CN106456746B - 用于免疫疗法的抗原负载壳聚糖纳米颗粒 - Google Patents

用于免疫疗法的抗原负载壳聚糖纳米颗粒 Download PDF

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CN106456746B
CN106456746B CN201580030088.4A CN201580030088A CN106456746B CN 106456746 B CN106456746 B CN 106456746B CN 201580030088 A CN201580030088 A CN 201580030088A CN 106456746 B CN106456746 B CN 106456746B
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nanoparticles
chitosan
microparticles
antigen
nanoparticle
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CN106456746A (zh
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A.哈内费尔德
M.魏冈特
M.沃尔夫
P.克诺勒
M.施勒德
R.舍利斯
P.瓦尔登
A.迪德里希
H.施特克尔
R.B.巴莱罗
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Merck Patent GmbH
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580030088.4A 2014-06-06 2015-05-12 用于免疫疗法的抗原负载壳聚糖纳米颗粒 Active CN106456746B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14001974.6 2014-06-06
EP14001974 2014-06-06
PCT/EP2015/000974 WO2015185180A1 (en) 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy

Publications (2)

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CN106456746A CN106456746A (zh) 2017-02-22
CN106456746B true CN106456746B (zh) 2021-03-26

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US (1) US10369217B2 (https=)
EP (1) EP3151856B1 (https=)
JP (1) JP6730937B2 (https=)
CN (1) CN106456746B (https=)
AR (1) AR100745A1 (https=)
AU (1) AU2015271295B2 (https=)
CA (1) CA2951063C (https=)
ES (1) ES2754507T3 (https=)
IL (1) IL249357B (https=)
WO (1) WO2015185180A1 (https=)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
EP3698773A1 (en) 2019-02-21 2020-08-26 Università degli Studi di Parma Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination
CN110974805A (zh) * 2019-12-23 2020-04-10 中国科学院海洋研究所 具有增强抗原提呈细胞提呈抗原作用的壳聚糖衍生物纳米粒及制备
GB202018665D0 (en) * 2020-11-26 2021-01-13 Provost Fellows And Scholars Of Trinity College Dublin Immunotherapy for cancer
WO2023168541A1 (en) * 2022-03-09 2023-09-14 Shenzhen Genius Biotech Service Co., Ltd. Chitosan nanoparticles (cnps) and preparation method thereof
CN117379393A (zh) * 2023-10-11 2024-01-12 北京安必奇生物科技有限公司 一种核酸药物黏膜给药制剂及其制备方法和应用
WO2024083221A1 (zh) * 2022-10-21 2024-04-25 北京安必奇生物科技有限公司 一种黏膜给药制剂及其制备方法和应用
WO2025040174A1 (zh) * 2023-08-24 2025-02-27 康希诺生物股份公司 一种表征吸入疫苗性能的方法
CN117398482B (zh) * 2023-09-18 2026-04-24 浙江理工大学 一种卵清蛋白负载硝基自由基氮氧化物纳米复合材料及其制备方法和应用
WO2025209535A1 (en) * 2024-04-03 2025-10-09 Suzhou Xinxin Biopharma Co., Ltd Compositions and associated methods for chitosan-based nano-carriers for therapeutic agents and their applications

Citations (4)

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CN1897975A (zh) * 2003-12-24 2007-01-17 株式会社三养社 口服给药的水溶性药物纳米颗粒组合物及其制备方法
CN101175486A (zh) * 2005-03-14 2008-05-07 先进离体细胞技术有限公司 壳聚糖及聚乙二醇纳米颗粒作为生物活性分子的给药体系
JP2010031003A (ja) * 2008-07-01 2010-02-12 Nitto Denko Corp 表面被覆微粒子の医薬組成物
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof

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DE602007013559D1 (de) * 2006-07-07 2011-05-12 Univ Aarhus Nanoteilchen zur abgabe von nukleinsäure
WO2008039390A2 (en) * 2006-09-22 2008-04-03 Government Of The Usa., Dept. Of Health & Human Services Compositions and methods for chitosan enhanced immune response
EP2819645A2 (en) * 2012-02-28 2015-01-07 Iceutica Holdings Inc. Bvi Inhalable pharmaceutical compositions

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN1897975A (zh) * 2003-12-24 2007-01-17 株式会社三养社 口服给药的水溶性药物纳米颗粒组合物及其制备方法
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
CN101175486A (zh) * 2005-03-14 2008-05-07 先进离体细胞技术有限公司 壳聚糖及聚乙二醇纳米颗粒作为生物活性分子的给药体系
JP2010031003A (ja) * 2008-07-01 2010-02-12 Nitto Denko Corp 表面被覆微粒子の医薬組成物

Non-Patent Citations (6)

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Title
"Chitosan Nanoparticle Encapsulated Hemagglutinin-Split Influenza Virus Mucosal Vaccine";Chompoonuch Sawaengsak et al.;《AAPS PharmSciTech》;20131217;第15卷(第2期);第317-325页 *
"Chitosan-based nanoparticles for topical genetic immunization";Zhengrong Cui et al.;《Journal of Controlled Release》;20011231;第75卷;第409-419页 *
"Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice";Ana Vila et al.;《European Journal of Pharmaceutics and Biopharmaceutics》;20041231;第57卷;第123-131页 *
"Monodisperse Chitosan Nanoparticles for Mucosal Drug";Hong Zhang et al.;《Biomacromolecules》;20040925;第5卷(第6期);第2461-2468页 *
"New developments in dry powder pulmonary vaccine delivery";Toma´s Sou et al.;《Trends in Biotechnology》;20111231;第29卷(第4期);第191-198页 *
"Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis";Maytal Bivas-Benita et al.;《Vaccine》;20041231;第22卷;第1609-1615页 *

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Publication number Publication date
WO2015185180A1 (en) 2015-12-10
EP3151856B1 (en) 2019-08-07
AR100745A1 (es) 2016-10-26
CN106456746A (zh) 2017-02-22
JP2017516834A (ja) 2017-06-22
AU2015271295B2 (en) 2020-04-16
IL249357B (en) 2021-01-31
JP6730937B2 (ja) 2020-07-29
EP3151856A1 (en) 2017-04-12
US10369217B2 (en) 2019-08-06
CA2951063A1 (en) 2015-12-10
US20170143822A1 (en) 2017-05-25
IL249357A0 (en) 2017-02-28
CA2951063C (en) 2022-10-04
AU2015271295A1 (en) 2017-01-19
ES2754507T3 (es) 2020-04-17

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