CN106565748A - 头孢呋辛钠及其制剂的制备方法 - Google Patents
头孢呋辛钠及其制剂的制备方法 Download PDFInfo
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- CN106565748A CN106565748A CN201610871443.7A CN201610871443A CN106565748A CN 106565748 A CN106565748 A CN 106565748A CN 201610871443 A CN201610871443 A CN 201610871443A CN 106565748 A CN106565748 A CN 106565748A
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- CN
- China
- Prior art keywords
- preparation
- cefuroxime
- added
- sodium
- solution
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610871443.7A CN106565748B (zh) | 2016-09-30 | 2016-09-30 | 头孢呋辛钠及其制剂的制备方法 |
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CN201610871443.7A CN106565748B (zh) | 2016-09-30 | 2016-09-30 | 头孢呋辛钠及其制剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN106565748A true CN106565748A (zh) | 2017-04-19 |
CN106565748B CN106565748B (zh) | 2019-03-22 |
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CN201610871443.7A Active CN106565748B (zh) | 2016-09-30 | 2016-09-30 | 头孢呋辛钠及其制剂的制备方法 |
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CN (1) | CN106565748B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110437260A (zh) * | 2019-08-27 | 2019-11-12 | 石药集团中诺药业(石家庄)有限公司 | 一种头孢呋辛钠原料和注射剂及其制备方法 |
CN110950892A (zh) * | 2019-12-16 | 2020-04-03 | 山东金城柯瑞化学有限公司 | 一种头孢呋辛中间体(3-去氨甲酰基-头孢呋酸)优化除杂的方法 |
CN114437111A (zh) * | 2022-02-14 | 2022-05-06 | 成都晶富医药科技有限公司 | 注射用头孢呋辛钠及其制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775750A (en) * | 1983-07-29 | 1988-10-04 | Glaxo Group Limited | Process for preparing sodium cefuroxime |
WO2000071547A1 (en) * | 1999-05-21 | 2000-11-30 | Antibioticos S.P.A. | A PROCESS FOR THE PREPARATION OF β-LACTAM DERIVATIVES |
CN101054386A (zh) * | 2006-11-12 | 2007-10-17 | 西南合成制药股份有限公司 | 头孢呋辛钠的合成方法 |
CN101613359A (zh) * | 2009-08-07 | 2009-12-30 | 哈药集团制药总厂 | 头孢呋辛钠合成方法 |
CN101812076A (zh) * | 2009-02-24 | 2010-08-25 | 丽珠医药集团股份有限公司 | 头孢呋辛钠及其制备方法 |
CN101941982A (zh) * | 2009-11-24 | 2011-01-12 | 中国医药集团总公司四川抗菌素工业研究所 | 药用头孢雷特的制备新方法 |
CN102134252A (zh) * | 2010-01-27 | 2011-07-27 | 四平市精细化学品有限公司 | 一种高纯头孢呋辛酸的制备方法 |
CN104513256A (zh) * | 2013-10-07 | 2015-04-15 | 鲁南贝特制药有限公司 | 一种头孢妥仑匹酯的制备方法 |
-
2016
- 2016-09-30 CN CN201610871443.7A patent/CN106565748B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775750A (en) * | 1983-07-29 | 1988-10-04 | Glaxo Group Limited | Process for preparing sodium cefuroxime |
WO2000071547A1 (en) * | 1999-05-21 | 2000-11-30 | Antibioticos S.P.A. | A PROCESS FOR THE PREPARATION OF β-LACTAM DERIVATIVES |
CN101054386A (zh) * | 2006-11-12 | 2007-10-17 | 西南合成制药股份有限公司 | 头孢呋辛钠的合成方法 |
CN101812076A (zh) * | 2009-02-24 | 2010-08-25 | 丽珠医药集团股份有限公司 | 头孢呋辛钠及其制备方法 |
CN101613359A (zh) * | 2009-08-07 | 2009-12-30 | 哈药集团制药总厂 | 头孢呋辛钠合成方法 |
CN101941982A (zh) * | 2009-11-24 | 2011-01-12 | 中国医药集团总公司四川抗菌素工业研究所 | 药用头孢雷特的制备新方法 |
CN102134252A (zh) * | 2010-01-27 | 2011-07-27 | 四平市精细化学品有限公司 | 一种高纯头孢呋辛酸的制备方法 |
CN104513256A (zh) * | 2013-10-07 | 2015-04-15 | 鲁南贝特制药有限公司 | 一种头孢妥仑匹酯的制备方法 |
Non-Patent Citations (2)
Title |
---|
刘哲封: "头孢呋辛酯及头孢呋辛钠合成工艺进展", 《河北化工》 * |
曹卫凯: "头孢呋辛钠的合成研究", 《精细石油化工进展》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110437260A (zh) * | 2019-08-27 | 2019-11-12 | 石药集团中诺药业(石家庄)有限公司 | 一种头孢呋辛钠原料和注射剂及其制备方法 |
CN110437260B (zh) * | 2019-08-27 | 2021-12-31 | 石药集团中诺药业(石家庄)有限公司 | 一种头孢呋辛钠原料和注射剂及其制备方法 |
CN110950892A (zh) * | 2019-12-16 | 2020-04-03 | 山东金城柯瑞化学有限公司 | 一种头孢呋辛中间体(3-去氨甲酰基-头孢呋酸)优化除杂的方法 |
CN114437111A (zh) * | 2022-02-14 | 2022-05-06 | 成都晶富医药科技有限公司 | 注射用头孢呋辛钠及其制备方法 |
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CB03 | Change of inventor or designer information |
Inventor after: Yang Mengde Inventor after: Du Jinsong Inventor after: Zheng Baoli Inventor after: Yoshida Inventor after: Gao Yanxia Inventor after: Zhang Suoqing Inventor after: Hu Limin Inventor after: Gong Junbo Inventor after: Liu Shiping Inventor after: Liu Haixi Inventor after: Liu Xuefei Inventor after: Jia Yujie Inventor before: Yang Mengde Inventor before: Yoshida Inventor before: Zhang Suoqing Inventor before: Hu Limin Inventor before: Liu Shiping Inventor before: Liu Haixi Inventor before: Liu Xuefei Inventor before: Jia Yujie Inventor before: Du Jinsong Inventor before: Zheng Baoli |
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