CN106588888A - 一种制备高纯度l-苹果酸舒尼替尼的方法 - Google Patents
一种制备高纯度l-苹果酸舒尼替尼的方法 Download PDFInfo
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- CN106588888A CN106588888A CN201510672610.0A CN201510672610A CN106588888A CN 106588888 A CN106588888 A CN 106588888A CN 201510672610 A CN201510672610 A CN 201510672610A CN 106588888 A CN106588888 A CN 106588888A
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- 0 CC*(CC)CC*(C)C(C1=C(C)*C(C(CC)=C2c3cc(N)ccc3*(*)C2=O)=C1C)=O Chemical compound CC*(CC)CC*(C)C(C1=C(C)*C(C(CC)=C2c3cc(N)ccc3*(*)C2=O)=C1C)=O 0.000 description 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN201510672610.0A CN106588888B (zh) | 2015-10-16 | 2015-10-16 | 一种制备高纯度l-苹果酸舒尼替尼的方法 |
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CN201510672610.0A CN106588888B (zh) | 2015-10-16 | 2015-10-16 | 一种制备高纯度l-苹果酸舒尼替尼的方法 |
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CN106588888A true CN106588888A (zh) | 2017-04-26 |
CN106588888B CN106588888B (zh) | 2021-02-26 |
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CN201510672610.0A Active CN106588888B (zh) | 2015-10-16 | 2015-10-16 | 一种制备高纯度l-苹果酸舒尼替尼的方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111138416A (zh) * | 2020-01-03 | 2020-05-12 | 南京华威医药科技集团有限公司 | 一种l-苹果酸舒尼替尼e式异构体的制备方法 |
CN112321569A (zh) * | 2020-10-12 | 2021-02-05 | 福建南方制药股份有限公司 | 抗肿瘤药物舒尼替尼合成中难除杂质的控制方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013162390A1 (en) * | 2012-04-27 | 2013-10-31 | Instytut Farmaceutyczny | Process for preparation of high purity n- [2- (diethylamine) ethyl] - 5 - formyl - 2, 4 - dimethyl - 1h - pyrrole - 3 - carboxyamide |
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2015
- 2015-10-16 CN CN201510672610.0A patent/CN106588888B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013162390A1 (en) * | 2012-04-27 | 2013-10-31 | Instytut Farmaceutyczny | Process for preparation of high purity n- [2- (diethylamine) ethyl] - 5 - formyl - 2, 4 - dimethyl - 1h - pyrrole - 3 - carboxyamide |
Non-Patent Citations (1)
Title |
---|
BERNARD MILLER: "《高等有机化学——反应和机理》", 31 March 2005, 华东理工大学出版社 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111138416A (zh) * | 2020-01-03 | 2020-05-12 | 南京华威医药科技集团有限公司 | 一种l-苹果酸舒尼替尼e式异构体的制备方法 |
CN111138416B (zh) * | 2020-01-03 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种l-苹果酸舒尼替尼e式异构体的制备方法 |
CN112321569A (zh) * | 2020-10-12 | 2021-02-05 | 福建南方制药股份有限公司 | 抗肿瘤药物舒尼替尼合成中难除杂质的控制方法 |
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CN106588888B (zh) | 2021-02-26 |
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Effective date of registration: 20180518 Address after: 226200 Jiangsu Qidong Economic Development Zone Binjiang Fine Chemical Park No. 3, Jiang Feng Road. Applicant after: JIANGSU ACEBRIGHT PHARMACEUTICALS Co.,Ltd. Applicant after: ARIZEST (SHANGHAI) PHARMATECH Co.,Ltd. Applicant after: SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP Co.,Ltd. Address before: 201203 room 687-21, 2 building, No. 351, Guo Shou Jing Road, Zhangjiang hi tech park, Pudong New Area, Shanghai. Applicant before: SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP Co.,Ltd. |
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Address after: 226200 No.3 Jiangfeng Road, Qidong life and Health Industrial Park, Nantong City, Jiangsu Province Patentee after: JIANGSU XIDI PHARMACEUTICAL Co.,Ltd. Patentee after: ARIZEST (SHANGHAI) PHARMATECH Co.,Ltd. Patentee after: SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP Co.,Ltd. Address before: 226200 Jiangsu Qidong Economic Development Zone Binjiang Fine Chemical Park No. 3, Jiang Feng Road. Patentee before: JIANGSU ACEBRIGHT PHARMACEUTICALS Co.,Ltd. Patentee before: ARIZEST (SHANGHAI) PHARMATECH Co.,Ltd. Patentee before: SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP Co.,Ltd. |
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