CN103638692B - There is the liquid distributor of the chromatographic column of secondary runner - Google Patents
There is the liquid distributor of the chromatographic column of secondary runner Download PDFInfo
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- CN103638692B CN103638692B CN201310628002.0A CN201310628002A CN103638692B CN 103638692 B CN103638692 B CN 103638692B CN 201310628002 A CN201310628002 A CN 201310628002A CN 103638692 B CN103638692 B CN 103638692B
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- distribution plate
- chute
- dish
- main distribution
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Abstract
A kind of liquid distributor with the chromatographic column of secondary runner, this liquid distributor is provided with main distribution plate, one side surface of this main distribution plate is provided with circumferential multiple radial chute, and the axially extending bore of the annular be communicated with described multiple chute is provided with at the middle part of main distribution plate, the proximal edge of the autonomous distribution plate of described chute is the shaped form upwarped to the longitudinal section of a section between axially extending bore, chute from axially extending bore to main distribution plate center between longitudinal section of a section be downward-sloping linear, secondary distribution dish is provided with at the opposite side of main distribution plate, annular channel is formed between secondary distribution dish and main distribution plate, this secondary distribution dish is provided with centre bore and multiple radial runner, multiple radial runner is connected with described annular channel and centre bore, secondary distribution dish is provided with liquid outlet or inlet tube.The present invention can shorten the longest distance that liquid flows in chute, improves uniformity and the chromatography efficiency of liquid distribution.
Description
[technical field]
The present invention relates to the chromatographic column in gel chromatography technology, particularly relate to a kind of liquid distributor with the chromatographic column of secondary runner.
[background technology]
Chromatography is a kind of gel separation method, typical in silica gel chromatography.It makes separating liquid and the gel in chromatographic column carry out molecular sieve, ion-exchange etc. react and be separated.Chromatographic column is the main body in gel chromatography technology, and generally with glass tube or lucite tube, it is built with gel, and two ends are provided with liquid distributing pan and sieve plate.Traditional chromatographic column liquid distributing pan is provided with radial chute in side, and center is provided with inlet or liquid outlet, and liquid enters from inlet, is flowed out by liquid distributing pan edge through radial chute stream; Or entered by Liquid distribution plate edge, then flowed out by liquid outlet through radial chute stream.Because the edge of oneself dish of its radial chute is to center, liquid must flow through longer path, therefore causes liquid skewness in gel, thus affects chromatography efficiency.
[summary of the invention]
The present invention is intended to solve the problem, and provides a kind of longest distance that effectively can shorten liquid and flow in chute, improves the uniformity of liquid distribution and the liquid distributor with the chromatographic column of secondary runner of chromatography efficiency.
For achieving the above object, the invention provides a kind of liquid distributor with the chromatographic column of secondary runner, this liquid distributor is provided with main distribution plate, one side surface of this main distribution plate is provided with circumferential multiple radial chute, and the axially extending bore of the annular be communicated with described multiple chute is provided with at the middle part of main distribution plate, the proximal edge of the autonomous distribution plate of described chute is the shaped form upwarped to the longitudinal section of a section between axially extending bore, chute from axially extending bore to main distribution plate center between longitudinal section of a section be downward-sloping linear, secondary distribution dish is provided with at the opposite side of main distribution plate, annular channel is formed between secondary distribution dish and main distribution plate, this secondary distribution dish is provided with centre bore and multiple radial runner, multiple radial runner is connected with described annular channel and centre bore, secondary distribution dish is provided with liquid outlet or inlet tube.
Main distribution plate is circular discoid body, described multiple radial chute is provided with at one side surface, the opposite side surface of main distribution plate is provided with secondary distribution dish storage tank, and the axially extending bore on described main distribution plate is by the chute to opposite side through bottom secondary distribution dish storage tank.
The discoid body that secondary distribution dish is corresponding with the secondary distribution dish storage tank shape on main distribution plate, described multiple radial runner is horizontally set, and its one end is communicated with the centre bore of secondary distribution dish, its other end and outside through.
Secondary distribution dish is fixed in the secondary distribution dish storage tank of main distribution plate, forms annular channel, sealed in the contact site of secondary distribution dish and main distribution plate by multiple sealing ring between the periphery of secondary distribution dish and the sidewall of secondary distribution dish storage tank.
Contribution of the present invention is, it efficiently solves the problem existing for existing chromatographic column Liquid distribution structure.The present invention, by arranging two-stage distribution plate, makes the distribution of liquid more reasonable, effectively shortens the longest distance that liquid flows in chute, thus improve the uniformity of the liquid of the gel entered in chromatographic column, improve chromatography efficiency.The features such as it is simple that the present invention also has structure, easy to implement.
[accompanying drawing explanation]
Fig. 1 is overall structure sectional view of the present invention.
Fig. 2 is main distribution plate structural representation of the present invention.
Fig. 3 is the top view of Fig. 2.
Fig. 4 is the upward view of Fig. 2.
Fig. 5 is secondary distribution dish structural representation of the present invention.
Fig. 6 is that the A of Fig. 5 is to sectional view.
[detailed description of the invention]
The following example is further explanation of the present invention, does not constitute any limitation the present invention.
Consult Fig. 1, the liquid distributor with the chromatographic column of secondary runner of the present invention comprises main distribution plate 10, secondary distribution dish 20, annular channel 30 and liquid outlet or inlet tube 40.
As shown in Figure 2 to 4, described main distribution plate 10 is circular discoid body, and it can be arranged on the two ends of chromatographic column (not shown) when practical application.In the present embodiment, multiple chute 11 is provided with at the lower surface of main distribution plate 10, multiple chute 11 is radially arranged at interval along main distribution plate 10 circumferencial direction, each chute 11 is made up of the chute of two sections of different grooveds, wherein, the proximal edge of autonomous distribution plate 10 is longitudinal section to one section of chute between axially extending bore is the shaped form chute upwarped, be longitudinal section from axially extending bore 12 to one section of chute between the center of main distribution plate 10 be downward-sloping linear chute, this groove design makes the liquid entering chute can flow to the proximal edge of main distribution plate 10 fast or flow to axially extending bore 12 fast by the proximal edge of main distribution plate 10, therefore Liquid distribution efficiency can be improved.In actual applications, being provided with sieve plate (not shown) in the side with chute of main distribution plate 10, for isolating main distribution plate 10 and the gel in chromatographic column, and making liquid drop onto gel through sieve plate hole.As Fig. 2, be provided with secondary distribution dish storage tank 13 on the opposite side surface of main distribution plate 10, for accommodating secondary distribution dish 20.This secondary distribution dish storage tank 13 is circular scalariform groove, is respectively equipped with the seal groove 131,132 of installing sealing ring in the bottom of groove and step place.In Fig. 2, be provided with ring shaped axial through hole 12 at the middle part of main distribution plate, this axially extending bore 12 extends to opposite side by bottom secondary distribution dish storage tank 13, and is connected with described multiple chutes 11.
As Fig. 1, at the secondary distribution dish storage tank 13 of main distribution plate 10 built with secondary distribution dish 20, its structure as shown in Figure 5, Figure 6, this secondary distribution dish 20 is rank shape discoid bodies corresponding with described secondary distribution dish storage tank 13 shape, this secondary distribution dish 20 is provided with centre bore 21 and multiple radial runner 22, multiple radial runner 22 is in horizontally set, and its one end is communicated with the centre bore 21 of secondary distribution dish, and its other end connects with outside annular channel 30.This secondary distribution dish 20 is located in the secondary distribution dish storage tank 13 of main distribution plate 10, and fix with screw and main distribution plate 10, the scalariform edge of secondary distribution dish is placed in the step place of secondary distribution dish storage tank, the diameter of its disk body part is less than secondary distribution dish storage tank diameter, makes to form annular channel 30 between the periphery and the sidewall of secondary distribution dish storage tank 13 of secondary distribution dish 20.As Fig. 2, the upper surface of secondary distribution dish 20 is concordant with the upper surface of main distribution plate 10, bottom secondary distribution dish storage tank 13 and in the seal groove 131,132,133 at step place, respectively sealing ring is housed, the contact site of secondary distribution dish 20 with main distribution plate 10 is sealed.
As Fig. 1, secondary distribution dish 20 is fixed with liquid inlet duct 40, according to actual needs, it also can be liquid outlet tube.Separating liquid can enter secondary distribution dish 20 by liquid inlet duct 40 and carry out Liquid distribution, and the liquid after distribution flows into chromatography in chromatographic column.
The operation principle with the liquid distributor of the chromatographic column of secondary runner of the present invention as shown in Figure 1, the liquid be separated enters secondary distribution dish 20 by the liquid inlet duct 40 on secondary distribution dish, liquid enters the annular channel 30 between secondary distribution dish 20 and main distribution plate 10 through the multiple radial runner 22 of secondary distribution dish, multiple chutes 11 of main distribution plate are distributed to again through the axially extending bore 12 of the annular of main distribution plate, liquid flows along chute 11 to surrounding, then the sieve plate hole on sieve plate falls in chromatographic column, completes the distribution of liquid.
Although by above embodiment to invention has been announcement, protection scope of the present invention is not limited thereto, under the condition not departing from the present invention's design, all will fall in right of the present invention the distortion, replacement etc. that above each component does.
Claims (4)
1. one kind has the liquid distributor of the chromatographic column of secondary runner, it is characterized in that, this liquid distributor is provided with main distribution plate (10), one side surface of this main distribution plate is provided with circumferential multiple radial chute (11), and the axially extending bore (12) of the annular be communicated with described multiple chute is provided with at the middle part of main distribution plate, the proximal edge of the autonomous distribution plate (10) of described chute (11) is the shaped form upwarped to the longitudinal section of a section between axially extending bore, chute (11) from axially extending bore (12) to main distribution plate (10) center between longitudinal section of a section be downward-sloping linear, secondary distribution dish (20) is provided with at the opposite side of main distribution plate (10), annular channel (30) is formed between secondary distribution dish (20) and main distribution plate, this secondary distribution dish (20) is provided with centre bore (21) and multiple radial runner (22), multiple radial runner (22) is connected with described annular channel (30) and centre bore (21), secondary distribution dish (20) is provided with liquid outlet or inlet tube (40).
2. there is the liquid distributor of the chromatographic column of secondary runner as claimed in claim 1, it is characterized in that, described main distribution plate (10) is circular discoid body, described multiple radial chute (11) is provided with at one side surface, the opposite side surface of main distribution plate (10) is provided with secondary distribution dish storage tank (13), and the axially extending bore (12) on described main distribution plate is by secondary distribution dish storage tank (13) the through chute to opposite side in bottom (11).
3. there is the liquid distributor of the chromatographic column of secondary runner as claimed in claim 2, it is characterized in that, described secondary distribution dish (20) is the discoid body corresponding with secondary distribution dish storage tank (13) shape on main distribution plate (10), described multiple radial runner (22) is in horizontally set, its one end is communicated with the centre bore (21) of secondary distribution dish, its other end and outside through.
4. there is the liquid distributor of the chromatographic column of secondary runner as claimed in claim 2, it is characterized in that, described secondary distribution dish (20) is fixed in the secondary distribution dish storage tank (13) of main distribution plate (10), form annular channel (30) between the periphery of secondary distribution dish (20) and secondary distribution dish storage tank (13) sidewall, sealed by multiple sealing ring in the contact site of secondary distribution dish (20) with main distribution plate (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310628002.0A CN103638692B (en) | 2013-11-29 | 2013-11-29 | There is the liquid distributor of the chromatographic column of secondary runner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310628002.0A CN103638692B (en) | 2013-11-29 | 2013-11-29 | There is the liquid distributor of the chromatographic column of secondary runner |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103638692A CN103638692A (en) | 2014-03-19 |
| CN103638692B true CN103638692B (en) | 2016-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310628002.0A Expired - Fee Related CN103638692B (en) | 2013-11-29 | 2013-11-29 | There is the liquid distributor of the chromatographic column of secondary runner |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436757B (en) * | 2014-11-26 | 2017-10-27 | 源创精科生物科技(长沙)有限公司 | Coupling pressure formula chromatographic column fluid distributor |
| CN106481816B (en) * | 2016-12-07 | 2018-05-18 | 苏州楚博生物技术有限公司 | For the Butt sealing structure of chromatographic column |
| CN109966779B (en) * | 2019-03-27 | 2021-05-04 | 润方（北京）生物医药研究院有限公司 | Liquid phase chromatographic distributor |
| CN116209510A (en) * | 2020-09-30 | 2023-06-02 | 安捷伦科技有限公司 | Chromatographic column |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1856346A (en) * | 2003-09-23 | 2006-11-01 | 通用电气健康护理生物科学股份公司 | Chromatography column distribution system |
| CN202366510U (en) * | 2011-11-28 | 2012-08-08 | 顾雄毅 | Liquid distributor of expanded bed device capable of being used in biological pharmacy |
| CN103285621A (en) * | 2012-02-27 | 2013-09-11 | 中国石油化工集团公司 | Device and method for distributing and collecting liquid material of adsorption and separation tower |
| CN203678007U (en) * | 2013-11-29 | 2014-07-02 | 栗云天 | Chromatographic column liquid distributor with secondary runner |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0111486D0 (en) * | 2001-05-11 | 2001-07-04 | Amersham Pharm Biotech Ab | Scalable inlet liquid distribution system for large scale chromatography columns |
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2013
- 2013-11-29 CN CN201310628002.0A patent/CN103638692B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1856346A (en) * | 2003-09-23 | 2006-11-01 | 通用电气健康护理生物科学股份公司 | Chromatography column distribution system |
| CN202366510U (en) * | 2011-11-28 | 2012-08-08 | 顾雄毅 | Liquid distributor of expanded bed device capable of being used in biological pharmacy |
| CN103285621A (en) * | 2012-02-27 | 2013-09-11 | 中国石油化工集团公司 | Device and method for distributing and collecting liquid material of adsorption and separation tower |
| CN203678007U (en) * | 2013-11-29 | 2014-07-02 | 栗云天 | Chromatographic column liquid distributor with secondary runner |
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| Publication number | Publication date |
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| CN103638692A (en) | 2014-03-19 |
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Owner name: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: LI YUNTIAN Effective date: 20141013 Free format text: FORMER OWNER: XIAO LIFENG Effective date: 20141013 |
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Effective date of registration: 20141013 Address after: 410000 Hunan city high tech Development Zone Changsha Changsha Wenxuan Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Applicant after: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. Address before: 518000 heroic hi tech Zone, big wave street, Longhua New District, Guangdong, Shenzhen Applicant before: Li Yuntian Applicant before: Xiao Lifeng |
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Address after: 410000 Hunan city high tech Development Zone Changsha Changsha Wenxuan Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Applicant after: Biotechnology (Changsha) Co., Ltd of Yuan Chuanjing section Address before: 410000 Hunan city high tech Development Zone Changsha Changsha Wenxuan Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Applicant before: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. |
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Free format text: CORRECT: APPLICANT; FROM: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. TO: YUANCHUANG JINGKE BIO-TECHNOLOGY (CHANGSHA) CO., LTD. |
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