CN103638692A - Liquid distributor with two stages of runners for chromatographic column - Google Patents
Liquid distributor with two stages of runners for chromatographic column Download PDFInfo
- Publication number
- CN103638692A CN103638692A CN201310628002.0A CN201310628002A CN103638692A CN 103638692 A CN103638692 A CN 103638692A CN 201310628002 A CN201310628002 A CN 201310628002A CN 103638692 A CN103638692 A CN 103638692A
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- Prior art keywords
- distribution plate
- main distribution
- main
- distribution dish
- dish
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- 239000007788 liquid Substances 0.000 title claims abstract description 52
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 5
- 238000004587 chromatography analysis Methods 0.000 abstract description 6
- 239000000499 gel Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 229920005479 Lucite® Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention relates to a liquid distributor with two stages of runners for a chromatographic column. The liquid distributor is provided with a main distribution disc, wherein a plurality of radial launders distributed along the circumference are formed in the surface of one side of the main distribution disc, an annular axial through hole communicated with the launders is formed in the middle of the main distribution disc, the longitudinal fracture surfaces of one sections, from the near edge of the main distribution disc to the axial through hole, of the launders are in tilted curve shapes, and the longitudinal fracture surfaces of one sections, from the axial through hole to the main distribution disc, of the launders are in downward-inclined linear shapes; a second-stage distribution disc is arranged on the other side of the main distribution disc, an annular runner is formed between the second-stage distribution disc and the main distribution disc, a central hole and a plurality of radial runners are formed in the second-stage distribution disc, the radial runners are communicated with the annular runner and the central hole, and a liquid outlet or inlet pipe is arranged on the second-stage distribution disc. According to the liquid distributor with two stages of runners, the longest flowing distances of liquid in the launders can be shortened, and the distribution uniformity and chromatography efficiency of the liquid are improved.
Description
[technical field]
The present invention relates to the chromatographic column in gel chromatography technology, particularly relate to a kind of liquid distributor with the chromatographic column of secondary runner.
[background technology]
Chromatography is a kind of gel separation method, typical in silica gel chromatography.It is to make separating liquid carry out the reactions such as molecular sieve, ion-exchange and obtain separated with the gel in chromatographic column.Chromatographic column is the main body in gel chromatography technology, generally, with glass tube or lucite tube, gel is housed in it, and two ends are provided with liquid distributing pan and sieve plate.Traditional chromatographic column liquid distributing pan is provided with radial chute in a side, and center is provided with inlet or liquid outlet, and liquid enters from inlet, through radial chute stream, by liquid distributing pan edge, is flowed out; Or entered by liquid distributing pan edge, then through radial chute stream, by liquid outlet, flowed out.The edge that oneself coils due to its radial chute is to center, and liquid must flow through longer path, therefore causes liquid skewness in gel, thereby affects chromatography efficiency.
[summary of the invention]
The present invention is intended to address the above problem, and a kind of liquid mobile longest distance in chute that can effectively shorten is provided, and improves the liquid distributor of the uniformity of liquid distribution and the chromatographic column with secondary runner of chromatography efficiency.
For achieving the above object, the invention provides a kind of liquid distributor with the chromatographic column of secondary runner, this liquid distributor is provided with main distribution plate, one side surface of this main distribution plate is provided with circumferential a plurality of radial chute, and at the middle part of main distribution plate, be provided with the annular axially extending bore being communicated with described a plurality of chutes, the proximal edge of the autonomous distribution plate of described chute to the longitudinal section of a section between axially extending bore is the shaped form upwarping, chute is downward-sloping linear from axially extending bore to the longitudinal section of a section between the center of main distribution plate, opposite side at main distribution plate is provided with secondary distribution dish, between secondary distribution dish and main distribution plate, be formed with annular channel, this secondary distribution dish is provided with centre bore and a plurality of radial runner, a plurality of radial runners are connected with described annular channel and centre bore, on secondary distribution dish, be provided with liquid outlet or inlet tube.
Main distribution plate is circular discoid body, at one side surface, be provided with described a plurality of radial chute, the opposite side surface of main distribution plate is provided with secondary distribution dish storage tank, and the axially extending bore on described main distribution plate connects the chute to opposite side by secondary distribution dish storage tank bottom.
The discoid body that secondary distribution dish is corresponding with secondary distribution dish storage tank shape on main distribution plate, described a plurality of radial runners are horizontally set, and its one end is communicated with the centre bore of secondary distribution dish, and its other end connects with outside.
Secondary distribution dish is fixed in the secondary distribution dish storage tank of main distribution plate, between the periphery of secondary distribution dish and the sidewall of secondary distribution dish storage tank, forms annular channel, in the contact site of secondary distribution dish and main distribution plate, by a plurality of sealing rings, is sealed.
Contribution of the present invention is, it efficiently solves the existing problem of existing chromatographic column liquid distribution structure.The present invention, by two-stage distribution plate is set, makes the distribution of liquid more reasonable, effectively shortened liquid mobile longest distance in chute, thereby improved the uniformity of the liquid that enters the gel in chromatographic column, improved chromatography efficiency.The features such as the present invention also has simple in structure, easy to implement.
[accompanying drawing explanation]
Fig. 1 is overall structure cutaway view of the present invention.
Fig. 2 is main distribution plate structural representation of the present invention.
Fig. 3 is the top view of Fig. 2.
Fig. 4 is the upward view of Fig. 2.
Fig. 5 is secondary distribution dish structural representation of the present invention.
Fig. 6 is that the A of Fig. 5 is to cutaway view.
[specific embodiment]
The following example is further explanation of the present invention, and the present invention is not constituted any limitation.
Consult Fig. 1, the liquid distributor with the chromatographic column of secondary runner of the present invention comprises main distribution plate 10, secondary distribution dish 20, annular channel 30 and liquid outlet or inlet tube 40.
As shown in Figure 2 to 4, described main distribution plate 10 is circular discoid body, and it can be arranged on the two ends of chromatographic column (not shown) when practical application.In the present embodiment, lower surface at main distribution plate 10 is provided with a plurality of chutes 11, a plurality of chutes 11 are radial interval along main distribution plate 10 circumferencial directions and arrange, each chute 11 consists of the chute of two sections of different grooveds, wherein, proximal edge to one section of chute between axially extending bore of autonomous distribution plate 10 is that longitudinal section is the shaped form chute upwarping, from axially extending bore 12 to one section of chute between main distribution plate 10 center, be that longitudinal section is downward-sloping linear chute, this groove design make to enter the liquid of chute can rapid flow to the proximal edge of main distribution plate 10 or by the proximal edge rapid flow of main distribution plate 10 to axially extending bore 12, therefore can improve liquid allocative efficiency.In actual applications, in the side with chute of main distribution plate 10, be provided with sieve plate (not shown), for isolating the gel in main distribution plate 10 and chromatographic column, and make liquid drop onto gel through sieve plate hole.As Fig. 2, on the opposite side surface of main distribution plate 10, be provided with secondary distribution dish storage tank 13, for accommodating secondary distribution dish 20.This secondary distribution dish storage tank 13 is circular scalariform groove, the seal groove 131,132 that is respectively equipped with installing sealing ring at bottom and the step place of groove.In Fig. 2, at the middle part of main distribution plate, be provided with ring shaped axial through hole 12, this axially extending bore 12 extends to opposite side by secondary distribution dish storage tank 13 bottoms, and is connected with described a plurality of chutes 11.
As Fig. 1, in the secondary distribution dish storage tank 13 of main distribution plate 10, secondary distribution dish 20 is housed, its structure as shown in Figure 5, Figure 6, this secondary distribution dish 20 is rank shape discoid bodies corresponding with described secondary distribution dish storage tank 13 shapes, this secondary distribution dish 20 is provided with centre bore 21 and a plurality of radial runner 22, a plurality of radial runners 22 are horizontally set, and its one end is communicated with the centre bore 21 of secondary distribution dish, and its other end and outside annular channel 30 connect.This secondary distribution dish 20 is located in the secondary distribution dish storage tank 13 of main distribution plate 10, and fixing with screw and main distribution plate 10, the scalariform edge of secondary distribution dish is placed in the step place of secondary distribution dish storage tank, the diameter of its disk body part is less than secondary distribution dish storage tank diameter, makes to form annular channel 30 between the periphery of secondary distribution dish 20 and the sidewall of secondary distribution dish storage tank 13.As Fig. 2, the upper surface of secondary distribution dish 20 is concordant with the upper surface of main distribution plate 10, the interior sealing ring that is equipped with respectively of seal groove 131,132,133 at secondary distribution dish storage tank 13 bottoms and step place, the contact site sealing by secondary distribution dish 20 with main distribution plate 10.
As Fig. 1, on secondary distribution dish 20, be fixed with liquid inlet duct 40, according to actual needs, it can be also liquid outlet tube.Separating liquid can enter secondary distribution dish 20 by liquid inlet duct 40 and carry out liquid distribution, and the liquid after distribution flows into chromatography in chromatographic column.
The operation principle of the liquid distributor of the chromatographic column with secondary runner of the present invention as shown in Figure 1, want separated liquid to enter secondary distribution dish 20 by the liquid inlet duct 40 on secondary distribution dish, liquid enters the annular channel 30 between secondary distribution dish 20 and main distribution plate 10 through a plurality of radial runner 22 of secondary distribution dish, through the annular axially extending bore 12 of main distribution plate, be distributed to again a plurality of chutes 11 of main distribution plate, liquid flows along chute 11 to surrounding, then the sieve plate hole on sieve plate falls in chromatographic column, has completed the distribution of liquid.
Although the present invention is disclosed by above embodiment, protection scope of the present invention is not limited to this, is not departing under the condition of the present invention's design, and the distortion that above each member is done, replacement etc. all will fall within the scope of claim of the present invention.
Claims (4)
1. a liquid distributor with the chromatographic column of secondary runner, it is characterized in that, this liquid distributor is provided with main distribution plate (10), one side surface of this main distribution plate is provided with circumferential a plurality of radial chutes (11), and at the middle part of main distribution plate, be provided with the annular axially extending bore (12) being communicated with described a plurality of chutes, proximal edge to the longitudinal section of a section between axially extending bore of the autonomous distribution plate (10) of described chute (11) is the shaped form upwarping, chute (11) is downward-sloping linear from axially extending bore (12) to the longitudinal section of a section between the center of main distribution plate (10), opposite side at main distribution plate (10) is provided with secondary distribution dish (20), between secondary distribution dish (20) and main distribution plate, be formed with annular channel (30), this secondary distribution dish (20) is provided with centre bore (21) and a plurality of radial runner (22), a plurality of radial runners (22) are connected with described annular channel (30) and centre bore (21), on secondary distribution dish (20), be provided with liquid outlet or inlet tube (40).
2. the liquid distributor with the chromatographic column of secondary runner as claimed in claim 1, it is characterized in that, described main distribution plate (10) is circular discoid body, at one side surface, be provided with described a plurality of radial chute (11), the opposite side surface of main distribution plate (10) is provided with secondary distribution dish storage tank (13), and the axially extending bore (12) on described main distribution plate connects the chute (11) to opposite side by secondary distribution dish storage tank (13) bottom.
3. the liquid distributor with the chromatographic column of secondary runner as claimed in claim 2, it is characterized in that, described secondary distribution dish (20) is the discoid body corresponding with secondary distribution dish storage tank (13) shape on main distribution plate (10), described a plurality of radial runners (22) are horizontally set, its one end is communicated with the centre bore (21) of secondary distribution dish, and its other end connects with outside.
4. the liquid distributor with the chromatographic column of secondary runner as claimed in claim 2, it is characterized in that, described secondary distribution dish (20) is fixed in the secondary distribution dish storage tank (13) of main distribution plate (10), between the periphery of secondary distribution dish (20) and secondary distribution dish storage tank (13) sidewall, form annular channel (30), in secondary distribution dish (20) and the contact site of main distribution plate (10), by a plurality of sealing rings, sealed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310628002.0A CN103638692B (en) | 2013-11-29 | 2013-11-29 | There is the liquid distributor of the chromatographic column of secondary runner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310628002.0A CN103638692B (en) | 2013-11-29 | 2013-11-29 | There is the liquid distributor of the chromatographic column of secondary runner |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103638692A true CN103638692A (en) | 2014-03-19 |
| CN103638692B CN103638692B (en) | 2016-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310628002.0A Expired - Fee Related CN103638692B (en) | 2013-11-29 | 2013-11-29 | There is the liquid distributor of the chromatographic column of secondary runner |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436757A (en) * | 2014-11-26 | 2015-03-25 | 长沙市源创精科生物技术有限公司 | Pressure coupling type chromatographic column fluid distributor |
| CN106481816A (en) * | 2016-12-07 | 2017-03-08 | 苏州楚博生物技术有限公司 | Butt sealing structure for chromatographic column |
| CN109966779A (en) * | 2019-03-27 | 2019-07-05 | 润方（北京）生物医药研究院有限公司 | A kind of liquid chromatography distributor |
| WO2022072213A1 (en) * | 2020-09-30 | 2022-04-07 | Agilent Technologies, Inc. | Chromatography column |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040140007A1 (en) * | 2001-05-11 | 2004-07-22 | Peter Bellqvist | Scalable inlet liquid distribution system for large scale chromatography columns |
| CN1856346A (en) * | 2003-09-23 | 2006-11-01 | 通用电气健康护理生物科学股份公司 | Chromatography column distribution system |
| CN202366510U (en) * | 2011-11-28 | 2012-08-08 | 顾雄毅 | Liquid distributor of expanded bed device capable of being used in biological pharmacy |
| CN103285621A (en) * | 2012-02-27 | 2013-09-11 | 中国石油化工集团公司 | Device and method for distributing and collecting liquid material of adsorption and separation tower |
| CN203678007U (en) * | 2013-11-29 | 2014-07-02 | 栗云天 | Chromatographic column liquid distributor with secondary runner |
-
2013
- 2013-11-29 CN CN201310628002.0A patent/CN103638692B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040140007A1 (en) * | 2001-05-11 | 2004-07-22 | Peter Bellqvist | Scalable inlet liquid distribution system for large scale chromatography columns |
| CN1856346A (en) * | 2003-09-23 | 2006-11-01 | 通用电气健康护理生物科学股份公司 | Chromatography column distribution system |
| CN202366510U (en) * | 2011-11-28 | 2012-08-08 | 顾雄毅 | Liquid distributor of expanded bed device capable of being used in biological pharmacy |
| CN103285621A (en) * | 2012-02-27 | 2013-09-11 | 中国石油化工集团公司 | Device and method for distributing and collecting liquid material of adsorption and separation tower |
| CN203678007U (en) * | 2013-11-29 | 2014-07-02 | 栗云天 | Chromatographic column liquid distributor with secondary runner |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436757A (en) * | 2014-11-26 | 2015-03-25 | 长沙市源创精科生物技术有限公司 | Pressure coupling type chromatographic column fluid distributor |
| CN106481816A (en) * | 2016-12-07 | 2017-03-08 | 苏州楚博生物技术有限公司 | Butt sealing structure for chromatographic column |
| CN106481816B (en) * | 2016-12-07 | 2018-05-18 | 苏州楚博生物技术有限公司 | For the Butt sealing structure of chromatographic column |
| CN109966779A (en) * | 2019-03-27 | 2019-07-05 | 润方（北京）生物医药研究院有限公司 | A kind of liquid chromatography distributor |
| CN109966779B (en) * | 2019-03-27 | 2021-05-04 | 润方（北京）生物医药研究院有限公司 | Liquid phase chromatographic distributor |
| WO2022072213A1 (en) * | 2020-09-30 | 2022-04-07 | Agilent Technologies, Inc. | Chromatography column |
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| Publication number | Publication date |
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| CN103638692B (en) | 2016-03-02 |
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Owner name: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: LI YUNTIAN Effective date: 20141013 Free format text: FORMER OWNER: XIAO LIFENG Effective date: 20141013 |
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Effective date of registration: 20141013 Address after: 410000 Hunan city high tech Development Zone Changsha Changsha Wenxuan Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Applicant after: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. Address before: 518000 heroic hi tech Zone, big wave street, Longhua New District, Guangdong, Shenzhen Applicant before: Li Yuntian Applicant before: Xiao Lifeng |
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Address after: 410000 Hunan city high tech Development Zone Changsha Changsha Wenxuan Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Applicant after: Biotechnology (Changsha) Co., Ltd of Yuan Chuanjing section Address before: 410000 Hunan city high tech Development Zone Changsha Changsha Wenxuan Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Applicant before: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. |
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Free format text: CORRECT: APPLICANT; FROM: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. TO: YUANCHUANG JINGKE BIO-TECHNOLOGY (CHANGSHA) CO., LTD. |
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Granted publication date: 20160302 Termination date: 20181129 |
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