CN106512479B - Vacuum type sealing structure for chromatographic column - Google Patents
Vacuum type sealing structure for chromatographic column Download PDFInfo
- Publication number
- CN106512479B CN106512479B CN201611162008.3A CN201611162008A CN106512479B CN 106512479 B CN106512479 B CN 106512479B CN 201611162008 A CN201611162008 A CN 201611162008A CN 106512479 B CN106512479 B CN 106512479B
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- CN
- China
- Prior art keywords
- seal circle
- chromatographic column
- base portion
- secondary seal
- vacuum type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16J—PISTONS; CYLINDERS; SEALINGS
- F16J15/00—Sealings
- F16J15/16—Sealings between relatively-moving surfaces
- F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
Abstract
The invention discloses a kind of vacuum type sealing structures for chromatographic column, it include: the support set in convex shape structure, it includes circular base portion and skirt section, and the skirt section integrally combines the base portion and the inner edge axial direction linear extension from the base portion in the inner circumferential of the base portion；The primary seal circle and secondary seal circle being sequentially arranged on the axially-extending line for supporting set；And the fit sealing set of the centre set on the secondary seal circle, the secondary seal circle is integrally combined in the inner circumferential of the secondary seal circle and from the secondary seal circle inner edge axial direction linear extension.According to the present invention, have disassembly, cleaning, assembly simple, sealing effect is good, can substantially reduce chromatographic column in docking injection process by the beneficial effect of the probability of secondary pollution.
Description
Technical field
The present invention relates to a kind of sealing structure, in particular to a kind of vacuum type sealing structure for chromatographic column.
Background technique
Chromatographic technique is in the advantage in separating and filtering field it is well known that can be used for from COMPLEX MIXED solution effectively
Target product is isolated, the impurity in object is removed, purifies final product or replacement product solution etc., chromatographic technique has
The characteristics of high separating efficiency, can separate the product of temperature-sensitive or easy in inactivation, such as protein, polysaccharide under conditions of condition is relatively mild
With polypeptide etc..Chromatographic column is the key that realize chromatography, and chromatographic column is generally by cylindric shell, the circle being sheathed in shell
Tubular splitter, the inlet for injecting solution to be separated, for export separation after solution outflux.
During toward liquid to be purified is injected inside chromatographic column, the sealing of chromatographic column inlet is particularly important, tradition
The upper Butt sealing component for chromatographic column is inconvenient in disassembly, cleaning and installation, and disassembly or assembling process are cumbersome, sealing
Effect is also undesirable.In view of this, it is really necessary to develop a kind of Butt sealing structure for chromatographic column, to solve above-mentioned ask
Topic.
Summary of the invention
Shortcoming present in view of the above technology, the object of the present invention is to provide a kind of vacuum type for chromatographic column
Sealing structure, disassembly, cleaning, assembly are simple, and sealing effect is good, can substantially reduce chromatographic column and meet in docking injection process
By the probability of secondary pollution.
In order to realize above-mentioned purpose according to the present invention and other advantages, it is close to provide a kind of vacuum type for chromatographic column
Seal structure, comprising:
In the support sleeve of convex shape structure comprising circular base portion and skirt section, the skirt section is in the base portion
The base portion and the inner edge axial direction linear extension from the base portion are integrally combined on week；
The primary seal circle and secondary seal circle being sequentially arranged on the axially-extending line of the support sleeve；And
Set on the fit sealing set of the centre of the secondary seal circle, the one in the inner circumferential of the secondary seal circle
Combine the secondary seal circle and from the secondary seal circle inner edge axial direction linear extension likes；
Wherein, returning spring, the root of the returning spring are equipped in the through-hole of the primary seal circle and secondary seal circle
Portion is supported by the skirt section top of the support sleeve, and the top of the returning spring is propped up by the top of the secondary seal circle
Support, the primary seal circle and secondary seal circle are under the support of the returning spring optionally close to or far from the branch
The base portion of support set, the fit sealing set, secondary seal circle, primary seal circle and returning spring are successively sheathed on injection pipe,
It is fixed on the inner wall of chromatographic column inlet to the support sleeve internal connecting type, when the base of the primary seal circle and the support sleeve
When portion is harmonious, the outer wall and support sleeve of the fit sealing set and injection pipe form confined space.
Preferably, the skirt section and the joint of the base portion form a L-shaped shoulder, and the shoulder is arranged with bullet
Property sealing ring.
Preferably, the top of the base portion is integrally connected with clamping ring, and the outer wall of the clamping ring is equipped with extremely
Lack three radially outwardly projecting guide pads.
Preferably, the inner wall of the primary seal circle is equipped with the guide groove being adapted with the guide pad.
Preferably, the fit sealing set is connected through a screw thread with injection pipe.
Preferably, the side wall of the fit sealing set is equipped with venthole, and the venthole is equipped with selectivity closure
Gas valve.
Preferably, the hardness of the elastic seal ring is 30~50A.
Compared with prior art, the present invention the beneficial effect is that: it is dismantled, cleaning, assembles simply, and sealing effect is good, energy
Chromatographic column is enough substantially reduced in docking injection process by the probability of secondary pollution.
Detailed description of the invention
Fig. 1 is the structure matched according to the vacuum type sealing structure of the present invention for chromatographic column with injection pipe
Figure；
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, foregoing end other objects of the invention, feature, side
Face and advantage will be apparent, and so that those skilled in the art can carry out according to the description.
In order to make it easy to understand, Fig. 1 shows and matches with injection pipe 200 for the Butt sealing structure 100 of chromatographic column
Structure chart.
Referring to Fig. 1, the vacuum type sealing structure 100 for chromatographic column includes:
In the support sleeve 110 of convex shape structure comprising circular base portion 111 and skirt section 112, skirt section 112 is in base portion
The base portion 111 and the inner edge axial direction linear extension from the base portion 111 are integrally combined in 111 inner circumferential；
The primary seal circle 120 and secondary seal circle 130 being sequentially arranged on the axially-extending line of support sleeve 110；And
Set on the fit sealing set 160 of the centre of secondary seal circle 130, one in the inner circumferential of secondary seal circle 130
Combine to body formula the secondary seal circle 130 and from the 130 inner edge axial direction linear extension of secondary seal circle；
Wherein, returning spring 140, returning spring are equipped in the through-hole of the primary seal circle 120 and secondary seal circle 130
140 root is supported by 112 top of skirt section of support sleeve 110, the top of returning spring 140 by secondary seal circle 130 top
End is supported, and primary seal circle 120 and secondary seal circle 130 are optionally close or remote under the support of returning spring 140
Base portion 111 from support sleeve 110, fit sealing set 160, secondary seal circle 130, primary seal circle 120 and returning spring 140 according to
It is secondary to be sheathed on injection pipe 200, it is fixed on the inner wall of chromatographic column inlet to 110 internal connecting type of support sleeve, when primary seal circle
120 with the base portion 111 of support sleeve 110 when being harmonious, outer wall and support sleeve 110 formation of fit sealing set 160 and injection pipe 200
Confined space.
Referring to Fig.1, skirt section 112 and the joint of base portion 111 form a L-shaped shoulder, and the shoulder is arranged flexible
Sealing ring 113.Elastic seal ring 113 can be reinforced close when primary seal circle 120 and the base portion 111 of support sleeve 110 are harmonious
Feng Xing.In a preferred embodiment, the hardness of elastic seal ring 113 is 30~50A.
Referring to Fig.1, the top of base portion 112 is integrally connected with clamping ring 150, and the outer wall of clamping ring 150 is equipped with extremely
Few three radially outwardly projecting guide pad 151, the inner wall of primary seal circle 120 are equipped with adaptable with guide pad 151
Guide groove 121 so that when primary seal circle 120 is harmonious or isolated process can be put down with the base portion 111 of support sleeve 110
Directly, stablize.
In a preferred embodiment, fit sealing set 160 is connected through a screw thread with injection pipe 200.
Referring to Fig.1, the side wall 161 of fit sealing set 160 is equipped with venthole 161a, and venthole 161a is equipped with selectivity
The gas valve of closure.When the base portion 111 of primary seal circle 120 and support sleeve 110 is harmonious, primary seal circle 120 and second level
Air in sealing ring 130 is squeezed out by venthole 161a, while can pass through venthole 161a with the use of vacuum evacuation device
Surplus air in primary seal circle 120 and secondary seal circle 130 is vacuumized, is then closed the gas valve, so far
Just complete the assembly between vacuum type sealing structure 100 and injection pipe 200 and chromatographic column inlet.
Number of devices and treatment scale described herein are for simplifying explanation of the invention.To application of the invention,
Modifications and variations will be readily apparent to persons skilled in the art.
Although the embodiments of the present invention have been disclosed as above, but it is not limited in listed fortune in specification and embodiments
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily real
Now other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is not limited to
Specific details and legend shown and described herein.
Claims (7)
1. a kind of vacuum type sealing structure for chromatographic column characterized by comprising
In the support sleeve of convex shape structure comprising circular base portion and skirt section, the skirt section is in the inner circumferential of the base portion
Integrally combine the base portion and the inner edge axial direction linear extension from the base portion；
The primary seal circle and secondary seal circle being sequentially arranged on the axially-extending line of the support sleeve；And
Set on the fit sealing set of the centre of the secondary seal circle, in the inner circumferential of the secondary seal circle integrally
In conjunction with the secondary seal circle and from the secondary seal circle inner edge axial direction linear extension；
Wherein, be equipped with returning spring in the through-hole of the primary seal circle and secondary seal circle, the root of the returning spring by
The skirt section top of the support sleeve is supported, and the top of the returning spring is supported by the top of the secondary seal circle, institute
Primary seal circle and secondary seal circle are stated under the support of the returning spring optionally close to or far from the support sleeve
Base portion, the fit sealing set, secondary seal circle, primary seal circle and returning spring are successively sheathed on injection pipe, described
It is fixed on the inner wall of chromatographic column inlet to support sleeve internal connecting type, when the base portion phase of the primary seal circle and the support sleeve
When conjunction, the outer wall and support sleeve of the fit sealing set and injection pipe form confined space.
2. being used for the vacuum type sealing structure of chromatographic column as described in claim 1, which is characterized in that the skirt section and the base
The joint in portion forms a L-shaped shoulder, and the shoulder is arranged with elastic seal ring.
3. being used for the vacuum type sealing structure of chromatographic column as claimed in claim 1 or 2, which is characterized in that the top of the base portion
End is integrally connected with clamping ring, and the outer wall of the clamping ring is equipped at least three radially outwardly projecting guiding
Block.
4. being used for the vacuum type sealing structure of chromatographic column as claimed in claim 3, which is characterized in that the primary seal circle
Inner wall is equipped with the guide groove being adapted with the guide pad.
5. being used for the vacuum type sealing structure of chromatographic column as described in claim 1, which is characterized in that fit sealing set with
Injection pipe is connected through a screw thread.
6. being used for the vacuum type sealing structure of chromatographic column as claimed in claim 5, which is characterized in that the fit sealing set
Side wall is equipped with venthole, and the venthole is equipped with the gas valve being selectively closed.
7. being used for the vacuum type sealing structure of chromatographic column as claimed in claim 2, which is characterized in that the elastic seal ring
Hardness is 30~50A.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611162008.3A CN106512479B (en) | 2016-12-15 | 2016-12-15 | Vacuum type sealing structure for chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611162008.3A CN106512479B (en) | 2016-12-15 | 2016-12-15 | Vacuum type sealing structure for chromatographic column |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106512479A CN106512479A (en) | 2017-03-22 |
| CN106512479B true CN106512479B (en) | 2018-12-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611162008.3A Active CN106512479B (en) | 2016-12-15 | 2016-12-15 | Vacuum type sealing structure for chromatographic column |
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| Country | Link |
|---|---|
| CN (1) | CN106512479B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201065852Y (en) * | 2007-07-17 | 2008-05-28 | 王建运 | Submersible pump sealing device |
| CN102937110A (en) * | 2011-08-15 | 2013-02-20 | 张菊梅 | Shaft seal device |
| CN204805538U (en) * | 2015-04-15 | 2015-11-25 | 苏义印 | Mechanical tighness system |
| CN205089979U (en) * | 2015-10-26 | 2016-03-16 | 玄兆丰 | Mechanical seal structure |
| EP3006789A1 (en) * | 2013-05-27 | 2016-04-13 | Eagle Industry Co., Ltd. | Mechanical seal device |
| CN206334399U (en) * | 2016-12-15 | 2017-07-18 | 苏州楚博生物技术有限公司 | Vacuum type sealing structure for chromatographic column |
-
2016
- 2016-12-15 CN CN201611162008.3A patent/CN106512479B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201065852Y (en) * | 2007-07-17 | 2008-05-28 | 王建运 | Submersible pump sealing device |
| CN102937110A (en) * | 2011-08-15 | 2013-02-20 | 张菊梅 | Shaft seal device |
| EP3006789A1 (en) * | 2013-05-27 | 2016-04-13 | Eagle Industry Co., Ltd. | Mechanical seal device |
| CN204805538U (en) * | 2015-04-15 | 2015-11-25 | 苏义印 | Mechanical tighness system |
| CN205089979U (en) * | 2015-10-26 | 2016-03-16 | 玄兆丰 | Mechanical seal structure |
| CN206334399U (en) * | 2016-12-15 | 2017-07-18 | 苏州楚博生物技术有限公司 | Vacuum type sealing structure for chromatographic column |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106512479A (en) | 2017-03-22 |
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