CN1064849C - Medicine for enriching the blood - Google Patents
Medicine for enriching the blood Download PDFInfo
- Publication number
- CN1064849C CN1064849C CN971118078A CN97111807A CN1064849C CN 1064849 C CN1064849 C CN 1064849C CN 971118078 A CN971118078 A CN 971118078A CN 97111807 A CN97111807 A CN 97111807A CN 1064849 C CN1064849 C CN 1064849C
- Authority
- CN
- China
- Prior art keywords
- kilograms
- medicine
- liquid
- minutes
- relative density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine composition for blood nourishment and hemogenesis, which is composed of donkey-hide gelatin, ginseng, old arable soil, tangshen, hawthorn fruits, etc. The present invention can be prepared into any medicinal dosage form which is suitable for being used clinically, and the present invention is used for treating anemia, leukopenia, etc.
Description
The present invention relates to a kind of medicine of the hemopoietic of enriching blood, be specifically a kind of be the Chinese patent medicine that main component is prepared from the Chinese medicine Colla Corii Asini, belong to the field of Chinese medicines.
Anemia is a kind of commonly encountered diseases and frequently-occurring disease, and sickness rate is higher.The medicament categories of treatment anemia is various at present, and the chalybeate based on iron supplement is arranged, and the blood-forming agent based on QI invigorating is arranged, and also has the qi-blood tonifying prescription to enrich blood.The characteristics of these medicines are the single treatment anemias that are mainly used in of effect, and to the leukopenia that other reasons causes, then act on not fairly obvious.Although there are some to rise leukocytic medicine at present, this class drug side effect is bigger, should not take for a long time.Particularly can not tolerate chalybeate or western medicine result when not good as patient, often lack further measure.Some ass hide gelatin preparations are also arranged in the market, though Colla Corii Asini is a kind of extraordinary hematonic, it is unsuitable too much and of a specified duration excessively to take Colla Corii Asini separately, because Colla Corii Asini is grown easily and greasyly hindered stomach, weak patient to be taken for a long time to be not easy to absorb.Therefore, inventing a kind of medicine that hematosis is extensive and be easy to absorb of enriching blood, is a demand of current field of medicaments.
The object of the invention provides a kind of preparation method of compound medicine of the hemopoietic of enriching blood, and the medicine for preparing with this method can be used for treating anemia and leukopenia.
The inventive method is to be crude drug with following pharmaceutical composition:
Colla Corii Asini 30-70 weight portion
Radix Ginseng 10-30 weight portion
Radix Rehmanniae Preparata 100-200 weight portion
Radix Codonopsis 100-200 weight portion
Fructus Crataegi 50-90 weight portion
The optimum ratio of above-mentioned each component of the present invention is:
Colla Corii Asini 50 weight portions
Radix Ginseng 25 weight portions
Radix Rehmanniae Preparata 175 weight portions
Radix Codonopsis 175 weight portions
Fructus Crataegi 75 weight portions
The pharmaceutical composition that the present invention is above-mentioned can be prepared into any pharmaceutical preparation that is suitable for using clinically according to the preparation process of routine, for example, and pill, tablet, unguentum, powder, oral liquid etc.
Medicament composing prescription of the present invention, with the Colla Corii Asini YIN nourishing, the generation of erythrocyte and hemoglobin in the accelerate blood; The Radix Ginseng strongly invigorating primordial QI, the hemopoietic organ makes hematopoietic function vigorous; The Radix Rehmanniae Preparata nourishing YIN and supplementing blood, the Radix Codonopsis benefiting qi and nourishing blood can increase erythrocyte and leukocyte by the effect of spleen; Fructus Crataegi is built diabetes involving middle-JIAO food, blood circulation promoting and blood stasis dispelling.More than all medicines play strongly invigorating primordial QI altogether, the function of nourishing YIN and supplementing blood is applicable to insufficiency of vital energy and blood, anemia is sallow, shortness of breath and fatigue, weakness due to chronic disease etc., and have and mend and oiliness advantage, clothes do not hinder spleen fortune for a long time.
The preferred dosage form of medicine of the present invention is an oral liquid.
When being prepared into oral liquid formulations, flavoring agent and antiseptic be can also add, for example, sucrose, sorbic acid added.
The preparation method of medicine oral liquid of the present invention is:
1, batching
120 kilograms in Colla Corii Asini
60 kilograms of Radix Ginsengs
420 kilograms of Radix Rehmanniae Preparata
420 kilograms of Radix Codonopsis
180 kilograms of Fructus Crataegis
120 kilograms of sucrose
2.4 kilograms of sorbic acid
2, soak
With adding 4800 kilograms in water in the medical material adding multipotency extractor of assorting, soaked 0.5-2.0 hour.
3, extract
To soak back medical material heating, straight gas and interlayer heat simultaneously, and pressure is less than or equal to 0.1MPa, after boiling, close straight gas, transfer interlayer steam pressure 0.03-0.06MPa, boiled 90 minutes, emit medicine juice for the first time, sampling detects relative density 1.025-1.035, and amount of liquid medicine is no less than 3500 kilograms; Amount of water 2880-3100 kilogram for the second time, heated and boiled, pressurization is the same, boils 60 minutes, emits medicine juice, and sampling detects relative density greater than 1.015, and amount of liquid medicine is no less than 2500 kilograms; Amount of water 1800-1850 kilogram for the third time, heated and boiled is transferred steam pressure 0.03-0.06MPa, boils 40 minutes, emits medicine juice for the third time, and sampling detects relative density more than 1.005, and amount of liquid medicine is no less than 650 kilograms.
4, separate
Three medicine juice are squeezed into seperator with pump to be separated, the medicinal liquid funnel adds a gauze layer before separating, separating rate must not be greater than 16,000 Grams Per Minutes, 30 minutes row's primary slags, earlier carry out deslagging more than 2 minutes again towards seperator before the deslagging with the water more than 70 ℃, to notice during deslagging whether observe medicinal liquid has separated, seal whether fully, and then carry out deslagging.
5, evaporation
Open vacuum, when triple effect vacuum reaches 0.06MPa, one, two, three medicine juice after separating is sucked in the triple effect evaporator with vacuum, advanced one imitates, advance two again, triple effect, each suction volume can not be too much, can evaporate to second 1/2 place of looking the border, evaporating pressure is less than or equal to 0.09MPa, and temperature one is imitated 70 ℃; Two imitate 60 ℃; 50 ℃ of triple effects.Vacuum one is imitated 0.03-0.04MPa; Two imitate 0.05-0.06MPa, and triple effect 0.07-0.08MPa, the relative density of medicine liquid after the evaporation about 1.05 get final product rewinding.
6, the water of getting 5 times of amounts of Colla Corii Asini is in jacketed pan, be heated to boil after, will Colla Corii Asini add in the pot and constantly stir, make after dissolve into uniform glue, turn glue foam and impurity defecation with foam, add sucrose again and dissolve fully, make its relative density (20 ℃) about 1.12.
7, mixed precipitation
With the medicinal liquid after the evaporation and the gum sugar liquid after carrying foam squeeze into pump in the settling box with heating function, slowly add sodium carbonate liquor and transfer pH value 5.5-6.5, heated and boiled 15-20 minute, leave standstill more than 16 hours.
8, the separation of mixed liquor and fine straining
The mixed liquor of post precipitation is separated with seperator, per 30 minutes deslagginves once, Slagoff method is the same, goes into all turning barrels after mixed liquor separates, carry out fine straining, the medicinal liquid that pressure is no more than behind 0.1MPa (fine straining pressure is that 0.04-0.06-0.1MPa the raises gradually) fine straining enters liquid receiver.
9, concentrate
With vacuum with in the medicinal liquid suction concentration pan in the liquid receiver, it is molten long-pending 1/2 that concentrating under reduced pressure, medicinal liquid must not surpass concentration pan, pressure 0.08-0.12MPa, temperature 60-75 ℃, vacuum 0.05-0.07MPa, after concentrating, sampling, detect relative density more than 1.085, pH value 4.5-6.5 is heated to and boils, and 100 ℃ were boiled 15 minutes.
10, medicinal liquid is squeezed into pump in the finished product liquid receiver that has 100 mesh sieves, covered and enclosed is no more than 6 hours standing time.Fill, sterilization promptly.
Medicament of the present invention has the good hemopoietic function of enriching blood, and compared with similar products, its function of increasing leukocyte is very obvious, and has no side effect, and experimental results show that medicine of the present invention has following outstanding advantage.
1, leukopenia and iron deficiency anemia are common hematopathy, generally take way treatments such as leucocyte increasing agent such as batilol and chalybeate, when patient can not tolerate chalybeate or western medicine result when not good, often lack further measure.Above-mentioned two diseases of oral liquid treatment of the present invention have good medical effect, have represented the another effective way for the treatment of two diseases to us.
2, treat leukopenia, iron deficiency anemia totally 415 examples with oral medicine liquid of the present invention, the leukopenia effective percentage is 79.33%, the iron deficiency anemia total effective rate is 67.80%, learn by statistics and handle, the numerical value before and after leukocyte and the hemoglobin treatment has highly significant difference.This illustrates that medicine of the present invention is effectively to leukocyte increasing and treatment iron deficiency anemia.
3, in leukopenia 179 examples, totally 52 examples such as the Secondary cases leukopenia that causes because of medicine, radiotherapy chemotherapy occupational factor etc., after taking medicine oral liquid of the present invention, obtained curative effect preferably, can think that the treatment of the Secondary cases leukopenia that medicine of the present invention causes as radiotherapy chemotherapy and other chemical factors has certain future.
4, medicine of the present invention can quicken the restore funcitons of hemorrhagic anemia, can significantly increase erythrocyte and content of hemoglobin.
5, medicine of the present invention can prevent granulocytopenia in the blood, and the effect that promotes that the neutrophilic granulocyte absolute value significantly increases is arranged.
6, medicine of the present invention has the cytotoxicity of partial prophylaxis cyclophosphamide to medulla hematopoietic system, and the damage of slight medulla hematopoietic system is had protective effect.
7, medicine of the present invention has the attenuating oxygen consumption, and the effect of tolerance normobaric hypoxia significantly prolongs the anoxybiotic time-to-live of asphyxiating.
8, medicine of the present invention can improve the ability (prolongation swimming time) of mice persistence physical sport.
9, medicine of the present invention can improve the phagocytic function of macrophage in the mouse peritoneal significantly, can improve the protection function of body.
Embodiment
Prescription:
120 kilograms in Colla Corii Asini
60 kilograms of Radix Ginsengs
420 kilograms of Radix Rehmanniae Preparata
420 kilograms of Radix Codonopsis
180 kilograms of Fructus Crataegis
120 kilograms of sucrose
2.4 kilograms of sorbic acid
With adding 4800 kilograms in water in the medical material adding multipotency extractor of assorting, soaked 0.5-2.0 hour.
To soak back medical material heating, straight gas and interlayer heat simultaneously, and pressure is less than or equal to 0.1MPa, after boiling, close straight gas, transfer interlayer steam pressure 0.03-0.06MPa, boiled 90 minutes, emit medicine juice for the first time, sampling detects relative density 1.025-1.035, and amount of liquid medicine is no less than 3500 kilograms; Amount of water 2880-3100 kilogram for the second time, heated and boiled, pressurization is the same, boils 60 minutes, emits medicine juice, and sampling detects relative density greater than 1.015, and amount of liquid medicine is no less than 2500 kilograms; Amount of water 1800-1850 kilogram for the third time, heated and boiled is transferred steam pressure 0.03-0.06MPa, boils 40 minutes, emits medicine juice for the third time, and sampling detects relative density more than 1.005, and amount of liquid medicine is no less than 650 kilograms.
Three medicine juice are squeezed into seperator with pump separate, the medicinal liquid funnel adds a gauze layer before separating, and separating rate must not be greater than 16,000 Grams Per Minutes, and 30 minutes row's primary slags carry out deslagging with the water more than 70 ℃ towards seperator earlier before the deslagging again more than 2 minutes.
Open vacuum, when triple effect vacuum reaches 0.06MPa, one, two, three medicine juice after separating is sucked in the triple effect evaporator with vacuum, advanced one imitates, advance two again, triple effect, each suction volume can not be too much, can evaporate to second 1/2 place of looking the border, evaporating pressure is less than or equal to 0.09MPa, and temperature one is imitated 70 ℃; Two imitate 60 ℃; 50 ℃ of triple effects.Vacuum one is imitated 0.03-0.04MPa; Two imitate 0.05-0.06MPa, and triple effect 0.07-0.08MPa, the relative density of medicine liquid after the evaporation about 1.05 get final product rewinding.
The water of getting 5 times of amounts of Colla Corii Asini in jacketed pan, be heated to boil after, will Colla Corii Asini add in the pot and constantly stir, make after dissolve into uniform glue, turn glue foam and impurity defecation with foam, add sucrose again and dissolve fully, make its relative density (20 ℃) about 1.12.
With the medicinal liquid after the evaporation and the gum sugar liquid after carrying foam squeeze into pump in the settling box with heating function, slowly add sodium carbonate liquor and transfer pH value 5.5-6.5, heated and boiled 15-20 minute, leave standstill more than 16 hours.
The mixed liquor of post precipitation is separated with seperator, per 30 minutes deslagginves once, Slagoff method is the same, goes into all turning barrels after mixed liquor separates, carry out fine straining, the medicinal liquid that pressure is no more than behind 0.1MPa (fine straining pressure is that 0.04-0.06-0.1MPa the raises gradually) fine straining enters liquid receiver.
With vacuum with in the medicinal liquid suction concentration pan in the liquid receiver, it is molten long-pending 1/2 that concentrating under reduced pressure, medicinal liquid must not surpass concentration pan, pressure 0.08-0.12MPa, temperature 60-75 ℃, vacuum 0.05-0.07MPa, after concentrating, sampling, detect relative density more than 1.085, pH value 4.5-6.5 is heated to and boils, and 100 ℃ were boiled 15 minutes.
Medicinal liquid is squeezed into pump in the finished product liquid receiver that has 100 mesh sieves, and covered and enclosed is no more than 6 hours standing time.Fill, sterilization promptly.
Claims (1)
1. the preparation method of the medicament of enriching blood is characterized in that the batching of this method and technology are:
120 kilograms in Colla Corii Asini
60 kilograms of Radix Ginsengs
420 kilograms of Radix Rehmanniae Preparata
420 kilograms of Radix Codonopsis
180 kilograms of Fructus Crataegis
120 kilograms of sucrose
2.4 kilograms of sorbic acid
With adding 4800 kilograms in water in the medical material adding multipotency extractor of assorting, soaked 0.5-2.0 hour;
To soak back medical material heating, straight gas and interlayer heat simultaneously, pressure is less than or equal to 0.1MPa, after boiling, close straight gas, transfer interlayer steam pressure 0.03-0.006MPa, boiled 90 minutes, emit medicine juice for the first time, sampling detects relative density 1.025-1.035, and amount of liquid medicine is no less than 3500 kilograms; Amount of water 2880-3100 kilogram for the second time, heated and boiled, pressurization is the same, boils 60 minutes, emits medicine juice, and sampling detects relative density greater than 1.015, and amount of liquid medicine is no less than 2500 kilograms; Amount of water 1800-1850 kilogram for the third time, heated and boiled is transferred steam pressure 0.03-0.06MPa, boils 40 minutes, emits medicine juice for the third time, and sampling detects relative density more than 1.005, and amount of liquid medicine is no less than 650 kilograms;
Three medicine juice are squeezed into seperator with pump separate, the medicinal liquid funnel adds a gauze layer before separating, and separating rate must not be greater than 16,000 Grams Per Minutes, 30 minutes row's primary slags;
Open vacuum, when triple effect vacuum reaches 0.06MPa, one, two, three medicine juice after separating sucked in the triple effect evaporator with vacuum evaporate, the relative density of medicine liquid after the evaporation is 1.05 to get final product rewinding;
The water of getting 5 times of amounts of Colla Corii Asini in jacketed pan, be heated to boil after, will Colla Corii Asini add in the pot and constantly stir, make after dissolve into uniform glue, turn glue foam and impurity defecation with foam, add sucrose again and dissolve fully, making its relative density is 1.12 in the time of 20 ℃;
With the evaporation after medicinal liquid and carry foam after gum sugar liquid squeeze into pump in the settling box with heating function, slowly add sodium carbonate liquor adjust pH 5.5-6.5, heated and boiled 15-20 minute, leave standstill more than 16 hours;
The mixed liquor of post precipitation is separated with seperator, and per 30 minutes deslagginves are once gone into all turning barrels after the mixed liquor separation, carry out fine straining, and pressure is no more than 0.1Mpa, and the medicinal liquid behind the fine straining enters liquid receiver;
With in the medicinal liquid suction concentration pan in the liquid receiver, concentrating under reduced pressure is concentrated into relative density more than 1.085 with vacuum, and pH value 4.5-6.5 is heated to and boils, and 100 ℃ were boiled 15 minutes;
Medicinal liquid is squeezed into pump in the finished product liquid receiver that has 100 mesh sieves, and covered and enclosed is no more than 6 hours standing time, fill, and sterilization is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN971118078A CN1064849C (en) | 1997-06-20 | 1997-06-20 | Medicine for enriching the blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN971118078A CN1064849C (en) | 1997-06-20 | 1997-06-20 | Medicine for enriching the blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1168805A CN1168805A (en) | 1997-12-31 |
| CN1064849C true CN1064849C (en) | 2001-04-25 |
Family
ID=5171896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN971118078A Expired - Lifetime CN1064849C (en) | 1997-06-20 | 1997-06-20 | Medicine for enriching the blood |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1064849C (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112448B (en) * | 2007-08-03 | 2011-03-30 | 山东东阿史美生阿胶保健股份有限公司 | Donkey-hide gelatin composition having immunity improving effect and method of making the same |
| CN104069241B (en) * | 2013-05-17 | 2016-09-28 | 山东东阿阿胶股份有限公司 | FUFANG EJIAO JIANG application in the medicine of preparation prevention or treatment Xinjiang hemorrhagic fever |
| CN104069242A (en) * | 2013-07-09 | 2014-10-01 | 山东东阿阿胶股份有限公司 | Nano composition of compound e-jiao slurry and preparation method thereof |
| CN103446327A (en) * | 2013-08-20 | 2013-12-18 | 李颖 | Antianemic oral liquid and preparation technology thereof |
| CN103566167B (en) * | 2013-09-29 | 2016-04-13 | 山东东阿阿胶股份有限公司 | A kind of Chinese medicine composition of not getting angry containing Colla Corii Asini and preparation method thereof |
| CN103610974B (en) * | 2013-11-21 | 2015-08-19 | 山东东阿阿胶股份有限公司 | Sugar-free compound colla corii asini pulp and preparation technology thereof |
| CN103655898B (en) * | 2013-11-21 | 2015-12-02 | 山东东阿阿胶股份有限公司 | The FUFANG EJIAO JIANG of dysmenorrhea can be treated |
| CN103599245B (en) * | 2013-11-21 | 2015-11-11 | 山东东阿阿胶股份有限公司 | FUFANG EJIAO JIANG and preparation technology thereof |
| CN103690764B (en) * | 2013-11-21 | 2016-05-18 | 山东东阿阿胶股份有限公司 | Promote the production of body fluid complex prescription glue mucilage and the preparation technology thereof of cough-relieving |
| CN103599244B (en) * | 2013-11-21 | 2016-01-20 | 山东东阿阿胶股份有限公司 | The FUFANG EJIAO JIANG of nourishing the stomach of can enriching blood and preparation technology thereof |
| CN103655908B (en) * | 2013-11-21 | 2015-10-28 | 山东东阿阿胶股份有限公司 | FUFANG EJIAO JIANG and preparation technology thereof |
| CN103735714A (en) * | 2013-12-30 | 2014-04-23 | 山东东阿阿胶股份有限公司 | Application of compound donkey-hide gelatin preparation to preparation of female menstrual health-care medicament |
| CN103705718B (en) * | 2014-01-02 | 2017-05-10 | 山东东阿阿胶股份有限公司 | Compound donkey-hide gelatin slurry and preparation process thereof |
| CN106109692A (en) * | 2016-08-26 | 2016-11-16 | 山东东阿东盛阿胶产品科技开发有限公司 | A kind of Colla Corii Asini panax ginseng and campanumaea pilosula rehmannia-root oral liquid and preparation method thereof |
| CN109620911B (en) * | 2019-01-30 | 2021-08-31 | 广州天睿生物科技有限公司 | Traditional Chinese medicine composition capable of improving neutropenia after chemotherapy and application thereof |
-
1997
- 1997-06-20 CN CN971118078A patent/CN1064849C/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 《中成药研究》86 1986.12.31 王永汉"阿胶补将的药理作用" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1168805A (en) | 1997-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1064849C (en) | Medicine for enriching the blood | |
| CN1274599A (en) | Cancer treating medicine and its preparation | |
| CN111686147A (en) | Eucommia ulmoides extract and application thereof in treating osteoporosis | |
| CN1116894C (en) | Medicine for treating cardiovascular disease and preparation process thereof | |
| CN101053621A (en) | Traditional Chinese medicinal composition for treating obesity and its preparation method | |
| CN100339111C (en) | Medicine for treating coronary heart disease and its prepn | |
| CN101077166A (en) | Assorted fruit can | |
| CN1209133C (en) | Medicine for preventing and curing rachitis and osteoporosis and method for preparing the same | |
| CN101234170A (en) | Sanweishengmai injection and preparation thereof | |
| CN1126092A (en) | Selenium-riched Chinese caterpillar fungus oral liquor and its prepn. method | |
| CN1857449A (en) | Chinese medicine for treating puerperal hypogalactia | |
| CN1520738A (en) | Cactus health care jelly | |
| CN1840000A (en) | Nutrition oral liquor | |
| CN1565465A (en) | Injection preparation containing breviscapine active component and its preparation method | |
| CN1899385A (en) | Process for preparing Chinese medicine compound injection for treating chronic renal failure and use | |
| CN1859922A (en) | Medicinal composition | |
| CN1283182C (en) | Black fungus health care food and its making method | |
| CN1085533C (en) | Pilose antler-wood frog oil oral liquor and preparing method thereof | |
| CN1628693A (en) | Glossy ganoderma preparation containing main active substance of glossy ganoderma herb and preparing method thereof | |
| CN103610068A (en) | Preparation method for blood-fat-reducing sea cucumber oral liquid | |
| CN1027959C (en) | Zn-Ca oral liquid and its preparing method | |
| CN1278620C (en) | Salty sweets | |
| CN1291722C (en) | Use of oligoxylose in preparing medicine for treating diabetes | |
| CN1075377C (en) | Composite mannosans peptides oral liquor | |
| CN1843434A (en) | Pharmaceutical composition for treating qi and blood deficiency and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20010425 |
|
| CX01 | Expiry of patent term |