CN106535909A - 双层双重释放益生菌片剂 - Google Patents
双层双重释放益生菌片剂 Download PDFInfo
- Publication number
- CN106535909A CN106535909A CN201580035164.0A CN201580035164A CN106535909A CN 106535909 A CN106535909 A CN 106535909A CN 201580035164 A CN201580035164 A CN 201580035164A CN 106535909 A CN106535909 A CN 106535909A
- Authority
- CN
- China
- Prior art keywords
- release
- layer
- layering
- formulation
- probio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 110
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 110
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 68
- 230000009977 dual effect Effects 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 135
- 238000009472 formulation Methods 0.000 claims abstract description 111
- 239000002253 acid Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims description 19
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 241000186000 Bifidobacterium Species 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 241000186660 Lactobacillus Species 0.000 claims description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 5
- 241000194017 Streptococcus Species 0.000 claims description 5
- 229940039696 lactobacillus Drugs 0.000 claims description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 5
- 241000194033 Enterococcus Species 0.000 claims description 4
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 4
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 4
- 241000606125 Bacteroides Species 0.000 claims description 3
- 241000192001 Pediococcus Species 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000007916 tablet composition Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 241001478240 Coccus Species 0.000 claims 2
- 241000186394 Eubacterium Species 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000002552 dosage form Substances 0.000 abstract description 81
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 18
- 235000015872 dietary supplement Nutrition 0.000 abstract description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 239000011241 protective layer Substances 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 description 65
- 239000003826 tablet Substances 0.000 description 57
- 239000010410 layer Substances 0.000 description 51
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 38
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 34
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 25
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 25
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 25
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 25
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 25
- 239000008108 microcrystalline cellulose Substances 0.000 description 25
- 229940016286 microcrystalline cellulose Drugs 0.000 description 25
- 239000003792 electrolyte Substances 0.000 description 24
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 24
- 235000010987 pectin Nutrition 0.000 description 22
- 229920001277 pectin Polymers 0.000 description 22
- 239000001814 pectin Substances 0.000 description 22
- 241000894006 Bacteria Species 0.000 description 21
- 229960000292 pectin Drugs 0.000 description 21
- 238000013270 controlled release Methods 0.000 description 19
- 235000021355 Stearic acid Nutrition 0.000 description 18
- 239000003607 modifier Substances 0.000 description 18
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 18
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 18
- 239000000377 silicon dioxide Substances 0.000 description 18
- 239000008117 stearic acid Substances 0.000 description 18
- 239000004310 lactic acid Substances 0.000 description 17
- 235000014655 lactic acid Nutrition 0.000 description 17
- 238000007906 compression Methods 0.000 description 16
- 244000005700 microbiome Species 0.000 description 16
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 230000006835 compression Effects 0.000 description 14
- 239000000945 filler Substances 0.000 description 13
- 239000000843 powder Substances 0.000 description 13
- 210000000813 small intestine Anatomy 0.000 description 13
- 244000163122 Curcuma domestica Species 0.000 description 11
- 235000003392 Curcuma domestica Nutrition 0.000 description 11
- 230000009286 beneficial effect Effects 0.000 description 11
- 239000007894 caplet Substances 0.000 description 11
- 235000003373 curcuma longa Nutrition 0.000 description 11
- 239000002274 desiccant Substances 0.000 description 11
- 235000013976 turmeric Nutrition 0.000 description 11
- 229920002472 Starch Polymers 0.000 description 10
- 235000012239 silicon dioxide Nutrition 0.000 description 10
- 235000019698 starch Nutrition 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 229940032147 starch Drugs 0.000 description 9
- 239000008107 starch Substances 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 9
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 9
- 241000186840 Lactobacillus fermentum Species 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 239000003086 colorant Substances 0.000 description 7
- 239000008273 gelatin Substances 0.000 description 7
- 229920000159 gelatin Polymers 0.000 description 7
- 229940014259 gelatin Drugs 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- 229920002907 Guar gum Polymers 0.000 description 6
- 229920002774 Maltodextrin Polymers 0.000 description 6
- 239000005913 Maltodextrin Substances 0.000 description 6
- 235000010417 guar gum Nutrition 0.000 description 6
- 239000000665 guar gum Substances 0.000 description 6
- 229960002154 guar gum Drugs 0.000 description 6
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 6
- 229940035034 maltodextrin Drugs 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 210000001072 colon Anatomy 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000002702 enteric coating Substances 0.000 description 5
- 238000009505 enteric coating Methods 0.000 description 5
- 230000002496 gastric effect Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 description 4
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 230000009089 cytolysis Effects 0.000 description 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000008176 lyophilized powder Substances 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 150000004804 polysaccharides Chemical class 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- -1 silicon dioxide Chemical compound 0.000 description 4
- 235000017550 sodium carbonate Nutrition 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 230000035899 viability Effects 0.000 description 4
- 241001608472 Bifidobacterium longum Species 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 240000006024 Lactobacillus plantarum Species 0.000 description 3
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 3
- 229920001131 Pulp (paper) Polymers 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 229940004120 bifidobacterium infantis Drugs 0.000 description 3
- 229940009291 bifidobacterium longum Drugs 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000003405 ileum Anatomy 0.000 description 3
- 229940012969 lactobacillus fermentum Drugs 0.000 description 3
- 229940072205 lactobacillus plantarum Drugs 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 241000207199 Citrus Species 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 2
- 229920000926 Galactomannan Polymers 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 244000199866 Lactobacillus casei Species 0.000 description 2
- 235000013958 Lactobacillus casei Nutrition 0.000 description 2
- 229920000161 Locust bean gum Polymers 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 229920002678 cellulose Chemical class 0.000 description 2
- 239000001913 cellulose Chemical class 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000007907 direct compression Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 238000013265 extended release Methods 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000001630 jejunum Anatomy 0.000 description 2
- 229940017800 lactobacillus casei Drugs 0.000 description 2
- 239000007942 layered tablet Substances 0.000 description 2
- 235000010420 locust bean gum Nutrition 0.000 description 2
- 239000000711 locust bean gum Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000541 pulsatile effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 244000106483 Anogeissus latifolia Species 0.000 description 1
- 235000011514 Anogeissus latifolia Nutrition 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241001134770 Bifidobacterium animalis Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241000186012 Bifidobacterium breve Species 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241001269524 Dura Species 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 241000520130 Enterococcus durans Species 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000001922 Gum ghatti Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 240000001929 Lactobacillus brevis Species 0.000 description 1
- 235000013957 Lactobacillus brevis Nutrition 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 241000186606 Lactobacillus gasseri Species 0.000 description 1
- 240000002605 Lactobacillus helveticus Species 0.000 description 1
- 235000013967 Lactobacillus helveticus Nutrition 0.000 description 1
- 241000186605 Lactobacillus paracasei Species 0.000 description 1
- 241000186604 Lactobacillus reuteri Species 0.000 description 1
- 241000186612 Lactobacillus sakei Species 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- 241000194036 Lactococcus Species 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- NASRDENTZCCAPN-UHFFFAOYSA-N OC([Na])=O Chemical compound OC([Na])=O NASRDENTZCCAPN-UHFFFAOYSA-N 0.000 description 1
- 241000191998 Pediococcus acidilactici Species 0.000 description 1
- 241000191996 Pediococcus pentosaceus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 210000001815 ascending colon Anatomy 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229940118852 bifidobacterium animalis Drugs 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 229940009289 bifidobacterium lactis Drugs 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229960005168 croscarmellose Drugs 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 239000002577 cryoprotective agent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000001731 descending colon Anatomy 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 229940124568 digestive agent Drugs 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010944 ethyl methyl cellulose Nutrition 0.000 description 1
- 239000001761 ethyl methyl cellulose Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000019314 gum ghatti Nutrition 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 229940054346 lactobacillus helveticus Drugs 0.000 description 1
- 229940001882 lactobacillus reuteri Drugs 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 238000012792 lyophilization process Methods 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 238000007745 plasma electrolytic oxidation reaction Methods 0.000 description 1
- 238000009428 plumbing Methods 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 230000007425 progressive decline Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 229960002181 saccharomyces boulardii Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 210000003384 transverse colon Anatomy 0.000 description 1
- ZSDSQXJSNMTJDA-UHFFFAOYSA-N trifluralin Chemical compound CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O ZSDSQXJSNMTJDA-UHFFFAOYSA-N 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
- C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
- C12Y115/01001—Superoxide dismutase (1.15.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462019717P | 2014-07-01 | 2014-07-01 | |
| US62/019,717 | 2014-07-01 | ||
| PCT/US2015/038254 WO2016003870A1 (en) | 2014-07-01 | 2015-06-29 | Bi-layer dual release probiotic tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106535909A true CN106535909A (zh) | 2017-03-22 |
Family
ID=55019868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580035164.0A Pending CN106535909A (zh) | 2014-07-01 | 2015-06-29 | 双层双重释放益生菌片剂 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10799541B2 (enExample) |
| EP (1) | EP3164145A4 (enExample) |
| JP (1) | JP2017520577A (enExample) |
| KR (1) | KR20170021350A (enExample) |
| CN (1) | CN106535909A (enExample) |
| AP (1) | AP2016009641A0 (enExample) |
| AU (1) | AU2015284425B2 (enExample) |
| BR (1) | BR112016031000B1 (enExample) |
| CA (1) | CA2951739C (enExample) |
| CL (1) | CL2016003306A1 (enExample) |
| MA (1) | MA40071A (enExample) |
| MX (1) | MX383492B (enExample) |
| PH (1) | PH12016502463A1 (enExample) |
| RU (1) | RU2736823C2 (enExample) |
| SG (1) | SG11201610250WA (enExample) |
| WO (1) | WO2016003870A1 (enExample) |
| ZA (1) | ZA201608433B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251474A (zh) * | 2019-07-15 | 2019-09-20 | 北京工商大学 | 一种淀粉基大肠靶向双层益生菌片的制备方法 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3048361B1 (fr) * | 2016-03-01 | 2020-12-18 | Biose | Compositions pour le traitement des candidoses |
| CN108066296B (zh) * | 2016-11-11 | 2020-11-17 | 南京益恒寿生命科技有限公司 | 一种生物学活性组分结肠靶向组合物及其应用 |
| EP3501503A1 (en) * | 2017-12-22 | 2019-06-26 | Cosmo Technologies Ltd. | Solid delivery composition |
| PE20210322A1 (es) * | 2018-01-05 | 2021-02-18 | Nubiyota Llc | Composiciones que comprenden microbiota coseleccionada y metodos para su uso |
| EP3556226B1 (de) * | 2018-04-20 | 2021-01-20 | Raab Vitalfood GmbH | Komplex-synbiotikum zum aufbau einer gesunden darmflora |
| MX2020013439A (es) | 2018-06-18 | 2021-05-12 | Probi Ab | Composiciones probioticas y usos de las mismas. |
| CA3102445A1 (en) | 2018-06-18 | 2019-12-26 | Probi Ab | Lactobacillus plantarum compositions and uses thereof |
| US12144834B2 (en) | 2018-09-13 | 2024-11-19 | Xbiome Inc. | Methods and compositions for treating gastrointestinal and inflammatory disorders |
| US20220175893A1 (en) * | 2019-03-05 | 2022-06-09 | The Texas A&M University System | Combinations of tannase and probiotic formulations and methods of use for improving tannin metabolism |
| GB201905386D0 (en) | 2019-04-16 | 2019-05-29 | Probi Ab | Probiotic compositions and uses thereof |
| GB201908154D0 (en) | 2019-06-07 | 2019-07-24 | Probi Ab | Lactobacillus compositions and uses thereof |
| GB201908706D0 (en) | 2019-06-18 | 2019-07-31 | Probi Ab | Lactobacillus compositions and uses thereof |
| CN117159485A (zh) * | 2023-08-11 | 2023-12-05 | 江中药业股份有限公司 | 一种益生菌香口丸及其制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6037953A (ja) * | 1983-08-11 | 1985-02-27 | Herusu Eido:Kk | カルシウムを主成分とする栄養補助食品 |
| US20040156895A1 (en) * | 2002-11-12 | 2004-08-12 | Elan Pharma International Ltd. | Solid dosage forms comprising pullulan |
| CN1913905A (zh) * | 2003-12-24 | 2007-02-14 | 弗罗桑公司 | 益生菌片剂 |
| WO2009020595A2 (en) * | 2007-08-03 | 2009-02-12 | Shaklee Corporation | Nutritional supplement system |
| CN100478026C (zh) * | 2001-09-28 | 2009-04-15 | 纽特休迪克斯公司 | 用于生物学组分的传递系统 |
| US20120034200A1 (en) * | 2007-02-01 | 2012-02-09 | Porubcan Randolph S | Formulations Including Digestive Enzymes, Polysorbate-Based Surfactants and Probiotics |
| CN103582486A (zh) * | 2011-03-17 | 2014-02-12 | 益生菌股份公司 | 具有抗氧化活性的益生菌及其用途 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
| GB9402203D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6241983B1 (en) | 1994-10-28 | 2001-06-05 | Metagenics, Inc. | Bacteria-and fiber-containing composition for human gastrointestinal health |
| US5531989A (en) | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| ES2173372T3 (es) * | 1997-12-19 | 2002-10-16 | Merck Patent Gmbh | Comprimidos multicapa que contienen microorganismos probioticos, como por ejemplo latobacilos o bifidobacterias. |
| JP2000302694A (ja) * | 1999-04-16 | 2000-10-31 | Fuyuki Mitsuyama | 医食兼用物質 |
| US6696057B1 (en) | 1999-09-22 | 2004-02-24 | Lacpro Industries, Inc. | Composition and method for treatment of gastrointestinal disorders and hyperlipidemia |
| US20020044926A1 (en) | 1999-12-10 | 2002-04-18 | Gregor Reid | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
| US20030118547A1 (en) * | 2000-01-27 | 2003-06-26 | Vandenberg Grant William | Composition for intestinal delivery |
| ATE340563T1 (de) * | 2000-02-04 | 2006-10-15 | Depomed Inc | DOSIERUNGSFORM DES TYPS ßHÜLLE UND KERNß MIT EINER WIRKSTOFFFREISETZUNG, DIE SICH DER NULLTEN ORDNUNG ANNÄHERT |
| EP1151673A3 (en) | 2000-05-03 | 2002-01-02 | Societe Des Produits Nestle S.A. | Confectionery product having a filling |
| ATE391509T1 (de) | 2000-12-18 | 2008-04-15 | Probio Health | Von lactobacillus casei ke01 stamm abgeleitete probiotische verbindungen |
| AUPR272901A0 (en) | 2001-01-25 | 2001-02-22 | Gainful Plan Limited | Method of preparing biological materials and preparations produced using same |
| EP1228769A1 (de) | 2001-02-02 | 2002-08-07 | Jörg-Peter Prof. Schür | Symbiontisches Regenerativum |
| CA2441108A1 (en) | 2001-04-05 | 2002-10-17 | Universite Laval | Process for making delivery matrix and uses thereof |
| US6627220B2 (en) | 2001-07-13 | 2003-09-30 | Scolr, Inc. | Tablets containing heat sensitive materials and method for forming thereof |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20070098784A1 (en) | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
| US7101565B2 (en) | 2002-02-05 | 2006-09-05 | Corpak Medsystems, Inc. | Probiotic/prebiotic composition and delivery method |
| EP1344458A1 (en) | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
| US20030175295A1 (en) | 2002-03-15 | 2003-09-18 | Richard Ticktin | Composition and method for reducing odors from metabolic processes |
| US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| GB0212975D0 (en) | 2002-06-06 | 2002-07-17 | Mars Uk Ltd | Mammalian animal composition |
| TW200404544A (en) | 2002-06-17 | 2004-04-01 | Kowa Co | Controlled release pharmaceutical composition |
| US20050266069A1 (en) | 2002-09-06 | 2005-12-01 | Simmons Donald L | Stable probiotic microsphere compositions and their methods of preparation |
| US8168170B2 (en) | 2002-10-03 | 2012-05-01 | The Procter And Gamble Company | Compositions having an inner core and at least three surrounding layers |
| US7105336B2 (en) | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
| US20060188563A1 (en) | 2003-03-27 | 2006-08-24 | Hisamitsu Pharmaceutical Co., Inc. | Medicinal oral preparations for colon delivery, medicinal oral preparations for treating colon cancer and medicinal oral preparations for treating colitis |
| US7025998B2 (en) | 2003-05-30 | 2006-04-11 | Rotta Research Laboratorium S.P.A. | Phytoestrogens and probiotic for women's health |
| DE602004030922D1 (de) | 2003-08-21 | 2011-02-17 | Otsuka Pharma Co Ltd | Milchsäurebakterien mit mucosa-immunpotenzierungseffekt |
| CA2547843A1 (en) | 2004-02-09 | 2005-08-18 | Transfert Plus Societe En Commandite | Composition comprising polymeric material and uses thereof |
| US20050260181A1 (en) | 2004-03-05 | 2005-11-24 | Immunopath Profile, Inc. | Compositions and methods for tissue repair |
| US7854927B2 (en) | 2004-05-11 | 2010-12-21 | Ganeden Biotech, Inc. | Methods and compositions for the dietary management of autoimmune disorders |
| GB0410785D0 (en) | 2004-05-14 | 2004-06-16 | Glycologic Ltd | Improved prebiotic |
| EP1750674A4 (en) | 2004-05-27 | 2012-05-23 | Advanced Bionutrition Corp | MICROPARTICLES FOR THE ORAL LEVY |
| DE102004026706A1 (de) | 2004-05-28 | 2005-12-15 | Merck Patent Gmbh | Orale Darreichungsform enthaltend probiotische Bakterien |
| US20060062773A1 (en) | 2004-09-21 | 2006-03-23 | The Procter & Gamble Company | Compositions for maintaining and restoring normal gastrointestinal flora |
| US20060115465A1 (en) | 2004-10-29 | 2006-06-01 | Macfarlane George | Treatment of gastrointestinal disorders |
| EP1885207B1 (en) | 2005-05-18 | 2011-07-06 | DSM IP Assets B.V. | Compositions for enteral application of microorganisms |
| AU2006296797B8 (en) | 2005-09-29 | 2012-06-28 | The Procter & Gamble Company | Method for stabilising pharmaceutical administration forms that contain micro-organisms |
| US7982066B2 (en) | 2005-12-09 | 2011-07-19 | Novalife, Inc. | High protein supplement |
| AU2005339139A1 (en) | 2005-12-14 | 2007-06-21 | Oxthera, Inc. | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
| US20070184111A1 (en) | 2006-02-03 | 2007-08-09 | Pharmavite Llc | Hybrid tablet |
| WO2008076975A1 (en) | 2006-12-18 | 2008-06-26 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
| DE102006062250A1 (de) | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
| US20080171085A1 (en) | 2007-01-11 | 2008-07-17 | Natrol, Inc. | Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration |
| EP2380564B1 (en) | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| WO2009037264A2 (en) | 2007-09-17 | 2009-03-26 | Da Volterra | Colonic delivery of antimicrobial agents |
| US9078824B2 (en) | 2007-09-24 | 2015-07-14 | The Procter & Gamble Company | Composition and method of stabilized sensitive ingredient |
| US20110223248A1 (en) | 2007-12-12 | 2011-09-15 | Ritter Pharmaceuticals, Inc. | Methods and compositions for treating lactose intolerance |
| WO2009092628A1 (en) | 2008-01-24 | 2009-07-30 | Nestec S.A. | Capsule containing nutritional ingredients and method of delivery of a nutritional liquid from the capsule |
| RU2010143460A (ru) | 2008-05-01 | 2012-06-10 | Дзе Проктер Энд Гэмбл Компани (US) | Способы и наборы для терапии восстановительных состояний кишечника |
| US8586029B2 (en) | 2008-06-04 | 2013-11-19 | Trustees Of Dartmouth College | Prevention or treatment of immune-relevant disease by modification of microfloral populations |
| CA2729072A1 (en) * | 2008-06-24 | 2010-01-21 | Wm. Wrigley Jr. Company | Probiotic chewing gum method of manufacture |
| US20100068268A1 (en) | 2008-09-15 | 2010-03-18 | Miloud Rahmouni | Starch-based microparticles for the release of agents disposed therein |
| CA2743639A1 (en) * | 2008-11-14 | 2010-05-20 | Patheon Inc. | Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low ph and methods of use thereof |
| GB0900551D0 (en) | 2009-01-14 | 2009-02-11 | Horton Richard | Ingestible compositions and processes of preparation |
| WO2010086705A2 (en) | 2009-01-27 | 2010-08-05 | Probiotical S.P.A. | Chocolate flavoured probiotic supplement |
| WO2010098822A1 (en) | 2009-02-24 | 2010-09-02 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
| AU2010221209C1 (en) | 2009-03-06 | 2015-09-03 | Tamarisk Technologies Group, L.L.C. | Microencapsulated bioactive agents for oral delivery and methods of use thereof |
| CA2760999A1 (en) | 2009-03-13 | 2010-09-16 | Mariana Barboza | Prebiotic oligosaccharides |
| US20100330151A1 (en) | 2009-06-25 | 2010-12-30 | Mary Elaine Freeland | Method of Promoting Gastrointestinal Health Using a Combination of a Probiotic Microorganism and Chocolate |
| US20120087902A1 (en) * | 2009-07-20 | 2012-04-12 | Bracco S.P.A. | Therapeutic Use Of Probiotics |
| ES2708450T3 (es) | 2009-07-30 | 2019-04-09 | Dupont Nutrition Biosci Aps | Bacterias ácido lácticas y bifidobacterias para tratar endotoxemia |
| US8313768B2 (en) | 2009-09-24 | 2012-11-20 | Mcneil-Ppc, Inc. | Manufacture of tablet having immediate release region and sustained release region |
| CA2785658C (en) | 2009-12-31 | 2017-10-24 | Ira Milton Trachtman | Compositions and method for treatment and prophylaxis of inflammatory bowel disease |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
| KR101143997B1 (ko) | 2010-03-04 | 2012-05-09 | 한미사이언스 주식회사 | 유산균 제제 및 5-ht4 수용체 효능제를 함유하는 경구 투여용 복합 제제 및 이의 제조방법 |
| US9301982B2 (en) | 2010-04-14 | 2016-04-05 | Ganeden Biotech, Inc. | Probiotic confection and lipid compositions |
| EP3202406A1 (en) | 2010-04-28 | 2017-08-09 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
| US9040302B2 (en) | 2010-05-19 | 2015-05-26 | North Carolina State University | Genetically modified Streptococcus thermophilus bacterium |
| US20140154312A1 (en) | 2010-09-17 | 2014-06-05 | Monica Gulati | Oral targetted drug delivery system |
| WO2012103411A2 (en) * | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| WO2012154738A1 (en) | 2011-05-09 | 2012-11-15 | The Cleveland Clinic Foundation | Composition and method to improve intestinal health |
| RU2651466C2 (ru) | 2011-05-16 | 2018-04-19 | ОРГАНОБАЛАНС Медикал АГ | Новые молочнокислые бактерии и содержащие их составы против бактериальных простудных заболеваний |
| CN202427429U (zh) * | 2012-01-09 | 2012-09-12 | 北京大北农科技集团股份有限公司 | 一种多层微囊制备设备 |
| US20130295227A1 (en) | 2012-05-01 | 2013-11-07 | Robbert H. ter Haar | Composition Comprising a Sensitive Ingredient |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| US20140112985A1 (en) | 2012-10-22 | 2014-04-24 | Polonez Therapeutics Llc | Method of prevention and treatment of clostridium difficile infection |
| CA2940226A1 (en) * | 2013-02-22 | 2014-08-28 | The Regents Of The University Of California | Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life |
| RU2015140610A (ru) * | 2013-03-14 | 2017-04-17 | ТЕРАБАЙОМ, ЭлЭлСи | Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств |
-
2015
- 2015-06-29 EP EP15814437.8A patent/EP3164145A4/en not_active Withdrawn
- 2015-06-29 US US15/318,262 patent/US10799541B2/en active Active
- 2015-06-29 SG SG11201610250WA patent/SG11201610250WA/en unknown
- 2015-06-29 MA MA040071A patent/MA40071A/fr unknown
- 2015-06-29 BR BR112016031000-4A patent/BR112016031000B1/pt active IP Right Grant
- 2015-06-29 AU AU2015284425A patent/AU2015284425B2/en active Active
- 2015-06-29 CA CA2951739A patent/CA2951739C/en active Active
- 2015-06-29 KR KR1020177002583A patent/KR20170021350A/ko not_active Ceased
- 2015-06-29 CN CN201580035164.0A patent/CN106535909A/zh active Pending
- 2015-06-29 WO PCT/US2015/038254 patent/WO2016003870A1/en not_active Ceased
- 2015-06-29 JP JP2016575355A patent/JP2017520577A/ja active Pending
- 2015-06-29 MX MX2016016773A patent/MX383492B/es unknown
- 2015-06-29 AP AP2016009641A patent/AP2016009641A0/en unknown
- 2015-06-29 RU RU2017102952A patent/RU2736823C2/ru active
-
2016
- 2016-12-07 ZA ZA2016/08433A patent/ZA201608433B/en unknown
- 2016-12-12 PH PH12016502463A patent/PH12016502463A1/en unknown
- 2016-12-22 CL CL2016003306A patent/CL2016003306A1/es unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6037953A (ja) * | 1983-08-11 | 1985-02-27 | Herusu Eido:Kk | カルシウムを主成分とする栄養補助食品 |
| CN100478026C (zh) * | 2001-09-28 | 2009-04-15 | 纽特休迪克斯公司 | 用于生物学组分的传递系统 |
| US20040156895A1 (en) * | 2002-11-12 | 2004-08-12 | Elan Pharma International Ltd. | Solid dosage forms comprising pullulan |
| CN1913905A (zh) * | 2003-12-24 | 2007-02-14 | 弗罗桑公司 | 益生菌片剂 |
| US20120034200A1 (en) * | 2007-02-01 | 2012-02-09 | Porubcan Randolph S | Formulations Including Digestive Enzymes, Polysorbate-Based Surfactants and Probiotics |
| WO2009020595A2 (en) * | 2007-08-03 | 2009-02-12 | Shaklee Corporation | Nutritional supplement system |
| CN103582486A (zh) * | 2011-03-17 | 2014-02-12 | 益生菌股份公司 | 具有抗氧化活性的益生菌及其用途 |
Non-Patent Citations (1)
| Title |
|---|
| 孟宪镛: "《实用消化病诊疗学》", 30 September 2006, 上海世界图书出版公司 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251474A (zh) * | 2019-07-15 | 2019-09-20 | 北京工商大学 | 一种淀粉基大肠靶向双层益生菌片的制备方法 |
| CN110251474B (zh) * | 2019-07-15 | 2022-01-07 | 北京工商大学 | 一种淀粉基大肠靶向双层益生菌片的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016003870A1 (en) | 2016-01-07 |
| KR20170021350A (ko) | 2017-02-27 |
| EP3164145A1 (en) | 2017-05-10 |
| ZA201608433B (en) | 2023-05-31 |
| CL2016003306A1 (es) | 2017-06-09 |
| US20170100442A1 (en) | 2017-04-13 |
| AU2015284425B2 (en) | 2021-04-01 |
| CA2951739A1 (en) | 2016-01-07 |
| CA2951739C (en) | 2023-09-19 |
| EP3164145A4 (en) | 2018-01-17 |
| RU2017102952A (ru) | 2018-08-01 |
| PH12016502463A1 (en) | 2017-04-10 |
| RU2017102952A3 (enExample) | 2019-02-01 |
| BR112016031000B1 (pt) | 2022-01-25 |
| MA40071A (fr) | 2016-01-07 |
| AU2015284425A1 (en) | 2017-01-05 |
| MX383492B (es) | 2025-03-04 |
| JP2017520577A (ja) | 2017-07-27 |
| MX2016016773A (es) | 2017-06-30 |
| RU2736823C2 (ru) | 2020-11-20 |
| SG11201610250WA (en) | 2017-01-27 |
| US10799541B2 (en) | 2020-10-13 |
| AP2016009641A0 (en) | 2016-12-31 |
| BR112016031000A2 (enExample) | 2017-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10799541B2 (en) | Bi-layer dual release probiotic tablets | |
| US20150050245A1 (en) | Methods and delivery system for beneficial additive and subtractive biological agents to promote balanced mammalian gastrointestinal flora | |
| US8540980B2 (en) | Delivery system for biological component | |
| CN105120847B (zh) | 益生生物和/或治疗剂的靶向胃肠道递送 | |
| AU2002330187B2 (en) | Delivery system for biological component | |
| JP6989154B2 (ja) | 生物学的活性成分の結腸標的組成物、およびその利用 | |
| TWI584824B (zh) | A capsule for delivery to a large intestine and a method of manufacturing the same | |
| AU2002330187A1 (en) | Delivery system for biological component | |
| JP5415232B2 (ja) | 生菌製剤の製造方法 | |
| JP5907796B2 (ja) | 腸内環境改善食品 | |
| JP5940869B2 (ja) | 腸内環境改善有核錠製剤及びハードカプセル製剤 | |
| WO2021152869A1 (ja) | 腸溶性組成物、該腸溶性組成物を含む飲食品、該腸溶性組成物の崩壊時間を制御する方法、及び該腸溶性組成物の製造方法 | |
| JP7583498B1 (ja) | 製剤組成物 | |
| HK1066969B (en) | Delivery system for biological component |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170322 |
|
| RJ01 | Rejection of invention patent application after publication |