CN101433776A - Large-sized chromatographic column for preparation with diameter of 50 millimetres or more - Google Patents
Large-sized chromatographic column for preparation with diameter of 50 millimetres or more Download PDFInfo
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- CN101433776A CN101433776A CNA2007101582851A CN200710158285A CN101433776A CN 101433776 A CN101433776 A CN 101433776A CN A2007101582851 A CNA2007101582851 A CN A2007101582851A CN 200710158285 A CN200710158285 A CN 200710158285A CN 101433776 A CN101433776 A CN 101433776A
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- chromatographic column
- ring
- preparative chromatography
- lower flange
- chromatography post
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Abstract
The invention relates to a preparative chromatographic column, in particular to a large-scale preparative chromatographic column the diameter of which is 50 millimeters or more than 50 millimeters. The large-scale preparative chromatographic column comprises a chromatographic column body, an upper flanged disc and a lower flanged disc, wherein external threads are arranged on both ends of the chromatographic column body respectively; internal threads are arranged on the inner wall of the lower flanged disc; both ends of the chromatographic column body are in threaded connection with the lower flanged disc respectively; and the lower flanged disc is in threaded connection with the upper flanged disc and screwed up. The preparative chromatographic column adopts threads and bolts for connection, thereby being simple, beautiful and practical, and having good sealability.
Description
Technical field
The present invention relates to the preparative chromatography post, specifically a kind of diameter is at the large-scale preparative chromatography post more than 50 or 50 millimeters.
Background technology
In the past, in order to guarantee sealing property high pressure resistant and height, domestic and international each company, for example external day island proper Tianjin, clear and electrician, Japan Cao Da company, U.S. Waters, Dupont company, domesticly all adopt ring flange and chromatogram cylinder to be welded according to Lyntech Corporation (US) 10177 South 77th East Avenue Tulsa, Oklahoma 74133 U.S., Han Bang company etc., the large-scale preparative chromatography post that processes like this exists certain defective.
Though in argon shield atmosphere, carry out when body of stainless steel and ring flange welding, still have part body of stainless steel surface oxidized, destroyed the aesthetic feeling of object, because local heating is inhomogeneous, cause the distortion of ring flange and cylinder in the welding process, need secondary operations.Come back on the lathe and proofread and correct, turning, the oxide layer of inner surface needs fine gtinding, reduces the deviation of tube wall benefit and minimizing axiality as far as possible.Though such processing technology can be qualified, require great effort, take a lot of work, expensive.
Summary of the invention
Based on above reason, the object of the present invention is to provide a kind of diameter at the large-scale preparative chromatography post more than 50 or 50 millimeters, guaranteeing that it adopts screw thread and bolt to couple together under the withstand voltage 100MPa situation between ring flange and the cylinder, not only simply but also both artistic and practical, favorable sealing property.
For achieving the above object, the technical solution used in the present invention is:
A kind of diameter is at the large-scale preparative chromatography post more than 50 or 50 millimeters, comprise chromatogram cylinder, upper flange plate, lower flange, two ends of chromatogram cylinder are respectively arranged with external screw thread, the inwall of the lower flange internal thread of having got on the bus, and two ends of chromatogram cylinder are threaded with lower flange respectively; Lower flange is threaded with upper flange plate and tightens.
Inner chamber top center position at upper flange plate is provided with material liquid entrance, around material liquid entrance, be provided with the ring-type seam, screen pack and distribution plate are housed in the ring-type seam successively, and the distribution plate arranged outside has the gasket seal gasket seal that screen pack and distribution plate are locked in the ring-type seam.
In ring-type seam arranged outside seal washer is arranged.
The present invention has following advantage:
1. simple in structure.The present invention adopts screw thread and bolted-on connection, does not see use in common chemical process, and employing is just arranged in the heating installation course of conveying in city; But be only limited to normal pressure.We are used for large-scale preparative chromatography post with this technology now, still belong to the first time in this industry.
2. easy installation and removal.Do not need welding, use screw thread and bolted flange dish and chromatogram cylinder except above advantage, it also is easy to dismounting and changes parts, no matter be that cylinder or ring flange are corroded owing to use throughout the year can cause ring flange damage or cylinder inner surface.If running into this situation, the preparative chromatography post of welded type can only throw away the preparative chromatography post that more renews.And with screw thread and bolted large-scale preparative chromatography post, which is partly bad, changes this part and gets final product.
3. cost is low.With 50 millimeters of diameters, length is that 250 millimeters large-scale preparative chromatography post is an example, processes 6,000 yuan of need RMB, if welded type, just damaged and can only throw away; If screw thread and bolted, lower flange has only damaged and has needed 150 yuan, and the chromatogram cylinder has damaged changes 1000 yuan of need.
4. effect is good.Adopt the present invention to design successively and use this large-scale preparative chromatography post, all obtain promising result in Nanjing University of Traditional Chinese Medicine, the little core bio tech ltd in Shenzhen, Military Medical Science Institute eight (Fengtai, Beijing), 1806 groups of experiments of Dalian Chemiclophysics Inst., Chinese Academy of Sciences.
Description of drawings
Fig. 1 is the structural representation of preparative chromatography post of the present invention.
The specific embodiment
As shown in Figure 1, a kind of diameter is at the large-scale preparative chromatography post more than 50 or 50 millimeters, comprise chromatogram cylinder 3, upper flange plate 1, lower flange 2, two ends of chromatogram cylinder are respectively arranged with external screw thread, the inwall of the lower flange internal thread of having got on the bus, two ends of chromatogram cylinder are threaded with lower flange respectively; Lower flange is threaded with upper flange plate and tightens.
Inner chamber top center position at upper flange plate is provided with material liquid entrance, around material liquid entrance, be provided with the ring-type seam, screen pack 4 and distribution plate 5 are housed in the ring-type seam successively, the distribution plate arranged outside has gasket seal 6, and gasket seal is locked at screen pack and distribution plate in the ring-type seam;
In ring-type seam arranged outside seal washer 7 is arranged.
On upper flange plate and lower flange outer wall, be respectively equipped with screw, during installation, two lower flanges are screwed to the two ends of chromatogram cylinder respectively, and the top of chromatogram cylinder protrudes in lower flange, chromatogram cylinder and lower flange are mounted on the upper flange plate, and upper and lower ring flange is tightened by the screw on the upper and lower ring flange outer wall with bolt 8, at this moment, the top of chromatogram cylinder is pressed on the seal washer.
Claims (3)
1. a diameter is at the large-scale preparative chromatography post more than 50 or 50 millimeters, comprise chromatogram cylinder (3), upper flange plate (1), lower flange (2), it is characterized in that: two ends of chromatogram cylinder (1) are respectively arranged with external screw thread, the inwall of lower flange (2) internal thread of having got on the bus, two ends of chromatogram cylinder are threaded with lower flange respectively; Lower flange (2) is threaded with upper flange plate (3) and tightens.
2. according to the described large-scale preparative chromatography post of claim 1, it is characterized in that: the inner chamber top center position at upper flange plate is provided with material liquid entrance, around material liquid entrance, be provided with the ring-type seam, screen pack (4) and distribution plate (5) are housed in the ring-type seam successively, the distribution plate arranged outside has gasket seal (6), and gasket seal is locked at screen pack and distribution plate in the ring-type seam.
3. according to the described large-scale preparative chromatography post of claim 2, it is characterized in that: seal washer (7) is arranged in ring-type seam arranged outside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101582851A CN101433776A (en) | 2007-11-14 | 2007-11-14 | Large-sized chromatographic column for preparation with diameter of 50 millimetres or more |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101582851A CN101433776A (en) | 2007-11-14 | 2007-11-14 | Large-sized chromatographic column for preparation with diameter of 50 millimetres or more |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101433776A true CN101433776A (en) | 2009-05-20 |
Family
ID=40708508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101582851A Pending CN101433776A (en) | 2007-11-14 | 2007-11-14 | Large-sized chromatographic column for preparation with diameter of 50 millimetres or more |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101433776A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912697A (en) * | 2010-08-13 | 2010-12-15 | 利穗科技(苏州)有限公司 | Quick-release type large-volume preparative chromatographic column |
| CN103083943A (en) * | 2011-11-03 | 2013-05-08 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN103629897A (en) * | 2013-11-18 | 2014-03-12 | 靖江市明星水蛭养殖专业合作社 | Leech air-drying device |
| CN106481816A (en) * | 2016-12-07 | 2017-03-08 | 苏州楚博生物技术有限公司 | Butt sealing structure for chromatographic column |
-
2007
- 2007-11-14 CN CNA2007101582851A patent/CN101433776A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912697A (en) * | 2010-08-13 | 2010-12-15 | 利穗科技(苏州)有限公司 | Quick-release type large-volume preparative chromatographic column |
| CN101912697B (en) * | 2010-08-13 | 2012-05-23 | 利穗科技(苏州)有限公司 | Quick-release type large-volume preparative chromatographic column |
| CN103083943A (en) * | 2011-11-03 | 2013-05-08 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN103083943B (en) * | 2011-11-03 | 2014-08-27 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN103629897A (en) * | 2013-11-18 | 2014-03-12 | 靖江市明星水蛭养殖专业合作社 | Leech air-drying device |
| CN103629897B (en) * | 2013-11-18 | 2015-12-30 | 靖江市明星水蛭养殖专业合作社 | A kind of leech drying device |
| CN106481816A (en) * | 2016-12-07 | 2017-03-08 | 苏州楚博生物技术有限公司 | Butt sealing structure for chromatographic column |
| CN106481816B (en) * | 2016-12-07 | 2018-05-18 | 苏州楚博生物技术有限公司 | For the Butt sealing structure of chromatographic column |
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Legal Events
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090520 |