CN106479990B - 用于制备羟基取代的氨基甲酸酯的生物催化剂 - Google Patents
用于制备羟基取代的氨基甲酸酯的生物催化剂 Download PDFInfo
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Y02P20/50—Improvements relating to the production of bulk chemicals
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| US201161561665P | 2011-11-18 | 2011-11-18 | |
| US61/561,665 | 2011-11-18 | ||
| CN201280067329.9A CN104053771B (zh) | 2011-11-18 | 2012-11-14 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
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| CN201280067329.9A Division CN104053771B (zh) | 2011-11-18 | 2012-11-14 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
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| CN201280067329.9A Active CN104053771B (zh) | 2011-11-18 | 2012-11-14 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
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| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| US20150087832A1 (en) | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
| US9809536B2 (en) | 2011-10-27 | 2017-11-07 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| WO2013074650A1 (en) | 2011-11-18 | 2013-05-23 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
| EP2970927A4 (en) * | 2013-03-15 | 2016-10-12 | Merck Sharp & Dohme | IMMOBILIZED KETOREDUCASTASES AND METHOD FOR THE PRODUCTION AND USE OF IMMOBILIZED KETOREDUCASTASES |
| HRP20191546T1 (hr) | 2013-03-15 | 2019-11-29 | Merck Sharp & Dohme | Postupak za pripravu beta 3 agonista i intermedijera |
| EP3256577B1 (en) | 2015-02-10 | 2020-08-26 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN106011095B (zh) * | 2016-07-27 | 2021-02-26 | 苏州汉酶生物技术有限公司 | 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法 |
| US12102638B2 (en) | 2017-06-06 | 2024-10-01 | Urovant Sciences Gmbh | Use of vibegron to treat overactive bladder |
| SG11202103662VA (en) | 2018-12-05 | 2021-06-29 | Urovant Sciences Gmbh | Vibegron for the treatment of overactive bladder symptoms |
| CN109943543B (zh) * | 2019-03-28 | 2020-12-11 | 上海健康医学院 | 醇脱氢酶突变体及其制备方法和应用 |
| CN114410599B (zh) * | 2022-01-29 | 2023-08-18 | 浙江工业大学 | 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用 |
| CN116814569B (zh) * | 2023-05-30 | 2025-07-25 | 华东理工大学 | 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用 |
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2012
- 2012-11-14 WO PCT/US2012/065046 patent/WO2013074650A1/en not_active Ceased
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- 2012-11-14 CN CN201280067329.9A patent/CN104053771B/zh active Active
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- 2023-06-12 US US18/333,393 patent/US12241093B2/en active Active
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| WO2009046153A4 (en) * | 2007-10-01 | 2009-06-25 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| WO2010025238A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025085A2 (en) * | 2008-08-29 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
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| US20190177702A1 (en) | 2019-06-13 |
| CN104053771A (zh) | 2014-09-17 |
| US10100287B2 (en) | 2018-10-16 |
| US20240018489A1 (en) | 2024-01-18 |
| US9803178B2 (en) | 2017-10-31 |
| US20180010100A1 (en) | 2018-01-11 |
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| US10851351B2 (en) | 2020-12-01 |
| EP2780448A1 (en) | 2014-09-24 |
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| US20140322769A1 (en) | 2014-10-30 |
| EP2780448B1 (en) | 2019-09-11 |
| US9139819B2 (en) | 2015-09-22 |
| HUE046089T2 (hu) | 2020-01-28 |
| SG11201402401TA (en) | 2014-06-27 |
| US20210071151A1 (en) | 2021-03-11 |
| IN2014CN04470A (enExample) | 2015-09-04 |
| IL232621B (en) | 2019-10-31 |
| US20180371427A1 (en) | 2018-12-27 |
| WO2013074650A1 (en) | 2013-05-23 |
| CN104053771B (zh) | 2016-11-09 |
| IL232621A0 (en) | 2014-06-30 |
| US9422531B2 (en) | 2016-08-23 |
| US12241093B2 (en) | 2025-03-04 |
| CN106479990A (zh) | 2017-03-08 |
| US20160319247A1 (en) | 2016-11-03 |
| US20150344850A1 (en) | 2015-12-03 |
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