CN106421657A - Traditional Chinese medicine composition for treating cancer-induced pain - Google Patents
Traditional Chinese medicine composition for treating cancer-induced pain Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cancer-induced pain. The composition is prepared from 300-100 parts of frankincense, 300-100 parts of rhizoma curcumae, 300-100 parts of rhizoma chuanxiong, 300-100 parts of herba sarcandrae and 200-100 parts of borneol, wherein the frankincense is a monarch drug, has a bitter taste and a warm property, has the effects of promoting flow of qi and blood circulation and stopping pain and promoting granulation, is a main drug for trauma department and surgical department, and is commonly used for treating pain caused by qi depression to blood stasis in clinics; the rhizoma curcumae and the rhizoma chuanxiong are ministerial drugs; the rhizoma curcumae has the effects of eradicating blood stasis and promoting the circulation of qi and expelling stasis and stopping pain; the rhizoma chuanxiong has the effects of activating blood and removing blood stasis, promoting flow of qi and blood circulation and dispersing blood stasis and stopping pain; the herba sarcandrae is an adjuvant drug and has the effects of activating meridians to stop pain and activating blood for resolving masses; the borneol is a conductant drug; after the borneol is added, the flavor is aromatic, and the borneol has an effect of a percutaneous absorption accelerant, so that the drug can directly reach an affected area; and all the drugs commonly have the effects of promoting the circulation of qi and breaking blood and dispersing blood stasis and stopping pain, and can be used for treating the cancer-induced pain of cancer patients.
Description
Technical field
Invention belongs to the field of Chinese medicines and in particular to a kind of Chinese medicine composition for the treatment of cancer pain and preparation method thereof in this.
Background technology
Pain is one of most common and the most painful symptom of cancer patient, and incidence rate late accounts for 70% in cancer, is shadow
Ring a key factor of quality of life in patients with cancer.If the pain management that cancer pain patients cannot be appropriate, Huan Zheyou
May bear the pain for a long time decocts, and their overall quality of life of extreme influence, activity, sleep and mood etc..
Commonly use " three ladder medicine analgesias " at present cancer pain is treated, i.e. the pain degree according to patient, by ladder
Select the analgesic drug product of varying strength.The medicine such as nonsteroidal used by the method and opiatess is although comparitive study is definite, but deposits
More in untoward reaction, additive strong, the not high defect of patient tolerability, also produce different degrees of gastrointestinal reaction simultaneously, cause
Make some patients' analgesic effect not good enough, simultaneously partly not good enough to medicine insensitive patient analgesic effect, shadow is produced to pain palliation efficacy
Ring.
The traditional Chinese medical science thinks cancerous pain mainly many, and due to the stagnation of QI, blood stasis, pyretic toxicity impatency passages through which vital energy circulates, QI-blood circulation is not freely caused,
Lead to stagnation of QI and blood may bring about pain, Etiological pathogenesis is qi depression to blood stasis, passages through which vital energy circulates impatency, treatment focuses on conditioning yin-Yang zang-fu differentiation it
QI and blood, thus reach the effect of pain relieving.
With strengthening vital QI to eliminate pathogenic factors, regulating QI and blood are the rule for the treatment of to the traditional Chinese medical science, using methods such as oral medicinal herb, externals, cancerous pain are controlled
Treat, by clinical observation, Chinese herbs decoction is in the curative effect treating tumor patient cancer pain and inconspicuous, and particularly patient acutely aches
During pain, its onset is slow, and its treatment cycle is longer, therefore limited by Clinical practice Chinese herbs decoction treatment cancer pain.And Chinese physical therapy, main
The analgesic effect of medicine is played certain based on external treatment of Chinese medicine, on the premise of the pain palliation efficacy not affecting Western medicine
Booster action.
Content of the invention
Object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cancer pain.The Chinese medicine composition of the present invention is controlled
Treat cancerous pain more than 60 example and obtain good therapeutic effect.Avoid the uncomfortable reaction that oral drugs cause, fully highlight tcm characteristic, increase
Different body constitution, to the toleration of this Comprehensive Treatment and compliance, reduce the misery of patient, mitigate its medical expense, improve patient by force
Quality of life.For different degrees of cancerous pain, all achieved with more satisfied curative effect.
A kind for the treatment of cancer pain Chinese medicine composition of the present invention, mainly by Olibanum 300-100 part of weight portion, Rhizoma Curcumae 300-
100 parts, Rhizoma Chuanxiong 300-100 part and Herba Sarcandrae 300-100 part composition.
Preferably, the treating cancer pain Chinese medicine composition of the present invention, mainly by 200 parts of Olibanum, 200 parts of Rhizoma Curcumae, Rhizoma Chuanxiong 200
Part, 200 parts of Herba Sarcandrae, 100 parts of compositions of Borneolum Syntheticum.
The treating cancer pain Chinese medicine composition of the invention described above, mainly by Olibanum 200g, Rhizoma Curcumae 200g, Rhizoma Chuanxiong 200g, swollen
Section wind 200g, Borneolum Syntheticum 100g composition.
The treating cancer pain Chinese medicine composition of the invention described above, its dosage form is tincture, by the Olibanum 300- of weight portion
100 parts, the Soaker of Rhizoma Curcumae 300-100 part, Rhizoma Chuanxiong 300-100 part and Herba Sarcandrae 300-100 part and Borneolum Syntheticum 200-100 part
Composition, described ethanol is the ethanol of 50%-95%, preferably 75% ethanol.
In one embodiment, a kind for the treatment of cancer pain Chinese medicine composition of the present invention, by the Olibanum of weight portion
200g, ethanol (preferably 75% ethanol) the leaching thing of the 50%-95% of Rhizoma Curcumae 200g, Rhizoma Chuanxiong 200g and Herba Sarcandrae 200g and Borneolum Syntheticum
2-1 part forms, and described compositionss are tincture.
Present invention also offers a kind of method for the treatment of cancer pain Chinese medicine composition, described Chinese medicine composition is tincture, its
Method includes for Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae, Borneolum Syntheticum being respectively ground into coarse powder, and Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong and Herba Sarcandrae are used
50%-95% ethanol, preferably 75% ethanol, consumption is the 6-10 times amount of Chinese medicine (Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong and Herba Sarcandrae) weight,
Preferably 8 times amount, merceration 10-35 days, preferably 15 days, or diafiltration 24-48 hour, preferably 48 hours, or be heated to reflux twice, every time
0.5-2 hour, after filtration, on the rocks obtains final product.
The method of the invention described above, preferably described Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae are each, be 200g, Borneolum Syntheticum
100g.
The treating cancer pain Chinese medicine composition of the present invention, by 200 parts of Olibanum, 200 parts of Rhizoma Curcumae, 200 parts of Rhizoma Chuanxiong, Herba Sarcandrae
200 parts, 100 parts of compositions of Borneolum Syntheticum, wherein, Olibanum is monarch drug, and acrid in the mouth is bitter, warm in nature, promoting flow of QI and blood, pain relieving granulation promoting, is traumatology with outward
The key medicine of section, clinic is usually used in treating the pain of caused by energy stagnation and blood stasis；Rhizoma Curcumae, Rhizoma Chuanxiong are ministerial drug altogether, Rhizoma Curcumae blood-breaking, removing food stagnancy
Pain relieving, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, strengthen promoting flow of QI and blood, the work(of eliminating stasis to stop pain；Herba Sarcandrae is adjuvant drug, removing obstruction in the collateral to relieve pain, blood circulation promoting and dispersing pathogen accumulation；Ice
Piece is to make medicine, adds Borneolum Syntheticum fragrant odour, plays Percutaneous absorption enhancer and be used, and makes medicine through disease institute, and side plays circulation of qi promoting altogether entirely
Removing blood stasis, the work(of eliminating stasis to stop pain.
The Chinese medicine composition of the present invention is also referred to as analgesic tincture, the method preparing analgesic tincture, by Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong,
The each 200g of Herba Sarcandrae, respectively it is ground into coarse powder for Borneolum Syntheticum, with 75% ethanol (consumption was not to have Chinese medicine for degree) merceration 12 days, filter
On the rocks 100g afterwards, is packed as every bottle of 100ml, sealing preserve.Analgesic tincture should use for external application：Pain portion is embrocated in the external that takes concoction
Position, embrocates 2 times daily.
The beneficial effect of the Chinese medicine composition of the present invention：The outer treatment wiped for cancerous pain, it is to avoid other oral medicines
The uncomfortable reaction that thing causes, can reduce the dosage of opioid drug, strengthen the toleration that different body constitution treat to analgesic tincture and according to
From property, reduce the misery of patient, mitigate its medical expense, improve patients ' life quality.Confirm through clinical trial, for different journeys
The cancerous pain of degree, all achieved with more satisfied curative effect.
Specific embodiment
Following examples are used for further understanding and illustrating the essence of the present invention, but limit the present invention's never in any form
Scope.
The preparation of compositionss：Process：
Technology point：Concentration of alcohol can be 50%-95% scope, preferably 75%；Ethanol 6-10 times amount；
Extracting method：
1. it is heated to reflux 2-3 time, each 0.5-2 hour, be preferably heated to reflux 2 times, 1 hour every time, ethanol 6-10 times amount,
Preferably 8 times amount；
2.8 times amount 75% ethanol merceration, 10-35 days, during immersion, stirring 1-2 time daily, was advisable with 15 days, and standing takes
Supernatant, filters, fill；
3. percolation：Pulverizing medicinal materials are coarse powder, plus the ethanol of 50%-95%, 6-10 times amount, after merceration 24-48 hour, delay
Slow percolation, speed 1-5mL/min/kg, collect percolate, standing, filtration, fill, obtain final product.Preferably 75% ethanol, 10 times amount, cold
Leaching 48h, infiltration rate 3mL/min/kg.
Note：Times amount specifically described herein is Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, the times amount of the gross weight of swollen section Chinese crude drug.
Embodiment 1 Chinese medicine composition (tincture)
Prescription：It is made up of Olibanum 200g, Rhizoma Curcumae 200g, Rhizoma Chuanxiong 200g, Herba Sarcandrae 200g, Borneolum Syntheticum 100g.
The preparation technology of tincture：Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, each 200g of Herba Sarcandrae, Borneolum Syntheticum 100g are respectively ground into slightly
Powder, uses 75% ethanol, and ethanol consumption is Chinese medicine weight 8 times amount, merceration 15 days, after filtration, on the rocks 100g of filtrate, and mix homogeneously
After be packed as every bottle of 100ml, sealing preserve.
Embodiment 2 Chinese medicine composition (tincture)
Prescription：It is made up of 200 parts of Olibanum, 200 parts of Rhizoma Curcumae, 200 parts of Rhizoma Chuanxiong, 200 parts of Herba Sarcandrae, 100 parts of Borneolum Syntheticum.
The preparation technology of tincture：Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae, Borneolum Syntheticum are respectively ground into coarse powder, by pulverize
Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae 75% ethanol, ethanol consumption is 6 times amount of Chinese medicine weight, merceration 15 days, after filtration, to
On the rocks 100 parts in filtrate, are packed as every bottle of 100ml, sealing preserve after mix homogeneously.
Embodiment 3 Chinese medicine composition (tincture)
Prescription：It is made up of 300 parts of Olibanum, 300 parts of Rhizoma Curcumae, 300 parts of Rhizoma Chuanxiong, 100 parts of Herba Sarcandrae, 200 parts of Borneolum Syntheticum.
The preparation technology of tincture：Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae, Borneolum Syntheticum are respectively ground into coarse powder, pulverize
Add 75% ethanol, ethanol consumption Chinese medicine 10 times amount in Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae, be heated to reflux 2-3 time, each 0.5-
2 hours, preferably it is heated to reflux 2 times, 1 hour every time, after cooled and filtered, on the rocks 100 parts in filtrate, after mix homogeneously point
Fill as every bottle of 100ml, sealing preserve.
Embodiment 4 Chinese medicine composition (tincture)
Prescription：It is made up of 100 parts of Olibanum, 100 parts of Rhizoma Curcumae, 100 parts of Rhizoma Chuanxiong, 300 parts of Herba Sarcandrae, 100 parts of Borneolum Syntheticum.
The preparation technology of tincture：Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae, Borneolum Syntheticum are respectively ground into coarse powder, by pulverize
Chinese medicine Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, Herba Sarcandrae 75% ethanol, ethanol consumption is Chinese medicine 10 times amount, merceration 48h, diafiltration, diafiltration speed
Degree 3mL/min/kg, collects percolate, standing, filtration, on the rocks 100 parts in filtrate, is packed as 100ml every after mix homogeneously
Bottle, sealing preserve.
Clinical case：
106 patients are divided into matched group 51, give oral hydrochloride oxycodone slow releasing tablet 10mg q12h, treatment group 53
Example, on the basis of matched group, is practiced Chinese medicine composition (hereinafter referred to as analgesic tincture) the external application painful area of example 1, often simultaneously
It is embrocated 2 times, is within 1 week 1 course for the treatment of.1 course for the treatment of post-evaluation curative effect for the treatment of.Before and after two groups of treatments, Clinical efficacy comparison treatment group is total
Effective percentage 92.45%.Matched group total effective rate 76.47%.Illustrate that the curative effect for the treatment of group is substantially better than matched group.
Clinical efficacy comparison (n) before and after 12 groups of treatments of table
During two groups of treatments, VRS (pain degree staging) scoring is compared, and treats the 7th day for two groups and compares, through the inspection of t in groups
Test, t=2.421, P=0.017 ＜ 0.05, have significant difference, because treatment group declines substantially (being shown in Table 2) compared with matched group, therefore
Show that treatment group's control pain curative effect is substantially better than matched group patient.
During treatment two groups of VRS scoring compare (point,) it is shown in Table 2.
The contrast in 7 days of table 2 treatment group and treatment of control group
| Group | Treat the 1st day | Treat the 3rd day | Treat the 7th day | t |
| Treatment group | 5.67±0.31 | 3.27±0.21 | 1.45±0.57*# | 3.699 |
| Matched group | 5.77±0.22 | 3.57±0.27 | 2.45±0.58△ | 1.546 |
Typical cases 1
Patient model xx, man, goes to a doctor in August in 2016 because of " postoperative more than 1 year of carcinoma of prostate, malaise 1 day " and is admitted to hospital on the 9th.
Dysuria in patient before 1 year, drop and under, in June, 2015 in big level ground hospital admission, row color ultrasound and CT examination prompting：
Prostate occupy-place it is considered to malignant tumor probability is big, row operative treatment, pathological biopsy shows：Carcinoma of prostate.Discharged patients occur
Whole body skeleton pain is uncomfortable, and in acupuncture sample pain, with right side for very, right side elbow joint is numb, and after cold and walking, pain increases,
It is unable to spontaneous remission.Row right arm DR shows：Right head of humerus, humerus neck, scapula, glenoid cavity and processus coracoideus, many of right side rib bone
Matter changes, and the multiple skeleton density of thorax increases it is considered to Bone tumour, in conjunction with patient medical history it is considered to osteogenic metastatic potential is big, gives
With oral hydrochloride morphine slow releasing tablet 10mg q12h pain management.
Now symptoms include：Spirit is poor, and malaise is uncomfortable, and right side elbow joint and the following tract pain of double knee joint are numb,
Double lower limb Mild edema, appetite and sleep be not good enough, and defecation is normal.
Have a medical check-up：KPS scoring 80. whole body superficial lymph knot is not laid one's hand on and enlargement, and cardiopulmonary, abdominal part are had a medical check-up all without exception.Right side elbow
Joint, double knee joint are obvious with lower portion tenderness, limited by the exercising elbow joint of right side, double lower limb Mild edema.Dimly red tongue, tongue
Huang, thready and hesitant pulse.
Diagnosis：Tcm diagnosis：Stranguria syndrome of blood stasis due to qi deficiency
Western medicine diagnose：With Bone tumour after prostate
Treatment：1st, middle treatment, with benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain, just selects Buyang Huanwu Decoction；
2nd, painful area gives appropriate analgesic tincture liniment, a day three times.
After 3 days, patient's edema, pain are gradually alleviated, and have withdrawn morphine hydrochloride slow releasing tablet, after 5 days, double lower limb edema disappears completely
Move back, patient continues to give the treatment of analgesic tincture liniment, freely, the following tract pain of double knee joint disappears right side exercising elbow joint on the 10th
Lose, still have slight feeling of numbness, spirit is clearly better.
Typical cases 2
Patient Deng xx, man, 53 years old, because " right lower extremity pain April increases with limping 10 days " goes to a doctor.Patient was because of 2016 2 months
No substantially right lower extremity pain in inducement, based on the hip arthralgia, goes to a doctor it is considered to be prolapse of lumbar intervertebral disc in local hospital.
At the beginning of 6 months the same years, patient's subjective symptomss increase, and with bottom right acroanesthesia it is impossible to stand it is impossible to upper lift, are only capable of translating.In Chongqing City doctor
Institute row lumbar vertebra MRI shows：1st, right iliac, acetabular bone change, it is considered to neoplastic lesion possibility, Bone tumour, add up right side gluteus minimus；2、
Right side femoral head and left side pubic symphysis tuberosity shadow, bone island transfer row lung X-ray piece shows：Lung occupy-place on bilateral, reason is undetermined.Consider
For pulmonary malignant tumour, bone malignant tumour, give OxyContin 30mg q12h pain relieving, but Pain management is not good, gives azoles simultaneously
Carry out the treatment of phosphoric acid anti-Bone tumour.Patient is to seek Integrative medicine therapy, goes to a doctor in my section.
Inscribe symptoms include：Ordinary circumstance is poor, spiritual poor, right lower extremity pain, numbness, difficulty in walking, and crutches are walked lamely, and whole body is weary
Power, diet, not good enough, constipation with dry stool of sleeping, urine is normal.
Have a medical check-up：KPS scoring 60. whole body superficial lymph knot is not laid one's hand on and enlargement, and cardiopulmonary, abdominal part are had a medical check-up all without exception.Right side hip
Articular pain substantially it is impossible to stand it is impossible to upper lift, is only capable of translating.Body of the tongue is light red, white and thin fur, and the sublingual vessel stasis of blood is bent, thready and hesitant pulse.
Diagnosis：Tcm diagnosis：Lump in the right hypochondrium syndrome of blood stasis due to qi deficiency
Western medicine diagnose：1st, malignant tumor of lung；2nd, bone secondary malignant tumor (clinical diagnosises)
Treatment：1st, middle treatment is with benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain, oral Buyang Huanwu Decoction；
2nd, painful area gives appropriate analgesic tincture liniment, a day three times.
After 1 week, patient's right hips tenderness mitigates when being relatively admitted to hospital, and patient continues to give the treatment of analgesic tincture liniment, current mouth
Take OxyContin 20mg q12h pain to can control, malaise and the mental status are obviously improved when being relatively admitted to hospital.
Typical cases 3
Gong patient xx, female, 59 years old, because " bilateral ovaries cancer postoperative April, first quarter moon after last chemotherapy " was in August in 2016 18 days
Medical.In March, 2016 shows because abdomen carries out color ultrasound in Five continents hospital：Mixed type bag based on the implementation of on the right side of uterus and uterus upper left side
It is considered to malignant tumor may be big, immediately after Chongqing Attached Hospital carries out related surgical, pathological examination results show block：<Bilateral ovum
Nest>Poor differentiated carcinoma, meets serous carcinoma.<Right side>Tunica serosa tubae uterinae meets personally cancerous tissue.<Omentum majuss, vesical peritoneal reflection, return
Intestinal, vermiform appendix>Serous coat is met personally cancer and is involved.<Right side>Lymph node is shown in cancerometastasis (2/3).<Left side>Lymph node has no cancerometastasis (0/
16).ImmunohistochemistryResults Results：ER weak (+), PR part (+), CA125 (+), WT-1 (+), P53 (-), P16 (+), ki6730%,
CEA (-), Vim (-).Postoperative give TPA (paclitaxel 240mg vein respectively on April 12nd, 2016, May 5, May 26
Treatment+cisplatin 170mg intraperitoneal chemotherapy), on June 18th, 2016, July 10, August give TP scheme on the 4th (paclitaxel 240mg+ are how
Reach platinum 140mg) chemotherapy.Malaise occurs after patient's postoperative chemotherapy, during wound, involves sample pain, can be slightly slow after massage
Solution.
Now symptoms include：Spiritual not good enough, malaise, involves sample pain at surgical wound, when light when weight, diet is not good enough, dislikes
Heart tending to vomit, insomnia and dreamful sleep, defecation is normal.
Have a medical check-up：KPS scoring 70, whole body superficial lymph knot is not laid one's hand on and enlargement, and cardiopulmonary portion haves a medical check-up without exception.The visible length of abdominal part
About 15cm operative scar, healing is good, and no redness is oozed out.Abdomen is flat, has no abdominal wall varicosis, has no gastrointestinal type and wriggling
Ripple.Abdomen is soft, light tenderness, no rebound tenderness and muscle tonus at abdominal wound.Extremity spinal column is no lopsided, and activity is freely.Physiological reflex is deposited
Pathologic reflex is not drawn.Body of the tongue is slightly dark, white and thin fur, thready and hesitant pulse.
Diagnosis：Tcm diagnosis：Abdominal mass syndrome of blood stasis due to qi deficiency
Western medicine diagnose：After bilateral ovaries low differentiation serous carcinoma IIIC phase postoperative chemotherapy
Treatment：1st, with benefiting QI for activating blood circulation, strong The spleen is closely related to the stomach for middle treatment, and oral BAZHEN TANG closes Liujunzi Tang plus-minus；
2nd, painful area gives appropriate analgesic tincture liniment, a day three times.
After 3 days, patient wound involves sample pain and gradually alleviates, and after one week, pain substantially mitigates, and diet increases, spiritual shape
State is good.
Typical cases 4
Patient Bearss xx, man, 66 years old, goes to a doctor in November, 2014 because of " Thoracic esophageal carcinoma 3 years breathes heavily tired tachypnea 1 day " and is admitted to hospital.Suffer from
Dysphagia in August, 2012 in person, and dysphagia, in the row gastroscopy prompting of Chong Yi Annex II institute：Esophaguses occupy-place is it is considered to dislike
Property tumor probability big, immediately in Chongqing Attached Hospital's row operative treatment, pathology prompting in art：Esophaguses well-differentiated squamous carcinoma,
Invade and esophageal wall adventitia.Postoperative row one course for the treatment of chemotherapy, because not being resistant to stop.The pain increased in October, 2014 patient's shoulder back,
Engender front chest wall pain, during cough, pain increases, go to a doctor in our hospital's hospitalization on November 19th, 2014, row after being admitted to hospital
Breast CT is shown：1st, Thoracic esophageal carcinoma changes, thickened stomach wall below anastomotic stoma, points out focus recurrence possibility, C7, T8, T9 and breastbone
Bottom, right side the 8th rib, left side the 9th rib bone destruction change, and point out transfer possible.Consider that patient breastbone pain and swells
Tumor Bone tumour is relevant, in our hospital's gamma knife central row Gamma knife treatment, the anti-Bone tumour treatment of parallel zoledronic acid.
Now symptoms include：Spirit is poor, and whole body is aching and limp weak, pale complexion, anterior part of chest, right side chest and cervical region, waist pain
Bitterly, anorexia, sleep is not good enough, and defecation is normal.
Have a medical check-up：KPS scoring 50, anemia looks, whole body superficial lymph knot is not laid one's hand on and enlargement, at the nearly midaxillary line of left side chest, can
See that one is about 10cm operative scar, prognosis bona, left side 4-5 intercostal leans on the visible diameter of median line about 4X5cm enclosed mass, prominent skin
Face, matter is hard, inertia, no tenderness.Cardiopulmonary, abdominal part are had a medical check-up all without exception.Sternal part, right side the 8th rib, left side the 9th rib and
Cervical region hypomere, waist tenderness are obvious.Light purplish tongue, white and thin fur, the sublingual vessel stasis of blood is bent, and deep pulse is thin and delicate.
Diagnosis：
Tcm diagnosis：Dysphagic deficiency of both QI and blood
Western medicine diagnose：After esophaguses differentiated scale cancer (IV phase) is with cervical vertebra, lumbar vertebra, breastbone transfer gamma knife radiotherapy；
Treatment：1st, middle treatment is with vigorate qi and replenish the blood, spleen benefiting and stimulating the appetite, removing obstruction in the collateral to relieve pain, oral BAZHEN TANG plus-minus；
2nd, painful area gives appropriate analgesic tincture liniment, a day three times.
After 10 days, entire patient many places pain is relieved when being relatively admitted to hospital, and patient continues to give the treatment of analgesic tincture liniment, pain
Pain controls well, and food of receiving increases, and the mental status is obviously improved.
Typical cases 5
Patient Xu xx, man, 72 years old, goes to a doctor in August in 2016 because of " the migrans pain of left side chest and back 2 months " and is admitted to hospital on the 20th.
Patient in June, 2016 no substantially inducement left side chest and back pain occurs, patient does not give attention, after increase because of pain symptom, in
In July, 2016 points out in emergency center of Chongqing City, row rabat：Upper left lung occupy-place, then row breast CT prompting superior lobe of left lung apicoposterior segment
, it is considered to pulmonary carcinoma, with double Lung metastases, many ribs of bilateral, multiple vertebral bodys shift, right breast pathologic bone for space occupying lesion, about 31*25cm
Folding may.On July 6th, 2016 percutaneous Transthoracic Biopsy is pointed out：Adenocarcinoma of lung.Patient's refusal row chemicotherapy and targeted therapy.Suffer from
Person is to seek Integrative medicine therapy, therefore section goes to a doctor in me.
Inscribe symptoms include：Spirit is poor, becomes thin, the migrans pain of left side chest and back, appetite, not good enough, constipation with dry stool of sleeping, little
Just measure few, onset one carrys out weight loss about 10kg.
Have a medical check-up：KPS scoring 70.Whole body superficial lymph knot is not laid one's hand on and enlargement, and cardiopulmonary, abdominal part are had a medical check-up all without exception.In left side
Back tenderness is obvious.Extremity spinal column is no lopsided, and activity is freely.Joint is no red and swollen, double lower limb no edema.Physiological reflex exists, disease
Reason reflection is not drawn.Tongue is dark red, white and thin fur, stringy and hesitant pulse.
Tcm diagnosis：Lump in the right hypochondrium syndrome of qi stagnation and blood stasis
Western medicine diagnose：The left adenocarcinoma of lung IV phase is with intrapulmonary, Bone tumour
Treatment：
1st, middle treatment, with promoting flow of QI and blood, removing obstruction in the collateral to relieve pain, invigorating the spleen and stomach, just selects decoction for removing blood stasis to close decoction of four noble drugs plus-minus；
2nd, painful area gives appropriate analgesic tincture liniment, a day three times.
After 3 days, patient's left chest and back pain is gradually alleviated when being relatively admitted to hospital, and continues to give the treatment of analgesic tincture liniment, one week rear left
Chest pain substantially mitigates earlier above, and spirit takes a turn for the better earlier above.
Claims (10)
1. a kind of Chinese medicine composition for the treatment of cancer pain, mainly by Olibanum 300-100 part of weight portion, Rhizoma Curcumae 300-100 part, river
Rhizome of chuanxiong 300-100 part, Herba Sarcandrae 300-100 part and Borneolum Syntheticum 200-100 part composition.
2. Chinese medicine composition as claimed in claim 1, by 200 parts of Olibanum, 200 parts of Rhizoma Curcumae, 200 parts of Rhizoma Chuanxiong, Herba Sarcandrae 200
Part, 100 parts of compositions of Borneolum Syntheticum.
3. Chinese medicine composition as claimed in claim 2, mainly by Olibanum 200g, Rhizoma Curcumae 200g, Rhizoma Chuanxiong 200g, Herba Sarcandrae
200g, Borneolum Syntheticum 100g form.
4. described Chinese medicine composition as arbitrary in claim 1-3, its dosage form is tincture.
5. Chinese medicine composition as claimed in claim 4, described tincture is by Olibanum 300-100 part of weight portion, Rhizoma Curcumae 300-100
The ethanol extraction of part, Rhizoma Chuanxiong 300-100 part and Herba Sarcandrae 300-100 part and Borneolum Syntheticum 200-100 part composition.
6. Chinese medicine composition as claimed in claim 5, described ethanol is the ethanol of 50%-95%.
7. a kind of method preparing the arbitrary described Chinese medicine composition of claim 1-6, including by Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong, swollen section
Wind, Borneolum Syntheticum are respectively ground into coarse powder, Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong and Herba Sarcandrae 50%-95% ethanol merceration 10-35 days or diafiltration 24-
48h or be heated to reflux twice, each 0.5-2 hour, after filtration, on the rocks obtains final product.
8. method as claimed in claim 7, described Olibanum, Rhizoma Curcumae, Rhizoma Chuanxiong and Herba Sarcandrae are respectively 200g, Borneolum Syntheticum 100g.
9. method as claimed in claim 7, ethanol consumption is Olibanum, the 6-10 times amount of Rhizoma Curcumae, Rhizoma Chuanxiong and Herba Sarcandrae gross weight,
Preferably 8 times amount.
10. the method as described in claim 7 or 9, described ethanol is 75% ethanol.
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|---|---|---|---|---|
| CN1088449A (en) * | 1993-08-16 | 1994-06-29 | 付耀华 | Cancer pain curing medicine and preparation method thereof |
| CN1120954A (en) * | 1995-07-31 | 1996-04-24 | 罗成棹 | Multieffect medicinal liquor |
| CN1386532A (en) * | 2002-06-07 | 2002-12-25 | 王济平 | External use pain-relieving medicine and its preparation method |
| CN1843493A (en) * | 2006-02-05 | 2006-10-11 | 高登胜 | Externally applied medicine for relieving pain and preparation method thereof |
| CN1872181A (en) * | 2006-04-26 | 2006-12-06 | 曲松有 | External use embrocation of Chinese traditional medicine for against cancer and stopping pain |
| CN102423466A (en) * | 2011-12-28 | 2012-04-25 | 李宗贤 | Pain relief tincture |
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2016
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|---|---|---|---|---|
| CN1088449A (en) * | 1993-08-16 | 1994-06-29 | 付耀华 | Cancer pain curing medicine and preparation method thereof |
| CN1120954A (en) * | 1995-07-31 | 1996-04-24 | 罗成棹 | Multieffect medicinal liquor |
| CN1386532A (en) * | 2002-06-07 | 2002-12-25 | 王济平 | External use pain-relieving medicine and its preparation method |
| CN1843493A (en) * | 2006-02-05 | 2006-10-11 | 高登胜 | Externally applied medicine for relieving pain and preparation method thereof |
| CN1872181A (en) * | 2006-04-26 | 2006-12-06 | 曲松有 | External use embrocation of Chinese traditional medicine for against cancer and stopping pain |
| CN102423466A (en) * | 2011-12-28 | 2012-04-25 | 李宗贤 | Pain relief tincture |
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