CN104162026A - Traditional Chinese medicine composition treating hypertension and preparation method thereof - Google Patents
Traditional Chinese medicine composition treating hypertension and preparation method thereof Download PDFInfo
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- CN104162026A CN104162026A CN201410371943.5A CN201410371943A CN104162026A CN 104162026 A CN104162026 A CN 104162026A CN 201410371943 A CN201410371943 A CN 201410371943A CN 104162026 A CN104162026 A CN 104162026A
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Abstract
The invention provides a traditional Chinese medicine composition treating hypertension and a preparation method thereof. The traditional Chinese medicine composition comprises radix puerariae, radix angelicae pubescentis, anemarrhena, cassia twig, dandelion, caulis polygoni multiflori, semen euryales, radix rehmanniae preparata, rhizoma phragmitis, ramulus uncariae cum uncis, herba lysimachiae, poria cocos, bamboo leaf, radix et rhizoma rhei, medulla junci, radix glycyrrhizae, radix scutellariae, radix astragali, drgon's bone, radix saposhnikoviae, spica prunellae, folium mori, flos chrysanthemi and apocynum venetum. The preparation method comprises firstly using ethanol to perform extraction on radix puerariae, radix angelicae pubescentis, anemarrhena, cassia twig and dandelion to obtain an extractive I, boiling caulis polygoni multiflori, semen euryales, radix rehmanniae preparata, rhizoma phragmitis, ramulus uncariae cum uncis, herba lysimachiae and poria cocos with water to obtain an extractive II, and using ethanol to perform extraction on bamboo leaf, radix et rhizoma rhei, medulla junci, radix glycyrrhizae, radix scutellariae and radix astragali to obtain an extractive III, then crushing the residual compositions to obtain a fine powder, mixing the extractive I, the extractive II, the extractive III and the fine powder to prepare a paste powder, and preparing an oral dosage form from the paste powder. The traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, is free of toxic and side effects and has substantial hypertension-reducing effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of hypertensive Chinese medicine composition and preparation method thereof for the treatment of.
Background technology
Hypertension is the modal cardiovascular disease in the world, is also one of maximum epidemic diseases, often causes the complication of the internal organs such as the heart, brain, kidney, and the mankind's health in serious harm.In hypertensive morbidity crowd, old people Geng Yi suffers from this disease, and this is because old people easily increases because blood vessel (tremulous pulse) sclerosis causes the blood flow resistance in blood vessel, thereby compressing small artery smooth muscle increases and generation hypertension its tension force.
Hypertension is that the pressure anomaly in arteries raises, if hypertension can not get controlling timely and effectively, the vital organ of the heart, brain, three Chinese medicines of kidney will be subject to mortality and hit, thereby produces serious complication.Such as, the heart: hypertensive heart disease, coronary heart disease, heart failure; Brain: hypertensive cerebral hemorrhage, cerebral infarction; Kidney: renal failure, uremia.At present the medicament categories of western medical treatment hypertension is a lot, mostly takes diuretic, reduce blood pressure by urinating, but urine is arranged manyly, has just increased the weight of the impaired severity of burden, especially kidney organ of the heart, liver, kidney.
In hypertensive treatment, people are being widely used various Western medicine depressor, though it can meet general blood pressure lowering requirement, but also there is obvious side effect, because Western medicine blood pressure lowering is all to take blood vessel dilating as main, and blood vessel dies down and hardens at continuous process of expansion Elastic, therefore make the people of life-time service depressor easily cause sclerosis of blood vessels and break, and cause the diseases such as cerebral vessels embolism, apoplexy.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and a kind of hypertensive Chinese medicine composition for the treatment of is provided, this Chinese medicine composition can effectively be cleared up rubbish in blood vessel, for blood vessel provides nutrient substance, strengthens blood vessel elasticity, make blood vessel recover normal function, finally make blood pressure recover normal.
Treat hypertensive Chinese medicine composition, in weight portion, comprise: 3～7 parts of Radix Puerariaes, 2～6 parts of Radix Angelicae Pubescentiss, 1～3 part of the Rhizoma Anemarrhenae, 2～5 parts of Ramulus Cinnamomi, 1～5 part of Herba Taraxaci, 2～6 parts of Caulis Polygoni Multiflori, 3～7 parts of Semen Euryaless, 1～4 part of Radix Rehmanniae Preparata, 2～6 parts of Rhizoma Phragmitiss, 3～7 parts of Ramulus Uncariae Cum Uncis, 2～7 parts of Herba Lysimachiaes, 1～5 part, Poria, 3～8 parts, Folium Bambusae, 1～5 part of Radix Et Rhizoma Rhei, 2～7 parts of Medulla Juncies, 1～6 part, Radix Glycyrrhizae, 2～6 parts of Radix Scutellariaes, 3～7 parts of the Radixs Astragali, 2～8 parts of Os Draconis, 1～4 part of Radix Saposhnikoviae, 2～5 parts of Spica Prunellaes, 1～4 part, Folium Mori, 3～8 parts of Flos Chrysanthemis, 2～6 parts of Herba Apocyni venetis.
Radix Puerariae: there is expelling pathogenic factors from muscles for reducing heat, deliver examine, the effect of promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal; Clinical for cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles from the beginning of, rash go out smooth, epidemic febrile disease is thirsty, diabetes, have loose bowels, dysentery, hypertension, coronary heart disease.
Radix Angelicae Pubescentis: modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Platelet aggregation is had to inhibitory action; And there is a hypotensive effect.
The Rhizoma Anemarrhenae: the effect with clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, the relieving restlessness of quenching the thirst; Clinical epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, the stranguria with turbid discharge of quenching one's thirst of curing mainly.
Ramulus Cinnamomi: the effect with expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI; Clinical exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea, mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, the dysuria of curing mainly.
Herba Taraxaci: the effect with heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation; The clinical acute mastitis, lung abscess, acute appendicitis, mumps, furuncle carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, stomach-fire, enteritis, dysentery, hepatitis, gallbladder of curing mainly frightens inflammation, urinary tract infection, snake bite and insect sting.
Caulis Polygoni Multiflori: there is tranquilizing by nourishing the heart, dispel the wind, the effect of dredging collateral; Clinical insomnia, dreaminess, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the rubella pruritus of curing mainly.
Semen Euryales: the effect with reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak; Clinical seminal emission, nebulousurine, stranguria with turbid discharge, leukorrhagia, incontinence of urine, the loose stool and diarrhea of curing mainly.
Radix Rehmanniae Preparata: there is the effect that moist, the beneficial essence of enriching blood is filled out marrow; Clinically cure mainly sallow, the dizzy cardiopalmus of blood tiger, menoxenia, collapse more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, soreness of the waist and knees, Hiccough and deaf, the head are dim-sighted, early whitening of beard and hair, quench one's thirst, constipation, the dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Rhizoma Phragmitis: there is clearing away heat and promoting production of body fluid, relieve restlessness and prevent vomiting, the effect of diuresis, rash; Clinical calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, pyretic stranguria, the measles of curing mainly.
Ramulus Uncariae Cum Uncis: have endogenous wind stopping relieving convulsion, heat clearing away suppressing the hyperactive liver, have the blood vessel of releiving, blood pressure lowering, convulsion, calmly wait effect.
Herba Lysimachiae: there is dampness removing jaundice eliminating, Tonglin Paishi, removing toxic substances and promoting subsidence of swelling, diuresis damp eliminating, rubbish in blood vessel is excreted to effect.
Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming, has diuresis, nourishes blood effect.
Folium Bambusae: the relieving restlessness that clears away heart-fire, inducing diuresis for treating stranguria syndrome, there is the dysphoria with smothery sensation of dispelling, logical blood vessel function.
Radix Et Rhizoma Rhei: heat and toxic materials clearing away, eliminating fire and detoxication, blood circulation promoting and blood stasis dispelling, removing damp-heat, cooling blood for hemostasis, have and rush down lower removing toxic substances, broad-spectrum antiseptic, shortening clotting time, promotion bile and pancreas digestive juice secretion, reduce cholesterol, cleaning blood vessel rubbish (tremulous pulse dirt) purifies blood vessel internal ring border, toxin in blood vessel is excreted, and reach blood pressure lowering spasmolysis.
Medulla Junci: the effect with relieving stranguria by diuresis, clearing heart fire; Clinical curing mainly: gonorrhea, edema, dysuria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, aphtha, wound.
Radix Glycyrrhizae: invigorating the spleen to arrest diarrhea, supplementing the kidney to control the nocturnal, damp eliminating leukorrhagia stopping, Bearberry Extract effect.
The Radix Astragali: the effect with invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing; Clinically cure mainly impractical swollen, the chronic nephritis of the cardiopalmus of breathing hard, asthenia, weak, spontaneous perspiration, night sweat, chronic diarrhea, proctoptosis, uterine prolapse, body, carbuncle is difficult bursts.
Os Draconis: the effect with clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral; Clinically cure mainly acute diseases such as cholera and sunstroke stranguria with turbid discharge, have loose bowels, rheumatic arthralgia, traumatic injury.
Radix Saposhnikoviae: have and deliver, dispel the wind, win effect wet, pain relieving; Clinically cure mainly that anemofrigid cold, flu folder are wet, headache, giddy, cold-damp is suffered from abdominal pain, have loose bowels, rheumatic arthralgia, spasm of the limbs, tetanus, conjunctival congestion, skin infection, hernia abdominal mass, scabies, rubella.
Spica Prunellae: the effect with liver heat removing and eyesight improving, powder detoxifcation; Clinical order also dizzy, the tinnitus of photophobia, ophthalmalgia, headache, scrofula, goiter, acute mastitis, mumps, carbuncle furuncle and phyma poison, acute hepatitis, chronic hepatitis, the hypertension of curing mainly.
Folium Mori: the effect with dispelling wind and heat pathogens, lung heat clearing, improving eyesight; Clinical cure mainly anemopyretic cold, pathogenic wind-warm from the beginning of disturbing on, fever and headache, perspiration and aversion to wind, cough chest pain, dryness of the lung dry cough without phlegm, dry throat and mouth, wind heat and liver-yang, conjunctival congestion and swelling pain.
Flos Chrysanthemi: have dispel the wind, dampness removing, treating stranguria, active effect; Clinical anemopyretic cold, rheumatic arthritis, little passing stool with blood and pus, lithangiuria, the traumatic injury of curing mainly.
Herba Apocyni veneti: the effect with heat clearing away suppressing the hyperactive liver, inducing diuresis to remove edema; Clinical hypertension, dizzy, headache, cardiopalmus, insomnia, the edema urine water of curing mainly.
As the further improvement of foregoing invention, the hypertensive Chinese medicine composition of described treatment, comprises in weight portion: 5 parts of Radix Puerariaes, 3 parts of Radix Angelicae Pubescentiss, 2 parts of the Rhizoma Anemarrhenaes, 4 parts of Ramulus Cinnamomi, 3 parts of Herba Taraxacis, 4 parts of Caulis Polygoni Multiflori, 6 parts of Semen Euryaless, 2 parts of Radix Rehmanniae Preparata, 5 parts of Rhizoma Phragmitiss, 6 parts of Ramulus Uncariae Cum Uncis, 5 parts of Herba Lysimachiaes, 3 parts, Poria, 7 parts, Folium Bambusae, 3 parts of Radix Et Rhizoma Rhei, 4 parts of Medulla Juncies, 5 parts, Radix Glycyrrhizae, 4 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali, 6 parts of Os Draconis, 2 parts of Radix Saposhnikoviaes, 3 parts of Spica Prunellaes, 3 parts, Folium Mori, 6 parts of Flos Chrysanthemis, 5 parts of Herba Apocyni venetis.
The preparation method of the hypertensive Chinese medicine composition of above-mentioned treatment, comprises the following steps:
Step 1, obtains extract I by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci with ethanol extraction; Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria together water boiling obtain extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and the Radix Astragali obtain extract III with ethanol extraction;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, is prepared into cream powder;
Step 4, is prepared into tablet, capsule, granule or oral liquid by step 3 gained cream powder and pharmaceutically acceptable carrier.
Further improvement as foregoing invention: in step 1, Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci are with after ethanol extraction, and alkalization, adds water, and reflux, extract, 1～3h, gets upper strata, except desolventizing, obtain extract I.
As the further improvement of foregoing invention, in step 1, Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria together also add the Alumen of 7～9 weight portions during boiling, and boiling is absolutely dry to water, stops boiling, obtains extract II.
As the further improvement of foregoing invention, in step 1, Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and the Radix Astragali are 40～50 ℃ by the temperature of alcohol steep, lixiviate 1～4 time.
As the further improvement of foregoing invention, the powder of cream described in step 3 is prepared by the method for centrifugal spray, and the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃.
Chinese medicine composition of the present invention can effectively be cleared up blood vessel rubbish (tremulous pulse dirt), dispel blood vessel toxin, purify blood vessel internal medium, vasa vasorum, allow blood vessel recover elasticity, the blood vessel wall lateral pressure that the blood that blood vessel can be cushioned pump from heart causes, thus make step by step blood pressure naturally lower, and do not rebound.Medicine of the present invention is pure Chinese medicinal preparation, has no side effect, and has significant antihypertensive effect.
The specific embodiment
Embodiment 1
Treat hypertensive Chinese medicine composition, in weight portion, comprise: 3 parts of Radix Puerariaes, 2 parts of Radix Angelicae Pubescentiss, 1 part of the Rhizoma Anemarrhenae, 2 parts of Ramulus Cinnamomi, 1 part of Herba Taraxaci, 2 parts of Caulis Polygoni Multiflori, 3 parts of Semen Euryaless, 1 part of Radix Rehmanniae Preparata, 2 parts of Rhizoma Phragmitiss, 3 parts of Ramulus Uncariae Cum Uncis, 2 parts of Herba Lysimachiaes, 1 part, Poria, 3 parts, Folium Bambusae, 1 part of Radix Et Rhizoma Rhei, 2 parts of Medulla Juncies, 1 part, Radix Glycyrrhizae, 2 parts of Radix Scutellariaes, 3 parts of the Radixs Astragali, 2 parts of Os Draconis, 1 part of Radix Saposhnikoviae, 2 parts of Spica Prunellaes, 1 part, Folium Mori, 3 parts of Flos Chrysanthemis, 2 parts of Herba Apocyni venetis.
The preparation method of the hypertensive Chinese medicine composition of above-mentioned treatment, comprises the following steps:
Step 1, by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci, with after ethanol extraction, alkalization, adds water, and reflux, extract, 1～3h, gets upper strata, except desolventizing, obtains extract I; The together water boiling of Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria, wherein adding the water yield is 5 times of Chinese medicinal components weight, also adds the Alumen of 7 weight portions during boiling, boiling is absolutely dry to water, stops boiling, obtains extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and Radix Astragali alcohol steep, temperature is 40～50 ℃, lixiviate 1～4 time, obtains extract III;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, by the method for centrifugal spray, prepares, and the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃, is prepared into cream powder;
Step 4, by step 2) gained cream powder and pharmaceutically acceptable carrier be prepared into tablet.
Embodiment 2
Treat hypertensive Chinese medicine composition, in weight portion, comprise: 4 parts of Radix Puerariaes, 3 parts of Radix Angelicae Pubescentiss, 2 parts of the Rhizoma Anemarrhenaes, 3 parts of Ramulus Cinnamomi, 2 parts of Herba Taraxacis, 3 parts of Caulis Polygoni Multiflori, 4 parts of Semen Euryaless, 2 parts of Radix Rehmanniae Preparata, 3 parts of Rhizoma Phragmitiss, 4 parts of Ramulus Uncariae Cum Uncis, 3 parts of Herba Lysimachiaes, 2 parts, Poria, 4 parts, Folium Bambusae, 3 parts of Radix Et Rhizoma Rhei, 4 parts of Medulla Juncies, 3 parts, Radix Glycyrrhizae, 4 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali, 3 parts of Os Draconis, 2 parts of Radix Saposhnikoviaes, 3 parts of Spica Prunellaes, 2 parts, Folium Mori, 3 parts of Flos Chrysanthemis, 5 parts of Herba Apocyni venetis.
The preparation method of the hypertensive Chinese medicine composition of above-mentioned treatment, comprises the following steps:
Step 1, by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci, with after ethanol extraction, alkalization, adds water, and reflux, extract, 1～3h, gets upper strata, except desolventizing, obtains extract I; The together water boiling of Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria, wherein adding the water yield is 4 times of Chinese medicinal components weight, also adds the Alumen of 7 weight portions during boiling, boiling is absolutely dry to water, stops boiling, obtains extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and Radix Astragali alcohol steep, temperature is 40～50 ℃, lixiviate 1～4 time, obtains extract III;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, by the method for centrifugal spray, prepares, and the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃, is prepared into cream powder;
Step 4, by step 2) gained cream powder and pharmaceutically acceptable carrier be prepared into granule.
Embodiment 3
Treat hypertensive Chinese medicine composition, in weight portion, comprise: 5 parts of Radix Puerariaes, 4 parts of Radix Angelicae Pubescentiss, 3 parts of the Rhizoma Anemarrhenaes, 4 parts of Ramulus Cinnamomi, 2 parts of Herba Taraxacis, 3 parts of Caulis Polygoni Multiflori, 4 parts of Semen Euryaless, 2 parts of Radix Rehmanniae Preparata, 3 parts of Rhizoma Phragmitiss, 4 parts of Ramulus Uncariae Cum Uncis, 3 parts of Herba Lysimachiaes, 2 parts, Poria, 4 parts, Folium Bambusae, 2 parts of Radix Et Rhizoma Rhei, 3 parts of Medulla Juncies, 2 parts, Radix Glycyrrhizae, 3 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali, 4 parts of Os Draconis, 2 parts of Radix Saposhnikoviaes, 4 parts of Spica Prunellaes, 3 parts, Folium Mori, 7 parts of Flos Chrysanthemis, 5 parts of Herba Apocyni venetis.
The preparation method of the hypertensive Chinese medicine composition of above-mentioned treatment, comprises the following steps:
Step 1, by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci, with after ethanol extraction, alkalization, adds water, and reflux, extract, 1～3h, gets upper strata, except desolventizing, obtains extract I; The together water boiling of Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria, wherein adding the water yield is 4 times of Chinese medicinal components weight, also adds the Alumen of 7 weight portions during boiling, boiling is absolutely dry to water, stops boiling, obtains extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and Radix Astragali alcohol steep, temperature is 40～50 ℃, lixiviate 1～4 time, obtains extract III;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, by the method for centrifugal spray, prepares, and the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃, is prepared into cream powder;
Step 4, by step 2) gained cream powder and pharmaceutically acceptable carrier be prepared into tablet.
Embodiment 4
Treat hypertensive Chinese medicine composition, in weight portion, comprise: 7 parts of Radix Puerariaes, 6 parts of Radix Angelicae Pubescentiss, 3 parts of the Rhizoma Anemarrhenaes, 5 parts of Ramulus Cinnamomi, 5 parts of Herba Taraxacis, 6 parts of Caulis Polygoni Multiflori, 7 parts of Semen Euryaless, 4 parts of Radix Rehmanniae Preparata, 6 parts of Rhizoma Phragmitiss, 7 parts of Ramulus Uncariae Cum Uncis, 7 parts of Herba Lysimachiaes, 5 parts, Poria, 8 parts, Folium Bambusae, 5 parts of Radix Et Rhizoma Rhei, 7 parts of Medulla Juncies, 6 parts, Radix Glycyrrhizae, 6 parts of Radix Scutellariaes, 7 parts of the Radixs Astragali, 8 parts of Os Draconis, 4 parts of Radix Saposhnikoviaes, 5 parts of Spica Prunellaes, 4 parts, Folium Mori, 8 parts of Flos Chrysanthemis, 6 parts of Herba Apocyni venetis.
The preparation method of the hypertensive Chinese medicine composition of above-mentioned treatment, comprises the following steps:
Step 1, by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci, with after ethanol extraction, alkalization, adds water, and reflux, extract, 1～3h, gets upper strata, except desolventizing, obtains extract I; The together water boiling of Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria, wherein adding the water yield is 4 times of Chinese medicinal components weight, also adds the Alumen of 7 weight portions during boiling, boiling is absolutely dry to water, stops boiling, obtains extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and Radix Astragali alcohol steep, temperature is 40～50 ℃, lixiviate 1～4 time, obtains extract III;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, by the method for centrifugal spray, prepares, and the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃, is prepared into cream powder;
Step 4, by step 2) gained cream powder and pharmaceutically acceptable carrier be prepared into oral liquid.
Embodiment 5
Treat hypertensive Chinese medicine composition, in weight portion, comprise: 5 parts of Radix Puerariaes, 3 parts of Radix Angelicae Pubescentiss, 2 parts of the Rhizoma Anemarrhenaes, 4 parts of Ramulus Cinnamomi, 3 parts of Herba Taraxacis, 4 parts of Caulis Polygoni Multiflori, 6 parts of Semen Euryaless, 2 parts of Radix Rehmanniae Preparata, 5 parts of Rhizoma Phragmitiss, 6 parts of Ramulus Uncariae Cum Uncis, 5 parts of Herba Lysimachiaes, 3 parts, Poria, 7 parts, Folium Bambusae, 3 parts of Radix Et Rhizoma Rhei, 4 parts of Medulla Juncies, 5 parts, Radix Glycyrrhizae, 4 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali, 6 parts of Os Draconis, 2 parts of Radix Saposhnikoviaes, 3 parts of Spica Prunellaes, 3 parts, Folium Mori, 6 parts of Flos Chrysanthemis, 5 parts of Herba Apocyni venetis.
The preparation method of the hypertensive Chinese medicine composition of above-mentioned treatment, comprises the following steps:
Step 1, by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci, with after ethanol extraction, alkalization, adds water, and reflux, extract, 1～3h, gets upper strata, except desolventizing, obtains extract I; The together water boiling of Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria, wherein adding the water yield is 4 times of Chinese medicinal components weight, also adds the Alumen of 7 weight portions during boiling, boiling is absolutely dry to water, stops boiling, obtains extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and Radix Astragali alcohol steep, temperature is 40～50 ℃, lixiviate 1～4 time, obtains extract III;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, by the method for centrifugal spray, prepares, and the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃, is prepared into cream powder;
Step 4, by step 2) gained cream powder and pharmaceutically acceptable carrier be prepared into capsule.
Medicine of the present invention is through routine clinical trials up to a hundred, and mainly with 60 years old above artificial object in old age.That most patient is when medical is dizzy, headache, the symptom such as dizzy, and symptom lasting for years, and what have even reaches more than ten years.The blood pressure of most of clients has reached low pressure 100～110mmHg, high pressure 170～189mmHg.During test by every day potion take, take after three doses, blood pressure degrades to low pressure 76～78mmHg, high pressure is 133～142mmHg.After again by every day potion take three doses, can keep blood pressure steadily.Test shows, pure Chinese medicinal preparation antihypertensive effect of the present invention is remarkable.
The clinical case of medicine of the present invention is as follows:
Case 1
Certain man, 65 years old, people from Nanjing.Patient is symptom at that time: dizzy, headache, giddy, and agnogenio.Patient's blood pressure is: low pressure 110mmhg, and high pressure 180mmhg, the state of an illness continues 3 years, full and large pulse, tongue is dark red, thick and greasy fur.Clinical diagnosis is: old deficient qi and blood, and arteries and veins mistake is moistened foster, and brain is hollow, congestion resistance network, the hepatic and renal YIN deficiency, excessive rising of liver-YANG, cause thus blood vessel rubbish (tremulous pulse dirt) overheap, vascular flow resistance is large, not general rule stifled (resistance), blood flow operation is not smooth, therefrom oppress small artery smooth muscle, cause small artery smooth muscle tension force to increase, small artery smooth muscle tension force is higher than normal value, thereby generation hypertension, therefore clinical diagnosis is hypertension.
The scheme for the treatment of is: patient takes 3 doses of embodiment 1 medicaments, every day potion.
Therapeutic effect: take after 5 doses of medicaments of above-mentioned medicament, patient's blood pressure is reduced to: low pressure 78mmhg, high pressure 136mmhg.After take again 3 doses (potions every day), blood pressure is at normal value held stationary, bounce-back.
Case 2
Certain man, 73 years old, Zhenjiang, Jiangsu people.Patient is symptom at that time: dizzy, dim eyesight, headache, conjunctival congestion sometimes, and agnogenio.Patient's blood pressure is: low pressure 116mmhg, and high pressure 189mmhg, the state of an illness continues 15 years, full and large pulse, dimly red tongue, thick and greasy fur.Clinical
Diagnosis is with case 1.
The scheme for the treatment of is: patient takes 3 doses of above-described embodiment 2 medicaments, every day potion.
Therapeutic effect: take after 3 doses of medicaments of above-mentioned medicament, patient's blood pressure is reduced to: low pressure 76mmhg, high pressure 142mmhg.Patient feels that body and mind is light, clearheaded; After take again 3 doses (potions every day), blood pressure is at normal value held stationary, bounce-back.
Case 3
Certain female, 66 years old, jiangsu wuxi people.Patient is symptom at that time: dizzy, dim eyesight, sleep is not good enough, and poor appetite is agnogenio.Patient's blood pressure is: low pressure 108mmhg, and high pressure 178mmhg, the state of an illness continues 7 years, full and large pulse, dimly red tongue, thick and greasy fur.
Clinical diagnosis is with case 1.
The scheme for the treatment of is: patient takes 3 doses of above-mentioned medicaments, every day potion.
Therapeutic effect: take after 3 doses of medicaments of above-mentioned medicament, patient's blood pressure is reduced to: low pressure 77mmhg, high pressure 133mmhg.Patient feels that body and mind is light, happiness.After take again 3 doses (potions every day), blood pressure is at normal value held stationary, bounce-back.
Claims (7)
1. treat hypertensive Chinese medicine composition, it is characterized in that: in weight portion, comprise: 3～7 parts of Radix Puerariaes, 2～6 parts of Radix Angelicae Pubescentiss, 1～3 part of the Rhizoma Anemarrhenae, 2～5 parts of Ramulus Cinnamomi, 1～5 part of Herba Taraxaci, 2～6 parts of Caulis Polygoni Multiflori, 3～7 parts of Semen Euryaless, 1～4 part of Radix Rehmanniae Preparata, 2～6 parts of Rhizoma Phragmitiss, 3～7 parts of Ramulus Uncariae Cum Uncis, 2～7 parts of Herba Lysimachiaes, 1～5 part, Poria, 3～8 parts, Folium Bambusae, 1～5 part of Radix Et Rhizoma Rhei, 2～7 parts of Medulla Juncies, 1～6 part, Radix Glycyrrhizae, 2～6 parts of Radix Scutellariaes, 3～7 parts of the Radixs Astragali, 2～8 parts of Os Draconis, 1～4 part of Radix Saposhnikoviae, 2～5 parts of Spica Prunellaes, 1～4 part, Folium Mori, 3～8 parts of Flos Chrysanthemis, 2～6 parts of Herba Apocyni venetis.
2. the hypertensive Chinese medicine composition for the treatment of according to claim 1, is characterized in that: in weight portion, comprise: 5 parts of Radix Puerariaes, 3 parts of Radix Angelicae Pubescentiss, 2 parts of the Rhizoma Anemarrhenaes, 4 parts of Ramulus Cinnamomi, 3 parts of Herba Taraxacis, 4 parts of Caulis Polygoni Multiflori, 6 parts of Semen Euryaless, 2 parts of Radix Rehmanniae Preparata, 5 parts of Rhizoma Phragmitiss, 6 parts of Ramulus Uncariae Cum Uncis, 5 parts of Herba Lysimachiaes, 3 parts, Poria, 7 parts, Folium Bambusae, 3 parts of Radix Et Rhizoma Rhei, 4 parts of Medulla Juncies, 5 parts, Radix Glycyrrhizae, 4 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali, 6 parts of Os Draconis, 2 parts of Radix Saposhnikoviaes, 3 parts of Spica Prunellaes, 3 parts, Folium Mori, 6 parts of Flos Chrysanthemis, 5 parts of Herba Apocyni venetis.
3. described in claim 1 or 2, treat the preparation method of hypertensive Chinese medicine composition, it is characterized in that: comprise the following steps:
Step 1, obtains extract I by Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci with ethanol extraction; Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria together water boiling obtain extract II; Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and the Radix Astragali obtain extract III with ethanol extraction;
Step 2, removes impurity by Os Draconis, Radix Saposhnikoviae, Spica Prunellae, Folium Mori, Flos Chrysanthemi and Herba Apocyni veneti, then cleans, and parch and dry, then crude drug is pulverized, cross 80～120 mesh sieves, obtain fine powder;
Step 3, mixes the extract obtained I of step 1, extract II, extract III and step 2 gained fine powder, is prepared into cream powder;
Step 4, is prepared into tablet, capsule, granule or oral liquid by step 3 gained cream powder and pharmaceutically acceptable carrier.
4. treat according to claim 3 the preparation method of hypertensive Chinese medicine composition, it is characterized in that: in step 1, Radix Puerariae, Radix Angelicae Pubescentis, the Rhizoma Anemarrhenae, Ramulus Cinnamomi and Herba Taraxaci, with after ethanol extraction, alkalize, add water, reflux, extract, 1～3h, gets upper strata, except desolventizing, obtain extract I.
5. treat according to claim 3 the preparation method of hypertensive Chinese medicine composition, it is characterized in that: in step 1, Caulis Polygoni Multiflori, Semen Euryales, Radix Rehmanniae Preparata, Rhizoma Phragmitis, Ramulus Uncariae Cum Uncis, Herba Lysimachiae and Poria together also add the Alumen of 7～9 weight portions during boiling, boiling is absolutely dry to water, stop boiling, obtain extract II.
6. treat according to claim 3 the preparation method of hypertensive Chinese medicine composition, it is characterized in that: in step 1, Folium Bambusae, Radix Et Rhizoma Rhei, Medulla Junci, Radix Glycyrrhizae, Radix Scutellariae and the Radix Astragali are 40～50 ℃ by the temperature of alcohol steep, lixiviate 1～4 time.
7. treat according to claim 3 the preparation method of hypertensive Chinese medicine composition, it is characterized in that: the powder of cream described in step 3 is prepared by the method for centrifugal spray, the inlet temperature of centrifugal spray equipment is 140～160 ℃, and leaving air temp is 85～95 ℃.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104719564A (en) * | 2015-03-24 | 2015-06-24 | 桂林浩新科技服务有限公司 | Decompression tea bag and preparation method thereof |
| CN113248371A (en) * | 2021-05-14 | 2021-08-13 | 王知斌 | Astragalus mongholicus and dandelion extract, preparation method thereof, composition thereof and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103223098A (en) * | 2013-05-17 | 2013-07-31 | 赵世校 | Traditional Chinese medicine pressure reduction tea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103223098A (en) * | 2013-05-17 | 2013-07-31 | 赵世校 | Traditional Chinese medicine pressure reduction tea |
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| Title |
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| 屠庆祝 等: "中药治疗高血压的用药规律探要", 《实用中医内科杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719564A (en) * | 2015-03-24 | 2015-06-24 | 桂林浩新科技服务有限公司 | Decompression tea bag and preparation method thereof |
| CN113248371A (en) * | 2021-05-14 | 2021-08-13 | 王知斌 | Astragalus mongholicus and dandelion extract, preparation method thereof, composition thereof and application thereof |
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Application publication date: 20141126 |