IN2014CN04470A - - Google Patents
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- Publication number
- IN2014CN04470A IN2014CN04470A IN4470CHN2014A IN2014CN04470A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A IN 4470CHN2014 A IN4470CHN2014 A IN 4470CHN2014A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A
- Authority
- IN
- India
- Prior art keywords
- ketoreductase polypeptides
- preparation
- present disclosure
- making
- methods
- Prior art date
Links
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 108091033319 polynucleotide Chemical class 0.000 abstract 1
- 239000002157 polynucleotide Chemical class 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161561665P | 2011-11-18 | 2011-11-18 | |
| PCT/US2012/065046 WO2013074650A1 (en) | 2011-11-18 | 2012-11-14 | Biocatalysts for the preparation of hydroxy substituted carbamates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN04470A true IN2014CN04470A (enExample) | 2015-09-04 |
Family
ID=47295185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN4470CHN2014 IN2014CN04470A (enExample) | 2011-11-18 | 2012-11-14 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US9139819B2 (enExample) |
| EP (1) | EP2780448B1 (enExample) |
| CN (2) | CN106479990B (enExample) |
| HU (1) | HUE046089T2 (enExample) |
| IL (1) | IL232621B (enExample) |
| IN (1) | IN2014CN04470A (enExample) |
| SG (1) | SG11201402401TA (enExample) |
| WO (1) | WO2013074650A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| WO2013062881A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
| CN106479990B (zh) | 2011-11-18 | 2020-09-18 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| JP6383403B2 (ja) | 2013-03-15 | 2018-08-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | β−３作動薬および中間体の製造方法 |
| US10150959B2 (en) * | 2013-03-15 | 2018-12-11 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| DK3256577T3 (da) | 2015-02-10 | 2020-09-14 | Codexis Inc | Ketoreduktase polypeptider til syntesen af chirale forbindelser |
| CN106011095B (zh) * | 2016-07-27 | 2021-02-26 | 苏州汉酶生物技术有限公司 | 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法 |
| KR20250099259A (ko) | 2017-06-06 | 2025-07-01 | 유로반트 사이언시즈 게엠베하 | 과민성 방광의 치료를 위한 비베그론의 용도 |
| TW202038963A (zh) | 2018-12-05 | 2020-11-01 | 瑞士商優洛凡特科學公司 | 維貝隆（ｖｉｂｅｇｒｏｎ）於治療患有良性前列腺增生之男性中膀胱過動症症狀之用途 |
| CN109943543B (zh) * | 2019-03-28 | 2020-12-11 | 上海健康医学院 | 醇脱氢酶突变体及其制备方法和应用 |
| CN114410599B (zh) * | 2022-01-29 | 2023-08-18 | 浙江工业大学 | 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用 |
| CN116814569B (zh) * | 2023-05-30 | 2025-07-25 | 华东理工大学 | 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用 |
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| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
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| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| SI2329014T1 (sl) | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| CN106479990B (zh) | 2011-11-18 | 2020-09-18 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
-
2012
- 2012-11-14 CN CN201610911937.3A patent/CN106479990B/zh active Active
- 2012-11-14 CN CN201280067329.9A patent/CN104053771B/zh active Active
- 2012-11-14 IN IN4470CHN2014 patent/IN2014CN04470A/en unknown
- 2012-11-14 WO PCT/US2012/065046 patent/WO2013074650A1/en not_active Ceased
- 2012-11-14 HU HUE12795954A patent/HUE046089T2/hu unknown
- 2012-11-14 SG SG11201402401TA patent/SG11201402401TA/en unknown
- 2012-11-14 US US14/357,964 patent/US9139819B2/en active Active
- 2012-11-14 EP EP12795954.2A patent/EP2780448B1/en active Active
-
2014
- 2014-05-14 IL IL23262114A patent/IL232621B/en active IP Right Grant
-
2015
- 2015-08-13 US US14/825,688 patent/US9422531B2/en active Active
-
2016
- 2016-07-15 US US15/211,990 patent/US9803178B2/en active Active
-
2017
- 2017-09-21 US US15/711,119 patent/US10100287B2/en active Active
-
2018
- 2018-09-10 US US16/126,044 patent/US10253303B2/en active Active
-
2019
- 2019-02-25 US US16/284,235 patent/US10851351B2/en active Active
-
2020
- 2020-10-29 US US17/084,405 patent/US11713451B2/en active Active
-
2023
- 2023-06-12 US US18/333,393 patent/US12241093B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150344850A1 (en) | 2015-12-03 |
| US20180371427A1 (en) | 2018-12-27 |
| SG11201402401TA (en) | 2014-06-27 |
| US20190177702A1 (en) | 2019-06-13 |
| US20240018489A1 (en) | 2024-01-18 |
| IL232621A0 (en) | 2014-06-30 |
| US10253303B2 (en) | 2019-04-09 |
| IL232621B (en) | 2019-10-31 |
| US9139819B2 (en) | 2015-09-22 |
| US10851351B2 (en) | 2020-12-01 |
| CN104053771B (zh) | 2016-11-09 |
| US20160319247A1 (en) | 2016-11-03 |
| US11713451B2 (en) | 2023-08-01 |
| CN104053771A (zh) | 2014-09-17 |
| US10100287B2 (en) | 2018-10-16 |
| US12241093B2 (en) | 2025-03-04 |
| WO2013074650A1 (en) | 2013-05-23 |
| US20180010100A1 (en) | 2018-01-11 |
| US9803178B2 (en) | 2017-10-31 |
| HUE046089T2 (hu) | 2020-01-28 |
| US20210071151A1 (en) | 2021-03-11 |
| CN106479990B (zh) | 2020-09-18 |
| EP2780448A1 (en) | 2014-09-24 |
| CN106479990A (zh) | 2017-03-08 |
| EP2780448B1 (en) | 2019-09-11 |
| US9422531B2 (en) | 2016-08-23 |
| US20140322769A1 (en) | 2014-10-30 |
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