CN106511901A - Medicine for treating dysmenorrhea and preparation method thereof - Google Patents

Medicine for treating dysmenorrhea and preparation method thereof Download PDF

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Publication number
CN106511901A
CN106511901A CN201611149263.4A CN201611149263A CN106511901A CN 106511901 A CN106511901 A CN 106511901A CN 201611149263 A CN201611149263 A CN 201611149263A CN 106511901 A CN106511901 A CN 106511901A
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radix
medicine
dried
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徐洪安
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicine for treating dysmenorrhea and a preparation method thereof. The medicine is prepared from radix bupleuri, radix paeoniae alba, angelica sinensis, radix curcumae and ligusticum wallichii at a certain weight ratio. The medicine disclosed by the invention has the effects of nourishing blood and liver, replenishing and activating blood, promoting Qi circulation and removing stagnation, regulating menstruation and relieving pain, cooling blood and eliminating stagnation as well as relieving pain, can quickly become effective in treating dysmenorrhea, has an excellent curative effect and is free from side effect.

Description

It is a kind of to treat medicine of dysmenorrhea and preparation method thereof
Technical field
The present invention relates to a kind of treat medicine of dysmenorrhea and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Dysmenorrhea be clinical common symptom refer to pass through before and after or menstrual phase there is lower abdominal pain, falling inflation, with the soreness of waist or Other are uncomfortable.The traditional Chinese medical science then thinks dysmenorrhea and deficient qi and blood, and stagnation of QI due to depression of the liver, feelings will are not smooth relevant.Due to western medicine large side effects, Therefore there is great demand to the Chinese medicine of effectively treatment dysmenorrhea in people, up to now, it has not been found that with regard to the present invention Relevant report.
The content of the invention
The present inventor have found effectively treatment dysmenorrhea finally according to the research and the checking repeatedly of clinical trial of theory of Chinese medical science Medicine, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment dysmenorrhea.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is to select Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Chuanxiong medicine to be combined preparation, by these medicines Combination causes each efficacy of drugs to produce synergism such that it is able to effectively treatment dysmenorrhea.Wherein its nature and flavor is because from Radix Bupleuri Hardship, cool, enter liver, gallbladder meridian, has reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, and fullness in the chest and hypochondriac pain, bitter taste are deaf, dysmenorrhea It is dizzy, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Its nature and flavor picric acid is because from the Radix Paeoniae Alba, cool, enter liver, spleen channel have The function of antiperspirant is received in nourishing blood to suppress the hyperactive liver, pain relieving in delaying, yin fluid astringing, controls chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, fever due to yin deficiency, the moon Jing is uncomfortable, metrorrhagia, leukorrhagia.Its nature and flavor sweet, acrid, warm is because from Radix Angelicae Sinensis, enter the heart, liver, spleen channel have replenishing and activating blood, and regulating menstruation stops Bitterly, the function of moisturize laxation, controls menoxenia, and amenorrhea stomachache, abdominal mass knot are poly-, and metrorrhagia, blood-deficiency type dysmenorrheal, dizziness, flaccidity syndrome and arthralgia syndrome, dryness of the intestine are difficult Just, weight, ulcer sores, incised wound, injury from falling down after bloody dysentery.It is because that its nature and flavor is worked hard from Radix Curcumae, cool, enter the heart, lung, Liver Channel, There is circulation of qi promoting solution with the function of removing heat from blood removing blood stasis with potent drugs controls all pains of chest and abdomen side of body rib, and the mistake heart is demented, and calentura coma is spitted blood, epistaxis, hematuria, blood Drench, women's vicarious menstruation, jaundice.It is because that its nature and flavor is pungent from Rhizoma Chuanxiong, temperature, enter liver, gallbladder meridian have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation The function of pain relieving, controls air-cooled dysmenorrhea rotation and swoons, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.
Specific embodiment
The drug dose of instant component be also inventor through groping in a large number to summarize what is drawn, the consumption of each component is following heavy All there is in the range of amount preferable curative effect：
4-8 gram of Radix Bupleuri, 10-20 gram of the Radix Paeoniae Alba, 6-12 gram of Radix Angelicae Sinensis, 6-12 gram of Radix Curcumae, 6-12 gram of Rhizoma Chuanxiong.
Preferably：
6 grams of Radix Bupleuri, 15 grams of the Radix Paeoniae Alba, 9 grams of Radix Angelicae Sinensis, 9 grams of Radix Curcumae, 9 grams of Rhizoma Chuanxiong.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Radix Bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, is pulled out, cut into slices after running through in time, dried immediately；
2nd, the Radix Paeoniae Alba：Impurity is picked, separates size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, moistened uniform to inside and outside humidity, cut Piece, is dried；
3rd, Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening slightly dries in the air, and section is dried；
4th, Radix Curcumae：It is soaked in water, cleans, pull solarization out and dry in the air, run through, cuts into slices, dry；
5th, Rhizoma Chuanxiong：Impurity is picked, is separated large and small, is soaked in water, solarization is dried in the air, cut into slices after moistening, be dried.
2nd, prepare
1st, the Radix Bupleuri after processing, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Chuanxiong are put in decocting container, add water for the first time 6 times and measure, soaked After 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain first time decoction liquor, first time decoction liquor is fallen Enter in container；
2nd, the medicinal residues of filtration are added into 4 times of amounts, is boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.
In prescription, the Radix Paeoniae Alba has nourishing blood to suppress the hyperactive liver, pain relieving in delaying, and it is monarch drug that yin fluid astringing receives the function of antiperspirant；Chinese angelica blood supplementing is invigorated blood circulation, regulating menstruation Pain relieving, moisturize laxation；Rhizoma Chuanxiong has an activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, and the two is ministerial drug, and three taste medicines are sent out jointly Nourishing blood to suppress the hyperactive liver is waved, pain relieving in delaying, replenishing and activating blood, menstruction regulating and pain relieving, moisturize laxation, the effect of activating QI to alleviate the depression, treatment dysmenorrhea effect are complete Face, and with nourishing blood to suppress the hyperactive liver, replenishing and activating blood, activating QI to alleviate the depression can be effected a permanent cure based on menstruction regulating and pain relieving, and Radix Bupleuri has reconciling superficies and interior, soothing the liver, yang invigorating Function be adjuvant drug, Radix Curcumae has circulation of qi promoting solution with the function of, removing heat from blood removing blood stasis with potent drugs to make medicine, is to take stopgap measures with remaining adjuvant drug.
Medicine of the present invention has nourishing blood to suppress the hyperactive liver, replenishing and activating blood, activating QI to alleviate the depression, menstruction regulating and pain relieving, removing heat from blood removing blood stasis with potent drugs, pain relieving in delaying Function, for treating dysmenorrhea, short treating period, instant effect, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Rabbit 30 is taken, male and female dual-purpose, 2.0 2.5kg of body weight are divided to two groups, 15 per group, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, serve on 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept dysmenorrhea out-patient totally 25 for medical treatment.
2nd, diagnostic criteria
Classical symptom is nausea,vomiting,diarrhea, dizziness, weak, and when serious, complexion is turned white, is in a cold sweat, pain often in spastic, On hypogastric region pubis, lumbosacral region and femoribus internus can be radiated to.
3rd, Therapeutic Method
From above-mentioned medicament, take to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 7 days a course for the treatment of, it is continuous to take With 2 courses for the treatment of.
4th, efficacy assessment standard
It is effective：Dysmenorrhea symptom disappears, and body constitution recovers normal, recovery from illness；
Take a turn for the better：Patients ' vomiting, diarrhoea, dizziness are weak, and the symptom mitigation of spasmic pain, dysmenorrhea symptom are clearly better, body Matter is progressively recovered；
It is invalid：Improvement standard person is not reached.
5th, therapeutic outcome（See the table below）
In above-mentioned treatment, with Drug therapy dysmenorrhea patient of the present invention 25, as a result effective 21, obvious effective rate is 84%, takes a turn for the better 3 Example, improvement rate is 12%, and invalid 1, total effective rate is 96%.

Claims (3)

1. a kind of medicine for treating dysmenorrhea, it is characterised in that：It is made up of the crude drug in following weight range：
4-8 gram of Radix Bupleuri, 10-20 gram of the Radix Paeoniae Alba, 6-12 gram of Radix Angelicae Sinensis, 6-12 gram of Radix Curcumae, 6-12 gram of Rhizoma Chuanxiong.
2. medicine according to claim 1, wherein the consumption of each crude drug is：
6 grams of Radix Bupleuri, 15 grams of the Radix Paeoniae Alba, 9 grams of Radix Angelicae Sinensis, 9 grams of Radix Curcumae, 9 grams of Rhizoma Chuanxiong.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Radix Bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, is pulled out, cut into slices after running through in time, dried immediately；
（2）The Radix Paeoniae Alba：Impurity is picked, separates size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, moisten uniform to inside and outside humidity, Section, is dried；
（3）Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening slightly dries in the air, and section is dried；
（4）Radix Curcumae：It is soaked in water, cleans, pull solarization out and dry in the air, run through, cuts into slices, dry；
（5）Rhizoma Chuanxiong：Impurity is picked, is separated large and small, is soaked in water, solarization is dried in the air, cut into slices after moistening, be dried；
（Two）Prepare
（1）Radix Bupleuri after processing, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Chuanxiong are put in decocting container, are added water 6 times and is measured, soaked 100 minutes Afterwards, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain first time decoction liquor, pour first time decoction liquor into container It is interior；
（2）The medicinal residues of filtration are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and is taken.
CN201611149263.4A 2016-12-14 2016-12-14 Medicine for treating dysmenorrhea and preparation method thereof Withdrawn CN106511901A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611149263.4A CN106511901A (en) 2016-12-14 2016-12-14 Medicine for treating dysmenorrhea and preparation method thereof

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Application Number Priority Date Filing Date Title
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Publications (1)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105012878A (en) * 2015-07-30 2015-11-04 王华荣 Traditional Chinese medicine composition for treating dysmenorrhea
CN105194584A (en) * 2015-11-09 2015-12-30 孙绪连 Medicine for treating dysmenorrhea
CN105213972A (en) * 2015-10-19 2016-01-06 翔宇药业股份有限公司 A kind of pharmaceutical preparation of promoting blood circulation to remove obstruction in the collateral and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105012878A (en) * 2015-07-30 2015-11-04 王华荣 Traditional Chinese medicine composition for treating dysmenorrhea
CN105213972A (en) * 2015-10-19 2016-01-06 翔宇药业股份有限公司 A kind of pharmaceutical preparation of promoting blood circulation to remove obstruction in the collateral and application thereof
CN105194584A (en) * 2015-11-09 2015-12-30 孙绪连 Medicine for treating dysmenorrhea

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张杰主编: "《杏林跬步 张杰临证医案经验集》", 31 August 2015, 上海科学技术出版社 *

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