CN206338411U - Butt sealing component for tandem chromatographic column - Google Patents
Butt sealing component for tandem chromatographic column Download PDFInfo
- Publication number
- CN206338411U CN206338411U CN201621355693.7U CN201621355693U CN206338411U CN 206338411 U CN206338411 U CN 206338411U CN 201621355693 U CN201621355693 U CN 201621355693U CN 206338411 U CN206338411 U CN 206338411U
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- CN
- China
- Prior art keywords
- ring
- hold
- sealing
- chromatographic column
- sealing ring
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
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Abstract
The utility model discloses a kind of Butt sealing component for tandem chromatographic column, including：Hold-down ring, undertaking ring and the sealing ring being coaxially disposed, wherein, elastic connection between the undertaking ring and sealing ring is embedded with dead ring between the hold-down ring and undertaking ring.According to the utility model, it has dismounting, cleaning, assembling simple, good sealing effect, can substantially reduce adjacent two-stage chromatographic column in docking injection process by secondary pollution probability beneficial effect.
Description
Technical field
The utility model is related to a kind of Butt sealing component, more particularly to a kind of Butt sealing for tandem chromatographic column
Component.
Background technology
Advantage of the chromatographic technique in separating and filtering field is it is well known that available for effective from COMPLEX MIXED solution
Target product is isolated, the impurity in object is removed, final product or replacement product solution etc. is purified, chromatographic technique has
The characteristics of high separating efficiency, the product of temperature-sensitive or easy in inactivation, such as protein, polysaccharide can be separated under conditions of condition is relatively mild
With polypeptide etc..Chromatographic column is the key for realizing chromatography, and chromatographic column is typically by cylindric shell, the circle being sheathed in shell
Tubular splitter, the inlet for injecting solution to be separated, the flow export for exporting solution after separation.
In chromatography post separation, Gao Zhuxiao is to ensure that chromatographic column has the important indicator of certain separating degree, in separation, carry
Gao Zhuxiao method is mainly the length using short grained chromatography post separation filler or extension splitter or is to adopt
Separation is sequentially connected in series with multistage chromatographic column.Wherein, using multistage chromatographic column be sequentially connected in series separation due to low cost, it is easy to operate, point
It is good from effect, approved by practical operation.
However, in the prior art, separation is sequentially connected in series using multistage chromatographic column, the docking of adjacent two-stage chromatography intercolumniation is close
Envelope is not ideal, especially under conditions of high post pressure, tends to occur sepage, leakage, even docks situation about coming off.In view of
This, is necessary to develop a kind of Butt sealing component for tandem chromatographic column in fact, to solve the above problems.
Utility model content
For weak point present in above-mentioned technology, the purpose of this utility model is to provide a kind of tandem that is used for and chromatographed
The Butt sealing component of post, it is dismantled, cleaned, assembling is simple, and good sealing effect can substantially reduce adjacent two-stage chromatographic column and exist
Dock the probability by secondary pollution in injection process.
It is used for tandem chromatographic column there is provided one kind according to above-mentioned purpose of the present utility model and other advantages to realize
Butt sealing component, including：
Hold-down ring, undertaking ring and the sealing ring being coaxially disposed,
Wherein, elastic connection between the undertaking ring and sealing ring, fastening is embedded between the hold-down ring and undertaking ring
Ring.
Preferably, be sequentially coaxially arranged with from top to bottom on higher level's chromatographic column flow export the hold-down ring, accept ring and
The hold-down ring is sequentially coaxially arranged with sealing ring, subordinate's chromatographic column inlet from the bottom up, ring and sealing ring is accepted.
Preferably, on higher level's chromatographic column flow export the hold-down ring, undertaking ring and sealing ring and subordinate's chromatographic column is noted
The hold-down ring, undertaking ring and sealing ring on entrance are mutually structure symmetrical above and below.
Preferably, the returning spring accepted provided with several circumferentially equidistantly distributeds between ring and sealing ring.
Preferably, the hold-down ring includes hold-down ring base portion and hold-down ring skirt section, and the hold-down ring skirt section is in the pressure
Integrally with reference to the hold-down ring base portion and from hold-down ring described in the inner edge of the hold-down ring base portion in the inner circumferential in tight ring group portion
Outside vertical direction extension.
Preferably, it is formed with platform-like shoulder, the shoulder and covers between the hold-down ring base portion and hold-down ring skirt section
Provided with hold-down ring sealing ring.
Preferably, it is described undertaking ring and the returning spring between be provided with ring-type bearing plate, the undertaking ring with it is described
Bumper ring is embedded between bearing plate.
Preferably, the sealing ring includes sealing ring base portion and sealing ring skirt section, and the sealing ring skirt section is described close
Integrally with reference to the sealing ring base portion and from the periphery of the sealing ring base portion along the sealing ring on the periphery of seal ring base portion
Outside vertical direction extension.
Preferably, sealing ring shoulder and the sealing ring shoulder are formed between the sealing ring base portion and sealing ring skirt section
On groove portion, the returning spring supported by the sealing ring shoulder, and the madial wall in the sealing ring skirt section is held with described
The lateral wall for connecing ring is in contact, and the undertaking ring can be lifted in the groove portion.
Compared with prior art, its advantage is the utility model：It is dismantled, cleaned, assembling is simple, sealing effectiveness
It is good, adjacent two-stage chromatographic column probability by secondary pollution in docking injection process can be substantially reduced.
Brief description of the drawings
Fig. 1 is according to the Butt sealing component described in the utility model for tandem chromatographic column and higher level's chromatographic column stream
The longitudinal component sectional view that outlet and subordinate's chromatographic column inlet are engaged；
Embodiment
The utility model is described in further detail below in conjunction with the accompanying drawings, of the present utility model foregoing and other mesh
, feature, aspect and advantage will be apparent, to make those skilled in the art can be real according to this with reference to specification word
Apply.
In order to make it easy to understand, Fig. 1 shows the Butt sealing component 100 and higher level's chromatographic column stream for tandem chromatographic column
The longitudinal component sectional view that outlet 300 and subordinate's chromatographic column inlet 200 are engaged.
Referring to Fig. 1, the Butt sealing component 100 for tandem chromatographic column includes：
Hold-down ring 130, undertaking ring 120 and the sealing ring 110 being coaxially disposed,
Wherein, elastic connection between ring 120 and sealing ring 110 is accepted, is embedded between hold-down ring 130 and undertaking ring 120
Dead ring 140.
In a preferred embodiment, hold-down ring is sequentially coaxially arranged with from top to bottom on higher level's chromatographic column flow export 300
130th, accept on ring 120 and sealing ring 110, subordinate's chromatographic column inlet 200 and be sequentially coaxially arranged with hold-down ring from the bottom up
130th, ring 120 and sealing ring 110 are accepted, wherein, hold-down ring 130 on higher level's chromatographic column flow export 300, accept ring 120 and
Sealing ring 110 and the hold-down ring 130 on subordinate chromatographic column inlet 200, accept ring 120 and sealing ring 110 be mutually it is symmetrical above and below
Structure.Using this structure, design cost on the one hand can be reduced, on the other hand can further simplify structure, while can also
The complexity of enough reduction assemblings.
Referring to Fig. 1, the returning spring provided with several circumferentially equidistantly distributeds between ring 120 and sealing ring 110 is accepted
113.In one embodiment, returning spring 113 is provided with 8.
Referring to Fig. 1, hold-down ring 130 includes hold-down ring base portion 131 and hold-down ring skirt section 132, and hold-down ring skirt section 132 is being compressed
The hold-down ring base portion 131 is integrally combined in the inner circumferential in ring group portion 131 and is compressed from the inner edge of the hold-down ring base portion 131
The outside vertical direction extension of ring 130.In a preferred embodiment, hold-down ring 130 respectively with higher level's chromatographic column flow export 300
And subordinate's chromatographic column inlet 200 is threadedly coupled, undertaking ring 120 can be pressed with sealing ring 110 by being threaded into or screwing out
It is tight or unclamp, and then realize docking or release for higher level's chromatographic column flow export 300 and subordinate chromatographic column inlet 200, reply bullet
The setting of spring 113 helps to provide auxiliary force when hold-down ring 130 is screwed out, consequently facilitating unblock.
Referring to Fig. 1, it is formed between hold-down ring base portion 131 and hold-down ring skirt section 132 on platform-like shoulder 133, shoulder 133
It is arranged with hold-down ring sealing ring 134.In a preferred embodiment, hold-down ring sealing ring 134 is made up of elastomeric material, on the one hand
The support force of the root of hold-down ring skirt section 132 can be strengthened, on the other hand can be carried between Butt sealing component 100 and protecting crust
For further sealing.
Referring to Fig. 1, accept and ring-type bearing plate 123 is provided between ring 120 and returning spring 113, accept ring 120 and bearing plate
Bumper ring 122 is embedded between 123.122, which are changed, due to buffering is sheathed on higher level's chromatographic column flow export 300 or subordinate's chromatographic column injection
On mouth 200, its one side can provide sealing, on the other hand can play cushioning effect to spring.
Referring to Fig. 1, sealing ring 110 includes sealing ring base portion 111 and sealing ring skirt section 112, and sealing ring skirt section 112 is in sealing
The sealing ring base portion 111 is integrally combined on the periphery in ring group portion 111 and is sealed from the periphery edge of the sealing ring base portion 111
The outside vertical direction extension of ring 110.In a preferred embodiment, shape between sealing ring base portion 111 and sealing ring skirt section 112
Into the groove portion having on sealing ring shoulder and the sealing ring shoulder, returning spring 113 is supported by the sealing ring shoulder, sealing
The madial wall in ring skirt section 112 is in contact with accepting the lateral wall of ring 120, and accepting ring 120 can lift in the groove portion.Using this
Structure is planted, ring 120 can will be accepted and returning spring 113 is fixed in predetermined scope, and prevent in the process locked or unlocked
The middle phenomenon for occurring accepting that ring 120 and returning spring 113 are slipped, improves the stability of assembling.
Number of devices and treatment scale described herein are for simplifying explanation of the present utility model.To the utility model
Application, modifications and variations will be readily apparent to persons skilled in the art.
Although embodiment of the present utility model is disclosed as above, it is not limited in institute in specification and embodiment
Row are used, and it can be applied to various suitable fields of the present utility model completely, can for those skilled in the art
Other modification is easily realized, therefore under the universal limited without departing substantially from claim and equivalency range, this practicality
It is new to be not limited to specific details and shown here as the legend with description.
Claims (9)
1. a kind of Butt sealing component for tandem chromatographic column, it is characterised in that including：
Hold-down ring, undertaking ring and the sealing ring being coaxially disposed,
Wherein, elastic connection between the undertaking ring and sealing ring, dead ring is embedded between the hold-down ring and undertaking ring.
2. it is used for the Butt sealing component of tandem chromatographic column as claimed in claim 1, it is characterised in that higher level's chromatographic column stream
The hold-down ring is sequentially coaxially arranged with outlet from top to bottom, is accepted on ring and sealing ring, subordinate's chromatographic column inlet under
Up sequentially coaxially it is arranged with the hold-down ring, accepts ring and sealing ring.
3. it is used for the Butt sealing component of tandem chromatographic column as claimed in claim 2, it is characterised in that higher level's chromatographic column stream
The hold-down ring in outlet, accept ring and sealing ring and the hold-down ring on subordinate's chromatographic column inlet, undertaking ring and
Sealing ring is mutually structure symmetrical above and below.
4. the Butt sealing component for tandem chromatographic column as described in any one of claims 1 to 3, it is characterised in that institute
State the returning spring accepted provided with several circumferentially equidistantly distributeds between ring and sealing ring.
5. the Butt sealing component for tandem chromatographic column as described in any one of claims 1 to 3, it is characterised in that institute
Stating hold-down ring includes hold-down ring base portion and hold-down ring skirt section, hold-down ring skirt section one in the inner circumferential of the hold-down ring base portion
Extend with reference to the hold-down ring base portion and from the outside vertical direction of hold-down ring described in the inner edge of the hold-down ring base portion likes.
6. the Butt sealing component for tandem chromatographic column as described in any one of claim 5, it is characterised in that the pressure
Tight be formed between ring group portion and hold-down ring skirt section on platform-like shoulder, the shoulder is arranged with hold-down ring sealing ring.
7. the Butt sealing component for tandem chromatographic column as described in any one of claim 4, it is characterised in that described to hold
Connect and ring-type bearing plate is provided between ring and the returning spring, bumper ring is embedded between the undertaking ring and the bearing plate.
8. the Butt sealing component for tandem chromatographic column as described in any one of claim 4, it is characterised in that described close
Seal ring include sealing ring base portion and sealing ring skirt section, the sealing ring skirt section on the periphery of the sealing ring base portion integrally
Extend with reference to the sealing ring base portion and from the periphery of the sealing ring base portion along the outside vertical direction of the sealing ring.
9. the Butt sealing component for tandem chromatographic column as described in any one of claim 8, it is characterised in that described close
The groove portion on sealing ring shoulder and the sealing ring shoulder, the returning spring are formed between seal ring base portion and sealing ring skirt section
Supported by the sealing ring shoulder, the madial wall in the sealing ring skirt section is in contact with the lateral wall of the undertaking ring, described
Accepting ring can lift in the groove portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621355693.7U CN206338411U (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621355693.7U CN206338411U (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206338411U true CN206338411U (en) | 2017-07-18 |
Family
ID=59307740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621355693.7U Withdrawn - After Issue CN206338411U (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206338411U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106481817A (en) * | 2016-12-12 | 2017-03-08 | 苏州楚博生物技术有限公司 | Butt sealing assembly for tandem chromatographic column |
-
2016
- 2016-12-12 CN CN201621355693.7U patent/CN206338411U/en not_active Withdrawn - After Issue
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106481817A (en) * | 2016-12-12 | 2017-03-08 | 苏州楚博生物技术有限公司 | Butt sealing assembly for tandem chromatographic column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20170718 Effective date of abandoning: 20190212 |