3mL/h，外层胶原为1 mL/h，接收距离为15cm，将得到的敷料于室温下真空干燥24h；
（4）将步骤（3）得到的敷料浸泡在0.1g/mL的京尼平的乙醇溶液中，反应3 h，用乙醇洗涤敷料3次，于室温下真空干燥24 h，得到纳米纤维敷料。
步骤（1）中利多卡因的纯度为98%，加入量为0.015g/mL。
步骤（2）中莫匹罗星的加入量为0.08 g/mL。
本发明提供的方法制备的纳米纤维敷料具有核壳纤维结构，在敷料纤维的外壳和内核之中分别负载了利多卡因和莫匹罗星，利多卡因是临床常用的局部麻药，吸收后可以有效抑制人体的疼痛感，莫匹罗星则可以用于预防和治疗各种细菌性皮肤感染，对伤口的感染起到良好的预防作用，内核的聚己内酯可以提供机械强度和维持敷料使用时的形状完整性，制备的纳米纤维敷料具有更高溶胀率和力学强度，更适合作为湿性敷料使用并在吸收伤口渗出液，在耐长期使用性和抗菌性等方面具有优势。
具体实施例方式
实施例1。
一种采用静电纺丝法制备纳米纤维敷料的方法，包括以下步骤：
（1）以六氟异丙醇为溶剂配制0.1g/mL的I型胶原蛋白溶液，加入利多卡因，得到外层纺丝液；
（2）以二氯甲烷为溶剂配制0.2 g/mL的聚己内酯溶液，并加入莫匹罗星，得到内层纺丝液；
（3）将步骤（1）和步骤（2）得到的外层纺丝液和内层纺丝液分别加入2个注射器中，由同轴针头连接形成同轴结构进行高压静电纺丝，纺丝参数：正电压17kV，负电压-3 kV，内层PCL流速为3mL/h，外层胶原为1 mL/h，接收距离为15cm，将得到的敷料于室温下真空干燥24h；
（4）将步骤（3）得到的敷料浸泡在0.1g/mL的京尼平的乙醇溶液中，反应3 h，用乙醇洗涤敷料3次，于室温下真空干燥24 h，得到纳米纤维敷料。
步骤（1）中利多卡因的纯度为98%，加入量为0.015g/mL。
步骤（2）中莫匹罗星的加入量为0.08 g/mL。

Claims (3)

1.一种采用静电纺丝法制备纳米纤维敷料的方法，其特征在于：包括以下步骤：
（1）以六氟异丙醇为溶剂配制0.1g/mL的I型胶原蛋白溶液，加入利多卡因，得到外层纺丝液；
（2）以二氯甲烷为溶剂配制0.2 g/mL的聚己内酯溶液，并加入莫匹罗星，得到内层纺丝液；
（3）将步骤（1）和步骤（2）得到的外层纺丝液和内层纺丝液分别加入2个注射器中，由同轴针头连接形成同轴结构进行高压静电纺丝，纺丝参数：正电压17kV，负电压-3 kV，内层PCL流速为3mL/h，外层胶原为1 mL/h，接收距离为15cm，将得到的敷料于室温下真空干燥24h；
（4）将步骤（3）得到的敷料浸泡在0.1g/mL的京尼平的乙醇溶液中，反应3 h，用乙醇洗涤敷料3次，于室温下真空干燥24 h，得到纳米纤维敷料。
2.根据权利要求1所述的一种采用静电纺丝法制备纳米纤维敷料的方法，其特征在于：步骤（1）中利多卡因的纯度为98%，加入量为0.015g/mL。
3. 根据权利要求1所述的一种采用静电纺丝法制备纳米纤维敷料的方法，其特征在于：步骤（2）中莫匹罗星的加入量为0.08 g/mL。
CN201611008759.XA 2016-11-16 2016-11-16 一种采用静电纺丝法制备纳米纤维敷料的方法 Pending CN106620811A (zh)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108324986A (zh) * 2018-05-03 2018-07-27 东华大学 一种急性创伤用多功能有序释药医用敷膜及其制备方法
CN108524999A (zh) * 2018-05-03 2018-09-14 东华大学 一种慢性伤口用pH敏感型长效修复医用敷膜及其制备方法
CN111330063A (zh) * 2020-01-21 2020-06-26 广东工业大学 一种纳米纤维膜及其制备方法
CN111793900A (zh) * 2020-06-15 2020-10-20 中国人民解放军陆军特色医学中心 一种壳聚糖/聚己内酯复合纳米纤维膜材料及其应用
CN113244438A (zh) * 2021-04-29 2021-08-13 五邑大学 一种三维糖尿病足溃疡功能性医用敷料的制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108324986A (zh) * 2018-05-03 2018-07-27 东华大学 一种急性创伤用多功能有序释药医用敷膜及其制备方法
CN108524999A (zh) * 2018-05-03 2018-09-14 东华大学 一种慢性伤口用pH敏感型长效修复医用敷膜及其制备方法
CN108324986B (zh) * 2018-05-03 2021-09-07 东华大学 一种急性创伤用多功能有序释药医用敷膜及其制备方法
CN111330063A (zh) * 2020-01-21 2020-06-26 广东工业大学 一种纳米纤维膜及其制备方法
CN111793900A (zh) * 2020-06-15 2020-10-20 中国人民解放军陆军特色医学中心 一种壳聚糖/聚己内酯复合纳米纤维膜材料及其应用
CN113244438A (zh) * 2021-04-29 2021-08-13 五邑大学 一种三维糖尿病足溃疡功能性医用敷料的制备方法

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Application publication date: 20170510