ES2754507T3 - Nanopartículas de quitosano cargadas con antígeno para inmunoterapia - Google Patents

Nanopartículas de quitosano cargadas con antígeno para inmunoterapia Download PDF

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Publication number
ES2754507T3
ES2754507T3 ES15722448T ES15722448T ES2754507T3 ES 2754507 T3 ES2754507 T3 ES 2754507T3 ES 15722448 T ES15722448 T ES 15722448T ES 15722448 T ES15722448 T ES 15722448T ES 2754507 T3 ES2754507 T3 ES 2754507T3
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Spain
Prior art keywords
nanoparticles
microparticles
chitosan
antigen
aqueous solution
Prior art date
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Active
Application number
ES15722448T
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English (en)
Spanish (es)
Inventor
Andrea Hanefeld
Markus Weigandt
Michael Wolf
Percy Knolle
Matthias Schroeder
Regina Scherliess
Peter Walden
Andrea Diedrich
Hartwig Steckel
Renato Brito Baleeiro
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of ES2754507T3 publication Critical patent/ES2754507T3/es
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55583Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087Polysaccharides; Lipopolysaccharides [LPS]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES15722448T 2014-06-06 2015-05-12 Nanopartículas de quitosano cargadas con antígeno para inmunoterapia Active ES2754507T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14001974 2014-06-06
PCT/EP2015/000974 WO2015185180A1 (en) 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy

Publications (1)

Publication Number Publication Date
ES2754507T3 true ES2754507T3 (es) 2020-04-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES15722448T Active ES2754507T3 (es) 2014-06-06 2015-05-12 Nanopartículas de quitosano cargadas con antígeno para inmunoterapia

Country Status (10)

Country Link
US (1) US10369217B2 (https=)
EP (1) EP3151856B1 (https=)
JP (1) JP6730937B2 (https=)
CN (1) CN106456746B (https=)
AR (1) AR100745A1 (https=)
AU (1) AU2015271295B2 (https=)
CA (1) CA2951063C (https=)
ES (1) ES2754507T3 (https=)
IL (1) IL249357B (https=)
WO (1) WO2015185180A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3698773A1 (en) 2019-02-21 2020-08-26 Università degli Studi di Parma Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination
CN110974805A (zh) * 2019-12-23 2020-04-10 中国科学院海洋研究所 具有增强抗原提呈细胞提呈抗原作用的壳聚糖衍生物纳米粒及制备
GB202018665D0 (en) * 2020-11-26 2021-01-13 Provost Fellows And Scholars Of Trinity College Dublin Immunotherapy for cancer
WO2023168541A1 (en) * 2022-03-09 2023-09-14 Shenzhen Genius Biotech Service Co., Ltd. Chitosan nanoparticles (cnps) and preparation method thereof
WO2024083221A1 (zh) * 2022-10-21 2024-04-25 北京安必奇生物科技有限公司 一种黏膜给药制剂及其制备方法和应用
CN117379393A (zh) * 2023-10-11 2024-01-12 北京安必奇生物科技有限公司 一种核酸药物黏膜给药制剂及其制备方法和应用
WO2025040174A1 (zh) * 2023-08-24 2025-02-27 康希诺生物股份公司 一种表征吸入疫苗性能的方法
CN117398482B (zh) * 2023-09-18 2026-04-24 浙江理工大学 一种卵清蛋白负载硝基自由基氮氧化物纳米复合材料及其制备方法和应用
WO2025209535A1 (en) * 2024-04-03 2025-10-09 Suzhou Xinxin Biopharma Co., Ltd Compositions and associated methods for chitosan-based nano-carriers for therapeutic agents and their applications

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100638041B1 (ko) * 2003-12-24 2006-10-23 주식회사 삼양사 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
ES2259914B1 (es) * 2005-03-14 2007-06-16 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas.
EP2295045A1 (en) * 2006-07-07 2011-03-16 Aarhus Universitet Nanoparticles for nucleic acid delivery
US20100150960A1 (en) * 2006-09-22 2010-06-17 The United States Of America, As Represented By The Secretary,Department Of Health And Human Servi Compositions and methods for chitosan enhanced immune response
RU2508093C2 (ru) * 2008-07-01 2014-02-27 Нитто Денко Корпорейшн Фармацевтическая композиция, содержащая микрочастицы с поверхностным покрытием
NZ629438A (en) * 2012-02-28 2016-10-28 Iceutica Holdings Inc Inhalable pharmaceutical compositions

Also Published As

Publication number Publication date
US10369217B2 (en) 2019-08-06
CN106456746A (zh) 2017-02-22
US20170143822A1 (en) 2017-05-25
WO2015185180A1 (en) 2015-12-10
IL249357A0 (en) 2017-02-28
JP2017516834A (ja) 2017-06-22
AU2015271295A1 (en) 2017-01-19
CA2951063C (en) 2022-10-04
JP6730937B2 (ja) 2020-07-29
AU2015271295B2 (en) 2020-04-16
IL249357B (en) 2021-01-31
AR100745A1 (es) 2016-10-26
CA2951063A1 (en) 2015-12-10
EP3151856A1 (en) 2017-04-12
CN106456746B (zh) 2021-03-26
EP3151856B1 (en) 2019-08-07

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