CN106459201A - 结合人和食蟹猴CD3ε的抗体 - Google Patents
结合人和食蟹猴CD3ε的抗体 Download PDFInfo
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- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
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- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14170140 | 2014-05-28 | ||
| EP14170140.9 | 2014-05-28 | ||
| EP14180572 | 2014-08-11 | ||
| EP14180572.1 | 2014-08-11 | ||
| PCT/EP2015/061457 WO2015181098A1 (en) | 2014-05-28 | 2015-05-22 | Antibodies binding to human and cynomolgus cd3 epsilon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106459201A true CN106459201A (zh) | 2017-02-22 |
Family
ID=53268799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580026998.5A Pending CN106459201A (zh) | 2014-05-28 | 2015-05-22 | 结合人和食蟹猴CD3ε的抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20170233475A1 (OSRAM) |
| EP (2) | EP3149041A1 (OSRAM) |
| JP (1) | JP6738285B2 (OSRAM) |
| KR (1) | KR20170003591A (OSRAM) |
| CN (1) | CN106459201A (OSRAM) |
| AU (1) | AU2015266077A1 (OSRAM) |
| BR (1) | BR112016022819A2 (OSRAM) |
| CA (1) | CA2942453A1 (OSRAM) |
| IL (1) | IL247740A0 (OSRAM) |
| MX (1) | MX2016015389A (OSRAM) |
| RU (1) | RU2016151235A (OSRAM) |
| SG (1) | SG11201609950YA (OSRAM) |
| WO (1) | WO2015181098A1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111417719A (zh) * | 2017-11-30 | 2020-07-14 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| WO2023273762A1 (zh) * | 2021-06-30 | 2023-01-05 | 苏州方德门达新药开发有限公司 | 介导细胞内有效滞留cd3的空间构象表位及其应用 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102850929B1 (ko) | 2015-12-09 | 2025-08-27 | 에프. 호프만-라 로슈 아게 | 항-약물 항체의 형성을 감소시키기 위한 ii형 항-cd20 항체 |
| WO2017150762A1 (ko) * | 2016-02-29 | 2017-09-08 | (주)메디톡스 | 항-CD3γε 항체 및 이의 용도 |
| EP3252078A1 (en) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| AU2018276419A1 (en) | 2016-06-02 | 2019-10-17 | F. Hoffmann-La Roche Ag | Type II anti-CD20 antibody and anti-CD20/CD3 bispecific antibody for treatment of cancer |
| IL267567B2 (en) * | 2016-12-22 | 2024-08-01 | Daiichi Sankyo Co Ltd | Anti-cd3 antibody for use in the treatment or prophylaxis of cancer, and molecules containing said antibody |
| EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| WO2018224441A1 (en) * | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
| US11319371B2 (en) * | 2017-06-05 | 2022-05-03 | Numab Therapeutics AG | Anti-CD3 antibodies |
| KR102324568B1 (ko) | 2017-06-21 | 2021-11-10 | 길리애드 사이언시즈, 인코포레이티드 | HIV gp120 및 CD3을 표적화하는 다중특이적 항체 |
| US12486325B2 (en) | 2017-09-21 | 2025-12-02 | WuXi Biologics Ireland Limited | Anti-CD3epsilon antibodies |
| CA3074130A1 (en) * | 2017-09-21 | 2019-03-28 | WuXi Biologics Ireland Limited | Novel anti-cd3epsilon antibodies |
| CN120399075A (zh) | 2018-03-14 | 2025-08-01 | 诺维莫尼公司 | 抗-CD3ε抗体及其应用方法 |
| JP7530299B2 (ja) | 2018-05-24 | 2024-08-07 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｃｄ３抗体及びその使用 |
| WO2019244107A1 (en) * | 2018-06-21 | 2019-12-26 | Daiichi Sankyo Company, Limited | Compositions including cd3 antigen binding fragments and uses thereof |
| CR20220594A (es) * | 2020-05-27 | 2023-01-17 | Janssen Biotech Inc | Proteins comprising cd3 antigen binding domains and uses thereof |
| CA3189473A1 (en) * | 2020-09-24 | 2022-03-31 | Andreas Bultmann | Novel human antibodies binding to human cd3 epsilon |
| CN114656562B (zh) | 2020-12-23 | 2023-11-03 | 北京天广实生物技术股份有限公司 | 结合人和猴cd3的抗体及其应用 |
| WO2022204316A2 (en) * | 2021-03-24 | 2022-09-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for cd3 |
| EP4330282A1 (en) | 2021-04-30 | 2024-03-06 | F. Hoffmann-La Roche AG | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| TW202244059A (zh) | 2021-04-30 | 2022-11-16 | 瑞士商赫孚孟拉羅股份公司 | 用抗ｃｄ２０／抗ｃｄ３雙特異性抗體進行治療之給藥 |
| CN113755435B (zh) * | 2021-10-15 | 2023-10-13 | 苏州药明康德新药开发有限公司 | 一种食蟹猴pbmc分离方法 |
| US20230295310A1 (en) * | 2022-03-20 | 2023-09-21 | Abcellera Biologics Inc. | CD3 T-Cell Engagers and Methods of Use |
| CN118922448A (zh) * | 2022-03-22 | 2024-11-08 | 莫佛塞斯公司 | Cd3特异性的去免疫抗体 |
| EP4496631A1 (en) | 2022-03-23 | 2025-01-29 | F. Hoffmann-La Roche AG | Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy |
| TW202404637A (zh) | 2022-04-13 | 2024-02-01 | 瑞士商赫孚孟拉羅股份公司 | 抗ｃｄ２０／抗ｃｄ３雙特異性抗體之醫藥組成物及使用方法 |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007042261A2 (en) * | 2005-10-11 | 2007-04-19 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
| CN103703024A (zh) * | 2011-05-21 | 2014-04-02 | 宏观基因有限公司 | 能够与人和非人cd3结合的cd3结合分子 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD272473B3 (de) * | 1988-06-13 | 1993-01-21 | Univ Leipzig | Verfahren zur herstellung monoklonaler antikoerper gegen die epsilon-kettedes cd 3-antigens humaner t-lymphozyten |
| JPH0630786A (ja) * | 1992-07-14 | 1994-02-08 | Kyowa Hakko Kogyo Co Ltd | バイスペシフィック抗体 |
| WO2005118635A2 (en) * | 2004-06-03 | 2005-12-15 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| NZ580746A (en) * | 2007-04-03 | 2012-05-25 | Micromet Ag | Cross-species-specific bispecific binders |
| CN107903325B (zh) * | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| JP2017521998A (ja) * | 2014-05-12 | 2017-08-10 | ヌマブ アクチェンゲゼルシャフト | 新規多重特異性分子及びかかる多重特異性分子に基づく新規治療方法 |
-
2015
- 2015-05-22 BR BR112016022819A patent/BR112016022819A2/pt not_active Application Discontinuation
- 2015-05-22 AU AU2015266077A patent/AU2015266077A1/en not_active Abandoned
- 2015-05-22 MX MX2016015389A patent/MX2016015389A/es unknown
- 2015-05-22 JP JP2016569639A patent/JP6738285B2/ja not_active Expired - Fee Related
- 2015-05-22 EP EP15725002.8A patent/EP3149041A1/en not_active Ceased
- 2015-05-22 WO PCT/EP2015/061457 patent/WO2015181098A1/en not_active Ceased
- 2015-05-22 CN CN201580026998.5A patent/CN106459201A/zh active Pending
- 2015-05-22 EP EP20163877.2A patent/EP3763739A1/en not_active Withdrawn
- 2015-05-22 KR KR1020167033022A patent/KR20170003591A/ko not_active Withdrawn
- 2015-05-22 CA CA2942453A patent/CA2942453A1/en not_active Abandoned
- 2015-05-22 RU RU2016151235A patent/RU2016151235A/ru not_active Application Discontinuation
- 2015-05-22 SG SG11201609950YA patent/SG11201609950YA/en unknown
-
2016
- 2016-09-11 IL IL247740A patent/IL247740A0/en unknown
- 2016-11-22 US US15/359,199 patent/US20170233475A1/en not_active Abandoned
-
2020
- 2020-01-23 US US16/751,046 patent/US20200325224A1/en not_active Abandoned
- 2020-01-23 US US16/751,062 patent/US20200299385A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007042261A2 (en) * | 2005-10-11 | 2007-04-19 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
| CN103703024A (zh) * | 2011-05-21 | 2014-04-02 | 宏观基因有限公司 | 能够与人和非人cd3结合的cd3结合分子 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111417719A (zh) * | 2017-11-30 | 2020-07-14 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| CN111417719B (zh) * | 2017-11-30 | 2023-08-29 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| WO2023273762A1 (zh) * | 2021-06-30 | 2023-01-05 | 苏州方德门达新药开发有限公司 | 介导细胞内有效滞留cd3的空间构象表位及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6738285B2 (ja) | 2020-08-12 |
| SG11201609950YA (en) | 2016-12-29 |
| RU2016151235A3 (OSRAM) | 2019-01-18 |
| MX2016015389A (es) | 2017-04-13 |
| US20200299385A1 (en) | 2020-09-24 |
| IL247740A0 (en) | 2016-11-30 |
| EP3763739A1 (en) | 2021-01-13 |
| CA2942453A1 (en) | 2015-12-03 |
| AU2015266077A1 (en) | 2016-09-29 |
| RU2016151235A (ru) | 2018-06-28 |
| US20200325224A1 (en) | 2020-10-15 |
| KR20170003591A (ko) | 2017-01-09 |
| JP2017516786A (ja) | 2017-06-22 |
| US20170233475A1 (en) | 2017-08-17 |
| WO2015181098A1 (en) | 2015-12-03 |
| EP3149041A1 (en) | 2017-04-05 |
| BR112016022819A2 (pt) | 2018-01-16 |
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