CN106390523A - Butt-joint sealing structure for injection hole of chromatographic column - Google Patents
Butt-joint sealing structure for injection hole of chromatographic column Download PDFInfo
- Publication number
- CN106390523A CN106390523A CN201611055838.6A CN201611055838A CN106390523A CN 106390523 A CN106390523 A CN 106390523A CN 201611055838 A CN201611055838 A CN 201611055838A CN 106390523 A CN106390523 A CN 106390523A
- Authority
- CN
- China
- Prior art keywords
- ring
- chromatographic column
- butt
- sealing ring
- sealing structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000007789 sealing Methods 0.000 title claims abstract description 66
- 238000002347 injection Methods 0.000 title abstract description 6
- 239000007924 injection Substances 0.000 title abstract description 6
- 238000000034 method Methods 0.000 abstract description 8
- 238000004140 cleaning Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000001174 ascending effect Effects 0.000 description 7
- 238000004587 chromatography analysis Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000003032 molecular docking Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L23/00—Flanged joints
- F16L23/02—Flanged joints the flanges being connected by members tensioned axially
- F16L23/032—Flanged joints the flanges being connected by members tensioned axially characterised by the shape or composition of the flanges
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L23/00—Flanged joints
- F16L23/16—Flanged joints characterised by the sealing means
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L23/00—Flanged joints
- F16L23/16—Flanged joints characterised by the sealing means
- F16L23/18—Flanged joints characterised by the sealing means the sealing means being rings
Abstract
The invention discloses a butt-joint sealing structure for an injection hole of a chromatographic column. The butt-joint sealing structure comprises an annular base, a hollow cylindrical connecting sleeve and an annular pressure seat, wherein the annular base is integrally and fixedly connected with the chromatographic column; the connecting sleeve is supported by the base; and the annular pressure seat is supported by the connecting sleeve and comprises annular base part and a skirt part, the skirt part is integrally combined with the periphery of an inner ring of the base part and extends downwards from the periphery of the inner ring of the base part, and the pressure seat is detachably connected with the base through a plurality of bolts. The butt-joint sealing structure has the beneficial effects that the detaching, cleaning and assembling are easy, the sealing effect is good, and the secondary pollution probability of the chromatographic column in an injection process can be greatly reduced.
Description
Technical field
The present invention relates to a kind of Butt sealing structure, particularly to a kind of Butt sealing structure of chromatographic column inlet.
Background technology
Chromatographic column can be used in industrial manufacture process to be purified to process liquid and to isolate from process liquid
Material interested.Inevitably be mixed into impurity when preparing the chemical productss such as protein and medicine, and actually used in
Purity requirement to protein and this kind of material of medicine is very high, therefore, typically protein and medicine etc. are entered using chromatographic column
Row purification, to obtain highly purified product.
During injecting liquid to be purified toward inside chromatographic column, the sealing between chromatographic column injection and ascending pipe is particularly
Important, the Butt sealing structure of traditional chromatographic column inlet is inconvenient in dismounting, cleaning and installation, and dismantles or assembling process
Loaded down with trivial details, sealing effectiveness is also undesirable.In view of this, it is necessary in fact to develop a kind of Butt sealing structure of chromatographic column inlet, with
Solve the above problems.
Content of the invention
For weak point present in above-mentioned technology, it is an object of the invention to provide a kind of docking of chromatographic column inlet
Sealing structure, its dismounting, cleaning, assembling are simple, and good sealing effect can substantially reduce chromatographic column and suffer from two in injection process
The probability of secondary pollution.
In order to realize the above-mentioned purpose according to the present invention and other advantages, there is provided a kind of docking of chromatographic column inlet is close
Seal structure, including：
The ring-shaped base affixed with chromatographic column integral type；
The cylindric adapter sleeve of the hollow being supported by described base；And
The ring-type wedge being supported by described adapter sleeve,
Wherein, described wedge includes base portion and the skirt section of ring-type, and described skirt section is in the internal ring periphery integral type of described base portion
Ground extends downwardly with reference to this base portion and from the internal ring periphery of this base portion, and described wedge passes through several bolts can with described base
Releasably connect.
Preferably, the inwall of described adapter sleeve is connected to the first sealing ring and the second sealing ring with intracardiac from top to bottom.
Preferably, mutually it is separated with a certain distance between described first sealing ring and the second sealing ring, and described first close
It is provided with several support springs between seal and the second sealing ring.
Preferably, the top of described first sealing ring is inserted among described wedge.
Preferably, the inwall of described base is connected to the 3rd sealing ring with intracardiac, and described second sealing ring is by the described 3rd
Sealing ring supports.
Preferably, on the top surface of described base portion integral type be connected with ring-shaped protrusion, described ring-shaped protrusion supports
Have in be inverted T-shaped structure tighten lid.
Preferably, described tightening is provided with elastic support ring between the inner space of lid and the top surface of described base portion.
Compared with prior art, its advantage is the present invention：Its dismounting, cleaning, assembling are simple, good sealing effect, energy
Enough substantially reduce the probability that chromatographic column suffers from secondary pollution in injection process.
Brief description
Fig. 1 is that the Butt sealing structure according to chromatographic column inlet of the present invention is joined with ascending pipe and chromatographic column body phase
The longitudinal sectional view closing.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, the foregoing end other objects of the present invention, feature, side
Face and advantage will be apparent from, to make those skilled in the art can implement according to this with reference to specification word.
In order to make it easy to understand, Fig. 1 shows Butt sealing structure 100 and ascending pipe 300 and the chromatography of chromatographic column inlet
The longitudinal sectional view that cylinder 200 matches, in Fig. 1, chromatography cylinder 200 has inlet 210.
Referring to Fig. 1, the Butt sealing structure 100 of chromatographic column inlet includes：
The ring-shaped base 110 affixed with chromatographic column 200 integral type；
The cylindric adapter sleeve 120 of the hollow being supported by base 110；And
The ring-type wedge 140 being supported by adapter sleeve 120,
Wherein, wedge 140 includes the base portion 140a and skirt section 140b of ring-type, and skirt section 140b is in the internal ring periphery of base portion 140a
Integrally extend downwardly with reference to this base portion 140a and from the internal ring periphery of this base portion 140a, wedge 140 passes through several spiral shells
Bolt 130 is detachably connected with base 110.In a preferred embodiment, it is provided with mounting groove at the inside edge of base 110
111, adapter sleeve 120 is installed in mounting groove 111, and base 110 is fixed at the shoulder 220 of chromatography cylinder 200, and ring-shaped base
110 central authorities allow the inlets 210 of chromatographic columns 200 to pass through, the outer wall of skirt section 140b of wedge 140 and the inwall of adapter sleeve 120
Phase clamping.
With continued reference to Fig. 1, the inwall of adapter sleeve 120 is connected to the first sealing ring 141 and the second sealing with intracardiac from top to bottom
Circle 142, further, is mutually separated with a certain distance between the first sealing ring 141 and the second sealing ring 124, and the first sealing ring
141 and second are provided with several support springs 143 between sealing ring 142.In a preferred embodiment, the first sealing ring 141
And second sealing ring 124 be sheathed on ascending pipe 300, the first sealing ring 141 and the second sealing ring 142 pass through support spring
143 are connected.In a preferred embodiment, the top of the first sealing ring 141 is inserted among wedge 140, i.e. the first sealing ring
141 top is compressed by the inwall of wedge 140, so that what wedge 140 was gradually tightened by bolt 130 and base 110
Meanwhile, it is capable to compress the first sealing ring 141, and the first sealing ring 141 is compressed downwards, and pressure is passed through support spring
143 pass to the second sealing ring 142, thus also having compressed the second sealing ring 142.
Further, the inwall of base 110 is connected to the 3rd sealing ring 112 with intracardiac, and the second sealing ring 142 is sealed by the 3rd
Circle 112 support.The inner side of the 3rd sealing ring 112 and the outer ring socket of inlet 210, for sealing inlet 210, prevent liquid
Overflow, when the pressure of compression wedge 140 passes to the second sealing ring 142 by support spring 143, finally also pass to the 3rd close
On seal 112, thus the outer ring compression sealing by the 3rd sealing ring 112 and inlet 210.
Referring again to Fig. 1, on the top surface of base portion 140a, integral type is connected with ring-shaped protrusion 140c, ring-shaped protrusion
140c is supported by and tightens lid 150 in be inverted T-shaped structure, tightens lid and 150 is socketed on ascending pipe 300, and and ascending pipe
300 is threaded, specifically, tighten during lid 150 is gradually tightened with ascending pipe 300 can further by wedge 140 with
Base 110 compresses.In a preferred embodiment, tighten and be provided with bullet between the inner space of lid 150 and the top surface of base portion 140a
Property support ring 151, elastic support ring 151 can tighten lid 150 gradually tighten during to tighten lid 150 provide inner side
Support force, and by this support force going down pressure seat 140 so that wedge 140 stress more all be additionally, since support ring
151 by resilient material, and in tightening lid 150 unloading process, it can provide easy-to-dismount support force again.
Number of devices described herein and treatment scale are used to simplify the explanation of the present invention.To the application of the present invention,
Modifications and variations will be readily apparent to persons skilled in the art.
Although embodiment of the present invention is disclosed as above, it is not limited in listed fortune in description and embodiment
With, it can be applied to various suitable the field of the invention completely, for those skilled in the art, can be easily real
Now other modification, therefore under the general concept being limited without departing substantially from claim and equivalency range, the present invention is not limited to
Specific details and shown here as the legend with description.
Claims (7)
1. a kind of Butt sealing structure of chromatographic column inlet is it is characterised in that include：
The ring-shaped base affixed with chromatographic column integral type；
The cylindric adapter sleeve of the hollow being supported by described base；And
The ring-type wedge being supported by described adapter sleeve,
Wherein, described wedge includes base portion and the skirt section of ring-type, and described skirt section is integrally tied in the internal ring periphery of described base portion
Close this base portion and extend downwardly from the internal ring periphery of this base portion, it is detachable with described base that described wedge passes through several bolts
Ground connects.
2. the Butt sealing structure of chromatographic column inlet as claimed in claim 1 is it is characterised in that the inwall of described adapter sleeve
It is connected to the first sealing ring and the second sealing ring with intracardiac from top to bottom.
3. chromatographic column inlet as claimed in claim 2 Butt sealing structure it is characterised in that described first sealing ring and
Mutually it is separated with a certain distance between second sealing ring, and between described first sealing ring and the second sealing ring, be provided with several supports
Spring.
4. the Butt sealing structure of chromatographic column inlet as claimed in claim 2 or claim 3 is it is characterised in that described first seals
The top of circle is inserted among described wedge.
5. the Butt sealing structure of chromatographic column inlet as claimed in claim 2 is it is characterised in that the inwall of described base is same
Intracardiac be connected to the 3rd sealing ring, described second sealing ring by described 3rd sealing ring support.
6. the Butt sealing structure of chromatographic column inlet as claimed in claim 1 is it is characterised in that on the top surface of described base portion
Integral type be connected with ring-shaped protrusion, described ring-shaped protrusion be supported by be inverted T-shaped structure tighten lid.
7. the Butt sealing structure of chromatographic column inlet as claimed in claim 6 is it is characterised in that the described inside tightening lid
It is provided with elastic support ring between the top surface of space and described base portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611055838.6A CN106390523B (en) | 2016-11-25 | 2016-11-25 | The Butt sealing structure of chromatographic column inlet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611055838.6A CN106390523B (en) | 2016-11-25 | 2016-11-25 | The Butt sealing structure of chromatographic column inlet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106390523A true CN106390523A (en) | 2017-02-15 |
| CN106390523B CN106390523B (en) | 2019-02-12 |
Family
ID=58081928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611055838.6A Active CN106390523B (en) | 2016-11-25 | 2016-11-25 | The Butt sealing structure of chromatographic column inlet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106390523B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040182789A1 (en) * | 2003-03-21 | 2004-09-23 | Melvyn Gill | Chromatographic column seal |
| CN102359599A (en) * | 2011-09-07 | 2012-02-22 | 武汉船用机械有限责任公司 | Movable sealing device for telescopic full-revolving rudder paddle |
| CN203355360U (en) * | 2013-07-02 | 2013-12-25 | 北京英智达科技有限公司 | Medium-pressure chromatographic column |
| CN204815790U (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Chromatography column coupling assembling |
| CN205330867U (en) * | 2016-01-11 | 2016-06-22 | 湖南云箭集团有限公司 | Shaft seal device and have device's axial flow turbine |
| CN206198766U (en) * | 2016-11-25 | 2017-05-31 | 苏州楚博生物技术有限公司 | The Butt sealing structure of chromatographic column inlet |
-
2016
- 2016-11-25 CN CN201611055838.6A patent/CN106390523B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040182789A1 (en) * | 2003-03-21 | 2004-09-23 | Melvyn Gill | Chromatographic column seal |
| CN102359599A (en) * | 2011-09-07 | 2012-02-22 | 武汉船用机械有限责任公司 | Movable sealing device for telescopic full-revolving rudder paddle |
| CN203355360U (en) * | 2013-07-02 | 2013-12-25 | 北京英智达科技有限公司 | Medium-pressure chromatographic column |
| CN204815790U (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Chromatography column coupling assembling |
| CN205330867U (en) * | 2016-01-11 | 2016-06-22 | 湖南云箭集团有限公司 | Shaft seal device and have device's axial flow turbine |
| CN206198766U (en) * | 2016-11-25 | 2017-05-31 | 苏州楚博生物技术有限公司 | The Butt sealing structure of chromatographic column inlet |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106390523B (en) | 2019-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181204 Address after: Room 412-2, Building 15, No. 8, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Applicant after: SUZHOU BOGEN BIOSEPARATION TECHNOLOGY CO.,LTD. Address before: 215000 Building 412, No. 18, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Applicant before: SUZHOU CHUBO BIOTECHNOLOGY CO.,LTD. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240326 Address after: Room B212, Incubation Site, No. 59 Mumu Street, Xiangfang District, Harbin City, Heilongjiang Province, 150000 RMB Patentee after: Heilongjiang moseidong Technology Co.,Ltd. Country or region after: China Address before: Room 412-2, Building 15, No. 8, Jinfeng Road, Suzhou High-tech Zone, Jiangsu Province Patentee before: SUZHOU BOGEN BIOSEPARATION TECHNOLOGY CO.,LTD. Country or region before: China |