CN106561998A - Micro-capsule coating sodium butyrate and preparation method thereof - Google Patents
Micro-capsule coating sodium butyrate and preparation method thereof Download PDFInfo
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- CN106561998A CN106561998A CN201610999456.2A CN201610999456A CN106561998A CN 106561998 A CN106561998 A CN 106561998A CN 201610999456 A CN201610999456 A CN 201610999456A CN 106561998 A CN106561998 A CN 106561998A
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Abstract
The invention discloses micro-capsule coating sodium butyrate and a preparation method thereof. The method comprises the steps of (1) accurately weighing raw materials in proportion, wherein the raw materials comprise sodium butyrate, antimicrobial peptide, tonifying powder, glucose, polyethylene glycol and drinking water; (2) mixing the sodium butyrate, the tonifying powder, the glucose and the drinking water; (3) heating the polyethylene glycol, and adding the heat polyethylene glycol into an obtained mixed material for continuously mixing; (4) naturally cooling an obtained mixed material, and then adding antimicrobial peptide for continuously mixing; (5) granulating a mixed material; (6) drying the granulated material; (7) sampling and inspecting; (8) packaging qualified products, and indicating batches; and (9) inspecting and putting in storage. The invention further discloses the micro-capsule coating sodium butyrate prepared by the invention. According to the micro-capsule coating sodium butyrate and the preparation method thereof provided by the invention, the intestine development of beasts and birds can be promoted, the growth and the propagation of harmful bacteria can be inhibited, the occurrence of intestinal diseases is prevented, and the economic benefit is increased.
Description
Technical field
The present invention relates to a kind of bio-additive, in particular it relates to a kind of micro-capsule coating sodium butyrate and preparation method thereof.
Background technology
The development of aquaculture more Come is more modernized, and resource is more and more nervous, and animal protection is increasingly stricter, and (foreign countries advocate always
Animal welfare is led, current China still belongs to blank), the such as how minimum maximum benefit of people's output of throwing is that all intensive cultures are supported
All over the most important thing being concerned about, but the breeding way of limitation at present, raising population density is big, scope of activities is little, and physique cannot be forged
Refining, eating and be conversion ratio by high complete feed, the function for causing livestock and poultry body is constantly weakened, physique is deteriorated, susceptible disease,
Under the influence of the stressed conditions such as environment, weather, often cause full mass-sending disease, increase expenses for medicine input, feed conversion rate is reduced, and is made
Into larger economic loss.
Healthy aquaculture has become the focus of aquaculture concern, is also very urgent requirement.Research shows, the enteron aisle of livestock and poultry
Health is in close relations with the health status of livestock and poultry, keeps complete health stomach, and feed nutrient can be avoided to be lost in, and reduces material
Egg ratio or feedstuff-meat ratio, excrement foul smell is significantly reduced, and disease resistance of livestock and poultry is significantly increased, and the incidence of disease and death rate are effectively controlled
System.It can be seen that, safeguard that poultry stomach health is to realize the key of poultry healthy aquaculture.
At present, because sodium butyrate is used as a kind of deacetylase inhibitor, it is possible to increase acetylation of histone level, can be with
Feed intake, the price of deed and daily gain are improved, strengthens animal health level, reduce diarrhoea and the death rate, therefore be widely used in poultry
Fowl feed adds.But sodium butyrate there is also in the application very big defect：For example there is cacosmia taste, impact is recognized feed quality
Can；It is stronger to the excitant of esophagus and stomach；Easily the moisture absorption, affects the crudy of feed；Enteron aisle each segmentation cannot be met right
The nutritional need of butyric acid, it is most by intestinal absorption, it is difficult to colon site can be reached；Active ingredient can not cross stomach, difficult
With into enteron aisle etc..
The content of the invention
It is an object of the invention to provide a kind of animal feed additive and preparation method thereof, existing sodium butyrate is overcome as adding
Plus the defect of agent, promote animal and bird intestines development, fundamentally improve animal and bird intestines and nutriment in feed is digested and assimilated, most
The performance animal body transformation of limits, suppresses pernicious bacteria growth and breeding, prevents the generation of intestines problem, improves livestock and poultry
Growth performance, increase economic benefit.
In order to achieve the above object, the invention provides a kind of micro-capsule is coated with the preparation method of sodium butyrate, wherein, the method bag
Contain：Step 1, accurately weighs in proportion each raw material, and described raw material includes sodium butyrate, antibacterial peptide, auxiliary beneficial powder, glucose, poly- second
Glycol and drinking water；Step 2, by the mixing of sodium butyrate, auxiliary beneficial powder, glucose and drinking water；Step 3, polyethylene glycol is heated
Add afterwards after step 2 mixing in the material of gained, continuation mixes；Step 4, the material Temperature fall of gained after step 3 is mixed,
Then antibacterial peptide is added, continues to mix；Step 5, the material that step 4 is mixed carries out particle making；Step 6, by step 5
Dry materials after granulation；Step 7, samples censorship；Step 8, certified products packaging indicates batch in packaging outer bag；Step 9,
Put in storage after inspection, pile up neat, cleaning.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, sodium butyrate, antibacterial peptide, auxiliary beneficial powder described in step 1,
Glucose, polyethylene glycol and drinking water, its weight ratio is 120:36:54:50:4:5.Described auxiliary beneficial powder is a kind of water-soluble
Solid dispersible carrier, main component is inorganic salts, soluble starch and other auxiliary materials, as the readily soluble auxiliary material of veterinary drug of new generation, is come
Source is commercially available.Described antibacterial peptide source is also commercially available.Antibacterial peptide is also known as antimicrobial peptide（antimicrobial petide）,
Be in insect body Jing induction and produce molecule amount in 4KD or so, the peptide material with antibacterial activity, be that body is natural
A part for immune defense system, while also can replace as additive for farm animal feed or partly replace used by current feeding animals
Antibiotic, reduce harm of the antibiotic to animal body.Antibacterial peptide has lot of advantages, for example：Acid resistance is good, in hydrochloric acid in gastric juice ring
It is stable in border, it is ensured that antibacterial peptide is not digested by gastric acid degradation；Heat endurance is good, 100 DEG C of water-baths 30 minutes, does not affect its sterilization to make
With suitable and all feeds mixing granulation；Has a broad antifungal spectrum, at least more than 113 kinds of different bacterium can be killed by antibacterial peptide
Go out, while being resistant to the disease that specific fungi and virus cause；Good water solubility, is soluble in and sleeps, and can mix with feed, it can also be used to
In drinking water, use and its facilitate；It is safe, do not find that antibacterial peptide has any toxic and side effect at present, using noresidue, without resistance to
Property of medicine phenomenon；Effect is quick, and antibacterial peptide molecule is less, when body is invaded, just can play a role in a few minutes.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 2 is by sodium butyrate, auxiliary beneficial powder, Portugal
Grape sugar and drinking water are added in trough type mixing machine, mix 5min.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 3 is that polyethylene glycol is heated to into 130
During the material obtained by after step 2 mixing is added after DEG C.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 3, the time for continuing to mix is
10min。
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 4, be step 3 is mixed after gained
Then material Temperature fall adds antibacterial peptide to room temperature, continues to mix 10min.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 5 is the material for mixing step 4
Being put in rotating type granulating machine carries out particle making.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 6, be dried obtained by material it is aqueous
Measure to be less than 2% by mass percentage.
Above-mentioned micro-capsule is coated with the preparation method of sodium butyrate, wherein, described step 7, inspection institute obtains butyric acid sodium content and is
By mass percentage 44% ~ 45%.
Present invention also offers micro-capsule coating sodium butyrate prepared by a kind of preparation method of above-mentioned micro-capsule coating sodium butyrate.
Micro-capsule coating sodium butyrate that the present invention is provided and preparation method thereof has advantages below：
Gained micro-capsule coating sodium butyrate of the invention, using the teaching of the invention it is possible to provide intestinal cell energy, improves little broiler chick, and raising is digested and assimilated,
Strengthen immunologic function；Selective depression harmful bacteria is bred, and adjusts the gastrointestinal tract micro ecological balance, prevention disease；Intestinal mucosa is promoted to repair
It is multiple, suppress intestinal inflammation.Promote animal and bird intestines development, improve little broiler chick, increase intestinal villi length, fundamentally carry
High animal and bird intestines are digested and assimilated to nutriment in feed, and animal body transformation is played to greatest extent, prevent enteron aisle
The generation of disease, improves the growth performance of livestock and poultry, increases economic benefit.
Specific embodiment
The specific embodiment of the present invention is further described below.
The micro-capsule that the present invention is provided is coated with the preparation method of sodium butyrate, comprising：
Step 1, accurately weighs in proportion each raw material, raw material comprising sodium butyrate, antibacterial peptide, auxiliary beneficial powder, glucose, polyethylene glycol with
And drinking water, its weight ratio is 120:36:54:50:4:5.
Auxiliary beneficial powder is a kind of water-soluble solid dispersible carrier, and main component is inorganic salts, soluble starch and other auxiliary materials,
As the readily soluble auxiliary material of veterinary drug of new generation, originate as commercially available.
Antibacterial peptide is also known as antimicrobial peptide（antimicrobial petide）, be in insect body Jing induction and produce one
Quasi-molecule amount, in 4KD or so, the peptide material with antibacterial activity, is a part for body natural immune defence system, while
Also can replace or partly replace the antibiotic used by current feeding animals as additive for farm animal feed, reduce antibiotic to animal
The harm of body.Source is also commercially available.
Step 2, sodium butyrate, auxiliary beneficial powder, glucose and drinking water are added in trough type mixing machine, mix 5min.
Step 3, after adding step 2 to mix after polyethylene glycol is heated to into 130 DEG C in the material of gained, continues to mix
10min。
Step 4, then the material Temperature fall of gained adds antibacterial peptide to room temperature after step 3 is mixed, and continues to mix
10min。
Step 5, the material that step 4 is mixed is put in rotating type granulating machine carries out particle making.
Step 6, the dry materials after step 5 is pelletized, the water content of the material obtained by drying is for by mass percentage
Less than 2%.
Step 7, samples censorship, and inspection institute obtains butyric acid sodium content for by mass percentage 44% ~ 45%.
Step 8, certified products packaging, preferably fills the standard bag of 35kg/ bags, and in packaging outer bag batch is indicated.
Step 9, puts in storage after inspection, piles up neat, cleaning.
Present invention also offers micro-capsule coating sodium butyrate prepared by the preparation method of the micro-capsule coating sodium butyrate.
Micro-capsule coating sodium butyrate provided the present invention with reference to embodiment and preparation method thereof is further described.
Embodiment 1
Micro-capsule coating sodium butyrate is prepared according to the following steps.
Step 1, accurately weighs in proportion each raw material, and raw material includes sodium butyrate, antibacterial peptide, auxiliary beneficial powder, glucose, poly- second two
Alcohol and drinking water, its weight ratio is 120:36:54:50:4:5.
Specially sodium butyrate 60kg（The 20kg/ bags content 97% of buying）；Antibacterial peptide 18kg；Auxiliary beneficial powder 27kg；Polyethylene glycol
25kg；Glucose 2kg；Drinking water 2.5kg.
Step 2, sodium butyrate, auxiliary beneficial powder, glucose and drinking water are added in trough type mixing machine, mix 5min.
Step 3, after adding step 2 to mix after polyethylene glycol is heated to into 130 DEG C in the material of gained, continues to mix
10min。
Step 4, then the material Temperature fall of gained adds antibacterial peptide to room temperature after step 3 is mixed, and continues to mix
10min。
Step 5, the material that step 4 is mixed is put in rotating type granulating machine carries out particle making.
Step 6, the dry materials after step 5 is pelletized, the water content of the material obtained by drying is for by mass percentage
Less than 2%.
Step 7, samples censorship, and inspection institute obtains butyric acid sodium content for by mass percentage 44% ~ 45%.
Step 8, certified products packaging, loads the standard bag of 35kg/ bags, and in packaging outer bag batch is indicated.
Step 9, puts in storage after inspection, piles up neat, cleaning.
The product of the gained of embodiment 1 is tested.
One. laying hen is tested.
1. experiment purpose：
（1）This experiment is coated with use of the sodium butyrate in laying hen in egg laying peak period mainly for micro-capsule.
（2）Investigate the product effect that micro-capsule coating sodium butyrate is embodied during laying hen abounds with phase use.
（3）Inquire into the economic worth that micro-capsule coating sodium butyrate brings in use.
2. experimental subjects：Certain large-scale breeding layer chicken enterprise, 23000 laying hens of No. 2 houses, age in days 170 days.
3. operational version：The micro-capsule coating sodium butyrate that the present invention is provided is allocated daily in addition feed, directly as habitually in the past
Feeding.Addition is 1g/kg.
3. experimental project：Excrement situation, eggshell color and size, per only day feed consumption, laying rate, rate of broken eggs, average egg
Weight, feedstuff-egg ratio, the death rate, the incidence of disease.
4. experimental result.
（1）Egg changes：According to the interval time photo comparison's eggshell color during experiment, eggshell spot is relative to be reduced,
Lopsided egg is reduced, and shape is relatively preferable, and regularity is significantly improved.It is mainly manifested in the 7th day and slightly has slight change afterwards.It is observed that
Father and mother are good for the egg shell outward appearance of egg.Illustrate that chicken all living creatures grows system health good.
（2）Excrement changes：When product is not used, loose and watery stool, the poor, lithate of shaping form uneven to excrement, by excrement
The picture display comparison of situation to the 7th day starts, and excrement is slightly good compared with first the Heavenly Stems, shaping, and lithate is formed uniformly, and loose stools subtracts
It is few, illustrate to be digested and assimilated after chicken group's medication relatively good, efficiency of feed utilization is increased.
（3）Laying rate：Product is laid eggs rising using after.
（4）Rate of broken eggs：Significantly reduced using rate of broken eggs after micro-capsule coating sodium butyrate.
（5）Chicken group spirit change：Chicken group health, material feeding is drunk water also without significant change, and body weight is up to standard, and the uniformity is good, essence
God is in good condition, and chicken group is active, illustrates that micro-capsule is coated with sodium butyrate product safety, does not affect palatability.
（6）Death condition：After micro-capsule coating sodium butyrate, the death toll of chicken group and superseded number progressively decline.
（7）Feed consumption situation：According to feedstuff-egg ratio and the observation analysis of feed consumption situation, feed consumption overall trend is to decline, and feed is used
Amount is relative to be reduced.
5. micro-capsule coating sodium butyrate uses rear value analysis.
（1）Mitigate workload：Chicken group is healthy during chicken group is coated with sodium butyrate using micro-capsule, and feeding is normal, and the incidence of disease is few.Greatly
The cost of chicken group's disease prevention and cure is reduced greatly, for laying rate the basic guarantee for providing is raised, mitigate the workload of staff.
（2）Improve egg quality：Reduced using the normal spot of eggshell color after micro-capsule coating sodium butyrate, chicken group's reproductive system
Health, beneficial to the growth of chicken group's laying rate；Commodity egg sale commercially can attract consumption because appearance color is uniform attractive in appearance
Person buys.
（3）Reduce feed consumption：According to tabular analysis, chicken group is integrally on a declining curve to the consumption of feed and feedstuff-egg ratio, treats steady
Material is fed after fixed can consider reduction, reduce feedstuff-egg ratio, reduce feeding cost.
6. summarize.
Micro-capsule is coated with application effect feedback of the sodium butyrate on egg fowl：
Using 3-5 days, loose stool was reduced, and was occurred without punishment in advance phenomenon.
Using 6-9 days, eggshell color was vivid, and without soft-shelled egg, lopsided egg, arenaceous shell egg occurs.
Using 10-15 days, laying rate increased 1-3 point, and feedstuff-egg ratio is reduced.
Using 20-30 days, the holistic health and production performance of chicken group is significantly improved.
Two. broiler chicken is tested.
1st, increasingly (AA) Broiler chicks 480 are pulled out from 1 age in days love, is randomly divided into 4 groups, per group of 3 repetitions, each repeats 40
Only.Without any antibiotic, antibiotic group adds antibiotic (Bacitracin Zinc 40mg/kg+ sulphur to control group on the basis of control group
Sour colistin 8mg/kg)；Pulvis sodium butyrate group adds 200mg/kg pulvis sodium butyrates on the basis of control group；Micro-capsule is coated with fourth
Sour sodium group adds the micro-capsule coating sodium butyrate that the present invention of 200mg/kg is provided on the basis of control group.Record 21 ages in days and 42 days
The average daily feed intake in age and average daily gain, and respectively at 14 ages in days and 35 ages in days, choose 12 chickens at per group at random and determine stomach
Intestinal pH, and take duodenum, jejunum and ileal contents measure VFA（Volatile fatty acid, volatile fat
Acid）.
As a result show：Compared with control group, sodium butyrate affects significantly (P ＜ 0.05) on the average daily feed intake of Broiler chicks, addition
Coating sodium butyrate significantly reduces the feed-weight ratio (P ＜ 0.05) of (6.25%) Broiler chicks 21-42 ages in days.Sodium butyrate is added with drop
The trend of low intestinal pH.Add 200mg/kg pulvis sodium butyrates in daily ration, the 6.72% of enteron aisle acetic acid content can be improved, carry
High 23.08% propionic acid content, improves 49.01% butyric acid content；Addition 200mg/kg Coating sodium butyrates, can improve enteron aisle
10.39% acetic acid content, improves 33.61% propionic acid content, improves 36.80% butyric acid content.Result above can illustrate,
Sodium butyrate can improve the feed conversion rate of Broiler chicks, improve production performance, reduce intestinal pH, and can improve enteron aisle VFA's
Content, and micro-capsule coating sodium butyrate effect is better than pulvis sodium butyrate.
Three. piglet is tested.
1st, the micro-capsule coating sodium butyrate that the present invention is provided is added in piglet diet, addition is 1g/kg, is then found,
The mucosal epithelium of Jejunum of Piglets and colon is complete after feed addition sodium butyrate, and intestinal villus is more sturdy；Mucosal absorption cell is in height
Column, marshalling, free surface has obvious striated border；Goblet cell is in goblet shape, is dispersed between columnar cell, cell
Quantity increases 1.4-1.7 times than antibiotic group.Show that sodium butyrate has and maintain Intestinal epithelial cells structural intergrity, and then promote
Enter the effect that weanling pig small intestine is digested and assimilated, and better than antibiotic.
2nd, add micro-capsule coating sodium butyrate group jejunal epithelium endolymph cell quantity and lift 29.3% than control group, show intestines
Road local immunity level gets a promotion, and enhances the resistance against diseases of animal.
3rd, feed after the micro-capsule coating sodium butyrate daily ration of 1700mg/kg to weanling pig, as a result show, micro-capsule coating butyric acid
The average daily gain of sodium group daily ration pig improves 23.5%, and average daily gain increased 8.9%, and food consumption reduces 11.8%.
20 8 week old piglets are chosen, research micro-capsule coating sodium butyrate shows the experiment that Production Performance of Weaning Pigs affects, in piglet day
Add sodium butyrate 0.8g/kg in grain, be respectively increased average daily gain 20% and the (P of average feed intake 16% of piglet<0.05).
Micro-capsule coating sodium butyrate, feeding is added to find after one week in 3 age in days piglet artificial breasts：Sodium butyrate makes Duodenal villi height
Reduce with mucous membrane thickness, jejunum and ileum Crypt depth, villus length and mucous membrane thickness increase.
4th, the contrast of each stage diarrhea of pigs rate see the table below 1.
Table 1：Each stage diarrhea of pigs rate table.
5th, fanning economics contrast see the table below 2.
Table 2：Gross profit is contrasted.
Micro-capsule coating sodium butyrate that the present invention is provided and preparation method thereof, gained micro-capsule coating sodium butyrate can be by supplementing livestock and poultry
Body function nutrient, promotes feed conversion rate, improves body and digests and assimilates, and corrects livestock and poultry inferior health, safeguards intestinal health, drops
The low neurological susceptibility to cause of disease, can safeguard intestinal acidity environment and physiological structure and integrality, reach the purpose of maintenance enteron aisle, most
The price of deed is improved eventually.
Although present disclosure has been made to be discussed in detail by above preferred embodiment, but it should be appreciated that above-mentioned
Description is not considered as limitation of the present invention.After those skilled in the art have read the above, for the present invention's
Various modifications and substitutions all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (10)
1. a kind of micro-capsule is coated with the preparation method of sodium butyrate, it is characterised in that the method is included：
Step 1, accurately weighs in proportion each raw material, and described raw material includes sodium butyrate, antibacterial peptide, auxiliary beneficial powder, glucose, poly- second
Glycol and drinking water；
Step 2, by the mixing of sodium butyrate, auxiliary beneficial powder, glucose and drinking water；
Step 3, after adding step 2 to mix after polyethylene glycol is heated in the material of gained, continues to mix；
Step 4, the material Temperature fall of gained after step 3 is mixed, then adds antibacterial peptide, continues to mix；
Step 5, the material that step 4 is mixed carries out particle making；
Step 6, the dry materials after step 5 is pelletized；
Step 7, samples censorship；
Step 8, certified products packaging indicates batch in packaging outer bag；
Step 9, puts in storage after inspection, piles up neat, cleaning.
2. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that sodium butyrate described in step 1,
Antibacterial peptide, auxiliary beneficial powder, glucose, polyethylene glycol and drinking water, its weight ratio is 120:36:54:50:4:5.
3. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that described step 2, is by fourth
Sour sodium, auxiliary beneficial powder, glucose and drinking water are added in trough type mixing machine, mix 5min.
4. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that described step 3, and being will be poly-
Ethylene glycol is added in the material obtained by after step 2 mixing after being heated to 130 DEG C.
5. micro-capsule as claimed in claim 4 is coated with the preparation method of sodium butyrate, it is characterised in that described step 3, continues mixed
The time of conjunction is 10min.
6. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that described step 4, is by step
Then the material Temperature fall of gained adds antibacterial peptide to room temperature after rapid 3 mixing, continues to mix 10min.
7. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that described step 5, is by step
Rapid 4 materials for mixing are put in rotating type granulating machine carries out particle making.
8. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that described step 6, is dried institute
The water content of the material for obtaining is less than by mass percentage 2%.
9. micro-capsule as claimed in claim 1 is coated with the preparation method of sodium butyrate, it is characterised in that described step 7, inspection institute
Butyric acid sodium content is obtained for by mass percentage 44% ~ 45%.
10. prepared by a kind of preparation method of the micro-capsule coating sodium butyrate as described in any one claim in claim 1 ~ 9
Micro-capsule coating sodium butyrate.
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| CN108244372A (en) * | 2017-12-26 | 2018-07-06 | 广州汇生饲料有限公司 | A kind of expanded pet feed that can promote intestinal health, improve immunity of organisms of the healthy particles containing double factor |
| CN109007363A (en) * | 2018-08-16 | 2018-12-18 | 新乡市佰牧饲料有限公司 | A kind of feed addictive for piggy health care |
| CN110897048A (en) * | 2019-12-30 | 2020-03-24 | 广州格雷特生物科技有限公司 | Enteric sodium butyrate microcapsule and preparation method and application thereof |
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Application publication date: 20170419 |