TWI673366B - 生物反應器過程之控制 - Google Patents
生物反應器過程之控制 Download PDFInfo
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- TWI673366B TWI673366B TW107146822A TW107146822A TWI673366B TW I673366 B TWI673366 B TW I673366B TW 107146822 A TW107146822 A TW 107146822A TW 107146822 A TW107146822 A TW 107146822A TW I673366 B TWI673366 B TW I673366B
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- Prior art keywords
- flow rate
- bioreactor
- concentration
- measured
- productivity
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- 238000000034 method Methods 0.000 title claims abstract description 109
- 230000008569 process Effects 0.000 title abstract description 52
- 238000004590 computer program Methods 0.000 claims abstract description 12
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 190
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 190
- 241000894006 Bacteria Species 0.000 claims description 73
- 239000000758 substrate Substances 0.000 claims description 73
- 239000002207 metabolite Substances 0.000 claims description 65
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- 238000006243 chemical reaction Methods 0.000 claims description 12
- 235000016709 nutrition Nutrition 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 134
- 230000001580 bacterial effect Effects 0.000 abstract description 28
- 239000000047 product Substances 0.000 abstract description 21
- 230000012010 growth Effects 0.000 abstract description 19
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- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 12
- 239000000908 ammonium hydroxide Substances 0.000 description 12
- 238000000855 fermentation Methods 0.000 description 12
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
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- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 2
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- 239000007864 aqueous solution Substances 0.000 description 2
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- 239000003245 coal Substances 0.000 description 2
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- 239000012467 final product Substances 0.000 description 2
- 239000003502 gasoline Substances 0.000 description 2
- 239000005431 greenhouse gas Substances 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
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- 229910052757 nitrogen Inorganic materials 0.000 description 2
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- 230000003204 osmotic effect Effects 0.000 description 2
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- 241001148471 unidentified anaerobic bacterium Species 0.000 description 2
- 241001468161 Acetobacterium Species 0.000 description 1
- QTXZASLUYMRUAN-QLQASOTGSA-N Acetyl coenzyme A (Acetyl-CoA) Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1.O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QTXZASLUYMRUAN-QLQASOTGSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 241001112696 Clostridia Species 0.000 description 1
- 241000186566 Clostridium ljungdahlii Species 0.000 description 1
- 241001611023 Clostridium ragsdalei Species 0.000 description 1
- 241000186541 Desulfotomaculum Species 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- 241000186394 Eubacterium Species 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000178985 Moorella Species 0.000 description 1
- 241000178986 Oxobacter Species 0.000 description 1
- 241000192031 Ruminococcus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000000789 acetogenic effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
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- 239000000809 air pollutant Substances 0.000 description 1
- 231100001243 air pollutant Toxicity 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000010310 bacterial transformation Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
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- 229910002090 carbon oxide Inorganic materials 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 230000001419 dependent effect Effects 0.000 description 1
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- 230000001627 detrimental effect Effects 0.000 description 1
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- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000002803 fossil fuel Substances 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- -1 hydroxide compound Chemical class 0.000 description 1
- 210000001822 immobilized cell Anatomy 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
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- 230000000670 limiting effect Effects 0.000 description 1
- ZDGGJQMSELMHLK-UHFFFAOYSA-N m-Trifluoromethylhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC(C(F)(F)F)=C1 ZDGGJQMSELMHLK-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000696 methanogenic effect Effects 0.000 description 1
- 239000003345 natural gas Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
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- 230000035899 viability Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/12—Bioreactors or fermenters specially adapted for specific uses for producing fuels or solvents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B99/00—Subject matter not provided for in other groups of this subclass
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Computer Hardware Design (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/329,881 | 2014-07-11 | ||
| US14/329,881 US9617566B2 (en) | 2014-07-11 | 2014-07-11 | Control of bioreactor processes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201920688A TW201920688A (zh) | 2019-06-01 |
| TWI673366B true TWI673366B (zh) | 2019-10-01 |
Family
ID=55064652
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW107146822A TWI673366B (zh) | 2014-07-11 | 2015-06-02 | 生物反應器過程之控制 |
| TW104117847A TWI649426B (zh) | 2014-07-11 | 2015-06-02 | 生物反應器過程之控制 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104117847A TWI649426B (zh) | 2014-07-11 | 2015-06-02 | 生物反應器過程之控制 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9617566B2 (enExample) |
| EP (2) | EP3766983A1 (enExample) |
| JP (2) | JP6599427B2 (enExample) |
| KR (1) | KR102531892B1 (enExample) |
| CN (1) | CN106574276B (enExample) |
| BR (1) | BR112017000449B1 (enExample) |
| CA (2) | CA3024631C (enExample) |
| EA (1) | EA033036B1 (enExample) |
| ES (1) | ES2841337T3 (enExample) |
| PL (1) | PL3167068T3 (enExample) |
| PT (1) | PT3167068T (enExample) |
| TW (2) | TWI673366B (enExample) |
| WO (1) | WO2016007216A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10017789B2 (en) | 2015-03-25 | 2018-07-10 | The Board Of Regents For Oklahoma State University | System and method for feedback control of gas supply for ethanol production via syngas fermentation using pH as a key control indicator |
| US10167445B2 (en) * | 2016-04-04 | 2019-01-01 | Hong Peng | Cell culture monitoring system with low power consumption |
| AU2018329846B2 (en) * | 2017-09-08 | 2024-01-11 | Lanzatech, Inc. | Processes and systems for metabolite production using hydrogen rich C1-containing substrates |
| JP7314151B2 (ja) * | 2018-02-09 | 2023-07-25 | グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー | バイオプロセッシングのための使い捨てキット |
| US10889792B2 (en) | 2018-02-09 | 2021-01-12 | Global Life Sciences Solutions Usa Llc | Cell expansion vessel systems and methods |
| KR102276219B1 (ko) * | 2019-02-15 | 2021-07-12 | 씨제이제일제당 (주) | 생물반응기의 운전 조건을 결정하는 장치 및 방법 |
| KR102494796B1 (ko) * | 2020-04-20 | 2023-02-01 | 현대제철 주식회사 | 바이오 연료 제조방법 |
| WO2022217282A1 (en) | 2021-04-09 | 2022-10-13 | Lanzatech, Inc. | Process and apparatus for providing a feedstock |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Family Cites Families (24)
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|---|---|---|---|---|
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
| WO2000019848A1 (en) | 1998-10-02 | 2000-04-13 | William Bruce Campbell Watkins | Measuring article and method for sizing compression garments |
| MXPA01011301A (es) | 1999-05-07 | 2003-07-14 | Bioengineering Resources Inc | Cepas clostridium que produce etanol a partir de gases que contienen substrato. |
| NZ523484A (en) * | 2000-07-25 | 2005-01-28 | Emmaus Foundation Inc | Methods for increasing the production of ethanol from microbial fermentation |
| US20090104594A1 (en) * | 2004-12-29 | 2009-04-23 | Biogen Idec | Bioreactor Process Control System and Method |
| NZ546496A (en) | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
| NZ553984A (en) | 2007-03-19 | 2009-07-31 | Lanzatech New Zealand Ltd | Alcohol production process |
| WO2009022925A1 (en) | 2007-08-15 | 2009-02-19 | Lanzatech New Zealand Limited | Processes of producing alcohols |
| NZ560757A (en) | 2007-10-28 | 2010-07-30 | Lanzatech New Zealand Ltd | Improved carbon capture in microbial fermentation of industrial gases to ethanol |
| KR20130084704A (ko) * | 2008-03-12 | 2013-07-25 | 란자테크 뉴질랜드 리미티드 | 미생물 알콜 생산 방법 |
| JP5726760B2 (ja) | 2009-01-29 | 2015-06-03 | ランザテク・ニュージーランド・リミテッド | アルコールの製造方法 |
| CA2784519A1 (en) | 2009-12-22 | 2011-06-30 | Ge Healthcare Bio-Sciences Ab | A method for controlling culture parameters in a bioreactor |
| TWI509073B (zh) | 2010-05-04 | 2015-11-21 | Lanzatech New Zealand Ltd | 改良之廢氣醱酵作用 |
| CA2786903C (en) * | 2010-07-28 | 2015-01-20 | Lanzatech New Zealand Limited | Novel bacteria and methods of use thereof for producing ethanol and acetate |
| US20130130339A1 (en) | 2010-07-31 | 2013-05-23 | Myriant Corporation | Fermentation process for the production of organic acids |
| MY159783A (en) | 2010-10-22 | 2017-01-31 | Lanzatech New Zealand Ltd | Methods and systems for the production of alcohols and/or acids |
| MY158746A (en) | 2010-10-22 | 2016-11-15 | Lanzatech New Zealand Ltd | Methods and systems for the production of hydrocarbon products |
| AU2011320544B2 (en) | 2010-10-29 | 2014-05-01 | Lanzatech Nz, Inc. | Methods and systems for the production of hydrocarbon products |
| US20130252277A1 (en) * | 2010-12-03 | 2013-09-26 | Ineos Bio Sa | Method of operation of fermentation of carbon monoxide containing gaseous substrate |
| US10233478B2 (en) | 2012-09-19 | 2019-03-19 | Ineos Bio Sa | Process for reducing CO2 emissions and increasing alcohol productivity in syngas fermentation |
| WO2014081848A1 (en) | 2012-11-20 | 2014-05-30 | Butamax Advanced Biofuels Llc | Butanol purification |
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| WO2013176948A2 (en) * | 2012-05-22 | 2013-11-28 | Ineos Bio Sa | Method of operation of a syngas fermentation process |
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