CN106481817A - Butt sealing assembly for tandem chromatographic column - Google Patents
Butt sealing assembly for tandem chromatographic column Download PDFInfo
- Publication number
- CN106481817A CN106481817A CN201611136621.8A CN201611136621A CN106481817A CN 106481817 A CN106481817 A CN 106481817A CN 201611136621 A CN201611136621 A CN 201611136621A CN 106481817 A CN106481817 A CN 106481817A
- Authority
- CN
- China
- Prior art keywords
- ring
- hold
- chromatographic column
- sealing
- sealing ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16J—PISTONS; CYLINDERS; SEALINGS
- F16J15/00—Sealings
- F16J15/16—Sealings between relatively-moving surfaces
- F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
- F16J15/3284—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings characterised by their structure; Selection of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention discloses a kind of Butt sealing assembly for tandem chromatographic column, including：Hold-down ring, undertaking ring and the sealing ring being coaxially disposed, wherein, elastic connection between described undertaking ring and sealing ring, it is embedded with dead ring between described hold-down ring and undertaking ring.According to the present invention, it has dismounting, cleaning, assembling simply, good sealing effect, can substantially reduce the beneficial effect that adjacent two-stage chromatographic column suffers from the probability of secondary pollution in docking injection process.
Description
Technical field
The present invention relates to a kind of Butt sealing assembly, particularly to a kind of Butt sealing group for tandem chromatographic column
Part.
Background technology
Chromatographic technique is in the advantage in separating and filtering field it is known that can be used for from COMPLEX MIXED solution effectively
Isolate target product, remove the impurity in object, purify final product or replacement product solution etc., chromatographic technique has
The feature of high separating efficiency, can separate the product of temperature-sensitive or easy in inactivation under conditions of condition is relatively mild, such as protein, polysaccharide
With polypeptide etc..Chromatographic column is the key realizing chromatography, and chromatographic column is typically by cylindric shell, the circle being sheathed in shell
Tubular detached dowel, inlet, the flow export for deriving solution after separation for injecting solution to be separated.
In chromatography post separation, Gao Zhuxiao is to ensure that chromatographic column has the important indicator of certain separating degree, in separation, carries
The method of Gao Zhuxiao mainly using short grained chromatography post separation filler or extends the length of detached dowel or is to adopt
It is sequentially connected in series with multistage chromatographic column and separate.Wherein, using multistage chromatographic column be sequentially connected in series separate due to low cost, easy to operate, point
Good from effect, approved by practical operation.
However, in the prior art, it is sequentially connected in series using multistage chromatographic column and separates, the docking that adjacent two-stage chromatographs intercolumniation is close
Envelope is not ideal, especially under conditions of high post pressure, tends to occur sepage, leakage, even docks situation about coming off.In view of
This, be necessary to develop a kind of Butt sealing assembly for tandem chromatographic column, in order to solve the above problems in fact.
Content of the invention
For weak point present in above-mentioned technology, it is an object of the invention to provide a kind of for tandem chromatographic column
Butt sealing assembly, its dismounting, cleaning, assembling are simple, good sealing effect, can substantially reduce adjacent two-stage chromatographic column in docking
Suffer from the probability of secondary pollution in injection process.
In order to realize the above-mentioned purpose according to the present invention and other advantages, there is provided a kind of right for tandem chromatographic column
Connect black box, including：
Hold-down ring, undertaking ring and the sealing ring being coaxially disposed,
Wherein, elastic connection between described undertaking ring and sealing ring, is embedded with fastening between described hold-down ring and undertaking ring
Ring.
Preferably, higher level's chromatographic column flow export is sequentially coaxially arranged with from top to bottom described hold-down ring, accept ring and
Sealing ring, subordinate's chromatographic column inlet is sequentially coaxially arranged with described hold-down ring from the bottom up, accepts ring and sealing ring.
Preferably, the described hold-down ring on higher level's chromatographic column flow export, undertaking ring and sealing ring and subordinate's chromatographic column note
Described hold-down ring on entrance, undertaking ring and sealing ring are mutually structure symmetrical above and below.
Preferably, described accept the returning spring being provided with several circumferentially equidistantly distributeds between ring and sealing ring.
Preferably, described hold-down ring includes hold-down ring base portion and hold-down ring skirt section, and described hold-down ring skirt section is in described pressure
This hold-down ring base portion is integrally combined on the inner circumferential in tight ring group portion and from hold-down ring described in the inner edge of this hold-down ring base portion
Outside vertical direction extend.
Preferably, it is formed with platform-like shoulder between described hold-down ring base portion and hold-down ring skirt section, described shoulder covers
It is provided with hold-down ring sealing ring.
Preferably, be provided with ring-type bearing plate between described undertaking ring and described returning spring, described undertaking ring with described
It is embedded with bumper ring between bearing plate.
Preferably, described sealing ring includes sealing ring base portion and sealing ring skirt section, and described sealing ring skirt section is described close
This sealing ring base portion is integrally combined on the periphery of seal ring base portion and from the periphery of this sealing ring base portion along described sealing ring
Outside vertical direction extend.
Preferably, it is formed with sealing ring shoulder and this sealing ring shoulder between described sealing ring base portion and sealing ring skirt section
On groove portion, described returning spring supported by described sealing ring shoulder, and the medial wall in described sealing ring skirt section is held with described
The lateral wall connecing ring contacts, and described undertaking ring can lift in described groove portion.
Compared with prior art, its advantage is the present invention：Its dismounting, cleaning, assembling are simple, good sealing effect, energy
Enough substantially reduce the probability that adjacent two-stage chromatographic column suffers from secondary pollution in docking injection process.
Brief description
Fig. 1 is according to the Butt sealing assembly for tandem chromatographic column of the present invention and higher level's chromatographic column flow export
And the longitudinal component sectional view that subordinate's chromatographic column inlet matches；
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, the foregoing end other objects of the present invention, feature, side
Face and advantage will be apparent from, to make those skilled in the art can implement according to this with reference to specification word.
In order to make it easy to understand, Fig. 1 shows Butt sealing assembly 100 and higher level's chromatographic column stream for tandem chromatographic column
Outlet 300 and the longitudinal component sectional view that matches of subordinate's chromatographic column inlet 200.
Referring to Fig. 1, the Butt sealing assembly 100 for tandem chromatographic column includes：
Hold-down ring 130, undertaking ring 120 and the sealing ring 110 being coaxially disposed,
Wherein, accept elastic connection between ring 120 and sealing ring 110, be embedded between hold-down ring 130 and undertaking ring 120
Dead ring 140.
In a preferred embodiment, higher level's chromatographic column flow export 300 is sequentially coaxially arranged with hold-down ring from top to bottom
130th, accept ring 120 and sealing ring 110, subordinate's chromatographic column inlet 200 is sequentially coaxially arranged with hold-down ring from the bottom up
130th, accept ring 120 and sealing ring 110, wherein, hold-down ring 130 on higher level's chromatographic column flow export 300, accept ring 120 and
Hold-down ring 130 on sealing ring 110 and subordinate chromatographic column inlet 200, accept ring 120 and sealing ring 110 be mutually symmetrical above and below
Structure.Using this structure, on the one hand can reduce design cost, on the other hand can simplify structure further, can also simultaneously
Enough complexities reducing assembling.
Referring to Fig. 1, accept the returning spring being provided with several circumferentially equidistantly distributeds between ring 120 and sealing ring 110
113.In one embodiment, returning spring 113 is provided with 8.
Referring to Fig. 1, hold-down ring 130 includes hold-down ring base portion 131 and hold-down ring skirt section 132, and hold-down ring skirt section 132 is in compression
This hold-down ring base portion 131 is integrally combined on the inner circumferential in ring group portion 131 and from the inner edge of this hold-down ring base portion 131 compression
The outside vertical direction of ring 130 extends.In a preferred embodiment, hold-down ring 130 respectively with higher level's chromatographic column flow export 300
And subordinate's chromatographic column inlet 200 is threaded, can will accept ring 120 and press with sealing ring 110 by being threaded into or screwing out
Tight or unclamp, and then realize docking or unclamping, reply bullet of higher level's chromatographic column flow export 300 and subordinate chromatographic column inlet 200
The setting of spring 113 contributes to the provided auxiliary power when hold-down ring 130 screws out, consequently facilitating unblock.
Referring to Fig. 1, it is formed with platform-like shoulder 133 between hold-down ring base portion 131 and hold-down ring skirt section 132, on shoulder 133
It is arranged with hold-down ring sealing ring 134.In a preferred embodiment, hold-down ring sealing ring 134 is made up of elastomeric material, on the one hand
The support force of hold-down ring skirt section 132 root can be strengthened, on the other hand can carry between Butt sealing assembly 100 and protecting crust
Seal for further.
Referring to Fig. 1, accept and be provided with ring-type bearing plate 123 between ring 120 and returning spring 113, accept ring 120 and bearing plate
It is embedded with bumper ring 122 between 123.Change 122 due to buffering and be sheathed on higher level's chromatographic column flow export 300 or subordinate's chromatographic column injection
On mouth 200, on the one hand it can provide sealing, on the other hand can play cushioning effect to spring.
Referring to Fig. 1, sealing ring 110 includes sealing ring base portion 111 and sealing ring skirt section 112, and sealing ring skirt section 112 is in sealing
This sealing ring base portion 111 is integrally combined on the periphery in ring group portion 111 and from the periphery of this sealing ring base portion 111 along sealing
The outside vertical direction of ring 110 extends.In a preferred embodiment, shape between sealing ring base portion 111 and sealing ring skirt section 112
Become to have the groove portion on sealing ring shoulder and this sealing ring shoulder, returning spring 113 is supported by described sealing ring shoulder, sealing
The medial wall in ring skirt section 112 is contacted with the lateral wall accepting ring 120, and accepting ring 120 can lift in described groove portion.Using this
Plant structure, undertaking ring 120 and returning spring 113 can be fixed in predetermined scope, prevent the process in locking or unblock
Middle occur accepting the phenomenon that ring 120 and returning spring 113 slip, and improves the stability of assembling.
Number of devices described herein and treatment scale are used to simplify the explanation of the present invention.To the application of the present invention,
Modifications and variations will be readily apparent to persons skilled in the art.
Although embodiment of the present invention is disclosed as above, it is not limited in listed fortune in description and embodiment
With, it can be applied to various suitable the field of the invention completely, for those skilled in the art, can be easily real
Now other modification, therefore under the general concept being limited without departing substantially from claim and equivalency range, the present invention is not limited to
Specific details and shown here as the legend with description.
Claims (9)
1. a kind of Butt sealing assembly for tandem chromatographic column is it is characterised in that include：
Hold-down ring, undertaking ring and the sealing ring being coaxially disposed,
Wherein, elastic connection between described undertaking ring and sealing ring, is embedded with dead ring between described hold-down ring and undertaking ring.
2. it is used for as claimed in claim 1 the Butt sealing assembly of tandem chromatographic column it is characterised in that higher level's chromatographic column stream
Described hold-down ring is sequentially coaxially arranged with from top to bottom on outlet, accepts ring and sealing ring, on subordinate's chromatographic column inlet under
Up sequentially coaxially it is arranged with described hold-down ring, accept ring and sealing ring.
3. it is used for as claimed in claim 2 the Butt sealing assembly of tandem chromatographic column it is characterised in that higher level's chromatographic column stream
Described hold-down ring in outlet, the described hold-down ring accepted on ring and sealing ring and subordinate's chromatographic column inlet, undertaking ring and
Sealing ring is mutually structure symmetrical above and below.
4. the Butt sealing assembly for tandem chromatographic column as described in any one of claims 1 to 3 is it is characterised in that institute
State and accept the returning spring being provided with several circumferentially equidistantly distributeds between ring and sealing ring.
5. the Butt sealing assembly for tandem chromatographic column as described in any one of claims 1 to 3 is it is characterised in that institute
State hold-down ring and include hold-down ring base portion and hold-down ring skirt section, described hold-down ring skirt section one in the inner circumferential of described hold-down ring base portion
Formula ground combines this hold-down ring base portion and extends from the outside vertical direction of hold-down ring described in the inner edge of this hold-down ring base portion.
6. the Butt sealing assembly for tandem chromatographic column as described in any one of claim 5 is it is characterised in that described pressure
Tightly it is formed with platform-like shoulder between ring group portion and hold-down ring skirt section, described shoulder is arranged with hold-down ring sealing ring.
7. the Butt sealing assembly for tandem chromatographic column as described in any one of claim 4 is it is characterised in that described hold
Connect and between ring and described returning spring, be provided with ring-type bearing plate, between described undertaking ring and described bearing plate, be embedded with bumper ring.
8. the Butt sealing assembly for tandem chromatographic column as described in any one of claim 4 is it is characterised in that described close
Seal ring includes sealing ring base portion and sealing ring skirt section, described sealing ring skirt section on the periphery of described sealing ring base portion integrally
Extend in conjunction with this sealing ring base portion and from the periphery of this sealing ring base portion along the outside vertical direction of described sealing ring.
9. the Butt sealing assembly for tandem chromatographic column as described in any one of claim 8 is it is characterised in that described close
It is formed with the groove portion on sealing ring shoulder and this sealing ring shoulder, described returning spring between seal ring base portion and sealing ring skirt section
Supported by described sealing ring shoulder, the medial wall in described sealing ring skirt section is contacted with the described lateral wall accepting ring, described
Accept ring to lift in described groove portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611136621.8A CN106481817B (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611136621.8A CN106481817B (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106481817A true CN106481817A (en) | 2017-03-08 |
| CN106481817B CN106481817B (en) | 2019-02-12 |
Family
ID=58275173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611136621.8A Active CN106481817B (en) | 2016-12-12 | 2016-12-12 | Butt sealing component for tandem chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106481817B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108905287A (en) * | 2018-08-22 | 2018-11-30 | 佛山科学技术学院 | One kind is for measuring the remaining solid-phase extraction column of flesh of fish Malachite Green |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080191480A1 (en) * | 2004-01-26 | 2008-08-14 | Suk-Yoon Kim | Joint for Plumbing |
| CN101254362A (en) * | 2008-04-11 | 2008-09-03 | 倪新忠 | Column chromatography equipment for separating compounds and use method thereof |
| CN103657148A (en) * | 2013-11-28 | 2014-03-26 | 苏州原点工业设计有限公司 | Sectional type glass chromatographic column |
| CN104208907A (en) * | 2013-12-02 | 2014-12-17 | 成都中医药大学 | Combined chromatographic column and column chromatography method for ingredient separation of traditional Chinese medicine/natural medicine |
| CN105465510A (en) * | 2014-08-18 | 2016-04-06 | 江苏新风环保科技有限公司 | External sleeve connection device of air purifier |
| CN206338411U (en) * | 2016-12-12 | 2017-07-18 | 苏州楚博生物技术有限公司 | Butt sealing component for tandem chromatographic column |
-
2016
- 2016-12-12 CN CN201611136621.8A patent/CN106481817B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080191480A1 (en) * | 2004-01-26 | 2008-08-14 | Suk-Yoon Kim | Joint for Plumbing |
| CN101254362A (en) * | 2008-04-11 | 2008-09-03 | 倪新忠 | Column chromatography equipment for separating compounds and use method thereof |
| CN103657148A (en) * | 2013-11-28 | 2014-03-26 | 苏州原点工业设计有限公司 | Sectional type glass chromatographic column |
| CN104208907A (en) * | 2013-12-02 | 2014-12-17 | 成都中医药大学 | Combined chromatographic column and column chromatography method for ingredient separation of traditional Chinese medicine/natural medicine |
| CN105465510A (en) * | 2014-08-18 | 2016-04-06 | 江苏新风环保科技有限公司 | External sleeve connection device of air purifier |
| CN206338411U (en) * | 2016-12-12 | 2017-07-18 | 苏州楚博生物技术有限公司 | Butt sealing component for tandem chromatographic column |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108905287A (en) * | 2018-08-22 | 2018-11-30 | 佛山科学技术学院 | One kind is for measuring the remaining solid-phase extraction column of flesh of fish Malachite Green |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106481817B (en) | 2019-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105508602B (en) | Retaining ring used in a kind of pressure vessel and the pressure vessel | |
| CN106481817A (en) | Butt sealing assembly for tandem chromatographic column | |
| CN206338411U (en) | Butt sealing component for tandem chromatographic column | |
| CN103638692B (en) | There is the liquid distributor of the chromatographic column of secondary runner | |
| CN206198766U (en) | The Butt sealing structure of chromatographic column inlet | |
| CN106492504B (en) | Chromatographic column seal assembly | |
| CN206018016U (en) | A kind of fluted tube clamp | |
| CN205664023U (en) | Turn -ups pipe | |
| CN104121369A (en) | High-strength sealing ring | |
| CN106390523A (en) | Butt-joint sealing structure for injection hole of chromatographic column | |
| CN106512479B (en) | Vacuum type sealing structure for chromatographic column | |
| CN105363405A (en) | Heterogeneous phase mixing, reaction and separation integrated cyclone reactor | |
| CN209192626U (en) | A kind of anti-clogging one-way exhaust plastic inner cap of fermented food Packaging Bottle | |
| CN207406891U (en) | A kind of air bleeding valve | |
| CN206972988U (en) | Split type fast loaded check valve | |
| CN206264721U (en) | A kind of aluminium alloy valve anti-gas-leak protective cap | |
| CN208011119U (en) | A kind of beverage pipe joint arrangement | |
| CN203175799U (en) | Oil-gas separating device of vacuum pump | |
| RU109448U1 (en) | VESSEL CAP | |
| CN205420370U (en) | Fermentation cylinder is used in teaching | |
| CN205639973U (en) | Joint | |
| CN206546943U (en) | A kind of novel removable formula spark plug | |
| CN206334399U (en) | Vacuum type sealing structure for chromatographic column | |
| CN106696616B (en) | A kind of aluminium alloy valve anti-gas-leak protective cap | |
| CN204032948U (en) | Assembly type teapot |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190103 Address after: Room 412-2, Building 15, No. 8, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Applicant after: Suzhou Bojin Biological Technology Co., Ltd. Address before: 215000 Building 412, No. 18, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Applicant before: Suzhou Bo Bo Biotechnology Co., Ltd. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |