CN106421725A - Traditional Chinese medicine composition for preventing and treating poultry Ankara disease and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of veterinary medicine, and particularly discloses a traditional Chinese medicine composition for preventing and treating a poultry Ankara disease and a preparation method thereof. The composition is prepared from, by weight, 15-25 parts of poria cocos, 5-15 parts of cassia twig, 10-15 parts of bighead atractylodes rhizomes, 5-15 parts of rhizoma zingiberis, 6-12 parts of asarum, 10-15 parts of pinellia ternata, 6-12 parts of ephedra herb, 6-10 parts of rhodiola rosea and 5-15 parts of licorice roots, wherein the sum of the parts by weight of the raw materials is 100. The traditional Chinese medicine composition can be prepared into powder or a drinking agent. According to market clinical verifications in almost two years, the good preventive effect on hydropericardium, liver necrosis lesions, kidney edema and the like caused by the poultry Ankara disease is achieved.

Description

A kind of Chinese medicine composition of preventing and treating poultry Ankara disease and preparation method thereof

Technical field

The invention belongs to veterinary medicine technical field and in particular to a kind of preventing and treating poultry Ankara disease Chinese medicine composition and its Preparation method.

Background technology

Over the past two years, there is a kind of dead disease with pericardial effusion as feature, morbidity on Shandong, Henan, Anhui and other places No feature, whole cage is dead, adds antibacterial drug therapy and accelerates, mortality rate is up to 10%--90%, with meat chicken, Sanhuang chicken, partridge chickens Based on, there is the peak mortality phase, laying hen falls ill relatively low, clinical veterinarian treatment no positive effect at present.

Confirm, this disease is to be caused by adenoviruss, mainly causes nephritis, inclusion body hepatitis, pericardial effusion, product through authoritative institution Egg drop syndrome etc..Adenoviruss adenoviruss are divided into I, II, III hypotype, and I hypotype loses, II hypotype（Haemorrhagic enteritis of turkey and Correlated virus）, III hypotype is exactly nephritis bubbling with noise, egg drop syndrome, inclusion body hepatitis and the pericardium making a noise in the recent period Hydrops syndrome（Because it breaks out earliest in Pakistani Ankara area, therefore it is Ankara disease again）.

This sick high-incidence season is 3～6 week old, earliest 5 age in days morbidities, but starts death more than 3 week old, and 4～5 week old reach height Peak, 4～8 days peak durations, 5～6 week old are dead to be reduced.The course of disease 8～15 days, mortality rate reaches 20～80%.Primary disease can vertically pass Broadcast and horizontal transmission, easily concurrent with infectious bursa of Fabricius and infections anaemia.

Their early stage non-evident sympton, dead in 24 hours after chicken lethargy, morbidity is anxious, and fatality rate is high.As too late When control spread to rapidly jumpbogroup, the double growth of mortality, there is no peak mortality, do not have resistance to cross chicken, mortality rate is close to percentage Hundred, do not take effective measures, most raiser finally do eliminate process.

Cut open inspection symptom aspect, hepatic lesions are obvious, and enlargement has inclusion body necrosis region, and pericardial effusion is obvious, great Liang Xin Bag hydrops makes pericardium such as balloon, and about in 10-30ml, it is regular inside pericardial effusion that the live chickens just having killed can also arrive heart to amount Beat.Kidney swelling, piebaldism, pale, there is the performance of bleeding glandular stomach it is also obvious that being to glandular stomach mostly from gland muscular stomach intersection Go out the bleeding of spreading property, gland muscular stomach intersection bleeding boundary is substantially.Typical glandular stomach thelorrhagia, intestinal is had after infection newcastle Lymph follicle, cecal tonsil swelling bleeding case, increases rapid disease progression.

Susceptible chicken group is laying hen（Adolescence）, 871, partridge chickens, yellow miscellaneous, soil miscellaneous, carnivorous greatly 20-30 age in days, grow fine Chicken mass-sending disease is rapid, and chicken group's growing way is better, and Liver and kidney is developed and the long speed of body is disproportionate, and over-burden for Liver and kidney, to this disease more Plus it is susceptible.Faster, morbidity is also more anxious, spreads rapider for lesions of liver and kidney.Immunity rapid decrease, antibody after body lesions of liver and kidney Level drastically consumes, and is not enough to protect the invasion of body opposing virus, newcastle can be availed oneself of the opportunity to get in.The generation aggravation disease of newcastle The development of feelings and the rising of mortality rate, another escherichia coli also can in liver amount reproduction liver injury.

For preventing and treating the appearance of above-mentioned poultry Ankara disease, in the market frequently with anti-stress, liver protection, shield kidney, antiviral, The treatment thoughts of lifting immunity or the thinking of vaccine injection, but because this disease has necessarily seasonal and changes rapid, often Rule medication and vaccine prevention and control all can not solve very well.

Content of the invention

For overcoming existing poultry Ankara disease treatment difficult problem, the purpose of the present invention aims to provide a kind of preventing and treating poultry Ankara Chinese medicine composition of disease and preparation method thereof.

For achieving the above object, the technical scheme that the present invention takes is as follows：

A kind of Chinese medicine composition of preventing and treating poultry Ankara disease, in terms of parts by weight, is made up of following crude drugs：Poria 15- 25 parts, Ramulus Cinnamomi 5-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Zingiberiss 5-15 part, Herba Asari 6-12 part, Rhizoma Pinelliae 10-15 part, Herba Ephedrae 6-12 part, red scape Its 6-10 part, Radix Glycyrrhizae 5-15, each raw material medicines in portions by weight number sum is 100 parts.

Preferably, the parts by weight of each crude drug are preferably：20 parts of Poria, 10 parts of Ramulus Cinnamomi, 12 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Rhizoma Zingiberiss, 9 parts of Herba Asari, 12 parts of the Rhizoma Pinelliae, 9 parts of Herba Ephedrae, 8 parts of Radix Rhodiolae, 10 parts of Radix Glycyrrhizae.

Preferably, described Ramulus Cinnamomi is preferably Ramulus Cinnamomi(peeled).

Preferably, described Herba Ephedrae is preferably Herba Ephedrae (processed).

Preferably, described Radix Glycyrrhizae is preferably Radix Glycyrrhizae Preparata.

Preferably, described Chinese medicine composition is preferably powder or drinking agent.

The invention provides powder and two kinds of drinking agent prepare scheme, specially：

Powder preparation method：Weigh each crude drug by described parts by weight, size-reduced, sieve, make granularity reach 60-200 mesh, point Dress obtains final product powder.

Drinking agent preparation method, comprises the steps：

（1）Weigh each crude drug by described parts by weight, be respectively crushed into coarse powder；

（2）Take step（1）Middle Poria, Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Herba Ephedrae, Radix Rhodiolae, Radix Glycyrrhizae coarse powder add water（Preferred feedstock medicine gross weight 6-10 times of amount）Decoct 30-50 minute, be subsequently adding Rhizoma Zingiberiss, Herba Asari coarse powder merges decoction 120-180 minute, leaching medicinal liquid；Again By medicinal residues（6-10 times of preferred medicinal residues weight）Add water, decoct 15-30 minute leaching medicinal liquid；Merge filtrate twice；

（3）By step（2）After merging filtrate sedimentation filtration, concentrating under reduced pressure under temperature 60-75 DEG C, vacuum 0.02-0.04Mpa Weight to medicinal liquid is 1.0 ± 0.1 times of crude drug gross weight, adds preservative, obtain final product drinking agent toward in concentrated medicament.

Preferably, described preservative is sodium benzoate and Nipagin ester, and the addition of sodium benzoate and Nipagin ester is respectively For concentrated medicament weight 0.05-0.1%'s and 0.05-0.1%.

The usage and dosage of powder：Every 1 ton of 2kg powder of the present invention product spice, free choice feeding, it is used in conjunction 3-5 days.

The usage and dosage of drinking agent：Every 250mL drinking agent of the present invention product is watered 100 kilograms, concentrates 2-3h to drink, is used in conjunction 3-5 days.

Chinese medicine has advantage in preventing and treating difficult complexity disease, therefore, inventor by the clinical practice of nearly 2 years, progressively There is deeper understanding to this cause of disease, pathogenesis and medicine for treatment.Chinese veterinarian is dialectical to be thought, this sick the heart attacked by pathogenic water is its pathogenesis, I.e. aqueous vapor superinverse, causes the pathological changes of heart, kidney yang deficiency, gasification is powerless, and aqueous are overflowed, upper Ling Yuxin, curb heart-yang, lead to the heart The pathological change of malfunction.Insult, the meaning of infringement.Due to deficiency of spleen-YANG and kidneyYANG, gasify obstacle, aqueous stop internal it is impossible to normal Excretion, produces phlegm retention, the diseases due to fluid retention such as edema, aqueous vapor superinverse, when stopping poly- chest and diaphragm impact heart-yang, can cause flaccidity of the heart-yang, unsteadiness of heart-QI, The symptoms such as cardiopalmus, tachypnea occur, though syndrome of water pathogen attacking heart has drink to hinder in wet general two pattern of syndrome of the heart and water, finally involve in the heart, The negative and positive that often may result in the heart all lose, notably Liver and kidney, lung splenic function exhaustion, so congestion occurs, jaundice, bleeding, kidney-Yang die de- Pathological.Control suitable warming YANG and invigorating QI, mind calming washs drink.Inventor groped out a kind of Chinese medicine composition of determined curative effect after nearly 2 years Thing, i.e. Chinese medicine composition of the present invention.

Beneficial effects of the present invention：

1st, the present invention according to poultry 3-6 week old section easily Ankara occurred frequently disease but clinical at present lack showing of effective prevention and control medicine Shape, the rule for the treatment of and prescription screen through science and obtain, and have the characteristics that formula uniqueness, safety are good, cheap and easy to get, can substantially meet Ankara disease that in people's actual production, prevention and control adenoviruss cause requires, and reduces the incidence of infection.

2nd, Chinese medicine composition of the present invention is after market clinical verification in nearly 2 years, to poultry Ankara and cause pericardial effusion, Hepatic necrosis stove, renal swelling etc. have good preventive and therapeutic effect.

Specific embodiment

Below in conjunction with specific embodiment, technical scheme is described in further detail, but the protection model of the present invention Enclose and be not limited thereto.

Embodiment 1

The manufacture method of powder of the present invention, comprises the steps：

Weigh Poria 200g, Ramulus Cinnamomi 100g, Rhizoma Atractylodis Macrocephalae 120g, Rhizoma Zingiberiss 100g, Herba Asari 90g, Rhizoma Pinelliae 120g, Herba Ephedrae (processed) 90g, Radix Rhodiolae 80g, Radix Glycyrrhizae Preparata 100g, above crude drug is mixed, and size-reduced, sieving makes granularity reach 60 mesh, subpackage gets product.

Embodiment 2

Another manufacture method of powder of the present invention, comprises the steps：

Weigh Poria 250g, Ramulus Cinnamomi 90g, Rhizoma Atractylodis Macrocephalae 100g, Rhizoma Zingiberiss 100g, Herba Asari 100g, Rhizoma Pinelliae 100g, Herba Ephedrae (processed) 80g, Radix Rhodiolae 90g, Radix Glycyrrhizae Preparata 90g, above crude drug is mixed, and size-reduced, sieving makes granularity reach 60 mesh, subpackage gets product.

Embodiment 3

The manufacture method of drinking agent of the present invention, comprises the steps：

（1）Weigh Poria 600g, Ramulus Cinnamomi 300g, Rhizoma Atractylodis Macrocephalae 360g, Rhizoma Zingiberiss 300g, Herba Asari 270g, Rhizoma Pinelliae 360g, Herba Ephedrae (processed) 270g, Radix Rhodiolae 240g, Radix Glycyrrhizae Preparata 300g, above crude drug is size-reduced respectively to form coarse powder；

（2）Take step（1）Middle Poria, Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Herba Ephedrae, Radix Rhodiolae, Radix Glycyrrhizae coarse powder add the water of its 8 times of weight by normal Rule water-boiling method decocts 40 minutes, is subsequently adding Rhizoma Zingiberiss, Herba Asari coarse powder merges decoction 150 minutes, leaching medicinal liquid；Again by medicinal residues plus its The water of 8 times of weight, decocts 20 minutes leaching medicinal liquids；Merge filtrate twice；

（3）By step（2）After merging filtrate sedimentation filtration, under 65 DEG C of temperature, vacuum 0.03Mpa, it is evaporated to medicinal liquid Weight is 1.0 times of crude drug gross weight, adds account for the sodium benzoate of its weight 0.1% and 0.05% Ni Bo toward in concentrated medicament Golden ethyl ester, obtains final product drinking agent.

Zoopery

Qinhuangdao Luan County plant, raises double A broiler 30000（Two hen houses, every each 15000 about）, 21 ages in days, Start lethargy occurs successively, cough, feed intake slightly drop, day death rate rise to 2% by 0.5%, cut open inspection discovery pericardial effusion, Hepatic necrosis, renal swelling, other organs no significant change, two situation mental status and cut open inspection situation are substantially similar, and veterinary in field sentences Break as doubtful Ankara disease symptoms, for preventing this disease from spreading, two chickens as immunized controls group and test group and are taken Corresponding quarantine measures.

Immunized controls group：From Qingdao foreign country newcastle disease, bird flu（H9 hypotype）, aviadenovirus（I group, 4 types）Three Inactivated vaccine（La Sota strain+YBF13 strain+YBAV-4 strain）, intramuscular injection, every chicken 0.5mL.

Test group：Every 250mL embodiment 3 product is watered 100 kilograms, concentrates 2-3h to drink, is used in conjunction 5 days.

Experimental result is as shown in Table 1.

Table one understands：Compared with immunized controls group, the 3rd -day-old of test group chicken mine massively appetite rise return to normal, Death rate reduces by 30% about compared with matched group, and immunized controls group feed intake in 5d returns to normal.Cut open inspection chicken, immunity is right All substantially mitigate according to group and test group pericardial effusion, renal swelling, the mental status is good.

Urgent immunity is a kind of common approach of the raw sudden virosiss of chicken mass-sending although this method has certain effect Really, but very strong immunological stress is caused to chicken group, lead to chicken group's death rate to increase.And pure Chinese medicinal preparation does not produce to chicken group and appoints What stimulates, and is better than urgent immunity on therapeutic effect.Illustrate that Chinese medicine preparation of the present invention can obtain in terms for the treatment of Ankara Good effect.

Claims (9)

1. a kind of Chinese medicine composition of preventing and treating poultry Ankara disease is it is characterised in that in terms of parts by weight, by following crude drugs Make：Poria 15-25 part, Ramulus Cinnamomi 5-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Zingiberiss 5-15 part, Herba Asari 6-12 part, Rhizoma Pinelliae 10-15 part, fiber crops Yellow 6-12 part, Radix Rhodiolae 6-10 part, Radix Glycyrrhizae 5-15, each raw material medicines in portions by weight number sum is 100 parts.

2. Chinese medicine composition as claimed in claim 1 is it is characterised in that the parts by weight of each crude drug are：20 parts of Poria, osmanthus 10 parts of branch, 12 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Rhizoma Zingiberiss, 9 parts of Herba Asari, 12 parts of the Rhizoma Pinelliae, 9 parts of Herba Ephedrae, 8 parts of Radix Rhodiolae, 10 parts of Radix Glycyrrhizae.

3. Chinese medicine composition as claimed in claim 1 it is characterised in that：Described Ramulus Cinnamomi is Ramulus Cinnamomi(peeled).

4. Chinese medicine composition as claimed in claim 1 it is characterised in that：Described Herba Ephedrae is Herba Ephedrae (processed).

5. Chinese medicine composition as claimed in claim 1 it is characterised in that：Described Radix Glycyrrhizae is Radix Glycyrrhizae Preparata.

6. Chinese medicine composition as claimed in claim 1 it is characterised in that：Described Chinese medicine composition is powder or drinking agent.

7. a kind of method of the Chinese medicine composition prepared as described in any one of claim 1-5 it is characterised in that：By described heavy Amount number weighs each crude drug, size-reduced, sieve, and makes granularity reach 60-200 mesh, subpackage obtains final product powder.

8. a kind of method of the Chinese medicine composition prepared as described in any one of claim 1-5 is it is characterised in that include as follows Step：

（1）Weigh each crude drug by described parts by weight, be respectively crushed into coarse powder；

（2）Take step（1）Middle Poria, Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Herba Ephedrae, Radix Rhodiolae, Radix Glycyrrhizae coarse powder add water to cook 30-50 minute, It is subsequently adding Rhizoma Zingiberiss, Herba Asari coarse powder merges decoction 120-180 minute, leaching medicinal liquid；Again medicinal residues are added water, decoct 15-30 minute, Leaching medicinal liquid；Merge filtrate twice；

（3）By step（2）After merging filtrate sedimentation filtration, concentrating under reduced pressure under temperature 60-75 DEG C, vacuum 0.02-0.04Mpa Weight to medicinal liquid is 1.0 ± 0.1 times of crude drug gross weight, adds preservative, obtain final product drinking agent toward in concentrated medicament.

9. preparation method as claimed in claim 8 it is characterised in that：Described preservative is sodium benzoate and Nipagin ester, benzene The addition of sodium formate and Nipagin ester is respectively 0.05-0.1% and 0.05-0.1% of concentrated medicament weight.