CN105596648A - Compound traditional Chinese medicine preparation for treating gallstone pain and preparation method thereof - Google Patents

Abstract

The invention relates to a compound traditional Chinese medicine, in particular to a compound traditional Chinese medicine preparation for treating gallstone pain and a preparation method thereof. The compound traditional Chinese medicine preparation is mainly prepared from, by weight, 10-15 parts of Xianmicao, 10-25 parts of Radix glycyrrhizae, 10-25 parts of Rhizoma dioscorease, 1-5 parts of Herba agrimoniae, 5-10 parts of Radix astragali, 6-15 parts of Drynaria fortunei, 6-15 parts of Cortex ulmoides, 6-15 parts of okra, 6-15 parts of Fructus lycii, 2-6 parts of Coreopsis tinctoria flower, 1-5 parts of Eurycoma longifolia and 1-5 parts of Lepidium meyenii. The compound traditional Chinese medicine preparation is high in treatment efficiency and speed, low in dosage and free of side effect when being used for treating the gallstone pain, and the gallstone pain can be treated generally within 1 min by taking 30-50 g of the preparation.

Description

A kind of Chinese traditional compound medicine that is used for the treatment of gall stone pain and preparation method thereof

Technical field

The present invention relates to a kind of Chinese traditional compound medicine, particularly a kind of Chinese traditional compound medicine that is used for the treatment of gall stone pain and preparation method thereof.

Background technology

Gall stone is mainly the excessively concentrated stone forming of intracapsular bile of gallbladder, has many types. Outbreak gets up can cause gall-bladder spasmic pain, causes making patient to be impatient at, and normal conditions can be considered oral drugs alleviation. Cholecystolithiasis patient is everlasting pain occurs night, is to change relevant with cholecystolithiasis position in gall-bladder. In the time that patient stands or be seated, at the bottom of gall-bladder, down, these calculus are to sink to bottom, once under lying on the back and sleeping. At the bottom of gall-bladder, just upward, neck is in extreme lower position down. Calculus in gall-bladder, due to gravity relation, is easily rolled in neck of gallbladder or cystic duct, and incarceration there, and the incarceration of calculus has caused the generation of cholecystalgia. If at this moment patient's Body Position Change, calculus is loosening, and landing, gets back in neck of gallbladder or gall-bladder, blocks releasing, and pain will alleviate or disappear so.

Gall stone generally in the time of gall-bladder inflammation or cause blocking Shi Caihui and cause that pain, treatment are mainly to add as cholelith is logical that with the medicine of row's stone cholagogic antiphlogistic etc. treats, it is also conceivable that and operates if repeatedly shown effect. But a lot of patients calculus fast again after operation, carries out for the second time, operation for the third time again, can not effect a radical cure, so some people selects herbal mixture to treat.

Summary of the invention

The invention provides a kind of Chinese traditional compound medicine that is used for the treatment of gall stone pain, this preparation for treating gall stone pain curative effect is high, and speed is fast, and dosage is little, without any side effect, just can treat gall stone pain as long as conventionally take (30 ~ 50) g in 1 minute.

The technical solution adopted for the present invention to solve the technical problems is:

Be used for the treatment of a Chinese traditional compound medicine for gall stone pain, said preparation is to be mainly made up of the component of following weight portion meter: celestial close careless 10 ~ 15 parts, and 10 ~ 25 parts, Radix Glycyrrhizae, 10 ~ 25 parts of Chinese yams, 1 ~ 5 part of hairyvein agrimony, 5 ~ 10 parts of the Radixs Astragali, 6 ~ 15 parts of monkey ginger, 6 ~ 15 parts of the barks of eucommia, 6 ~ 15 parts of okras, 6 ~ 15 parts of the fruits of Chinese wolfberry, 2 ~ 6 parts of the Kunlun snow chrysanthemums, 1 ~ 5 part of Tongkat Ali, 1 ~ 5 part, agate card.

Celestial close grass (another name: the close grass in mountain, longevity grass, Hami grass, cold sugar grass): cool, thirst-quenching, clearing heat and detoxicating, convenient must urine, strengthening spleen and nourishing stomach, moisturizing beauty treatment, mend qi-restoratives, improve memory, regain one's strength of body delay senility, anti-inflammatory protects inflammation; Can control various common diseases, as tooth, throat inflammation, tracheitis, cough, acute toothache are protected in anti-inflammatory.

Radix Glycyrrhizae: invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription. For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion.

Chinese yam: heat-clearing, removing toxic substances. Be used for the treatment of cold, fever, toxic-heat and blood stasis, large carbuncle, pyogenic infections, scrofula, anal fistula and hypoglycemic activity, regulate body to non-specific IR effect.

Hairyvein agrimony: hemostasis, stomach invigorating. Can control spitting of blood, spit blood, hematuria, has blood in stool, dysentery, and under uterine bleeding band, internal lesion caused by overexertion take off power, and carbuncle is swollen, falls dozen, traumatic bleeding.

The Radix Astragali: enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, anti-stress, step-down and antibacterial action more widely.

Monkey ginger: the strong bone of kidney tonifying, continues and hinder pain relieving. For lumbago due to the kidney deficiency, Hiccough and deaf, tooth mobility.

The bark of eucommia: filling liver kidney, strengthening the bones and muscles, antiabortive. Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and threatened abortion is wanted to fall.

Okra: kidney tonifying, help digest, strengthen muscle power, protection liver, strong kidney, qi-restoratives.

The fruit of Chinese wolfberry: matrimony vine taste is sweet, property is flat. Enter liver, kidney channel. Nourshing kidney, moistening lung, tonifying liver, improving eyesight. Control liver-kidney Yin deficiency, soreness and weakness of waist and knees, dizziness, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission. Because there is function of improving eyesight, so be commonly called as " bright eye ". What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing dusk.

The Kunlun snow chrysanthemum: cool in nature, there are the effects such as wind and heat dispersing, brain nourishing and eyesight improving, removing toxicity for detumescence. And snow chrysanthemum has higher curative effect to staphylococcus aureus, corynebacterium diphtheriae and shigella dysenteriae.

Tongkat Ali: it is Yang invigorating medicine that effect runs far deeper than. Malaysia's university clinical testing proves its multiple function, and by the checking and examining of cytotoxic activity effect, these extract compounds and also have anti-H IV and antivirus action in vitro experiment. Up to the present, medical circle not yet finds that Tongkat Ali has any side effect.

Agate card: eat it and have a feeling of satisfaction, make us feeling very comfortable, its taste is sweet and refreshing. Agate card is rich in high unit nutrient, human body is had to the function of nourishing and fit keeping function, and that the people who ate has is full of physical strength, spirit is vigorous can be tired.

A kind of preparation method of the described Chinese traditional compound medicine that is used for the treatment of gall stone pain, after each component being pulverized according to proportioning, first use soaking in Chinese liquor, the effective component extracting that is soaked in water again, after leaching liquor merges, being configured to alcohol concentration with white wine is 45% ~ 48% preparation.

As preferably, the method is specially:

1. each raw meal is broken to 120 order ~ 150 orders;

2. after getting the fruit of Chinese wolfberry, the Kunlun snow chrysanthemum, Tongkat Ali and Ma Ka and mixing, be 55% ~ 60%(mass concentration by alcohol content) white wine at 50 DEG C ~ 55 DEG C temperature, soak 48h ~ 56h, after filtering, retain leaching liquor A, get after the submergence of filter residue water boils, naturally be cooled at 80 DEG C ~ 85 DEG C and soak 8h ~ 10h, obtain leaching liquor B;

3. get after celestial close grass, Radix Glycyrrhizae, Chinese yam, hairyvein agrimony, the Radix Astragali, monkey ginger, the bark of eucommia and the submergence of okra water boil, be naturally cooled at 80 DEG C ~ 85 DEG C and soak 8h ~ 10h, obtain leaching liquor C;

4. leaching liquor B and leaching liquor C merge with leaching liquor A through reduced pressure concentration after merging again, and being configured to alcohol concentration with white wine is 45% ~ 48% preparation.

As preferably, while immersion, stir 3 ~ 5 times at every turn.

Chinese traditional compound medicine of the present invention, not containing western medicine composition, keeps 80 DEG C ~ 85 DEG C immersion 8h effective component extracting recovery rates high, and active ingredient is not easy to decompose, and simple to operate, production cost is lower. This preparation for treating gall stone pain curative effect is high, and speed is fast, and dosage is little, without any side effect, just can treat gall stone pain as long as conventionally take (30 ~ 50) g in 1 minute. This preparation does not all detect lower than 0.01mg/kg(through relevant department's detection harmful heavy metal lead, mercury, chromium, arsenic, cadmium).

Detailed description of the invention

Below by specific embodiment, technical scheme of the present invention is described in further detail. Should be appreciated that enforcement of the present invention is not limited to the following examples, any pro forma accommodation that the present invention is made and/or change all will fall into protection domain of the present invention.

In the present invention, if not refer in particular to, all part, percentages are unit of weight, and equipment and the raw material etc. adopting all can be buied from market or this area is conventional. Method in following embodiment, if no special instructions, is the conventional method of this area.

Be used for the treatment of a Chinese traditional compound medicine for gall stone pain, said preparation is to be made up of the component of following weight portion meter: celestial close careless 10 ~ 15 parts, and 10 ~ 25 parts, Radix Glycyrrhizae, 10 ~ 25 parts of Chinese yams, 1 ~ 5 part of hairyvein agrimony, 5 ~ 10 parts of the Radixs Astragali, 6 ~ 15 parts of monkey ginger, 6 ~ 15 parts of the barks of eucommia, 6 ~ 15 parts of okras, 6 ~ 15 parts of the fruits of Chinese wolfberry, 2 ~ 6 parts of the Kunlun snow chrysanthemums, 1 ~ 5 part of Tongkat Ali, 1 ~ 5 part, agate card. The preparation method of this Chinese traditional compound medicine is:

1. each raw meal is broken to 120 ~ 150 orders;

2. get the fruit of Chinese wolfberry, the Kunlun snow chrysanthemum, Tongkat Ali and the rear white wine that is 55% ~ 60% by alcohol content of Ma Ka mixing and soak 48h-56h at 50 DEG C ~ 55 DEG C temperature, stir every day 3 ~ 5 times, after filtering, retain leaching liquor A, get after the submergence of filter residue water boils, naturally be cooled at 80 DEG C ~ 85 DEG C and soak 8h-10h, obtain leaching liquor B;

3. get after celestial close grass, Radix Glycyrrhizae, Chinese yam, hairyvein agrimony, the Radix Astragali, monkey ginger, the bark of eucommia and the submergence of okra water boil, be naturally cooled at 80 DEG C ~ 85 DEG C and soak 8h-10h, obtain leaching liquor C;

4. leaching liquor B and leaching liquor C merge with leaching liquor A through reduced pressure concentration after merging again, and being configured to alcohol concentration with white wine is 45% ~ 48% preparation.

Embodiment 1:

Be used for the treatment of a Chinese traditional compound medicine for gall stone pain, said preparation is to be made up of the component of following weight portion meter: celestial close careless 15 parts, and 25 parts, Radix Glycyrrhizae, 25 parts of Chinese yams, 5 parts of hairyvein agrimonies, 10 parts of the Radixs Astragali, 15 parts of monkey ginger, 15 parts of the barks of eucommia, 15 parts of okras, 15 parts of the fruits of Chinese wolfberry, 6 parts of the Kunlun snow chrysanthemums, 5 parts of Tongkat Alis, 5 parts, agate card.

The preparation method of this Chinese traditional compound medicine is:

1. each raw meal is broken to 120 ~ 150 orders;

2. after getting the fruit of Chinese wolfberry, the Kunlun snow chrysanthemum, Tongkat Ali and Ma Ka and mixing, be 60%(mass concentration by alcohol content) white wine at 55 DEG C of temperature, soak 48h, stir every day 5 times, after filtering, retain leaching liquor A, get after the submergence of filter residue water boils, naturally be cooled at 80 DEG C ~ 85 DEG C and soak 8h, obtain leaching liquor B;

3. get after celestial close grass, Radix Glycyrrhizae, Chinese yam, hairyvein agrimony, the Radix Astragali, monkey ginger, the bark of eucommia and the submergence of okra water boil, be naturally cooled at 80 DEG C ~ 85 DEG C and soak 8h, obtain leaching liquor C;

4. leaching liquor B and leaching liquor C merge with leaching liquor A through reduced pressure concentration after merging again, and being configured to alcohol concentration with white wine is 48% preparation.

Embodiment 2:

Be used for the treatment of a Chinese traditional compound medicine for gall stone pain, said preparation is to be made up of the component of following weight portion meter: celestial close careless 10 parts, and 10 parts, Radix Glycyrrhizae, 10 parts of Chinese yams, 1 part of hairyvein agrimony, 5 parts of the Radixs Astragali, 6 parts of monkey ginger, 6 parts of the barks of eucommia, 6 parts of okras, 6 parts of the fruits of Chinese wolfberry, 2 parts of the Kunlun snow chrysanthemums, 1 part of Tongkat Ali, 1 part, agate card. Preparation method's reference example 1 of this Chinese traditional compound medicine.

Embodiment 3:

Be used for the treatment of a Chinese traditional compound medicine for gall stone pain, said preparation is to be made up of the component of following weight portion meter: celestial close careless 12 parts, and 12 parts, Radix Glycyrrhizae, 12 parts of Chinese yams, 3 parts of hairyvein agrimonies, 8 parts of the Radixs Astragali, 8 parts of monkey ginger, 8 parts of the barks of eucommia, 8 parts of okras, 6 parts of the fruits of Chinese wolfberry, 4 parts of the Kunlun snow chrysanthemums, 2 parts of Tongkat Alis, 3 parts, agate card. Preparation method's reference example 1 of this Chinese traditional compound medicine.

Embodiment 4:

Described in a kind of embodiment 3, the preparation method of Chinese traditional compound medicine is:

1. each raw meal is broken to 120 ~ 150 orders;

2. after getting the fruit of Chinese wolfberry, the Kunlun snow chrysanthemum, Tongkat Ali and Ma Ka and mixing, be 55%(mass concentration by alcohol content) white wine at 50 DEG C of temperature, soak 56h, stir every day 5 times, after filtering, retain leaching liquor A, get after the submergence of filter residue water boils, naturally be cooled at 80 DEG C ~ 85 DEG C and soak 10h, obtain leaching liquor B;

3. get after celestial close grass, Radix Glycyrrhizae, Chinese yam, hairyvein agrimony, the Radix Astragali, monkey ginger, the bark of eucommia and the submergence of okra water boil, be naturally cooled at 80 DEG C ~ 85 DEG C and soak 10h, obtain leaching liquor C;

4. leaching liquor B and leaching liquor C merge with leaching liquor A through reduced pressure concentration after merging again, and being configured to alcohol concentration with white wine is 45% preparation.

Test example, clinical comparison test

1, experimental condition

Experimental group MethodsThe cases enrolled 80 examples, patient age is between 28～66 years old.

Control group MethodsThe cases enrolled 30 examples, patient age is between 28～66 years old.

2, include in case standard meet in, calculus pain case in the neck of gallbladder of Western medicine diagnose standard or cystic duct; One or two people suffer from rheumatoid arthritis, rheumatic arthritis person, can include test case in.

3, Excluded cases rated age person below 28 years old or more than 66 years old, gestation or women breast-feeding their children, to alcohol or this medicine allergy sufferers; Be associated with liver, kidney, cardiovascular disease, mental patient; Late deformity, maimed person, disability person.

4, test specimen

The 4.1 test group embodiment of the present invention 2 make sample, 30g/ bag.

4.2 control group Nanjing Tongrentang PAISHI KELIs, 20g/ bag.

4.3 administrated methods and the course for the treatment of: the each boiling water of Nanjing Tongrentang PAISHI KELI is taken after mixing it with water, one time 1 bag, 3 times on the one; 2 weeks is a course for the treatment of, other similar drugs of stopping using during treatment. Sample of the present invention, patient does not usually drink: add 30g warm boiled water, 1 time 1 bag, 2 times on the 1st. 2 weeks is a course for the treatment of, other similar drugs of stopping using during treatment.

5, test group therapeutic evaluation

5.1 cure evaluation: each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 3 courses for the treatment of, health check-up gall stone is dwindled almost and disappeared.

5.2 effective evaluations: each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 3 courses for the treatment of, health check-up gall stone is dwindled.

5.3 effective evaluations: each serving just can treat gall stone pain within a few minutes with this preparation 30g, more than total took for 3 courses for the treatment of, health check-up gall stone is dwindled. Comprise and curing and the effective statistics of listing in.

5.4 invalid evaluations: each serving not treating gall stone pain with this preparation 30g within a few minutes, more than total took for 3 courses for the treatment of, health check-up gall stone is without dwindling.

6, result of the test

Test group obvious effective rate 87.5%, total effective rate is 96.27%; Control group obvious effective rate 33.33%, total effective rate is 53.33%, and result shows, and test group curative effect is obviously better than control group, in table 1.

Table 1 clinical test results

Group	Sum	Cure	Effective	Effectively	Invalid	Obvious effective rate %	Total effective rate %
								Test group	80	2	70	77	3	87.5	96.27
Control group	30	0	10	16	4	33.33	53.33

Model case:

1. Mr. Huang, man, 63 years old, before 7 years, gall stone pain was crossed more than 10 time, each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 3 courses for the treatment of, within 2015, there is no pain again, and health check-up gall stone in 2015 is dwindled almost and is disappeared.

2. Mrs Chen, 62 years old, before 15 years, gall stone pain was crossed more than 10 time, each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 3 courses for the treatment of, within 2015, there is no pain again, and health check-up gall stone in 2015 is dwindled almost and is disappeared.

3. Mr. Lu, 63 years old, before 15 years, gall stone pain was crossed more than 20 time, before 5 years after second operation quick calculus again. Each serving just treating gall stone pain with this preparation (30 ~ 40) g in 1 minute, after total took for 3 courses for the treatment of, the second half year in 2015 does not have pain again, and within 2015, health check-up gall stone is dwindled.

4. Mr. Huang, man, 62 years old, before 10 years, gall stone pain was crossed more than 10 time, and each serving just treating gall stone pain with this preparation (30 ~ 40) g in 1 minute, after total took for 3 courses for the treatment of, the second half year in 2015 does not have pain again, and within 2015 years, health check-up gall stone is dwindled.

5. Mrs Lin, 60 years old, before 12 years, gall stone pain was crossed more than 10 time, each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 2 courses for the treatment of, within 2015, there is no pain again, and within 2015, health check-up gall stone is dwindled.

6. Mrs Zheng, 50 years old, before 8 years, gall stone pain was crossed 6 times, and each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 2 courses for the treatment of, the second half year in 2015 does not have pain again, and within 2015, health check-up gall stone is dwindled.

7. with Ms, 51 years old, before 6 years, gall stone pain was crossed 5 times, and each serving just can treat gall stone pain in 1 minute with this preparation 30g, after total took for 2 courses for the treatment of, the second half year in 2015 does not have pain again, and within 2015, health check-up gall stone is dwindled.

8. Mr. Hong, man, 65 years old, before 10 years, gall stone pain was crossed more than 10 time, and each serving just treating gall stone pain with this preparation (30 ~ 40) g in 1 minute, after total took for 2 courses for the treatment of, the second half year in 2015 does not have pain again, and within 2015 years, health check-up gall stone is dwindled.

Above-described embodiment is preferably scheme of one of the present invention, not the present invention is done to any pro forma restriction, also has other variant and remodeling under the prerequisite that does not exceed the technical scheme that claim records.

Claims (4)

1. be used for the treatment of a Chinese traditional compound medicine for gall stone pain, it is characterized in that said preparation is to be mainly made up of the component of following weight portion meter: celestial close careless 10 ~ 15 parts, 10 ~ 25 parts, Radix Glycyrrhizae, 10 ~ 25 parts of Chinese yams, 1 ~ 5 part of hairyvein agrimony, 5 ~ 10 parts of the Radixs Astragali, 6 ~ 15 parts of monkey ginger, 6 ~ 15 parts of the barks of eucommia, 6 ~ 15 parts of okras, 6 ~ 15 parts of the fruits of Chinese wolfberry, 2 ~ 6 parts of the Kunlun snow chrysanthemums, 1 ~ 5 part of Tongkat Ali, 1 ~ 5 part, agate card.

2. the preparation method of a Chinese traditional compound medicine that is used for the treatment of gall stone pain claimed in claim 1, it is characterized in that: after according to proportioning, each component being pulverized, first use soaking in Chinese liquor, the effective component extracting that is soaked in water again, after leaching liquor merges, being configured to alcohol concentration with white wine is 45% ~ 48% preparation.

3. preparation method according to claim 2, is characterized in that the method is specially:

1. each raw meal is broken to 120 order ~ 150 orders;

2. after getting the fruit of Chinese wolfberry, the Kunlun snow chrysanthemum, Tongkat Ali and Ma Ka and mixing, be 55% ~ 60%(mass concentration by alcohol content) white wine at 50 DEG C ~ 55 DEG C temperature, soak 48h ~ 56h, after filtering, retain leaching liquor A, get after the submergence of filter residue water boils, naturally be cooled at 80 DEG C ~ 85 DEG C and soak 8h ~ 10h, obtain leaching liquor B;

3. get after celestial close grass, Radix Glycyrrhizae, Chinese yam, hairyvein agrimony, the Radix Astragali, monkey ginger, the bark of eucommia and the submergence of okra water boil, be naturally cooled at 80 DEG C ~ 85 DEG C and soak 8h ~ 10h, obtain leaching liquor C;

4. leaching liquor B and leaching liquor C merge with leaching liquor A through reduced pressure concentration after merging again, and being configured to alcohol concentration with white wine is 45% ~ 48% preparation.

4. preparation method according to claim 1, is characterized in that: while immersion, stir 3 ~ 5 times at every turn.