AU2015271295B2 - Antigen-loaded chitosan nanoparticles for immunotherapy - Google Patents

Antigen-loaded chitosan nanoparticles for immunotherapy Download PDF

Info

Publication number
AU2015271295B2
AU2015271295B2 AU2015271295A AU2015271295A AU2015271295B2 AU 2015271295 B2 AU2015271295 B2 AU 2015271295B2 AU 2015271295 A AU2015271295 A AU 2015271295A AU 2015271295 A AU2015271295 A AU 2015271295A AU 2015271295 B2 AU2015271295 B2 AU 2015271295B2
Authority
AU
Australia
Prior art keywords
nanoparticles
chitosan
microparticles
antigen
kda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015271295A
Other languages
English (en)
Other versions
AU2015271295A1 (en
Inventor
Renato Brito BALEEIRO
Andrea DIEDRICH
Andrea Hanefeld
Percy Knolle
Regina SCHERLIESS
Matthias Schroeder
Hartwig Steckel
Peter Walden
Markus Weigandt
Michael Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2015271295A1 publication Critical patent/AU2015271295A1/en
Application granted granted Critical
Publication of AU2015271295B2 publication Critical patent/AU2015271295B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2015271295A 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy Active AU2015271295B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14001974.6 2014-06-06
EP14001974 2014-06-06
PCT/EP2015/000974 WO2015185180A1 (en) 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy

Publications (2)

Publication Number Publication Date
AU2015271295A1 AU2015271295A1 (en) 2017-01-19
AU2015271295B2 true AU2015271295B2 (en) 2020-04-16

Family

ID=50897334

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015271295A Active AU2015271295B2 (en) 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy

Country Status (10)

Country Link
US (1) US10369217B2 (https=)
EP (1) EP3151856B1 (https=)
JP (1) JP6730937B2 (https=)
CN (1) CN106456746B (https=)
AR (1) AR100745A1 (https=)
AU (1) AU2015271295B2 (https=)
CA (1) CA2951063C (https=)
ES (1) ES2754507T3 (https=)
IL (1) IL249357B (https=)
WO (1) WO2015185180A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3698773A1 (en) 2019-02-21 2020-08-26 Università degli Studi di Parma Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination
CN110974805A (zh) * 2019-12-23 2020-04-10 中国科学院海洋研究所 具有增强抗原提呈细胞提呈抗原作用的壳聚糖衍生物纳米粒及制备
GB202018665D0 (en) * 2020-11-26 2021-01-13 Provost Fellows And Scholars Of Trinity College Dublin Immunotherapy for cancer
WO2023168541A1 (en) * 2022-03-09 2023-09-14 Shenzhen Genius Biotech Service Co., Ltd. Chitosan nanoparticles (cnps) and preparation method thereof
CN117379393A (zh) * 2023-10-11 2024-01-12 北京安必奇生物科技有限公司 一种核酸药物黏膜给药制剂及其制备方法和应用
WO2024083221A1 (zh) * 2022-10-21 2024-04-25 北京安必奇生物科技有限公司 一种黏膜给药制剂及其制备方法和应用
WO2025040174A1 (zh) * 2023-08-24 2025-02-27 康希诺生物股份公司 一种表征吸入疫苗性能的方法
CN117398482B (zh) * 2023-09-18 2026-04-24 浙江理工大学 一种卵清蛋白负载硝基自由基氮氧化物纳米复合材料及其制备方法和应用
WO2025209535A1 (en) * 2024-04-03 2025-10-09 Suzhou Xinxin Biopharma Co., Ltd Compositions and associated methods for chitosan-based nano-carriers for therapeutic agents and their applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100638041B1 (ko) * 2003-12-24 2006-10-23 주식회사 삼양사 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법
ES2259914B1 (es) * 2005-03-14 2007-06-16 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas.
DE602007013559D1 (de) * 2006-07-07 2011-05-12 Univ Aarhus Nanoteilchen zur abgabe von nukleinsäure
WO2008039390A2 (en) * 2006-09-22 2008-04-03 Government Of The Usa., Dept. Of Health & Human Services Compositions and methods for chitosan enhanced immune response
JP5841708B2 (ja) * 2008-07-01 2016-01-13 日東電工株式会社 表面被覆微粒子の医薬組成物
EP2819645A2 (en) * 2012-02-28 2015-01-07 Iceutica Holdings Inc. Bvi Inhalable pharmaceutical compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHANG HONG ET AL, "Monodisperse chitosan nanoparticles for mucosal drug delivery", BIOMACROMOLECULES, (2004-11), vol. 5, no. 6, ISSN 1525-7797, pages 2461 - 2468 *

Also Published As

Publication number Publication date
WO2015185180A1 (en) 2015-12-10
EP3151856B1 (en) 2019-08-07
AR100745A1 (es) 2016-10-26
CN106456746A (zh) 2017-02-22
JP2017516834A (ja) 2017-06-22
IL249357B (en) 2021-01-31
JP6730937B2 (ja) 2020-07-29
EP3151856A1 (en) 2017-04-12
US10369217B2 (en) 2019-08-06
CA2951063A1 (en) 2015-12-10
US20170143822A1 (en) 2017-05-25
CN106456746B (zh) 2021-03-26
IL249357A0 (en) 2017-02-28
CA2951063C (en) 2022-10-04
AU2015271295A1 (en) 2017-01-19
ES2754507T3 (es) 2020-04-17

Similar Documents

Publication Publication Date Title
AU2015271295B2 (en) Antigen-loaded chitosan nanoparticles for immunotherapy
Chen et al. STING activator c-di-GMP-loaded mesoporous silica nanoparticles enhance immunotherapy against breast cancer
Kwon et al. Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles
Yao et al. Preventative vaccine-loaded mannosylated chitosan nanoparticles intended for nasal mucosal delivery enhance immune responses and potent tumor immunity
JP5841708B2 (ja) 表面被覆微粒子の医薬組成物
Kunda et al. Bovine Serum Albumin Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery via Dry Powder Inhalation: Kunda et al.
Lin et al. Enhanced immune responses to mucosa by functionalized chitosan-based composite nanoparticles as a vaccine adjuvant for intranasal delivery
Sharma et al. Nebulised siRNA encapsulated crosslinked chitosan nanoparticles for pulmonary delivery
JP2020169195A (ja) ポリマータンパク質微粒子
Wu et al. Development of effective tumor vaccine strategies based on immune response cascade reactions
Yu et al. Autologous-cancer-cryoablation-mediated nanovaccine augments systematic immunotherapy
Luzardo-Alvarez et al. Biodegradable microspheres alone do not stimulate murine macrophages in vitro, but prolong antigen presentation by macrophages in vitro and stimulate a solid immune response in mice
US8343551B2 (en) Nanocomposite particles
Wang et al. Improving adjuvanticity of quaternized chitosan–based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect
Fang et al. Muco-adhesive chitosan-coated polyphenol nanoparticle for treatment of infectious acute pneumonia through sustained pulmonary delivery of polymyxin B
Sezer et al. Comparison on in vitro characterization of fucospheres and chitosan microspheres encapsulated plasmid DNA (pGM-CSF): Formulation design and release characteristics
WO2023040127A1 (zh) 基于全细胞组分的癌症疫苗系统在制备交叉预防或治疗异种癌症药物中的应用
WO2011052706A1 (ja) トラニラストの易溶性粉末吸入製剤
JP2023508096A (ja) 癌治療強化のためのポリマーナノ粒子
Chuang et al. Microfluidic Synthesis of Quaternary Chitosan Coated Liposome to Enhance Cellular Uptake and In Vivo Immune Responses
Goudanavar Inhalable Microparticulate System for Tuberculosis: An Updated Review.
Sarath Chandran et al. Chitosan-based drug delivery systems for respiratory diseases
Li et al. Porous Si-based nanosystems for immunotherapy applications
Buske Chitosan as adjuvant and particle forming excipient in a nano-in-microparticulate dry powder for nasal and pulmonary vaccine delivery
Heidland Chitosan Nanoparticles for Mucosal Vaccination–Understanding the Particle Formation Process and Formulation for Nasal Application

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)