CN108403797A - A kind of warm abdomen patch and preparation method thereof - Google Patents
A kind of warm abdomen patch and preparation method thereof Download PDFInfo
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- CN108403797A CN108403797A CN201810460325.6A CN201810460325A CN108403797A CN 108403797 A CN108403797 A CN 108403797A CN 201810460325 A CN201810460325 A CN 201810460325A CN 108403797 A CN108403797 A CN 108403797A
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- ethyl alcohol
- abdomen
- pain
- volatile oil
- precipitation
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- 210000001015 abdomen Anatomy 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 34
- 229940079593 drug Drugs 0.000 claims abstract description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 22
- 241000522254 Cassia Species 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 74
- 235000019441 ethanol Nutrition 0.000 claims description 35
- 239000000341 volatile oil Substances 0.000 claims description 22
- 238000010828 elution Methods 0.000 claims description 19
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 10
- 235000019477 peppermint oil Nutrition 0.000 claims description 10
- 238000001556 precipitation Methods 0.000 claims description 10
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 8
- 238000012869 ethanol precipitation Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 239000011787 zinc oxide Substances 0.000 claims description 8
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 7
- 238000002604 ultrasonography Methods 0.000 claims description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000003647 oxidation Effects 0.000 claims description 2
- 238000007254 oxidation reaction Methods 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 235000014692 zinc oxide Nutrition 0.000 claims description 2
- 238000010792 warming Methods 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 27
- 230000036407 pain Effects 0.000 abstract description 27
- 239000008280 blood Substances 0.000 abstract description 10
- 210000004369 blood Anatomy 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 3
- 239000006071 cream Substances 0.000 description 11
- 206010013935 Dysmenorrhoea Diseases 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 9
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- 238000000926 separation method Methods 0.000 description 6
- 208000004998 Abdominal Pain Diseases 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000003821 menstrual periods Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 241000227129 Aconitum Species 0.000 description 3
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- 238000003825 pressing Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 240000007890 Leonurus cardiaca Species 0.000 description 2
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
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- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
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- 238000007872 degassing Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000009274 endometriosis of uterus Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention belongs to health care drug fields, and in particular to a kind of warm abdomen posts agent and preparation method thereof.The mass ratio of the warm abdomen posts agent, each bulk pharmaceutical chemicals folium artemisiae argyi used, radix aconiti lateralis preparata and Chinese cassia tree is 8 10：4‑5：0.5‑1.The radix aconiti lateralis preparata that is used in the present invention, Chinese cassia tree and folium artemisiae argyi cooperate, and effect brings out the best in each other, and can effectively treat the qi and blood cold of insufficiency type, the waist abdomen pain when moon caused by Gong Leng stagnates is premenstrual and passes through.
Description
Technical field
The invention belongs to health care drug fields, and in particular to a kind of warm abdomen posts agent and preparation method thereof.
Background technology
Dysmenorrhoea is one of most common gynaecology's symptom, refers to before and after passing through or lower abdominal pain, falling inflation occurs in the menstrual period, with
The soreness of waist or other uncomfortable, serious symptom influence quality of life persons.Dysmenorrhoea is divided into primary dysmenorrhea and secondary two class, primary pain
Through referring to dysmenorrhoea of the reproductive organs without organic disease；Acquired dysmenorrhea refers to by pelvic cavity organic disease, as endometriosis,
Dysmenorrhoea caused by adenomyosis etc..
Chinese medicine thinks that the occurrence of this disease is appointed with punching, the variation of the cyclical physiological of uterus is closely related.Main pathogenesis is heresy
Volt or blood element lose in gas, the physiological change for being more worth the menstrual period front and back wantonly two arteries and veins qi and blood of punching is hurried, leads to the QI-blood circulation of uterus not
Freely, " not general rule pain " or uterus lose in supporting, " not Rong Ze pains ", therefore dysmenorrhoea is made to break out.The common type of dysmenorrhoea has kidney qi to lose
Damage, deficient qi and blood, qi depression to blood stasis, cold blood stasis and damp-heat accumulation.
There are similar externally applied drug, such as moxa-moxibustion to the treatment of this illness at present.Moxa-moxibustion is very traditional quality method, is lighted
Moxa stick toasts around patient's navel, is goed deep into using local pyrexia after baking internal, promotes blood circulation, and mitigates abdominal pain.But it ends
Moxibustion is inconvenient for use, and the place in relatively secret is needed to use, when use patient cannot activity simultaneously or work, it is also not portable
Band.
Invention content
The technical problem to be solved in the present invention is, provides a kind of warm abdomen posts agent, for dysmenorrheal caused by qi stagnation and blood stasis, has and lives
The effect of blood stagnation resolvation, promoting qi circulation and relieving pain, and therapeutic effect is fast, toxic side effect is small, easy to use.
The present invention also provides a kind of preparation methods of above-mentioned warm abdomen posts agent, and this method is simple, and production efficiency is high, technique ginseng
Number is easily controllable, and production process is pollution-free.
In order to solve the above technical problems, the technical solution adopted in the present invention is as follows：
The mass ratio of a kind of warm abdomen posts agent, each bulk pharmaceutical chemicals folium artemisiae argyi used, radix aconiti lateralis preparata and Chinese cassia tree is 8-10：4-5：0.5-1.
A kind of preparation method of above-mentioned warm abdomen posts agent, which is characterized in that prepared using following steps：
（1）Each bulk pharmaceutical chemicals are weighed by the parts by weight；
（2）Weigh step（1）Each bulk pharmaceutical chemicals add 10 times of water, and carrying out conjunction with double extraction methods carries, extraction time 2h, extraction
3 times, collect extracting solution and volatile oil；
（3）By step（2）The extracting solution is concentrated into liquid than 1.5:After 1, with 80% ethanol precipitation, 24 hours are stood, point
From, ethyl alcohol is recycled, precipitation is dissolved, adjustment liquor strength to crude drug 0.47g/mL；
（4）By step（3）The precipitation liquid is inhaled by D101 large pore resin absorption columns into Mobile state with the flow velocity of 2BV/h
It is attached, first use the pure water elutions of 2BV, then use 60% ethanol elutions of 9BV, elution speed is 2BV/h, collect alcohol eluen, recycle
Ethyl alcohol obtains dry powder drug；
（5）On the basis of the dosage of pressure sensitive adhesive, the raw material of following parts by weight is weighed：Absolute ethyl alcohol is 80%, glycerine 12%, oxidation
Zinc is 3% ,+5% peppermint oil of 3% azone, 12% drug extract and corresponding volatile oil）, by prescription, mixing, ultrasound are de- in order
It after gas 5min, is uniformly coated on backing, 55 DEG C of dry 42h；
Wherein, the pressure sensitive adhesive, absolute ethyl alcohol, glycerine, zinc oxide, azone, peppermint oil are auxiliary material.
In the present invention, radix aconiti lateralis preparata and Chinese cassia tree are a pair of of partners, and monkshood is the yang aspect of yang, and property is floating without heavy, with walking
Without keeping, the current twelve regular channels.Chinese cassia tree specially mends fire from the gater of life, keeps without walking, wonderful more to draw kidney fire downlink, to pacify kidney
It is dirty.Monkshood obtains the property that Chinese cassia tree stands fast at the gate of vitality, cannot be leapt though passage three is burnt；Chinese cassia tree obtains wandering away for monkshood, and heavy except internal organs is trembled with fear,
Fainting for three cokes is inverse, and temperature compensation is without dull.The two was not only walked but also was kept, and the two matches, and is perfect pair, brings out the best in each other.Above three taste
Compatibility of drugs, except abdomen product is cold, the gynaecology that dispels is cold to imitate with fixed attention.
Advantageous effect
（1）Radix aconiti lateralis preparata, Chinese cassia tree and the folium artemisiae argyi used in the present invention cooperates, and effect brings out the best in each other, and can effectively treat asthenia of qi and blood
Waist abdomen pain when the moon is premenstrual caused by cold, Gong Leng stagnates and passes through.
（2）This preparation has easy to carry compared with traditional puncture, and easy to use, when use does not influence work, will not
A large amount of dense smoke pollution environment is generated, patient will not be caused to come to harm because of baking time and distance, abdomen can be pasted for a long time,
Progressively reach warm middle cold extermination, the purpose of dredging the channel, to alleviate and eliminate pain.
（3）This preparation production technique is simple, and production efficiency is high, and technological parameter is easily controllable, and production process is pollution-free.
Specific implementation mode
With reference to specific embodiment come through one description the present invention, the advantages and features of the present invention will be with description and
It is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.People in the art
Member is it should be understood that can be to the details and shape of technical solution of the present invention in the case where buying the spirit and scope of that without departing from this hair
Formula is modified or is replaced, but these modifications and replacement each fall within protection scope of the present invention.
Embodiment 1
Take folium artemisiae argyi 10g, radix aconiti lateralis preparata 5g, Chinese cassia tree 1g.Add 10 times of water, carrying out conjunction with double formulations carries, and extraction time 2h is extracted 3 times,
Extracting solution and volatile oil are collected, wherein the volatile oil extracted is 0.1ml, spare, extracting solution is concentrated into liquid than 1.5:After 1, use
80% ethanol precipitation stands 24 hours, separation, and precipitation solution recycles ethyl alcohol to no alcohol taste, and concentrate adjustment concentration is to being equivalent to crude drug
0.47g/mL；Dynamic Adsorption is carried out by preprocessed good D101 large pore resin absorption columns with the flow velocity of 2BV/h, is first used
The pure water elutions of 2BV, then with 60% ethanol elutions of 9BV, elution speed is 2BV/h, aqueous abandons, and collects alcohol eluen, returns
It receives ethyl alcohol and continues dry dry powder drug 0.92g；Pressure sensitive adhesive 5g, absolute ethyl alcohol 4g, glycerine 0.6g, zinc oxide 0.15g are taken,
0.15g azones, 0.25g peppermint oils, 0.54g drugs extract dry powder and 0.06ml volatile oil, and above-mentioned raw materials mixing in order surpasses
Sound deaerates after 5min, is spread evenly across on backing, 55 DEG C of dry 42h.
This is two doses of patches, and cream face viscosity is suitable, and adhesion is appropriate, and pressing lightly on can paste, and is noticed conveniently, no skin
Sense is torn, takes rear skin surface off without any residue.It sticks rear patient feeling in great pain gradually to mitigate, ache after 12 hours
The anesthesia of pain.Patient does as usual movable during sticking, and does not interfere any life or work.
Embodiment 2
Folium artemisiae argyi 8g, radix aconiti lateralis preparata 4g, Chinese cassia tree 0.5g are taken, 10 times of water are added, carrying out conjunction with double formulations carries, extraction time 2h, extraction 3
It is secondary, extracting solution and volatile oil are collected, wherein the volatile oil extracted is 0.1ml, spare, extracting solution is concentrated into liquid than 1.5:After 1,
With 80% ethanol precipitation, 24 hours are stood, separation, precipitation solution recycles ethyl alcohol to no alcohol taste, and concentrate adjustment concentration is to being equivalent to life
Medicine 0.47g/mL；Dynamic Adsorption is carried out by preprocessed good D101 large pore resin absorption columns with the flow velocity of 2BV/h, is first used
The pure water elutions of 2BV, then with 60% ethanol elutions of 9BV, elution speed is 2BV/h, aqueous abandons, and collects alcohol eluen, returns
It receives ethyl alcohol and continues dry dry powder drug 0.69g；Pressure sensitive adhesive 5g, absolute ethyl alcohol 4g, glycerine 0.6g, zinc oxide 0.15g are taken,
0.15g azones, 0.25g peppermint oils, 0.54g drugs extract dry powder and 0.06ml volatile oil, and above-mentioned raw materials mixing in order surpasses
Sound deaerates after 5min, is spread evenly across on backing, 55 DEG C of dry 42h.
This is two doses of patches, and cream face viscosity is suitable, and adhesion is appropriate, and pressing lightly on can paste, and is noticed conveniently, no skin
Sense is torn, takes rear skin surface off without any residue.Patient takes a patch patch to remove isolation film, by cream face paste in navel, patch
Patient's feeling in great pain gradually mitigates after applying, and the feeling of pain disappears substantially after 12 hours.Patient lives as usual during sticking
It is dynamic, any life or work are not interfered.
Comparative example
Comparative example 1
Folium artemisiae argyi 10g, radix aconiti lateralis preparata 3g, Chinese cassia tree 1g are taken, 10 times of water are added, carrying out conjunction with double formulations carries, and extraction time 2h is extracted 3 times,
Collect extracting solution and volatile oil.The volatile oil 0.1ml wherein extracted, spare, extracting solution is concentrated into liquid than 1.5:After 1, with 80%
Ethanol precipitation stands 24 hours, separation, and precipitation solution recycles ethyl alcohol to no alcohol taste, and concentrate adjustment concentration is to being equivalent to crude drug
0.47g/mL；Dynamic Adsorption is carried out by preprocessed good D101 large pore resin absorption columns with the flow velocity of 2BV/h, is first used
The pure water elutions of 2BV, then with 60% ethanol elutions of 9BV, elution speed is 2BV/h, aqueous abandons, and collects alcohol eluen, returns
It receives ethyl alcohol and continues dry dry powder drug 0.81g；Pressure sensitive adhesive 5g, absolute ethyl alcohol 4g, glycerine 0.6g, zinc oxide 0.15g are taken,
0.15g azones, 0.25g peppermint oils, 0.54 drug extract dry powder and 0.06ml volatile oil, by above-mentioned raw materials mixing in order,
After ultrasound degassing 5min, it is spread evenly across on backing, 55 DEG C of dry 42h.
This is two doses of patches, and cream face viscosity is suitable, and adhesion is appropriate, and pressing lightly on can paste, and is noticed conveniently, no skin
Sense is torn, takes rear skin surface off without any residue.Patient takes a patch patch to remove isolation film, by cream face paste in navel, patch
Patient's feeling in great pain gradually mitigates after medication 6h after applying, but it is slow to disappear, and above for 24 hours could need to substantially disappear.Patch
Patient does as usual movable during applying, and does not interfere any life or work.
Comparative example 2
Take folium artemisiae argyi 10g, radix aconiti lateralis preparata 5g, Chinese cassia tree 1g.Add 10 times of water, carrying out conjunction with double formulations carries, and extraction time 2h is extracted 3 times,
Collect extracting solution and volatile oil.The volatile oil wherein extracted is 0.1ml, and spare, extracting solution is concentrated into liquid than 1.5:After 1, use
80% ethanol precipitation stands 24 hours, separation, and precipitation solution recycles ethyl alcohol to no alcohol taste, continues dry dry powder drug 1.53g；It takes
Pressure sensitive adhesive 5g, absolute ethyl alcohol 4g, glycerine 0.6g, zinc oxide 0.15g, 0.15g azone, 0.25g peppermint oils, the extraction of 0.6g drugs
Object dry powder and 0.06ml volatile oil, by above-mentioned raw materials, mixing, ultrasound deaerate after 5min, are spread evenly across on backing, 55 in order
DEG C dry 42h.
This is two doses of patches, and appearance is good, and cream face viscosity is larger, and taking rear skin surface off has lotion residual, it has not been convenient to take off
Note.Patient takes patch patch removal isolation film to stick rear patient feeling in great pain after medication by cream face paste in navel
Gradually mitigate within 12 hours, the feeling of pain disappears substantially after 26 hours.
Comparative example 3
Take folium artemisiae argyi 10g, motherwort 10g, Chinese cassia tree 1g
With double formulations close and carry, extraction time 2h is extracted 3 times, extracting solution and volatile oil is collected, wherein the volatile oil extracted
Spare for 0.1ml, extracting solution is concentrated into liquid than 1.5:After 1, with 80% ethanol precipitation, 24 hours are stood, separation, precipitation solution is returned
Ethyl alcohol is received to no alcohol taste, concentrate adjustment concentration is to being equivalent to crude drug 0.47g/mL；Passed through with the flow velocity of 2BV/h preprocessed
Good D101 large pore resin absorption columns carry out Dynamic Adsorption, first use the pure water elutions of 2BV, then use 60% ethanol elutions of 9BV, elute
Speed is 2BV/h, and aqueous abandons, and collects alcohol eluen, recycles ethyl alcohol and continues dry dry powder drug 1.24g；Pressure is quick
Glue 5g, absolute ethyl alcohol 4g, glycerine 0.6g, zinc oxide 0.15g, 0.15g azone, 0.25g peppermint oils, 0.54g drug extracts
Dry powder and 0.06ml volatile oil, by above-mentioned raw materials, mixing, ultrasound deaerate after 5min, are spread evenly across on backing, 55 DEG C in order
Dry 42h.
This is two doses of patches, and appearance is good, and cream face viscosity is larger, takes rear skin surface off and is remained without lotion, nothing tears sense
.Patient takes patch patch removal isolation film to stick rear patient feeling in great pain in medication 8 hours by cream face paste in navel
It there is no and mitigate sign
Comparative example 4
Take motherwort 10g, safflower 5g, peach kernel 1g
With double formulations close and carry, extraction time 2h is extracted 3 times, collects extracting solution and volatile oil.The volatile oil wherein extracted
Spare for 0.1ml, extracting solution is concentrated into liquid than 1.5:After 1, with 80% ethanol precipitation, 24 hours are stood, separation, precipitation solution is returned
Ethyl alcohol is received to no alcohol taste, concentrate adjustment concentration is to being equivalent to crude drug 0.47g/mL；Passed through with the flow velocity of 2BV/h preprocessed
Good D101 large pore resin absorption columns carry out Dynamic Adsorption, first use the pure water elutions of 2BV, then use 60% ethanol elutions of 9BV, elute
Speed is 2BV/h, and aqueous abandons, and collects alcohol eluen, recycles ethyl alcohol and continues dry dry powder drug 0.91g；Pressure is quick
Glue 5g, absolute ethyl alcohol 4g, glycerine 0.6g, zinc oxide 0.15g, 0.15g azone, 0.25g peppermint oils, 0.54g drug extracts
Dry powder and 0.06ml volatile oil, by above-mentioned raw materials, mixing, ultrasound deaerate after 5min, are spread evenly across on backing, 55 DEG C in order
Dry 42h.
This is two doses of patches, and appearance is good, and cream face viscosity is larger, takes rear skin surface off and is remained without lotion, is noticed conveniently
.Patient takes patch patch removal isolation film to stick the mark that rear patient feeling in great pain does not mitigate by cream face paste in navel
As the mitigation of symptom is unrelated with medication.Numerical example experimenter's menstrual cycle internal haemorrhage amount increases.
1 object and method
1.1 case selections and grouping
180 patients are chosen, the clinical test of invention formulation is carried out, this 180 patient ages are 18-25 Sui, random point
It is 6 groups, respectively 1 group of embodiment, 2 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example, 4 groups of comparative example.
1.2 diagnostic criteria
Diagnostic criteria reference《Gynecology of Chinese Medicine》In diagnostic criteria make a definite diagnosis.Dysmenorrhoea is that women renovates menstrual period or menstrual period front and back appearance
Periodical underbelly pain or even severe pain cause syncope person, and just as mammary swelling, trick be not ice-cold etc. with other, so that shadow
Ring work and life.Married woman's gynecologial examination, unmarried female send reproductive organs organic disease through B-mode ultrasonography.
According to《New Chinese medicine guideline of clinical investigations》Pain degree point is light, in, weigh 3 grades（Ministry of Health of the People's Republic of China.It is important
Clinical Researches of New Drugs guideline：1st volume of [S] .1993:252）.
1.3 therapy
Abdominal pain, which starts to stick warm abdomen at navel position, pastes.It exchanges cards with personal and family details when becoming sworn brothers within two days primary
1.4 the results are shown in Table 1
Model case clinical effectiveness
Case one：Female, 20 years old, menstruation rule, menstruation first day and second day lower abdomen abdomen spasm, pain, gastric disorder causing nausea was dizzy, waist
Pain, needs to lie in bed, and it is invalid to buy antalgica by oneself, can through amount.Menstruation daystart docile warms up abdomen patch, same day pain relief.
Case two：Female, 22 years old, premenstrua abdomen dropped, ice-cold, pain, Low Back Pain, and hot-water bag hot compress can be alleviated, menses
Lumpy, color depth.Other treatment is not done.The docile that premenstrual abdominal pain starts warms up abdomen patch, and same day pain relief continues to stick, and clot subtracts
Few, discoloration is red.
Case three：Female, 19 years old, premenstruum (premenstrua) dizziness vomiting, the pain of lower abdomen, trick was ice-cold, pain in the back.Bellyache in menstrual period starts to stick warm
Abdomen pastes, and the ice-cold phenomenon of trick improves, and abdominal pain mitigates, and pain in the back mitigates, and vomiting sense mitigates.
The foregoing is merely the preferred embodiment of the present invention, are merely illustrative for the purpose of the present invention, and not restrictive；
Those of ordinary skill in the art understand, in the spirit and scope defined by the claims in the present invention can to carrying out many changes,
Modification or even equivalent change, but fall in protection scope of the present invention.
Claims (2)
1. a kind of warm abdomen posts agent, which is characterized in that the mass ratio of each bulk pharmaceutical chemicals folium artemisiae argyi used, radix aconiti lateralis preparata and Chinese cassia tree is 8-10：4-
5：0.5-1.
2. warming up the preparation method of abdomen posts agent described in a kind of claim 1, which is characterized in that prepared using following steps：
（1）Each bulk pharmaceutical chemicals are weighed by the parts by weight；
（2）Weigh step（1）Each bulk pharmaceutical chemicals add 10 times of water, and carrying out conjunction with double extraction methods carries, extraction time 2h, extraction
3 times, collect extracting solution and volatile oil；
（3）By step（2）The extracting solution is concentrated into liquid than 1.5：After 1, with 80% ethanol precipitation, 24 hours are stood, point
From, ethyl alcohol is recycled, precipitation is dissolved, adjustment liquor strength to crude drug 0.47g/mL；
（4）By step（3）The precipitation liquid is inhaled by D101 large pore resin absorption columns into Mobile state with the flow velocity of 2BV/h
It is attached, first use the pure water elutions of 2BV, then use 60% ethanol elutions of 9BV, elution speed is 2BV/h, collect alcohol eluen, recycle
Ethyl alcohol obtains dry powder drug；
（5）On the basis of the dosage of pressure sensitive adhesive, the raw material of following parts by weight is weighed：Absolute ethyl alcohol is 80%, glycerine 12%, oxidation
Zinc is 3% ,+5% peppermint oil of 3% azone, 12% drug extract and corresponding volatile oil）, by prescription, mixing, ultrasound are de- in order
It after gas 5min, is uniformly coated on backing, 55 DEG C of dry 42h；
Wherein, the pressure sensitive adhesive, absolute ethyl alcohol, glycerine, zinc oxide, azone, peppermint oil are auxiliary material.
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| CN109481537A (en) * | 2018-11-02 | 2019-03-19 | 无锡华粹堂健康管理有限公司 | A kind of Moxibustion strip and preparation method thereof |
Citations (1)
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|---|---|---|---|---|
| KR20170082962A (en) * | 2016-01-07 | 2017-07-17 | 랜기어 테크놀로지 컴퍼니 리미티드 | A chinese medicine for treating cold pathogen stomach |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20170082962A (en) * | 2016-01-07 | 2017-07-17 | 랜기어 테크놀로지 컴퍼니 리미티드 | A chinese medicine for treating cold pathogen stomach |
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| HTTP://WWW.360DOC.COM/CONTENT/14/1112/10/3218641_424672324.SHTML: "附子配伍汇粹", 《无》 * |
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| CN109481537A (en) * | 2018-11-02 | 2019-03-19 | 无锡华粹堂健康管理有限公司 | A kind of Moxibustion strip and preparation method thereof |
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