CN106421694A - Externally used Chinese herba preparation for treating dysmenorrhea - Google Patents

Externally used Chinese herba preparation for treating dysmenorrhea Download PDF

Info

Publication number
CN106421694A
CN106421694A CN201610850232.5A CN201610850232A CN106421694A CN 106421694 A CN106421694 A CN 106421694A CN 201610850232 A CN201610850232 A CN 201610850232A CN 106421694 A CN106421694 A CN 106421694A
Authority
CN
China
Prior art keywords
parts
medicine
traditional chinese
moxibustion
chinese medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201610850232.5A
Other languages
Chinese (zh)
Other versions
CN106421694B (en
Inventor
王昕�
孙晶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FIRST AFFILIATED HOSPITAL OF LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Original Assignee
FIRST AFFILIATED HOSPITAL OF LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FIRST AFFILIATED HOSPITAL OF LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE filed Critical FIRST AFFILIATED HOSPITAL OF LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Priority to CN201610850232.5A priority Critical patent/CN106421694B/en
Publication of CN106421694A publication Critical patent/CN106421694A/en
Application granted granted Critical
Publication of CN106421694B publication Critical patent/CN106421694B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an externally used Chinese herba preparation for treating primary dysmenorrhea caused by nerve, internal secretion and immune network unbalance and uterine local microcirculation disturbance. The externally used Chinese herba preparation comprises the following raw material components in parts by weight: 10-20 parts of Cortex Cinnamomi, 5-10 parts of Rhizoma Zingiberis, 5-10 parts of Herba Asari, 10-20 parts of Rhizoma Corydalis, 5-10 parts of Oletum Trogopterori, 5-10 parts of Pollen Typhae, 5-10 parts of Rhizoma Cyperi, 5-10 parts of Scorpio and 2-5 parts of Squama Manis. The externally used Chinese herba preparation is used with a medicine-separated moxibustion method, can treat primary dysmenorrhea, is targeted and has remarkable effects.

Description

A kind of traditional Chinese medicine for outer use treating dysmenorrhoea
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly, to one kind treat nerve, endocrine, immunological network is unbalance and uterus The traditional Chinese medicine for outer use of the primary dysmenorrhea that local microcirculation obstacle is led to.
Background technology
Primary dysmenorrhea(Primary Dysmenorrhea, PD)Refer to that women is expert at through in front and back or under intermenstrual period appearance Abdominal pain, falling inflation, with symptoms such as the soreness of waist.Shown by multinomial epidemiology survey, sexual maturing period women more than half, All dysmenorrhoea phenomenon in different times, and whenever menstrual onset, pain will be shown effect therewith.Patient not only can be made to produce suppression Strongly fragrant, anxiety mood, or even cannot be carried out normally daily work and rest, drastically influence the Health and Living of women.Therefore, for The study on prevention of primary dysmenorrhea is extremely urgent, urgently to be resolved hurrily.
The definite cause of disease of primary dysmenorrhea is not completely clear and definite at present, and modern medicine thinks the pathomechanism of primary dysmenorrhea With prostaglandin(PGs)In close relations.PGF in dysmenorrhoea patient uterine's inner membrance and menstrual blood、PGE2Content is all bright compared with normal women Aobvious rising, PGFContent height can cause the too strong contraction of uterine smooth muscle, blood vessel contracture, cause uterus ischemic, anoxia state and go out Existing dysmenorrhoea;PGE2The generation of pain plays an important role, being organized in sustains damage can release with local during inflammation PGE2, the inflammatory algogenic substance such as histamine and leukotriene and cause pain, the prostaglandin increasing enters blood circulation, also can cause The symptom such as angiocarpy and alimentary canal.In addition, other metabolism endocrine factors such as nitric oxides(NO), Endothelin(ET), urge Produce element(0T), estrogen(ESG), progestational hormone() etc. P also all in the mechanism that PD occurs, play certain effect.Also there is research Find to be derived from the uterus and its annex near-end nerve conduction to backbone by cut-out(I.e. presacral sympathectomy)Treatment PD, Evident in efficacy, and norepinephrine can cause uterine smooth muscle and vasospastic to shrink, thus leading to dysmenorrhoea, points out Nerve, neurotransmitter are relevant with primary dysmenorrhea.Meanwhile there are some researches show, the T lymphocyte CD 3 in Dysmenorrhea Rats serum +, CD4+ level be significantly lower than Normal group, there is obvious immunologic hypofunction.Except factors above, there is scholar's application colored Doppler ultrasound detects Uterine Artery Blood Flow parameter, and result shows, the resistance of blood flow of dysmenorrhoea patient is high compared with healthy person, uterine artery Resistance of blood flow is big, and Uterine Blood Flow amount reduces, and leads to microcirculation disorder.In sum, it is now recognized that primary dysmenorrhea send out Raw mainly relevant with two aspect factors:One is nerve, endocrine, immunological network is unbalance;Two is uterus local microcirculation obstacle.
Modern medicine, in terms of the treatment of primary dysmenorrhea, adopts nonsteroidal anti-inflammatory drug and contraceptive, with only at present Pain is calm, inhibitory hormone is secreted and carried out therapeutic intervention although there being quickness and high efficiency for Main Means, but effect can not be held Long it is necessary to Long-term taking medicine, but long-term taking can bring various bad reactions and toxic and side effect to body.Therefore, need research one badly Plant with strong points, the medicine of the treatment dysmenorrhoea of effect is significant.
Content of the invention
The present invention is directed to the problems referred to above, provides a kind of traditional Chinese medicine for outer use treating dysmenorrhoea.This Chinese medicine coordinates moxibustion, Primary dysmenorrhea, effect is significant can be treated.
To achieve these goals, the traditional Chinese medicine for outer use of the treatment dysmenorrhoea that the present invention provides, its material composition is by weight Number proportioning is as follows:Chinese cassia tree 10-20 part, rhizoma zingiberis 5-10 part, root of Chinese wild ginger 5-10 part, corydalis tuber 10-20 part, excrementum pteropi 5-10 part, cattail pollen 5-10 part, rhizoma cyperi 5-10 part, scorpio 5-10 part, pangolin 2-5 part.
Described preparation is powder.
Described external preparation is specially herbs-partition moxibustion powder.
To achieve these goals, present invention also offers the preparation method of above-mentioned traditional Chinese medicine for outer use.
The medicine materical crude slice of needed raw material is pulverized(Cross No. 7-8 sieve, 120-150 mesh), mix;Yellow rice wine is added to be modulated into dry paste Shape(Every 10g traditional Chinese powder medicine, need to use yellow rice wine 10ml);Make a diameter of 3-5cm, thickness is the medicine cake of 1-1.5cm, standby.
The raw medicinal material that the present invention chooses, its Toxicity Analysis is as follows.
Chinese cassia tree has the effect of mends fire supporing yang, conducting the fire back to its origin, eliminating cold to stop pain, invigorate blood circulation.Modern pharmacological research shows meat There are platelet aggregation-against, anticoagulant effect in osmanthus, and the ANIMAL PAIN reaction simultaneously various stimulations being caused all has inhibitory action, because It has obvious facilitation to adrenal cortex function, and therefore Endocrine function has certain impact.
Rhizoma zingiberis has the effect of warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm.Prompting rhizoma zingiberis equally has modern pharmacological research Antithrombotic effect, and the APFI of animal used as test can be obviously prolonged.Rhizoma zingiberis ether extract, water extract have simultaneously Analgesic activity, can reduce acetic acid and cause mouse writhing reaction times.
The root of Chinese wild ginger has the effect of relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, sensible, Wenfei of drink.Modern pharmacological research shows the root of Chinese wild ginger There is analgesic activity, meanwhile the root of Chinese wild ginger can improve the metabolic function of body, detached higenamine has from the root of Chinese wild ginger The extensive pharmacodynamics effect of beta-receptor agonist-like, has cardiac stimulant, expansion of blood vessels, relaxing smooth muscle etc. to act on.Know the first root of three-nerved spicebush Alkali is contained in the Chinese medicine of multiple property of medicine warm, such as the root of Chinese wild ginger, monkshood, evodia rutaecarpa etc., the pharmacological action that it presents and Chinese medicine dissipates cold or Dispelling cold effect matches, and therefore can be regarded as one of important substance basis of dissipates cold drug effect.
Corydalis tuber has the effect of promoting blood circulation to remove blood stasis, regulating qi-flowing for relieving pain.Modern pharmacology shows that corydalis tuber has significant analgesic activity, and right Muscle has relexation.Corydalis tuber extract tetrahydropalmatine plays the role of excited pitutary-adrenal system, so Endocrine system System has regulatory function.
Excrementum pteropi promoting blood circulation to remove blood stasis;Cattail pollen hemostasis, stagnation resolvation, treating stranguria.Modern pharmacological research prompting both of which has antiplatelet to gather Collection, anticoagulation, research shows, excrementum pteropi also has the effect alleviating smooth muscle spasm.
Effect of rhizoma cyperi is soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.There are some researches show that Rhizoma Cyperi volatile oil has removed analgesia and made With outer, the intestinal smooth muscle that also can relax, alleviation bronchial muscular spasm, make uterine leio muscular relaxation, Muscle tensility declines simultaneously, receive Contracting power weakens.
Scorpio can ceases wind antispastic, remove obstruction in channels to relieve pain, dispersing pathogen accumulation.Research prompting scorpio has analgesic activity.
Pangolin blood circulation promoting and dispersing pathogen accumulation, stimulate the menstrual flow lower breast, anti-stain in solid.Research shows that the decocting liquid of pangolin is obviously prolonged little Bai Mouse clotting time and the effect reducing Blood of Mice viscosity.
This prescription Medicinal Trait:Wherein Chinese cassia tree, rhizoma zingiberis, the root of Chinese wild ginger are good at Wen Yang, dissipates cold, pain relieving altogether for monarch;Corydalis tuber, five spirits Fat, cattail pollen blood-activating analgetic are minister;Rhizoma cyperi promoting qi circulation and relieving pain is assistant;Scorpio, pangolin stimulate the menstrual flow and dredging collateral, pain relieving are to make medicine.
The prescription adopting in the present invention is SHAOFU ZHUYN DECOCTION plus-minus side:SHAOFU ZHUYN DECOCTION goes the fennel seeds of eliminating cold to stop pain, plus Equally have pungent-warm power but row dissipate fragrance thoroughly reach the more preferably root of Chinese wild ginger;Excrementum pteropi work(arrogates to oneself promoting blood circulation, removing blood stasis and relieving pain, all for treatment blood stasis The key medicine of pain, and help effect to use with cattail pollen mutual reinforcement between, pungent scattered temperature is led in addition, can the stagnation of the circulation of vital energy in promoting circulation of blood, stasis in gas, specially control upper and lower all over the body The corydalis tuber of all pains, the effect of its blood-activating analgetic be enough to, and Gu Fangzhong removes the slightly inferior Ligusticum wallichii of the power of promoting blood circulation, Radix Angelicae Sinensis, the radix paeoniae rubrathe, myrrh;Rhizoma cyperi For the key medicine of soothing liver-qi stagnation, promoting qi circulation and relieving pain, add and take its qi being the governor of blood, gas row then blood, the meaning that the stasis of blood is only unsting;Pangolin It is apt to walk to alter, inside reach zang-fu differentiation, can be promoting blood circulation and removing blood stasis, disappear long-pending, qualcomm meridian;Full scorpion obstruction removing pain relieving.Entirely just play warming channel and expelling cold altogether, live The work(of blood and relieving pain.
Beneficial effects of the present invention.
In the present invention, herbs-partition moxibustion, as the important component part of external treatment of traditional Chinese medicine, is the characteristic medical science of China and important Medical and health resource, with its letter, just, honest and clean, test, prompt and hurtless measure, the advantage of without pain disease preventing and treating and characteristic be on applying There are deep clinical accumulation and long-range promotional value.Herbs-partition moxibustion be with basic theory of tcm for instruct, in conjunction with moxibustion therapy, in Medicine and one kind of being formed excites channels and collaterals, acupuncture point, play the therapy of complex treatment effect, thus playing medicine, acupuncture point, moxibustion therapy three knot The effect closed.One side moxibustion therapy and medicine act on the acupuncture point that directly have stimulated on channels and collaterals, produce certain curative effect;On the other hand, exist Apply every medicinal vesiculation moxibustion on acupuncture point, the time that medicine retains at acupuncture point is longer, be allowed to along channel course to dredge through gas, medicine reaches disease Institute, and there is the warming channel and expelling cold, regulation of qi and blood, the effect of Yin Yang balancing.PD generation multiple system dysfunction may be had with body Close, and herbs-partition moxibustion ruling by law is treated dysmenorrhoea and focused on adjusting body function on the whole, therefore adjust neuro-endocrine-immune network And improve the important component part that uterus microcirculation is that primary dysmenorrhea action pathway is treated in herbs-partition moxibustion ruling by law.
In the present invention, we screen active drug on the basis of having carried out a large amount of clinical applications and form effective prescription, grind Make the medicine cake of topical administration, and carry out the clinical contrast observation of the treatment primary dysmenorrhea of this medicine with the time of 2 years, Confirm that this prescription has warming channel and expelling cold, effect of promoting blood circulation and stopping pain.Herbs-partition moxibustion is scoring to primary dysmenorrhea patient abdominal pain VAS And the improvement aspect of dysmenorrhoea tcm syndrome is superior to simple moxibustion therapy, dysmenorrhoea symptom can be mitigated in the short period of time, curative effect is true Cut.
We are by 40 primary dysmenorrheas(Cold blood stasis are demonstrate,proved)Patient is randomly divided into two groups, and treatment group is carried out using herbs-partition moxibustion Treatment, control group is treated using simple moxibustion, each menstrual cycle moxibustion 7 times, continuous 3 menstrual cycles.Observation is controlled Treat 3 menstrual cycle postabdomen pain VAS scorings and the change of Chinese medicine syndrome integral, and compare the difference between two groups.Result Abdominal pain VAS scoring comparing difference statistically significant (P < 0.05) before and after treating with simple moxibustion group for herbs-partition moxibustion group, And herbs-partition moxibustion group curative effect is better than simple moxibustion group (P < 0.05);In terms of tcm syndrome curative effect, herbs-partition moxibustion group and simple moxa-moxibustion Group is efficient to be respectively 95%, 80%, and the curative effect of herbs-partition moxibustion group is better than control group.The external application Chinese medicine of the present invention is former in clinical treatment There is preferable therapeutic action in the property sent out dysmenorrhoea.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated.
Embodiment 1.
The traditional Chinese medicine for outer use for the treatment of dysmenorrhoea, its material composition proportioning by weight is as follows:20 parts of Chinese cassia tree, rhizoma zingiberis 10 Part, 10 parts of the root of Chinese wild ginger, 18 parts of corydalis tuber, 8 parts of excrementum pteropi, 10 parts of cattail pollen, 10 parts of rhizoma cyperi, 7 parts of scorpio, 4 parts of pangolin.
Above-mentioned traditional Chinese medicine for outer use is prepared into the herbs-partition moxibustion medicine cake for the treatment of primary dysmenorrhea, and its preparation method is specially:Press Parts by weight proportioning weighs each bulk drug medicine materical crude slice, is crushed to granularity for, after 120-150 mesh, mixing.After taking above-mentioned pulverizing Drug powder 10g, is modulated with 10ml yellow rice wine, and the medicine cake specification that medication cake mould is made is:Diameter 3cm, thick 1cm, sealing, standby With.
The using method of the herbs-partition moxibustion medicine cake for the treatment of primary dysmenorrhea:Medicine cake is respectively placed on SHENQUE acupoint and Guanyuan point, Again Ai Zhu is placed on two medicine cakes and lights.In menstrual onset, first 5 days start moxibustion, the continuous moxibustion of each menstrual cycle 7 days, be a course for the treatment of, continuous 3 menstrual cycles, i.e. 3 courses for the treatment of.
1st, clinical data.
1.1 physical data.
40 experimenters meeting inclusive criteria, are respectively derived from Liaoning University of TCM, Liaoning University and Liaoning traditional Chinese medical science The outpatient service of affiliated hospital of medicine university.Experimenter is randomly divided into herbs-partition moxibustion group(Treatment group)With simple moxibustion group(Control group)Each 20 Example.Two groups of patient all not statistically significant (P of comparing difference in terms of age, the course of disease>0.05), there is comparativity.
1.2 inclusive criteria.
(1)Meet primary dysmenorrhea(Cold blood stasis are demonstrate,proved)Diagnostic criteria;(2)Age >=18 year old ,≤35 years old;(3)Menstruation Periodic law (28 ± 7) d;(4)Signature Informed Consent Form;(5)VAS scores >=3 points;(6)10 points of CMSS total score >.
1.3 exclusion standard.
(1)Doctor trained in Western medicine diagnosis belongs to acquired dysmenorrhea, confirms on inspection by pelvic infecton, endometriosis, fibroid, ovum Acquired dysmenorrhea person caused by nest pathology etc.;(2)It is associated with the former of the serious threat to life such as cardiovascular and cerebrovascular, liver, kidney and hemopoietic system The property sent out disease and mental patient, are unsuitable for the other diseases patient of moxa-moxibustion;(3)Women breast-feeding their children and pregnant or recent standard The women of standby gestation;(4)Allergic constitution person, or known to this medicine composition allergy sufferers;(5)Treat take in first 1 month anodyne, Sedative and hormone medicine;(6)Participating in other clinical testing persons;(7)Participate in the medical personnel of this clinical research.
2nd, treatment method.
2.1 herbs-partition moxibustion groups(Treatment group).
2.1.1 medicine composition(Dysmenorrhoea dissipates):Prepare patent medicine cake by embodiment 1.
2.1.2 the making of moxa cone.
According to national regular higher education traditional Chinese medicine class fine works teaching material《Subject of acupuncture and moxibustion technique》Carry out making by hand of moxa cone, directly Footpath about 2cm, high about 2.5cm.
2.1.3 method of operating.
(1)Acupoint selection:Patient takes dorsal position, fully exposes umbilical region and lower abdomen.SHENQUE acupoint:In the middle part of abdomen, acromphalus.Guan Yuan Cave:On lower abdomen, anterior median line, lower 3 cun when Qizhong.According to《National Standard of the People's Republic of China》(GB12346-90) Carry out acupuncture point positioning.
(2)With 75% ethanol navel local and Guanyuan point at routine disinfection.
(3)Medicine cake is respectively placed at SHENQUE acupoint and Guanyuan point.
(4)Moxa cone is placed on two medicine cakes, moxibustion 6 is strengthened, about 20 minutes.
(5)The moxibustion time:Every each moxibustion in cave 20 minutes, 1 times/day, totally 7 times.
2.1.4 the regulation of moxibustion opportunity and the course for the treatment of.
In menstrual onset, first 5 days start moxibustion, each menstrual cycle continuous moxibustion 7 days, continuous 3 menstrual cycles.
2.2 simple moxibustion group(Control group).
2.2.1 method of operating.
(1)Acupoint selection:With herbs-partition moxibustion group.
(2)Mild-warm moxibustion:One end of moxa roll is lighted, be aligned answers the acupoint region of moxibustion, about carries out moxa-moxibustion away from skin 2 3cm, Make patient local have a warmth sensation and no cusalgia is advisable, every cave moxibustion 20 minutes, to skin blush moist for degree.
(3)The moxibustion time:With herbs-partition moxibustion group.
2.2.2 the regulation of moxibustion opportunity and the course for the treatment of:With herbs-partition moxibustion group.
3 therapeutic effects.
3.1 observation index.
3.1.1 abdominal pain VAS scores.
Evaluate the pain degree of dysmenorrhoea stomachache using international conventional visual analogue scales (VAS), comparison therapy group and Before and after treatment of control group organize in and group between VAS integration change.
3.1.2 tcm syndrome efficacy evaluation.
Before and after comparison therapy group and treatment of control group organize in and group between Syndrome in TCM marquis integration change.
Curative effect determinate standard with reference to Nimodipine method and《New Chinese medicine guideline of clinical investigations》Draft.
(1)Recovery from illness:Menstrual period lower abdominal pain disappears, n >=95%.
(2)Effective:Menstrual period lower abdominal pain substantially mitigates, 70%≤n < 95%.
(3)Effectively:Menstrual period lower abdominal pain mitigates, 30%≤n < 70%.
(4)Invalid:Menstrual period lower abdominal pain is not improved, n < 30%.
Therapeutic index(n)=(Chinese medicine syndrome integral after 3 menstrual cycles of Chinese medicine syndrome integral-treatment before treatment)In before/treatment Doctor's syndrome integral × 100%.
3.1.3 bad reaction observation.
The bad reaction relevant with curative possibility, record in detail.
3.2 statistical method.
Carry out statistical procedures with SPSS19.0 statistical software, testing result is represented with mean ± standard deviation;Between two groups The conspicuousness of difference adopts t to check.P < 0.05 is the statistically significant mark of difference.Ranked data are analyzed with Ridit.
4 treatment results.
Pain VAS scoring before and after 4.1 liang of group treatments is compared, and is shown in Table 1.
Compare before and after 1 liang of group patient pain VAS scoring of table.
Note:With this group before treatment, * P < 0.01;Compare with after treatment of control group, △ P < 0.05.Table 1 result table Bright, after treatment, two groups of VAS integrations substantially reduce (P < 0.05) before all relatively treating, and treatment group is less than control group (P < 0.05).
Tcm syndrome efficacy determination before and after 4.2 liang of group treatments.
In treatment group 20, fully recover 2, effective 12, effective 5, invalid 1, total effective rate is 95%;Control group 20 In example, fully recover 2, effective 6, effective 8, invalid 4, total effective rate is 80%.Ridit analysis display, the curative effect for the treatment of group Better than control group, it is shown in Table 2.
2 liang of group patient's tcm syndrome comparitive study of table.
By above test illustrate external application Chinese medicine of the present invention in treatment because of nerve, endocrine, immunological network is unbalance and uterus The primary dysmenorrhea aspect that local microcirculation obstacle is led to has significant curative effect, and treatment curative effect is better than simple moxibustion treatment comparison Group.Conclusion:The external application Chinese medicine of the present invention has preferable therapeutic action in clinical treatment primary dysmenorrhea.Do not occur under observation Bad reaction.
Embodiment 2.
17 parts of Chinese cassia tree, 5 parts of rhizoma zingiberis, 5 parts of the root of Chinese wild ginger, 20 parts of corydalis tuber, 5 parts of excrementum pteropi, 5 parts of cattail pollen, 7 parts of rhizoma cyperi, 10 parts of scorpio, 2 parts of pangolin.
Embodiment 3.
10 parts of Chinese cassia tree, 7 parts of rhizoma zingiberis, 8 parts of the root of Chinese wild ginger, 10 parts of corydalis tuber, 10 parts of excrementum pteropi, 9 parts of cattail pollen, 5 parts of rhizoma cyperi, 5 parts of scorpio, 5 parts of pangolin.

Claims (8)

1. a kind of traditional Chinese medicine for outer use treating dysmenorrhoea is it is characterised in that its material composition proportioning by weight includes:Meat silicon 10-20 part, rhizoma zingiberis 5-10 part, root of Chinese wild ginger 5-10 part, corydalis tuber 10-20 part, five spirits refer to 5-10 part, cattail pollen 5-10 part, rhizoma cyperi 5-10 part, Entirely have a rest 5-10 part, pangolin 2-5 part.
2. traditional Chinese medicine for outer use as claimed in claim 1 is it is characterised in that described preparation is powder etc..
3. traditional Chinese medicine for outer use as claimed in claim 1 is it is characterised in that described external preparation is herbs-partition moxibustion powder.
4. traditional Chinese medicine for outer use as claimed in claim 1 is it is characterised in that its material composition proportioning by weight is as follows: Chinese cassia tree 20, rhizoma zingiberis 10, the root of Chinese wild ginger 10, corydalis tuber 18, excrementum pteropi 8, cattail pollen 10, rhizoma cyperi 10, scorpio 7, pangolin 4.
5. traditional Chinese medicine for outer use as claimed in claim 1 is it is characterised in that its material composition proportioning by weight is as follows: 27 parts of Chinese cassia tree, 15 parts of rhizoma zingiberis, 5 parts of the root of Chinese wild ginger, 20 parts of corydalis tuber, 5 parts of excrementum pteropi, 5 parts of cattail pollen, 7 parts of rhizoma cyperi, 10 parts of scorpio, pangolin 20 parts.
6. traditional Chinese medicine for outer use as claimed in claim 1 is it is characterised in that its material composition proportioning by weight is as follows: 10 parts of Chinese cassia tree, 7 parts of rhizoma zingiberis, 8 parts of the root of Chinese wild ginger, 10 parts of corydalis tuber, 10 parts of excrementum pteropi, 9 parts of cattail pollen, 5 parts of rhizoma cyperi, 5 parts of scorpio, pangolin 5 Part.
7. the traditional Chinese medicine for outer use as described in claim 1 to 6 is it is characterised in that its material composition is as follows by weight ratio:Will Medicine materical crude slice is pulverized(No. 7-8 sieve, 120-150 mesh), after mixing, add yellow rice wine to be modulated into dry pasty state(Every 10g traditional Chinese powder medicine, needs Use yellow rice wine 10ml);Make a diameter of 3-5cm, thickness is the medicine cake of 1-1.5cm, standby.
8. the using method of traditional Chinese medicine for outer use as claimed in claim 1 is it is characterised in that be respectively placed in SHENQUE acupoint by medicine cake And on Guanyuan point, then Ai Zhu is placed on two medicine cakes lights, in menstrual onset, first 5 days start moxibustion, each menstruation Cycle continuous moxibustion 7 days, is a course for the treatment of, continuous 3 menstrual cycles, i.e. 3 courses for the treatment of.
CN201610850232.5A 2016-09-27 2016-09-27 External traditional Chinese medicine preparation for treating dysmenorrhea Active CN106421694B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610850232.5A CN106421694B (en) 2016-09-27 2016-09-27 External traditional Chinese medicine preparation for treating dysmenorrhea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610850232.5A CN106421694B (en) 2016-09-27 2016-09-27 External traditional Chinese medicine preparation for treating dysmenorrhea

Publications (2)

Publication Number Publication Date
CN106421694A true CN106421694A (en) 2017-02-22
CN106421694B CN106421694B (en) 2020-02-14

Family

ID=58169438

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610850232.5A Active CN106421694B (en) 2016-09-27 2016-09-27 External traditional Chinese medicine preparation for treating dysmenorrhea

Country Status (1)

Country Link
CN (1) CN106421694B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050123A (en) * 2017-05-10 2017-08-18 吉安长江生物药业有限公司 A kind of body surface externally-used embrocation for alleviating dysmenorrhoea

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102362943A (en) * 2011-08-24 2012-02-29 成都绿迪科技有限公司 Traditional Chinese medicine preparation for treating dysmenorrhea
CN103933292A (en) * 2014-04-24 2014-07-23 陈筠 Dysmenorrhea treating patch
CN103990099A (en) * 2014-06-13 2014-08-20 山东省医学科学院基础医学研究所 Traditional Chinese medicine composition for treating dysmenorrhea
CN104107299A (en) * 2014-06-28 2014-10-22 蚌埠火鹤制药有限公司 Traditional Chinese medicine mixture for treating dysmenorrhoea
CN104983989A (en) * 2015-06-25 2015-10-21 广州中医药大学 Traditional Chinese medicine drug for treating dysmenorrheal and gel paste and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102362943A (en) * 2011-08-24 2012-02-29 成都绿迪科技有限公司 Traditional Chinese medicine preparation for treating dysmenorrhea
CN103933292A (en) * 2014-04-24 2014-07-23 陈筠 Dysmenorrhea treating patch
CN103990099A (en) * 2014-06-13 2014-08-20 山东省医学科学院基础医学研究所 Traditional Chinese medicine composition for treating dysmenorrhea
CN104107299A (en) * 2014-06-28 2014-10-22 蚌埠火鹤制药有限公司 Traditional Chinese medicine mixture for treating dysmenorrhoea
CN104983989A (en) * 2015-06-25 2015-10-21 广州中医药大学 Traditional Chinese medicine drug for treating dysmenorrheal and gel paste and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
于跃: "痛经散在痛经外治法应用上的临床效果观察", 《中国优秀硕士学位论文全文数据库》 *
姚玉荣: "消痛宁敷脐治疗痛经90例", 《中国民间疗法》 *
陈卫华等: "痛经贴外敷关元穴治疗痛经188例", 《安徽中医学院学报》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050123A (en) * 2017-05-10 2017-08-18 吉安长江生物药业有限公司 A kind of body surface externally-used embrocation for alleviating dysmenorrhoea
CN107050123B (en) * 2017-05-10 2020-08-11 吉安长江生物药业有限公司 Body surface external application liniment for relieving dysmenorrhea

Also Published As

Publication number Publication date
CN106421694B (en) 2020-02-14

Similar Documents

Publication Publication Date Title
CN103751310B (en) A kind of traditional Chinese medicine for external application and its preparation method treating fascitis
CN102319327A (en) Traditional Chinese medicine for internally and externally treating diabetic foot
CN104043022A (en) Traditional Chinese medicine composition for treating gynecologic inflammation
CN103495055A (en) Traditional Chinese medicine decoction for treating female endocrine disorders and preparation method thereof
CN104971253A (en) Traditional Chinese medicine composition preparation for treating allergic rhinitis
CN102512647B (en) Chinese herbal composition for treating abdominal pain due to deficiency-cold
CN101700391B (en) Oral traditional Chinese medicine composition for treating psoriasis
CN106421694A (en) Externally used Chinese herba preparation for treating dysmenorrhea
CN103330888A (en) Cleaning fluid for treatment of pruritus vulvae
CN103585483B (en) Traditional Chinese medicine composition for treating knee osteoarthritis and preparation method of same
CN102579607B (en) Chinese medicine composition for treating acne
CN103110756B (en) Traditional Chinese medicine composition for treating renal hematuria
CN105233078A (en) Traditional Chinese medicine composition for treating viral hepatitis
CN103800561A (en) Traditional Chinese medicine for treating renal hematuria
CN104096103A (en) Traditional Chinese medicine agent for treating uroschesis
CN104162026A (en) Traditional Chinese medicine composition treating hypertension and preparation method thereof
CN103301374B (en) Pharmaceutical composition for treating postpartum non-specificity vaginitis
CN106139042A (en) A kind of new medicine composition treating cervical spondylopathy and preparation method thereof
CN104666824A (en) Traditional Chinese medicinal composition for treating psoriasis
CN105687865A (en) Traditional Chinese medicine composition for treating stranguria
CN104998106A (en) Traditional Chinese medicine composition for treating allergic rhinitis
CN104367862A (en) Traditional Chinese medicinal composition for treating urethral calculus
CN103495050B (en) Chinese medicinal composition for treating blood-heat stasis type acne
CN104338086A (en) Chinese medicinal enema for treating chronic endometritis and preparation method thereof
CN103127352B (en) Chinese medicine composition for treating blood stasis type irregular menstruation

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant