CN106481816A - Butt sealing structure for chromatographic column - Google Patents
Butt sealing structure for chromatographic column Download PDFInfo
- Publication number
- CN106481816A CN106481816A CN201611112720.2A CN201611112720A CN106481816A CN 106481816 A CN106481816 A CN 106481816A CN 201611112720 A CN201611112720 A CN 201611112720A CN 106481816 A CN106481816 A CN 106481816A
- Authority
- CN
- China
- Prior art keywords
- sealing
- chromatographic column
- outside
- inlet
- butt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16J—PISTONS; CYLINDERS; SEALINGS
- F16J15/00—Sealings
- F16J15/02—Sealings between relatively-stationary surfaces
- F16J15/021—Sealings between relatively-stationary surfaces with elastic packing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16J—PISTONS; CYLINDERS; SEALINGS
- F16J15/00—Sealings
- F16J15/02—Sealings between relatively-stationary surfaces
- F16J15/06—Sealings between relatively-stationary surfaces with solid packing compressed between sealing surfaces
- F16J15/061—Sealings between relatively-stationary surfaces with solid packing compressed between sealing surfaces with positioning means
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention discloses a kind of Butt sealing structure for chromatographic column, including：Fixed cover, its are removably fixed on the outside of the inlet of chromatographic column；Sealing shroud, its are coaxially socketed on the outside of the inlet of chromatographic column with the fixed cover；And adapter sleeve, which is removably fixed on the outside of the geat of ascending pipe, wherein, the adapter sleeve includes socket part and sealing, the socket part is socketed on the outside of the inlet of ascending pipe, and the sealing integral type is socketed on the outside of the socket part, and the sealing shroud includes ring-type groove portion formed therein and ring-type support sector, the support sector is contacted with the inlet outer surface of chromatographic column, and the sealing is supported by the top of the support sector and both keep sealing.According to the present invention, which has dismounting, cleaning, assembling simply, and good sealing effect can substantially reduce the beneficial effect that chromatographic column is subjected to the probability of secondary pollution in injection process.
Description
Technical field
The present invention relates to a kind of Butt sealing structure, more particularly to a kind of Butt sealing structure for chromatographic column.
Background technology
Chromatographic column can be used for be purified to process liquid and isolate from process liquid in industrial manufacture process
Material interested.Inevitably be mixed into impurity when the chemical products such as protein and medicine are prepared, and actually used in
Purity requirement to protein and this kind of material of medicine is very high, therefore, typically protein and medicine etc. is entered using chromatographic column
Row purifying, to obtain highly purified product.
During liquid to be purified is injected toward inside chromatographic column, the sealing between chromatographic column injection and ascending pipe is particularly
Important, inconvenient when being conventionally used to the Butt sealing structure of chromatographic column in dismounting, cleaning and installing, and dismantle or assembling process is numerous
Trivial, sealing effectiveness is also undesirable.In view of this, it is necessary in fact to develop a kind of Butt sealing structure for chromatographic column, to solve
The problems referred to above.
Content of the invention
For weak point present in above-mentioned technology, it is an object of the invention to provide a kind of docking for chromatographic column is close
Seal structure, its dismounting, cleaning, assembling are simple, good sealing effect, can substantially reduce chromatographic column be subjected in injection process secondary
The probability of pollution.
In order to realize above-mentioned purpose and other advantages according to the present invention, there is provided a kind of Butt sealing for chromatographic column
Structure, including：
Fixed cover, its are removably fixed on the outside of the inlet of chromatographic column；
Sealing shroud, its are coaxially socketed on the outside of the inlet of chromatographic column with the fixed cover；And
Adapter sleeve, its are removably fixed on the outside of the geat of ascending pipe,
Wherein, the adapter sleeve includes socket part and sealing, and the socket part is socketed on the outside of the inlet of ascending pipe,
The sealing integral type is socketed on the outside of the socket part, and the sealing shroud includes ring-type groove portion formed therein and ring
Shape support sector, the support sector are contacted with the inlet outer surface of chromatographic column, and the sealing is by the top of the support sector
Supported and both are kept sealing.
Preferably, the groove portion is embedded with sealing ring, and the sealing ring includes vertical portion and rake, the rake
Form an angle with the vertical portion, so that structure of width of the sealing ring in top less than the width of bottom.
Preferably, the vertical portion is affixed with the lateral wall of the groove portion, and the vertical portion is separated by necessarily with rake
Distance so as to formed be located between the two allow bit space, the bottom of the rake is offseted with the root of the support sector
Touch.
Preferably, the sealing ring is made up of elastomeric material, and the hardness of the sealing ring is 30～50A.
Preferably, elastic insert is provided between the sealing and support sector, and the hardness of the liner is 50～70A.
Preferably, the angle between the rake and the vertical portion is 15 °～30 °.
Preferably, elastic washer is provided between the sealing shroud and fixed cover, the hardness of the elastic washer is 20～
40A.
Compared with prior art, its advantage is the present invention：Its dismounting, cleaning, assembling are simple, good sealing effect, energy
Probability that chromatographic column in injection process be subjected to secondary pollution is enough substantially reduced.
Description of the drawings
Fig. 1 be according to the Butt sealing structure for chromatographic column of the present invention and ascending pipe and chromatographic column mates
Longitudinal sectional view；
Fig. 2 is the structure sectional view according to sealing ring in the Butt sealing structure for chromatographic column of the present invention.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, the foregoing end other objects of the present invention, feature, side
Face and advantage will be apparent from, to make those skilled in the art implement according to this with reference to specification word.
In order to make it easy to understand, Fig. 1 shows Butt sealing structure 100 and ascending pipe 300 and the chromatographic column for chromatographic column
The longitudinal sectional view that the inlet 200 of body matches.
Referring to Fig. 1, include for the Butt sealing structure 100 of chromatographic column：
Fixed cover 110, its are removably fixed in 200 outside of inlet of chromatographic column；
Sealing shroud 120, its are coaxially socketed on 200 outside of inlet of chromatographic column with fixed cover 110；And
Adapter sleeve 140, its are removably fixed on the outside of the geat of ascending pipe 300,
Wherein, adapter sleeve 140 includes socket part 141 and sealing 142, and socket part 141 is socketed on the injection of ascending pipe 300
On the outside of mouthful, 142 integral type of sealing is socketed on the outside of socket part 141, and sealing shroud 120 includes ring-type groove portion formed therein
123 and ring-type support sector 124, support sector 124 is contacted with 200 outer surface of inlet of chromatographic column, and sealing 142 is by support sector
124 top is supported and both keep sealing.In a preferred embodiment, lead between fixed cover 110 and sealing shroud 120
Cross multiple bolts 121 and realize detachable being fixedly connected.
With reference to Fig. 1 and Fig. 2, groove portion 123 is embedded with sealing ring 130, and sealing ring 130 includes vertical portion 131 and rake
132, rake 132 is formed an angle with vertical portion 131, so that width of width of the sealing ring 130 in top less than bottom
The structure of degree.In a preferred embodiment, the angle between rake 132 and vertical portion 131 is 15 °～30 °.Preferred
In embodiment, vertical portion 131 is affixed with the lateral wall of groove portion 123, and vertical portion 131 is with rake 132 at intervals
So as to form the bit space that allows being located between the two, the bottom 132 of rake 132 is inconsistent with the root of support sector 124.Using
This structure can enable sealing ring 130 to provide certain elastic anchorage force to support sector 124, at the same vertical portion 131 with
The bit space that allows between rake 132 contributes to sealing ring 130 is taken out from groove portion 123 cleaning or changes.Preferred
In embodiment, sealing ring 130 is made up of elastomeric material, and the hardness of sealing ring 130 is 30～50A.
With reference to Fig. 1, between sealing 142 and support sector 124, be provided with elastic insert 143, the hardness of liner 143 for 50～
70A.Snap groove 111 is provided with the inside of the upper surface of fixed cover 110, and the lower surface of sealing shroud 120 is provided with corresponding protuberance 125,
Sealing 120 passes through to fasten and the tight fit that realizes in snap groove 111 with fixed cover 110, sealing shroud its protuberance 125
Elastic washer 122 is provided between 120 and fixed cover 110, and the hardness of elastic washer 122 is 20～40A.Preferred embodiment
In, elastic washer 122 is located at the root of protuberance 125.
Number of devices described herein and treatment scale are used to the explanation of the simplification present invention.Application to the present invention,
Modifications and variations will be readily apparent to persons skilled in the art.
Although embodiment of the present invention is disclosed as above, but which is not limited in specification and embodiment listed fortune
With, it can be applied to various suitable the field of the invention completely, for those skilled in the art, can be easily real
Now other modification, therefore under the universal limited without departing substantially from claim and equivalency range, the present invention is not limited to
Specific details and shown here as the legend with description.
Claims (7)
1. a kind of Butt sealing structure for chromatographic column, it is characterised in that include：
Fixed cover, its are removably fixed on the outside of the inlet of chromatographic column；
Sealing shroud, its are coaxially socketed on the outside of the inlet of chromatographic column with the fixed cover；And
Adapter sleeve, its are removably fixed on the outside of the geat of ascending pipe,
Wherein, the adapter sleeve includes socket part and sealing, and the socket part is socketed on the outside of the inlet of ascending pipe, described
Sealing integral type is socketed on the outside of the socket part, and the sealing shroud includes that ring-type groove portion formed therein and ring-type are propped up
Portion is held, the support sector is contacted with the inlet outer surface of chromatographic column, and the sealing is propped up by the top of the support sector
Hold and both keep sealing.
2. the Butt sealing structure of chromatographic column is used for as claimed in claim 1, it is characterised in that the groove portion is embedded with sealing
Circle, the sealing ring include vertical portion and rake, and the rake is formed an angle with the vertical portion, so that described
Width of the sealing ring in top is less than the structure of the width of bottom.
3. the Butt sealing structure of chromatographic column is used for as claimed in claim 2, it is characterised in that the vertical portion and the groove
The lateral wall in portion is affixed, and the vertical portion is with rake at intervals so as to form the resigning sky being located between the two
Between, the bottom of the rake is inconsistent with the root of the support sector.
4. the Butt sealing structure of chromatographic column is used for as claimed in claim 2 or claim 3, it is characterised in that the sealing ring is by bullet
Property material make, the hardness of the sealing ring is 30～50A.
5. the Butt sealing structure for chromatographic column as described in any one of claims 1 to 3, it is characterised in that the sealing
Elastic insert is provided between portion and support sector, and the hardness of the liner is 50～70A.
6. the Butt sealing structure of chromatographic column is used for as claimed in claim 2 or claim 3, it is characterised in that the rake and institute
It is 15 °～30 ° to state the angle between vertical portion.
7. the Butt sealing structure for chromatographic column as described in any one of claims 1 to 3, it is characterised in that the sealing
Elastic washer is provided between set and fixed cover, and the hardness of the elastic washer is 20～40A.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611112720.2A CN106481816B (en) | 2016-12-07 | 2016-12-07 | For the Butt sealing structure of chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611112720.2A CN106481816B (en) | 2016-12-07 | 2016-12-07 | For the Butt sealing structure of chromatographic column |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106481816A true CN106481816A (en) | 2017-03-08 |
| CN106481816B CN106481816B (en) | 2018-05-18 |
Family
ID=58275614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611112720.2A Active CN106481816B (en) | 2016-12-07 | 2016-12-07 | For the Butt sealing structure of chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106481816B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714074A (en) * | 1993-04-26 | 1998-02-03 | Pharmacia Biotech Ab | Method and apparatus for liquid chromatography |
| CN101433776A (en) * | 2007-11-14 | 2009-05-20 | 中国科学院大连化学物理研究所 | Large-sized chromatographic column for preparation with diameter of 50 millimetres or more |
| CN103083943A (en) * | 2011-11-03 | 2013-05-08 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN103638692A (en) * | 2013-11-29 | 2014-03-19 | 栗云天 | Liquid distributor with two stages of runners for chromatographic column |
| CN204815790U (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Chromatography column coupling assembling |
| CN206234358U (en) * | 2016-12-07 | 2017-06-09 | 苏州楚博生物技术有限公司 | For the Butt sealing structure of chromatographic column |
-
2016
- 2016-12-07 CN CN201611112720.2A patent/CN106481816B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714074A (en) * | 1993-04-26 | 1998-02-03 | Pharmacia Biotech Ab | Method and apparatus for liquid chromatography |
| CN101433776A (en) * | 2007-11-14 | 2009-05-20 | 中国科学院大连化学物理研究所 | Large-sized chromatographic column for preparation with diameter of 50 millimetres or more |
| CN103083943A (en) * | 2011-11-03 | 2013-05-08 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN103638692A (en) * | 2013-11-29 | 2014-03-19 | 栗云天 | Liquid distributor with two stages of runners for chromatographic column |
| CN204815790U (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Chromatography column coupling assembling |
| CN206234358U (en) * | 2016-12-07 | 2017-06-09 | 苏州楚博生物技术有限公司 | For the Butt sealing structure of chromatographic column |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106481816B (en) | 2018-05-18 |
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