CN106479990B - 用于制备羟基取代的氨基甲酸酯的生物催化剂 - Google Patents
用于制备羟基取代的氨基甲酸酯的生物催化剂 Download PDFInfo
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| US201161561665P | 2011-11-18 | 2011-11-18 | |
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| CN201280067329.9A CN104053771B (zh) | 2011-11-18 | 2012-11-14 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
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| CN201610911937.3A Active CN106479990B (zh) | 2011-11-18 | 2012-11-14 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
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| CN (2) | CN104053771B (enExample) |
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| CN101784669B (zh) | 2007-08-24 | 2015-02-18 | 科德克希思公司 | 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽 |
| WO2013062878A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Process for making beta 3 angonists and intermediates |
| JP6063948B2 (ja) | 2011-10-27 | 2017-01-18 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ベータ３アゴニストおよび中間体を製造するプロセス |
| CN104053771B (zh) | 2011-11-18 | 2016-11-09 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| WO2014150633A1 (en) * | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| LT2968269T (lt) | 2013-03-15 | 2019-10-25 | Merck Sharp & Dohme | Beta 3 agonistų ir tarpinių junginių gamybos būdas |
| US10696953B2 (en) * | 2015-02-10 | 2020-06-30 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN106011095B (zh) * | 2016-07-27 | 2021-02-26 | 苏州汉酶生物技术有限公司 | 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法 |
| EP4410295A3 (en) | 2017-06-06 | 2024-10-16 | Urovant Sciences GmbH | Use of vibegron to treat overactive bladder |
| NZ774649A (en) | 2018-12-05 | 2025-07-25 | Urovant Sciences Gmbh | Vibegron for the treatment of overactive bladder symptoms |
| CN109943543B (zh) * | 2019-03-28 | 2020-12-11 | 上海健康医学院 | 醇脱氢酶突变体及其制备方法和应用 |
| CN114410599B (zh) * | 2022-01-29 | 2023-08-18 | 浙江工业大学 | 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用 |
| CN116814569B (zh) * | 2023-05-30 | 2025-07-25 | 华东理工大学 | 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用 |
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| WO2009046153A4 (en) * | 2007-10-01 | 2009-06-25 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| WO2010025238A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
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| US20140322769A1 (en) | 2014-10-30 |
| WO2013074650A1 (en) | 2013-05-23 |
| US20150344850A1 (en) | 2015-12-03 |
| US20180371427A1 (en) | 2018-12-27 |
| US20190177702A1 (en) | 2019-06-13 |
| US12241093B2 (en) | 2025-03-04 |
| CN106479990A (zh) | 2017-03-08 |
| HUE046089T2 (hu) | 2020-01-28 |
| US9422531B2 (en) | 2016-08-23 |
| US20240018489A1 (en) | 2024-01-18 |
| US9803178B2 (en) | 2017-10-31 |
| CN104053771A (zh) | 2014-09-17 |
| US20160319247A1 (en) | 2016-11-03 |
| CN104053771B (zh) | 2016-11-09 |
| IL232621B (en) | 2019-10-31 |
| US10253303B2 (en) | 2019-04-09 |
| SG11201402401TA (en) | 2014-06-27 |
| US10851351B2 (en) | 2020-12-01 |
| IL232621A0 (en) | 2014-06-30 |
| EP2780448A1 (en) | 2014-09-24 |
| EP2780448B1 (en) | 2019-09-11 |
| US10100287B2 (en) | 2018-10-16 |
| US20180010100A1 (en) | 2018-01-11 |
| US9139819B2 (en) | 2015-09-22 |
| US11713451B2 (en) | 2023-08-01 |
| US20210071151A1 (en) | 2021-03-11 |
| IN2014CN04470A (enExample) | 2015-09-04 |
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