CN106574276B - 生物反应器过程的控制 - Google Patents

生物反应器过程的控制 Download PDF

Info

Publication number
CN106574276B
CN106574276B CN201580042314.0A CN201580042314A CN106574276B CN 106574276 B CN106574276 B CN 106574276B CN 201580042314 A CN201580042314 A CN 201580042314A CN 106574276 B CN106574276 B CN 106574276B
Authority
CN
China
Prior art keywords
flow rate
set point
measured
containing substrate
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580042314.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN106574276A (zh
Inventor
C·科利特
G·W·沃特斯
J·C·布罗姆利
J·Y·杨
J·N·威尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanzatech NZ Inc
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Publication of CN106574276A publication Critical patent/CN106574276A/zh
Application granted granted Critical
Publication of CN106574276B publication Critical patent/CN106574276B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/12—Bioreactors or fermenters specially adapted for specific uses for producing fuels or solvents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201580042314.0A 2014-07-11 2015-05-06 生物反应器过程的控制 Active CN106574276B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/329,881 2014-07-11
US14/329,881 US9617566B2 (en) 2014-07-11 2014-07-11 Control of bioreactor processes
PCT/US2015/029563 WO2016007216A1 (en) 2014-07-11 2015-05-06 Control of bioreactor processes

Publications (2)

Publication Number Publication Date
CN106574276A CN106574276A (zh) 2017-04-19
CN106574276B true CN106574276B (zh) 2020-11-06

Family

ID=55064652

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580042314.0A Active CN106574276B (zh) 2014-07-11 2015-05-06 生物反应器过程的控制

Country Status (13)

Country Link
US (2) US9617566B2 (enExample)
EP (2) EP3766983A1 (enExample)
JP (2) JP6599427B2 (enExample)
KR (1) KR102531892B1 (enExample)
CN (1) CN106574276B (enExample)
BR (1) BR112017000449B1 (enExample)
CA (2) CA3024631C (enExample)
EA (1) EA033036B1 (enExample)
ES (1) ES2841337T3 (enExample)
PL (1) PL3167068T3 (enExample)
PT (1) PT3167068T (enExample)
TW (2) TWI673366B (enExample)
WO (1) WO2016007216A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10017789B2 (en) 2015-03-25 2018-07-10 The Board Of Regents For Oklahoma State University System and method for feedback control of gas supply for ethanol production via syngas fermentation using pH as a key control indicator
US10167445B2 (en) * 2016-04-04 2019-01-01 Hong Peng Cell culture monitoring system with low power consumption
AU2018329846B2 (en) * 2017-09-08 2024-01-11 Lanzatech, Inc. Processes and systems for metabolite production using hydrogen rich C1-containing substrates
JP7314151B2 (ja) * 2018-02-09 2023-07-25 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー バイオプロセッシングのための使い捨てキット
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
KR102276219B1 (ko) * 2019-02-15 2021-07-12 씨제이제일제당 (주) 생물반응기의 운전 조건을 결정하는 장치 및 방법
KR102494796B1 (ko) * 2020-04-20 2023-02-01 현대제철 주식회사 바이오 연료 제조방법
WO2022217282A1 (en) 2021-04-09 2022-10-13 Lanzatech, Inc. Process and apparatus for providing a feedstock

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1444658A (zh) * 2000-07-25 2003-09-24 生物工程资源股份有限公司 提高微生物发酵生产乙醇的方法
CN102016052A (zh) * 2007-08-15 2011-04-13 兰扎泰克新西兰有限公司 生产醇的工艺
CN102471783A (zh) * 2009-07-02 2012-05-23 新西兰郎泽科技公司 醇生产方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
WO2000019848A1 (en) 1998-10-02 2000-04-13 William Bruce Campbell Watkins Measuring article and method for sizing compression garments
MXPA01011301A (es) 1999-05-07 2003-07-14 Bioengineering Resources Inc Cepas clostridium que produce etanol a partir de gases que contienen substrato.
US20090104594A1 (en) * 2004-12-29 2009-04-23 Biogen Idec Bioreactor Process Control System and Method
NZ546496A (en) 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
NZ553984A (en) 2007-03-19 2009-07-31 Lanzatech New Zealand Ltd Alcohol production process
NZ560757A (en) 2007-10-28 2010-07-30 Lanzatech New Zealand Ltd Improved carbon capture in microbial fermentation of industrial gases to ethanol
KR20130084704A (ko) * 2008-03-12 2013-07-25 란자테크 뉴질랜드 리미티드 미생물 알콜 생산 방법
JP5726760B2 (ja) 2009-01-29 2015-06-03 ランザテク・ニュージーランド・リミテッド アルコールの製造方法
CA2784519A1 (en) 2009-12-22 2011-06-30 Ge Healthcare Bio-Sciences Ab A method for controlling culture parameters in a bioreactor
TWI509073B (zh) 2010-05-04 2015-11-21 Lanzatech New Zealand Ltd 改良之廢氣醱酵作用
CA2786903C (en) * 2010-07-28 2015-01-20 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof for producing ethanol and acetate
US20130130339A1 (en) 2010-07-31 2013-05-23 Myriant Corporation Fermentation process for the production of organic acids
MY159783A (en) 2010-10-22 2017-01-31 Lanzatech New Zealand Ltd Methods and systems for the production of alcohols and/or acids
MY158746A (en) 2010-10-22 2016-11-15 Lanzatech New Zealand Ltd Methods and systems for the production of hydrocarbon products
AU2011320544B2 (en) 2010-10-29 2014-05-01 Lanzatech Nz, Inc. Methods and systems for the production of hydrocarbon products
US20130252277A1 (en) * 2010-12-03 2013-09-26 Ineos Bio Sa Method of operation of fermentation of carbon monoxide containing gaseous substrate
US10100338B2 (en) * 2012-05-22 2018-10-16 Ineos Bio S.A. Method of operation of a syngas fermentation process
US10233478B2 (en) 2012-09-19 2019-03-19 Ineos Bio Sa Process for reducing CO2 emissions and increasing alcohol productivity in syngas fermentation
WO2014081848A1 (en) 2012-11-20 2014-05-30 Butamax Advanced Biofuels Llc Butanol purification

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1444658A (zh) * 2000-07-25 2003-09-24 生物工程资源股份有限公司 提高微生物发酵生产乙醇的方法
CN102016052A (zh) * 2007-08-15 2011-04-13 兰扎泰克新西兰有限公司 生产醇的工艺
CN102471783A (zh) * 2009-07-02 2012-05-23 新西兰郎泽科技公司 醇生产方法

Also Published As

Publication number Publication date
JP2019193636A (ja) 2019-11-07
CA2954496A1 (en) 2016-01-14
CA2954496C (en) 2019-01-08
US20170175064A1 (en) 2017-06-22
BR112017000449A2 (pt) 2017-11-07
EP3167068A1 (en) 2017-05-17
US9617566B2 (en) 2017-04-11
TW201625801A (zh) 2016-07-16
JP2017521077A (ja) 2017-08-03
BR112017000449B1 (pt) 2022-10-25
TWI673366B (zh) 2019-10-01
PL3167068T3 (pl) 2021-04-19
CA3024631A1 (en) 2016-01-14
KR102531892B1 (ko) 2023-05-11
EA201790136A1 (ru) 2017-05-31
TW201920688A (zh) 2019-06-01
EP3167068B1 (en) 2020-10-28
KR20170028389A (ko) 2017-03-13
US20160010116A1 (en) 2016-01-14
US11753612B2 (en) 2023-09-12
EA033036B1 (ru) 2019-08-30
EP3766983A1 (en) 2021-01-20
WO2016007216A1 (en) 2016-01-14
JP6955531B2 (ja) 2021-10-27
ES2841337T3 (es) 2021-07-08
PT3167068T (pt) 2020-12-21
EP3167068A4 (en) 2018-03-21
CA3024631C (en) 2022-03-15
TWI649426B (zh) 2019-02-01
JP6599427B2 (ja) 2019-10-30
CN106574276A (zh) 2017-04-19

Similar Documents

Publication Publication Date Title
CN106574276B (zh) 生物反应器过程的控制
JP5726760B2 (ja) アルコールの製造方法
CN107002012B (zh) 多阶段生物反应器方法
CN102471783A (zh) 醇生产方法
CN112689680A (zh) 一氧化碳和二氧化碳生物转化方法
CN103443282B (zh) 含有一氧化碳和氢气的气态底物的发酵操作方法
KR20140010010A (ko) 비 co-흡수 조절을 포함하는 발효 방법
CN114929884A (zh) 生物转化的过程控制

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP02 Change in the address of a patent holder
CP02 Change in the address of a patent holder

Address after: Illinois, America

Patentee after: LANZATECH NEW ZEALAND Ltd.

Address before: Oakland, New Zealand

Patentee before: LANZATECH NEW ZEALAND Ltd.