CN106481817B - Butt sealing component for tandem chromatographic column - Google Patents
Butt sealing component for tandem chromatographic column Download PDFInfo
- Publication number
- CN106481817B CN106481817B CN201611136621.8A CN201611136621A CN106481817B CN 106481817 B CN106481817 B CN 106481817B CN 201611136621 A CN201611136621 A CN 201611136621A CN 106481817 B CN106481817 B CN 106481817B
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- CN
- China
- Prior art keywords
- ring
- sealing
- chromatographic column
- sealing ring
- compression
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16J—PISTONS; CYLINDERS; SEALINGS
- F16J15/00—Sealings
- F16J15/16—Sealings between relatively-moving surfaces
- F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
- F16J15/3284—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings characterised by their structure; Selection of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention discloses a kind of Butt sealing components for tandem chromatographic column, comprising: the compression ring of coaxial arrangement accepts ring and sealing ring, wherein elastic connection between undertaking ring and the sealing ring is embedded with dead ring between the compression ring and undertaking ring.According to the present invention, have disassembly, cleaning, assembly simple, sealing effect is good, can substantially reduce adjacent two-stage chromatographic column in docking injection process by the beneficial effect of the probability of secondary pollution.
Description
Technical field
The present invention relates to a kind of Butt sealing component, in particular to a kind of Butt sealing group for tandem chromatographic column
Part.
Background technique
Chromatographic technique is in the advantage in separating and filtering field it is well known that can be used for from COMPLEX MIXED solution effectively
Target product is isolated, the impurity in object is removed, purifies final product or replacement product solution etc., chromatographic technique has
The characteristics of high separating efficiency, can separate the product of temperature-sensitive or easy in inactivation, such as protein, polysaccharide under conditions of condition is relatively mild
With polypeptide etc..Chromatographic column is the key that realize chromatography, and chromatographic column is generally by cylindric shell, the circle being sheathed in shell
Tubular splitter, the inlet for injecting solution to be separated, for export separation after solution outflux.
In chromatography post separation, Gao Zhuxiao is to guarantee that there is chromatographic column the important indicator of certain separating degree to mention in separation
The method of Gao Zhuxiao is mainly using the short grained length for chromatographing post separation filler or extending splitter or is to adopt
Separation is sequentially connected in series with multistage chromatographic column.Wherein, using multistage chromatographic column be sequentially connected in series separation due to it is at low cost, easy to operate, point
It is good from effect, the approval by practical operation.
However, in the prior art, being sequentially connected in series separation using multistage chromatographic column, the docking of adjacent two-stage chromatography intercolumniation is close
It seals not satisfactory, especially under conditions of high column pressure, tends to occur sepage, leakage, even docking the case where falling off.In view of
This, it is really necessary to develop a kind of Butt sealing component for tandem chromatographic column, to solve the above problems.
Summary of the invention
Shortcoming present in view of the above technology, the object of the present invention is to provide a kind of for tandem chromatographic column
Butt sealing component, disassembly, cleaning, assembly are simple, and sealing effect is good, can substantially reduce adjacent two-stage chromatographic column and dock
By the probability of secondary pollution in injection process.
In order to realize above-mentioned purpose according to the present invention and other advantages, a kind of pair for tandem chromatographic column is provided
Connect seal assembly, comprising:
The compression ring of coaxial arrangement accepts ring and sealing ring,
Wherein, elastic connection between undertaking ring and the sealing ring is embedded with fastening between the compression ring and undertaking ring
Ring is sequentially coaxially arranged with the compression ring on higher level's chromatographic column outflux from top to bottom, accepts ring and sealing ring, junior's layer
The compression ring is sequentially coaxially arranged on analysis column inlet from the bottom up, accepts ring and sealing ring, higher level's chromatographic column outflux
On the compression ring, accept the compression ring on ring and sealing ring and junior's chromatographic column inlet, accept ring and sealing
Ring is mutually structure symmetrical above and below.
Preferably, described to accept the recovery spring that several circumferentially equidistantly distributeds are equipped between ring and sealing ring.
Preferably, the compression ring includes compression ring base portion and compression ring skirt section, and the compression ring skirt section is in the pressure
Integrally in conjunction with the compression ring base portion and from compression ring described in the inner edge of the compression ring base portion in the inner circumferential in tight ring group portion
External vertical direction extend.
Preferably, it is formed with platform-like shoulder between the compression ring base portion and compression ring skirt section, is covered on the shoulder
Equipped with compression ring sealing ring.
Preferably, be equipped with cyclic annular bearing plate between the undertaking ring and the recovery spring, the undertaking ring with it is described
Bumper ring is embedded between bearing plate.
Preferably, the sealing ring includes sealing ring base portion and sealing ring skirt section, and the sealing ring skirt section is described close
Integrally in conjunction with the sealing ring base portion and from sealing ring described in the outer periphery of the sealing ring base portion on the periphery of seal ring base portion
External vertical direction extend.
Preferably, sealing ring shoulder and the sealing ring shoulder are formed between the sealing ring base portion and sealing ring skirt section
On groove portion, the recovery spring supported by the sealing ring shoulder, and the inner sidewall in the sealing ring skirt section is held with described
The lateral wall for connecing ring is in contact, and the undertaking ring can be gone up and down in the groove portion.
Compared with prior art, the present invention the beneficial effect is that: it is dismantled, cleaning, assembles simply, and sealing effect is good, energy
Adjacent two-stage chromatographic column is enough substantially reduced in docking injection process by the probability of secondary pollution.
Detailed description of the invention
Fig. 1 is according to the Butt sealing component of the present invention for tandem chromatographic column and higher level's chromatographic column outflux
And the longitudinal portion cross-sectional view that junior's chromatographic column inlet matches；
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, foregoing end other objects of the invention, feature, side
Face and advantage will be apparent, and so that those skilled in the art can carry out according to the description.
In order to make it easy to understand, Fig. 1 shows the Butt sealing component 100 and higher level's chromatographic column stream for tandem chromatographic column
The longitudinal portion cross-sectional view that outlet 300 and junior's chromatographic column inlet 200 match.
Referring to Fig. 1, the Butt sealing component 100 for tandem chromatographic column includes:
The compression ring 130 of coaxial arrangement accepts ring 120 and sealing ring 110,
Wherein, elastic connection between ring 120 and sealing ring 110 is accepted, is embedded between compression ring 130 and undertaking ring 120
Dead ring 140.
In a preferred embodiment, it is sequentially coaxially arranged with compression ring from top to bottom on higher level's chromatographic column outflux 300
130, ring 120 and sealing ring 110 are accepted, is sequentially coaxially arranged with compression ring from the bottom up on junior's chromatographic column inlet 200
130, ring 120 and sealing ring 110 are accepted, wherein compression ring 130 on higher level's chromatographic column outflux 300, accept ring 120 and
Sealing ring 110 on junior chromatographic column inlet 200 compression ring 130, accept ring 120 and sealing ring 110 be mutually it is symmetrical above and below
Structure.Using this structure, design cost on the one hand can be reduced, on the other hand can be further simplified structure, while can also
Enough complexities for reducing assembly.
Referring to Fig. 1, the recovery spring that several circumferentially equidistantly distributeds are equipped between ring 120 and sealing ring 110 is accepted
113.In one embodiment, restore spring 113 and be equipped with 8.
Referring to Fig. 1, compression ring 130 includes compression ring base portion 131 and compression ring skirt section 132, and compression ring skirt section 132 is compressing
The compression ring base portion 131 is integrally combined in the inner circumferential in ring group portion 131 and is compressed from the inner edge of the compression ring base portion 131
The external vertical direction of ring 130 extends.In a preferred embodiment, compression ring 130 respectively with higher level's chromatographic column outflux 300
And junior's chromatographic column inlet 200 is threadedly coupled, and can will be accepted ring 120 by being threaded into or screwing out and be pressed with sealing ring 110
It is tight or unclamp, so realize higher level's chromatographic column outflux 300 and junior chromatographic column inlet 200 dock or release, recovery bullet
The setting of spring 113 helps to provide auxiliary force when compression ring 130 screws out, consequently facilitating unlock.
Referring to Fig. 1, it is formed with platform-like shoulder 133 between compression ring base portion 131 and compression ring skirt section 132, on shoulder 133
It is arranged with compression ring sealing ring 134.In a preferred embodiment, compression ring sealing ring 134 is made of elastic material, on the one hand
The support force of 132 root of compression ring skirt section can be strengthened, on the other hand can be mentioned between Butt sealing component 100 and protecting crust
For further sealing.
Referring to Fig. 1, accepts ring 120 and restore to be equipped with cyclic annular bearing plate 123 between spring 113, accept ring 120 and bearing plate
Bumper ring 122 is embedded between 123.122, which are changed, due to buffering is sheathed on higher level's chromatographic column outflux 300 or the injection of junior's chromatographic column
On mouth 200, one side can provide sealing, on the other hand can play buffer function to spring.
Referring to Fig. 1, sealing ring 110 includes sealing ring base portion 111 and sealing ring skirt section 112, and sealing ring skirt section 112 is sealing
The sealing ring base portion 111 is integrally combined on the periphery in ring group portion 111 and is sealed from the outer periphery of the sealing ring base portion 111
The external vertical direction of ring 110 extends.In a preferred embodiment, shape between sealing ring base portion 111 and sealing ring skirt section 112
At the groove portion having on sealing ring shoulder and the sealing ring shoulder, restores spring 113 and supported by the sealing ring shoulder, sealed
The inner sidewall in ring skirt section 112 is in contact with the lateral wall for accepting ring 120, and accepting ring 120 can go up and down in the groove portion.Using this
Kind structure can will accept ring 120 and restore spring 113 being fixed in predetermined range, prevent in the process locked or unlocked
Middle appearance accepts ring 120 and restores the phenomenon that spring 113 slips, and improves the stability of assembly.
Number of devices and treatment scale described herein are for simplifying explanation of the invention.To application of the invention,
Modifications and variations will be readily apparent to persons skilled in the art.
Although the embodiments of the present invention have been disclosed as above, but it is not limited in listed fortune in specification and embodiments
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily real
Now other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is not limited to
Specific details and legend shown and described herein.
Claims (7)
1. a kind of Butt sealing component for tandem chromatographic column characterized by comprising
The compression ring of coaxial arrangement accepts ring and sealing ring,
Wherein, elastic connection between undertaking ring and the sealing ring is embedded with dead ring between the compression ring and undertaking ring, on
The compression ring is sequentially coaxially arranged on grade chromatographic column effluent mouth from top to bottom, accepts ring and sealing ring, junior's chromatographic column note
The compression ring is sequentially coaxially arranged on entrance from the bottom up, accepts ring and sealing ring, the institute on higher level's chromatographic column outflux
Compression ring, undertaking ring and sealing ring is stated to be mutually with the compression ring, undertaking ring and the sealing ring on junior's chromatographic column inlet
Structure symmetrical above and below.
2. as described in claim 1 be used for tandem chromatographic column Butt sealing component, which is characterized in that the undertakings ring and
The recovery spring of several circumferentially equidistantly distributeds is equipped between sealing ring.
3. being used for the Butt sealing component of tandem chromatographic column as described in claim 1, which is characterized in that the compression ring packet
Compression ring base portion and compression ring skirt section are included, the compression ring skirt section integrally combines in the inner circumferential of the compression ring base portion should
Compression ring base portion and from the external vertical direction of compression ring described in the inner edge of the compression ring base portion extend.
4. being used for the Butt sealing component of tandem chromatographic column as claimed in claim 3, which is characterized in that the compression ring group
It is formed with platform-like shoulder between portion and compression ring skirt section, compression ring sealing ring is arranged on the shoulder.
5. as claimed in claim 2 be used for tandem chromatographic column Butt sealing component, which is characterized in that the undertakings ring and
It is equipped with cyclic annular bearing plate between the recovery spring, is embedded with bumper ring between the undertaking ring and the bearing plate.
6. being used for the Butt sealing component of tandem chromatographic column as claimed in claim 2, which is characterized in that the sealing ring packet
Sealing ring base portion and sealing ring skirt section are included, the sealing ring skirt section integrally combines on the periphery of the sealing ring base portion should
Sealing ring base portion and from the external vertical direction of sealing ring described in the outer periphery of the sealing ring base portion extend.
7. being used for the Butt sealing component of tandem chromatographic column as claimed in claim 6, which is characterized in that the sealing ring group
The groove portion being formed on sealing ring shoulder and the sealing ring shoulder between portion and sealing ring skirt section, the recovery spring is by described
Sealing ring shoulder is supported, and the inner sidewall in the sealing ring skirt section is in contact with the lateral wall for accepting ring, the undertaking ring
It can be gone up and down in the groove portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611136621.8A CN106481817B (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611136621.8A CN106481817B (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106481817A CN106481817A (en) | 2017-03-08 |
| CN106481817B true CN106481817B (en) | 2019-02-12 |
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ID=58275173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611136621.8A Active CN106481817B (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
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| Country | Link |
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| CN (1) | CN106481817B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108905287A (en) * | 2018-08-22 | 2018-11-30 | 佛山科学技术学院 | One kind is for measuring the remaining solid-phase extraction column of flesh of fish Malachite Green |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR200347218Y1 (en) * | 2004-01-26 | 2004-04-08 | 김석윤 | Joint for Plumbing |
| CN101254362A (en) * | 2008-04-11 | 2008-09-03 | 倪新忠 | Column chromatography equipment for separating compounds and use method thereof |
| CN103657148A (en) * | 2013-11-28 | 2014-03-26 | 苏州原点工业设计有限公司 | Sectional type glass chromatographic column |
| CN104208907B (en) * | 2013-12-02 | 2016-09-07 | 成都中医药大学 | A kind of combined type chromatographic column separated for Chinese medicine/natural medicinal ingredients and column chromatography methods |
| CN105465510A (en) * | 2014-08-18 | 2016-04-06 | 江苏新风环保科技有限公司 | External sleeve connection device of air purifier |
| CN206338411U (en) * | 2016-12-12 | 2017-07-18 | 苏州楚博生物技术有限公司 | Butt sealing component for tandem chromatographic column |
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2016
- 2016-12-12 CN CN201611136621.8A patent/CN106481817B/en active Active
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| CN106481817A (en) | 2017-03-08 |
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| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190103 Address after: Room 412-2, Building 15, No. 8, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Applicant after: Suzhou Bojin Biological Technology Co., Ltd. Address before: 215000 Building 412, No. 18, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Applicant before: Suzhou Bo Bo Biotechnology Co., Ltd. |
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