CN107335089A - 一种改性亲水性聚氨酯敷料及其制备方法 - Google Patents

一种改性亲水性聚氨酯敷料及其制备方法 Download PDF

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CN107335089A
CN107335089A CN201611269241.1A CN201611269241A CN107335089A CN 107335089 A CN107335089 A CN 107335089A CN 201611269241 A CN201611269241 A CN 201611269241A CN 107335089 A CN107335089 A CN 107335089A
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吴代斌
殷星
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ANHUI JIANYUAN MEDICAL INSTRUMENT EQUIPMENT Co Ltd
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Abstract

一种改性亲水性聚氨酯敷料及其制备方法，该敷料包括如下组分：聚氨酯20‑40份，胶原蛋白25‑40份，透明质酸5‑10份，壳聚糖5‑8份，蛋清1‑4份，海藻酸钠20‑30份，虫草提取物1‑4份，银纳米溶液8‑13份，羧甲基纤维素10‑20份，竹纤维12‑18份，乙酰基纤维素钠12‑20份。制备方法：按重量份称取各组分；将聚氨酯、胶原蛋白、透明质酸、壳聚糖、蛋清和海藻酸钠在反应釜中融化，降至50‑60℃后，加入其余原料，降温脱泡得第一混合物备用；将第一混合物涂布在胶体层上，自然干燥后封装得改性亲水性聚氨酯敷料。与现有技术相比，具有较好的保湿性能，对皮肤无刺激，抑菌效果好，适合大面积推广和应用。

Description

一种改性亲水性聚氨酯敷料及其制备方法
技术领域
本发明涉及生物医用敷料领域，具体涉及一种改性亲水性聚氨酯敷料及其制备方法。
背景技术
近年来医用辅料市场增长空间很大，传统敷料为脱脂纱布，吸收生理液能力有限，并且更换时易触碰到伤口，引起二次感染。
当前，医生使用敷料的目的不仅是覆盖创面，更是为了促进伤口愈合。现有敷料的性能多样，但是敷料本身的性能有待提高，如防水，吸收伤口渗透液的能力较差，并且使用2-3小时，敷料上细菌数目较多，急需要研发一种促进伤口愈合、为人们减轻疼痛。
发明内容
针对现有技术的不足，本发明的目的在于提供一种改性亲水性聚氨酯敷料及其制备方法，该敷料抗菌效果好，吸收渗透液效果好，对皮肤无刺激，不易引起二次污染。
为解决现有技术问题，本发明采取的技术方案为：
一种改性亲水性聚氨酯敷料，包括如下按重量份计的组分：聚氨酯20-40份，胶原蛋白25-40份，透明质酸5-10份，壳聚糖5-8份，蛋清1-4份，海藻酸钠20-30份，虫草提取物1-4份，银纳米溶液8-13份，羧甲基纤维素10-20份，竹纤维12-18份，乙酰基纤维素钠12-20份。
作为改进的是，上述改性亲水性聚氨酯敷料，包括如下按重量份计的组分：聚氨酯25-35份，胶原蛋白28-35份，透明质酸6-8份，壳聚糖6-7份，蛋清2-3份，海藻酸钠22-28份，虫草提取物2-3份，银纳米溶液10-12份，羧甲基纤维素12-18份，竹纤维14-16份，乙酰基纤维素钠14-16份。
作为改进的是，上述改性亲水性聚氨酯敷料，包括如下按重量份计的组分：聚氨酯30份，胶原蛋白30份，透明质酸7份，壳聚糖7份，蛋清3份，海藻酸钠28份，虫草提取物3份，银纳米溶液11份，羧甲基纤维素16份，竹纤维15份，乙酰基纤维素钠15份。
上述改性亲水性聚氨酯敷料的制备方法，包括以下步骤：
步骤1，按重量份称取各组分；
步骤2，将聚氨酯、胶原蛋白、透明质酸、壳聚糖、蛋清和海藻酸钠在反应釜中融化，降至50-60℃后，加入其余原料，降温脱泡得第一混合物备用；
步骤3，将第一混合物涂布在胶体层上，自然干燥后封装得改性亲水性聚氨酯敷料。
作为改进的是，步骤2中融化温度为200-210℃。
作为改进的是，步骤3中涂布方式为旋涂。
有益效果
与现有技术相比，本发明改性亲水性聚氨酯敷料具有较好的保湿性能，抑菌效果好，对皮肤无刺激，制备方法简单，对设备要求较低，适合大面积推广和应用。
具体实施方式
以下对本发明的具体实施方式进行详细说明。
实施例1
一种改性亲水性聚氨酯敷料，包括如下按重量份计的组分：聚氨酯20份，胶原蛋白25份，透明质酸5份，壳聚糖5份，蛋清1份，海藻酸钠20份，虫草提取物1份，银纳米溶液8份，羧甲基纤维素10份，竹纤维12份，乙酰基纤维素钠12份。
上述改性亲水性聚氨酯敷料的制备方法，包括以下步骤：
步骤1，按重量份称取各组分；
步骤2，将聚氨酯、胶原蛋白、透明质酸、壳聚糖、蛋清和海藻酸钠在反应釜中融化，降至50℃后，加入其余原料，降温脱泡得第一混合物备用；
步骤3，将第一混合物涂布在胶体层上，自然干燥后封装得改性亲水性聚氨酯敷料。
其中，步骤2中融化温度为200℃；步骤3中涂布方式为旋涂。
实施例2
一种改性亲水性聚氨酯敷料，包括如下按重量份计的组分：聚氨酯30份，胶原蛋白30份，透明质酸7份，壳聚糖7份，蛋清3份，海藻酸钠28份，虫草提取物3份，银纳米溶液11份，羧甲基纤维素16份，竹纤维15份，乙酰基纤维素钠15份。
上述改性亲水性聚氨酯敷料的制备方法，包括以下步骤：
步骤1，按重量份称取各组分；
步骤2，将聚氨酯、胶原蛋白、透明质酸、壳聚糖、蛋清和海藻酸钠在反应釜中融化，降至55℃后，加入其余原料，降温脱泡得第一混合物备用；
步骤3，将第一混合物涂布在胶体层上，自然干燥后封装得改性亲水性聚氨酯敷料。
其中，步骤2中融化温度为205℃；步骤3中涂布方式为旋涂。
实施例3
一种改性亲水性聚氨酯敷料，包括如下按重量份计的组分：聚氨酯40份，胶原蛋白40份，透明质酸10份，壳聚糖8份，蛋清4份，海藻酸钠30份，虫草提取物4份，银纳米溶液13份，羧甲基纤维素20份，竹纤维18份，乙酰基纤维素钠20份。
上述改性亲水性聚氨酯敷料的制备方法，包括以下步骤：
步骤1，按重量份称取各组分；
步骤2，将聚氨酯、胶原蛋白、透明质酸、壳聚糖、蛋清和海藻酸钠在反应釜中融化，降至50-60℃后，加入其余原料，降温脱泡得第一混合物备用；
步骤3，将第一混合物涂布在胶体层上，自然干燥后封装得改性亲水性聚氨酯敷料。
其中，步骤2中融化温度为210℃；步骤3中涂布方式为旋涂。
性能测试：
分别测定本发明实施例1-3制备的敷料的性能，包括皮肤致敏反应测定和保湿效果测定，结果如表1 所示。
皮肤致敏反应测定：按GB/T16886.10-2005规定的封闭式致敏试验方法进行测定。
表1
组别 皮肤致敏反应 12小时后细菌增长率（%））
实施例1 无致敏 10
实施例2 无致敏 8
实施例3 无致敏 12
由上表可以看出，本发明制备的皮肤用亲水性聚氨酯创伤敷料生物相容性好，对皮肤无刺激，此外保湿效果好且持久，抑菌效果好，其中实施例2的效果最佳。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (6)

1.一种改性亲水性聚氨酯敷料，其特征在于，包括如下按重量份计的组分：聚氨酯20-40份，胶原蛋白25-40份，透明质酸5-10份，壳聚糖5-8份，蛋清1-4份，海藻酸钠20-30份，虫草提取物1-4份，银纳米溶液8-13份，羧甲基纤维素10-20份，竹纤维12-18份，乙酰基纤维素钠12-20份。
2.根据权利要求1所述的改性亲水性聚氨酯敷料，其特征在于，包括如下按重量份计的组分：聚氨酯25-35份，胶原蛋白28-35份，透明质酸6-8份，壳聚糖6-7份，蛋清2-3份，海藻酸钠22-28份，虫草提取物2-3份，银纳米溶液10-12份，羧甲基纤维素12-18份，竹纤维14-16份，乙酰基纤维素钠14-16份。
3.根据权利要求1所述的改性亲水性聚氨酯敷料，其特征在于，包括如下按重量份计的组分：聚氨酯30份，胶原蛋白30份，透明质酸7份，壳聚糖7份，蛋清3份，海藻酸钠28份，虫草提取物3份，银纳米溶液11份，羧甲基纤维素16份，竹纤维15份，乙酰基纤维素钠15份。
4.基于一种权利要求1所述的改性亲水性聚氨酯敷料的制备方法，其特征在于，包括如下步骤：
步骤1，按重量份称取各组分；
步骤2，将聚氨酯、胶原蛋白、透明质酸、壳聚糖、蛋清和海藻酸钠在反应釜中融化，降至50-60℃后，加入其余原料，降温脱泡得第一混合物备用；
步骤3，将第一混合物涂布在胶体层上，自然干燥后封装得改性亲水性聚氨酯敷料。
5.根据权利要求4所述的改性亲水性聚氨酯敷料的制备方法，其特征在于，步骤2中融化温度为200-210℃。
6.根据权利要求4所述的改性亲水性聚氨酯敷料的制备方法，其特征在于，步骤3中涂布方式为旋涂。
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CN109224114A (zh) * 2018-10-10 2019-01-18 广州润虹医药科技股份有限公司 一种泡沫敷料及其制备方法和应用
CN109432486A (zh) * 2018-11-08 2019-03-08 广州润虹医药科技股份有限公司 一种速效止血纱、其制备方法以及应用
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