CN107050123A - A kind of body surface externally-used embrocation for alleviating dysmenorrhoea - Google Patents
A kind of body surface externally-used embrocation for alleviating dysmenorrhoea Download PDFInfo
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- CN107050123A CN107050123A CN201710326611.9A CN201710326611A CN107050123A CN 107050123 A CN107050123 A CN 107050123A CN 201710326611 A CN201710326611 A CN 201710326611A CN 107050123 A CN107050123 A CN 107050123A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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Abstract
The present invention relates to a kind of body surface externally-used embrocation for alleviating dysmenorrhoea, the body surface externally-used embrocation includes the material composition of following parts by weight：The parts by weight of dimethyl sulfoxide (DMSO) 36, the parts by weight of mustard oil 36, pepper 0.1 0.2 parts by weight of element, the parts by weight of absolute ethyl alcohol 85 95.The body surface externally-used embrocation raw material of the present invention is simple and easy to get, and without the medicine for having infringement property to skin, and application method is simple, easy to learn；And there is good lenitive effect to slight, moderate dysmenorrhoea.
Description
Technical field
The disclosure relates generally to medicine field, and more particularly, to a kind of effective, safety, rapid recovery women
The body surface externally-used embrocation of dysmenorrhoea.
Background technology
Dysmenorrhoea is unmarried young woman's puberty, particularly maiden's first menses phase, the result of most common physiological dysfunction.
Dysmenorrhoea has had a strong impact on the physiology and mental health of young woman, periodically influence work and study.Alleviate the shadow of dysmenorrhoea
Ringing has obvious social effect.But, effective, safety, the effective means of rapid recovery menstrual period pain are still lacked at present.
The dysmenorrhoea occurrence cause of physiological is complicated, it is now recognized that the topmost reason of dysmenorrhea is that endocrine is different
Often, as luteal phase progesterone is raised or prostaglandin E2 (PGE2) too high levels of endometrium or palace blood neutron.Obviously dysmenorrhoea
Cause be uterus a kind of inflammatory process, the exaggerated reflex release that nervous system participates in inflammatory cytokine is that it is main former
Cause.In addition, stress, hyperalgia constitution, uterine contraction excessively or uterus structure sexual abnormality all can be through interim induction dysmenorrhoea.Bitterly
Through lower abdomen can be induced in paroxysmal distending pain or Crampy Pain and with symptoms such as Nausea and vomitings, or even the serious disease such as collapse can be induced
Shape.Pain is sustainable to be up to 48-72 hours.
Dysmenorrhoea carrys out pain of alleviation often through antalgesic is taken, and psychotherapy is also tried out in the recent period, Chinese medicine or acupuncture is taken
It is also conventional method, still, a kind for the treatment of method developed according to its pathogenic factor is not still found at present.
The content of the invention
Basic research of the invention according to neuro-physiology, based on the specific nerve fibre from skin to deep tissue
The related afferent nerve activity of course inflammatory activity has the research of regulating and controlling effect, develops the inflammation for the regulation and control uterus menstrual cycle
The external used medicine of the secretory activity of cell factor, the dysmenorrhoea process of specific alleviation menstrual cycle.
According to the present invention there is provided a kind of body surface externally-used embrocation for alleviating dysmenorrhoea, the body surface externally-used embrocation includes following weight
The material composition of number：Dimethyl sulfoxide (DMSO) 3-6 parts by weight, mustard oil 3-6 parts by weight, pepper element 0.1-0.2 parts by weight, anhydrous second
Alcohol 85-95 parts by weight.
In one embodiment of the invention, body surface externally-used embrocation includes the material composition of following parts by weight：Dimethyl
Sulfoxide 3-5 parts by weight, mustard oil 3-5 parts by weight, pepper element 0.15-0.2 parts by weight, absolute ethyl alcohol 85-90 parts by weight.
In another embodiment of the present invention, body surface externally-used embrocation includes the material composition of following parts by weight：Diformazan
The parts by weight of base sulfoxide 5, the parts by weight of mustard oil 5, pepper 0.15 parts by weight of element, the parts by weight of absolute ethyl alcohol 90.
Further, dimethyl sulfoxide (DMSO) and absolute ethyl alcohol used in the present invention are that chemistry is pure；Mustard oil and the pepper
Element is food-grade.
Further, body surface externally-used embrocation of the invention is light yellow transparent liquid.
The major function of each raw material is as follows：Absolute ethyl alcohol is as solvent；DMSO (dimethyl sulfoxide (DMSO)) is enhancing skin
Transparency；Mustard oil is the stimulant for the nerve fibre (C- fibers) that pain signal is transmitted as skin；Pepper element is also thorn
Swash the stimulant of C- fibers.The mixture of above-mentioned raw materials is to promote quickly to activate the incoming electrical activity of C- fibers tip generation, to branch
The afferent activity of C- fibers with uterus produces quick inhibitory action.
According to the present invention there is provided a kind of preparation method of body surface externally-used embrocation as above, including according to parts by weight by two
Methyl sulfoxide, mustard oil and pepper element are dissolved in the step in absolute ethyl alcohol.
In one embodiment of the invention, method of the invention is comprised the steps of：
1) mustard oil and pepper element are added and mixed liquor is mixed into dimethyl sulfoxide (DMSO) according to above-mentioned parts by weight；
2) absolute ethyl alcohol is added in mixed liquor, and is stirred simultaneously using magnetic stirring apparatus until being formed yellowish transparent
Liquid, obtain body surface externally-used embrocation, the stimulation taste of certain alcohol can be had by being heard with nose.
Further, step 2) magnetic stirring apparatus be stirred at 20-26 DEG C, mixing speed is 500-1000rpm.
The application method of the body surface externally-used embrocation of the present invention：This paint is used to alleviate mild or moderate dysmenorrhoea, and application method is as follows：
During the dysmenorrhoea occurred in the menstrual period, navel is applied directly to this paint to lower abdomen median line skin region (the most benefit of pubis
Smeared in clinostatism), even spread, is gently massaged, medicine is dried quickly with swab by each half milliliter to 1 milliliter.Smear position not
The patches such as adhesive plaster are covered, also should not be locally using hot-water bottle or electric kettle heating or insolation under sunlight.Coating process is avoided
Medicine touches the skin of breakage, eyes or mucous membrane, to prevent decoction from penetrating into introitus etc., preferably with clinostatism during coating.Medicine
Thing starts display and alleviates dysmenorrhoea effect in 20 to 30 minutes after smearing.
The side effect of the body surface externally-used embrocation of the present invention：This paint is free of the medicine for having infringement property to skin, skin
It is normal phenomenon to produce endurable burning heat sensation using area, is completely eliminated after generally after use 1-2 days.Animal skin excess makes
Pathologic lesion will not be produced with experiment proof.If once indivedual triers belong to very sensitive constitution, serious burn is run into
The allergic reaction such as pain or redness, can stop using and be smeared with warm suds and be cleaned, side effect is generally disappeared quickly.Now one
It wouldn't in a few days be had a bath with hot water, to weaken Burning Pain sense.
The women of more than 16 years old that the body surface externally-used embrocation of the present invention is used for dysmenorrhoea symptom is used, the women category less than 16 years old
Used with caution in non-menstrual period pain person.User if necessary daily can Reusability, but do not exceed 3-4 times daily.Contact medicine
Palm, which finally needs to be cleaned with suds, could contact oral cavity and eyes, otherwise can produce burn feeling.
The body surface externally-used embrocation of the present invention, which should be placed on children, can not touch part.
Beneficial effects of the present invention：
The body surface externally-used embrocation raw material of the present invention is simple and easy to get, without the medicine for having infringement property to skin, and uses
Method is simple, safety；There is good lenitive effect to slight, moderate dysmenorrhoea.
The disclosure summarizes each side of embodiment, and bel not applied to limit claim.According to described herein
Technology, it is contemplated that other implementations, this is for those of ordinary skill in the art by checking that the following drawings and detailed description will
Be it will be apparent that and these implementations be intended within the scope of application.
Brief description of the drawings
Fig. 1 be according to an embodiment of the invention body surface externally-used embrocation to animal ease pain behavior measure；
Fig. 2 is showing for the nerve fibre record experiment of the domination skin of body surface externally-used embrocation according to an embodiment of the invention
It is intended to；
Fig. 3 be according to an embodiment of the invention body surface externally-used embrocation to CFA (complete Freund ' s
Adjuvant, complete Freund's adjuvant) induce deep tissue inflammatory pain C- fiber Afferent Discharges record schematic diagram.
Embodiment
Although the present invention can be implemented in a variety of manners, it is shown in the drawings and will be described below some and show
Example property and non-limiting example, while understanding that the disclosure is considered as that example of the invention is not intended to limit the invention to
Shown specific embodiment.
Embodiment 1
According to the body surface externally-used embrocation of the alleviation dysmenorrhoea of the present embodiment, the material composition of following parts by weight is included：Diformazan
The parts by weight of base sulfoxide 5, the parts by weight of mustard oil 5, pepper 0.15 parts by weight of element, the parts by weight of absolute ethyl alcohol 90.Wherein, dimethyl sulfoxide (DMSO)
It is that chemistry is pure with absolute ethyl alcohol, mustard oil and pepper element are food grade materials.
Mustard oil and pepper element are added and mixed liquor is mixed into dimethyl sulfoxide (DMSO) according to above-mentioned parts by weight；
The absolute ethyl alcohol of above-mentioned parts by weight is added in mixed liquor, and is entered simultaneously using magnetic stirring apparatus at 20-26 DEG C
Row stirring, speed is under 1000rpm, liquid of the stirring up to forming water white transparency obtains body surface externally-used embrocation, being heard with nose to have
The stimulation taste of certain faints.
As shown in figure 1, body surface externally-used embrocation manufactured in the present embodiment is induced into pain behavior to animal deep tissue CFA has
Analgesic activity.Under normal conditions, the support body weight that left and right sides lower limb receive is (to be stood close to identical by animal in body weight
Determined on measuring instrument), so the load-bearing that the body weight that left side lower limb are born subtracts right side lower limb is almost nil (L.-R. ≈ 0).But when a left side
After side injection proinflammatory agent induced pain, then the weight loss that left side limb is born, therefore the body weight born for subtracting right side is less than zero, uses negative value table
Show (L.-R. ＜ 0).* L.vs R.p are represented<0.05., the point explanation with * using paint to region of interest skin region 30 minutes
Afterwards in 130 minutes, the difference that the body weight that left side limb is born subtracts the load-bearing on right side reduces, and is drawn close to zero line, illustrates pain of alleviation,
With statistical significance.
As shown in Fig. 2 optionally inducing C- fibers using body surface externally-used embrocation manufactured in the present embodiment on skin
Tonicity Afferent Discharge, the high exoelectrical reaction of tufted can record for 5 minutes after inducing reaction, paint on probation for the feeler of A- fibers
Reflect the C- fiber tonicity Afferent Discharges of cutaneous pain.
As shown in figure 3, the C- fibers for the deep tissue inflammatory pain that body surface externally-used embrocation manufactured in the present embodiment is induced CFA
The record of Afferent Discharge.The Afferent Discharge frequency of the later C- fibers from deep inflammation tissue of body surface externally-used embrocation prepared by embodiment
Rate gradually weakens.The fiber that this paint of proof implementation body surface can suppress the pain sensation is incoming.This description of test has one in spinal cord
The suppression mechanism of the dorsal root reflex of the incoming C- fibers to deep tissue of individual body surface C- fibers.
Embodiment 2
According to the body surface externally-used embrocation of the alleviation dysmenorrhoea of the present embodiment, the material composition of following parts by weight is included：Diformazan
The parts by weight of base sulfoxide 3, the parts by weight of mustard oil 3, pepper 0.1 parts by weight of element, the parts by weight of absolute ethyl alcohol 85.Wherein, dimethyl sulfoxide (DMSO)
It is that chemistry is pure with absolute ethyl alcohol, mustard oil and pepper element are food grade materials.
Mustard oil and pepper element are added to dimethyl sulfoxide (DMSO) and is mixed into mixed liquor according to above-mentioned parts by weight；
The absolute ethyl alcohol of above-mentioned parts by weight is added in mixed liquor, and is entered simultaneously using magnetic stirring apparatus at 20-26 DEG C
Row stirring, speed is under 800rpm, liquid of the stirring up to forming pale yellow transparent obtains body surface externally-used embrocation, being heard with nose can
There is the stimulation taste of certain faints.
Embodiment 3
According to the body surface externally-used embrocation of the alleviation dysmenorrhoea of the present embodiment, the material composition of following parts by weight is included：Diformazan
The parts by weight of base sulfoxide 6, the parts by weight of mustard oil 6, pepper 0.2 parts by weight of element, the parts by weight of absolute ethyl alcohol 95.Wherein, dimethyl sulfoxide (DMSO)
It is that chemistry is pure with absolute ethyl alcohol, mustard oil and pepper element are food grade materials.
Mustard oil and pepper element are added to dimethyl sulfoxide (DMSO) and is mixed into mixed liquor according to above-mentioned parts by weight；
The absolute ethyl alcohol of above-mentioned parts by weight is added in mixed liquor, and is entered simultaneously using magnetic stirring apparatus at 20-26 DEG C
Row stirring, speed is under 500rpm, liquid of the stirring up to forming water white transparency obtains body surface externally-used embrocation, being heard with nose to have
The stimulation taste of certain alcohol.
Embodiment 4
According to the body surface externally-used embrocation of the alleviation dysmenorrhoea of the present embodiment, the material composition of following parts by weight is included：Diformazan
The parts by weight of base sulfoxide 4, the parts by weight of mustard oil 4, pepper 0.15 parts by weight of element, the parts by weight of absolute ethyl alcohol 88.Wherein, dimethyl sulfoxide (DMSO)
It is that chemistry is pure with absolute ethyl alcohol, mustard oil and pepper element are food grade materials.
Above-mentioned raw materials are dissolved in absolute ethyl alcohol, and the liquid of pale yellow transparent, i.e. body surface external application are fully obtained after dissolving and is applied
Agent, the stimulation taste that can have certain alcohol is heard with nose.Pepper element or Capsaicinoids can be soluble in ethanol and DMSO.
It may occur to persons skilled in the art that, mixing, stirring, dissolving or other promotions commonly used in the art form equal
The other method of even liquid may be incorporated for the present invention, and above-described embodiment is not exhaustive, be merely illustrative to explain
The present invention, rather than limitation of the present invention.
There is the normal individual trial result of dysmenorrhoea symptom：
The body surface externally-used embrocation of embodiments of the invention is respectively used to 48 young womans for suffering from dysmenorrhoea torment,
Smeared with this paint under navel to the skin region (equivalent to the conception vessel area of part channels and collaterals) between pubic symphysis, smearing method is：Month
During dysmenorrhoea through interim generation, be applied directly to this paint navel to pubis lower abdomen median line skin region (preferably at
Clinostatism is smeared), even spread, is gently massaged, medicine is dried quickly with cotton swab by each half milliliter to 1 milliliter.Smearing position should not
The patches such as adhesive plaster are covered, also locally should not heat or be exposed to the sun under sunlight using hot-water bottle or electric kettle.Smearing process avoids medicine
Thing touches the skin of breakage, eyes or mucous membrane, to prevent decoction from penetrating into introitus etc., preferably with clinostatism during coating.Medicine
Start display after smearing in 20 to 30 minutes and alleviate dysmenorrhoea effect.Effective analgesic effect can be also obtained in 20 minutes, is being had
Human test's description of test of limit, subject's almost decrease process of subjective description pain without any exception.
Above-described embodiment is the possibility example realized, and proposed only for the principle of the present invention is expressly understood.Can
Changed and modifications with carrying out many to above-described embodiment in the case where not departing from the spirit and principle of techniques described herein.
All modifications are intended to be included in the scope of the present disclosure and are protected by the appended claims.
Claims (8)
1. a kind of body surface externally-used embrocation for alleviating dysmenorrhoea, it is characterised in that the body surface externally-used embrocation includes following parts by weight
Material composition：Dimethyl sulfoxide (DMSO) 3-6 parts by weight, mustard oil 3-6 parts by weight, pepper element 0.1-0.2 parts by weight, absolute ethyl alcohol
85-95 parts by weight.
2. body surface externally-used embrocation according to claim 1, it is characterised in that the body surface externally-used embrocation includes following weight
The material composition of number：Dimethyl sulfoxide (DMSO) 3-5 parts by weight, mustard oil 3-5 parts by weight, pepper element 0.15-0.2 parts by weight are anhydrous
Ethanol 85-90 parts by weight.
3. body surface externally-used embrocation according to claim 1, it is characterised in that the body surface externally-used embrocation includes following weight
The material composition of number：The parts by weight of dimethyl sulfoxide (DMSO) 5, the parts by weight of mustard oil 5, pepper 0.15 parts by weight of element, the weight of absolute ethyl alcohol 90
Measure part.
4. the body surface externally-used embrocation according to any one of claim 1-3, it is characterised in that the dimethyl sulfoxide (DMSO) and institute
It is that chemistry is pure to state absolute ethyl alcohol；The mustard oil and the pepper are plain for food-grade.
5. body surface externally-used embrocation according to claim 4, it is characterised in that the body surface externally-used embrocation is pale yellow transparent
Liquid.
6. a kind of preparation method of the body surface externally-used embrocation any one of claim 1-5, it is characterised in that including according to
Dimethyl sulfoxide (DMSO), mustard oil and pepper element are dissolved in the step in absolute ethyl alcohol by parts by weight.
7. preparation method according to claim 6, is comprised the steps of：
1) mustard oil and pepper element are added and mixed liquor is mixed into dimethyl sulfoxide (DMSO) according to above-mentioned parts by weight；
2) absolute ethyl alcohol is added in the mixed liquor, while being stirred using magnetic stirring apparatus until forming pale yellow transparent
Liquid, obtain body surface externally-used embrocation.
8. preparation method according to claim 7, it is characterised in that the step 2) magnetic stirring apparatus at 20-26 DEG C
Under be stirred, mixing speed is 500-1000rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710326611.9A CN107050123B (en) | 2017-05-10 | 2017-05-10 | Body surface external application liniment for relieving dysmenorrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710326611.9A CN107050123B (en) | 2017-05-10 | 2017-05-10 | Body surface external application liniment for relieving dysmenorrhea |
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| Publication Number | Publication Date |
|---|---|
| CN107050123A true CN107050123A (en) | 2017-08-18 |
| CN107050123B CN107050123B (en) | 2020-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710326611.9A Active CN107050123B (en) | 2017-05-10 | 2017-05-10 | Body surface external application liniment for relieving dysmenorrhea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652708A (en) * | 2022-03-07 | 2022-06-24 | 宁波奇致年华医疗科技有限公司 | Composition for treating deep tissue pain |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421694A (en) * | 2016-09-27 | 2017-02-22 | 辽宁中医药大学附属医院 | Externally used Chinese herba preparation for treating dysmenorrhea |
-
2017
- 2017-05-10 CN CN201710326611.9A patent/CN107050123B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421694A (en) * | 2016-09-27 | 2017-02-22 | 辽宁中医药大学附属医院 | Externally used Chinese herba preparation for treating dysmenorrhea |
Non-Patent Citations (3)
| Title |
|---|
| 王浴生等: "《中药药理与应用》", 30 September 1983, 人民卫生出版社 * |
| 罗超权等: "《英汉生物化学与分子医学词典》", 31 January 2004, 中国医药科技出版社 * |
| 胡敏: "《选对食材健康100分》", 31 October 2010, 中国轻工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652708A (en) * | 2022-03-07 | 2022-06-24 | 宁波奇致年华医疗科技有限公司 | Composition for treating deep tissue pain |
| CN114652708B (en) * | 2022-03-07 | 2024-04-26 | 宁波奇致年华医疗科技有限公司 | Composition for treating deep tissue pain |
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| CN107050123B (en) | 2020-08-11 |
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Denomination of invention: A topical coating for relieving dysmenorrhea Effective date of registration: 20230713 Granted publication date: 20200811 Pledgee: Ji'an Jingkai District Xiaowei sub branch of Jiujiang Bank Co.,Ltd. Pledgor: JI'AN CHEUNG KONG BIO-PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980048466 |