CN104587016B - A kind of Chinese traditional medicine navel patch and preparation method for treating constipation - Google Patents
A kind of Chinese traditional medicine navel patch and preparation method for treating constipation Download PDFInfo
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- CN104587016B CN104587016B CN201510015217.4A CN201510015217A CN104587016B CN 104587016 B CN104587016 B CN 104587016B CN 201510015217 A CN201510015217 A CN 201510015217A CN 104587016 B CN104587016 B CN 104587016B
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Abstract
The invention discloses a kind of Chinese traditional medicine navel patch and preparation method for treating constipation, described Chinese traditional medicine navel patch is made up of following Chinese medicine material by weight percentage:The rhubarb 16% 20%, bark of official magnolia 16% 20%, honey 16% 20%, the saltcake 8% 12%, dried immature fruit of citron orange 8% 12%, Radix Angelicae Sinensis 8% 12%, radish seed 4% 8%, fructus cannabis 3% 5%, brush-cherry seed 3% 5%, dried orange peel 2%.Its preparation method is:A, rhubarb, the bark of official magnolia, saltcake, the dried immature fruit of citron orange, Radix Angelicae Sinensis, radish seed, fructus cannabis, brush-cherry seed, dried orange peel are ground into medicinal powder, be sufficiently mixed uniform.B, honey and medicinal powder are pressed 1:1 ratio reconciles into pasty state.C, take 3g sizes and spread onto on anti-anaphylaxis adhesive plaster, then covered with waterproof membrane.The present invention have passed through the experiment of preclinical and clinical pharrnacokinetics.Chinese traditional medicine navel patch of the invention is easy to use, and patient compliance is good, evident in efficacy to improving constipation, safe.With significant QI invigorating promoting the circulation of qi, replenishing and activating blood, the de-swelling that helps digestion, effect of moisturize laxation.
Description
Technical field
The present invention relates to a kind of external used medicine and preparation, a kind of Chinese traditional medicine navel patch for treating constipation and preparation side are mainly proposed
Method.
Background technology
With traffic convenience and social senilization, because injure senile osteoporosis outward and caused by the patient that fractures increasingly increase
It is many, need long-term bed mostly after fracture.Because food-intake is reduced, enterocinesia slows down and constipation occurs after patient's long-term bed.
Constipation often makes patient body uncomfortable, and original disease aggravation, quality of life declines, and systemic toxicity profiles symptom, intestinal obstruction, blood vessel danger
As even inducing acute myocardial infarction AMI, arrhythmia cordis and sudden death etc..Constipation was generally released using methods such as laxative, bowel lavage in the past,
But effect persistently, can also not produce physiological dependence.And traditional Chinese medicine is in the aspect definite effect such as heat-clearing, promoting blood circulation, promoting the circulation of qi, defaecation, but
Stilled need deeply in terms of prescription, formulation, technique, curative effect, the reasonability of application, feasibility, validity, ease for use and security
Research.
The content of the invention
It is an object of the invention to provide the Chinese traditional medicine navel patch and preparation method of a kind for the treatment of constipation of external application, peace is made it have
Entirely, it is effective, the characteristics of facilitate.
Chinese traditional medicine navel patch of the present invention is made up of following Chinese medicine material by weight percentage；Rhubarb 16% 20%,
The bark of official magnolia 16% 20%, honey 16% 20%, the saltcake 8% 12%, dried immature fruit of citron orange 8% 12%, Radix Angelicae Sinensis 8% 12%, radish seed 4% 8%, fire
Edestan 3% 5%, brush-cherry seed 3% 5%, dried orange peel 2%.
The preparation method of navel patch of the present invention：
A, rhubarb, the bark of official magnolia, saltcake, the dried immature fruit of citron orange, Radix Angelicae Sinensis, radish seed, fructus cannabis, brush-cherry seed, dried orange peel are ground into medicinal powder, filled
Divide well mixed.
B, honey and medicinal powder are pressed 1:1 ratio reconciles into pasty state.
C, take 3g sizes and spread onto on anti-anaphylaxis adhesive plaster, then covered with waterproof membrane.
Compound basis of the invention.
The present invention is on the basis of the various medicines of research and medical literature is summarized, according to a large amount of Basic Experiment Studies
As a result, proposed with reference to a large amount of clinical cases；By the study of pharmacy of system, optimization formulation and technique are prepared from.
The basic pathogenesis of constipation is evil stagnant large intestine, and internal organs is gas-tight, and that the obstructed or intestines of plug lose is gentle, promotes powerless, causes large intestine to conduct
Malfunction.Orthopedics and traumatology patient is due to long-term bed operation wound, whole body qi depression to blood stasis, gas not promoting circulation of blood, hematogenous blockage, intestines in addition
Network stasis blocking or the deficiency of blood, the deficiency of vital energy are powerless, conduction mistake department, and cause constipation；According to its stagnation of the circulation of vital energy, blood stasis, intestines network stasis blocking, the deficiency of vital energy deficiency of blood master
Want the interpretation of the cause, onset and process of an illness, Chinese medicine should be with " QI invigorating promoting the circulation of qi, promoting blood circulation and removing blood stasis, blood-supplementing blood-nourishing, relax bowel " for the rules for the treatment of.
Traditional chinese medicine research shows that rhubarb has functions that purgating heat and bowels, it is adaptable to which Gastrointestinal excess heat is stagnant, stool
Constipated, belly turgor treatment.The bark of official magnolia has a promoting the circulation of qi de-swelling, effect of consumer product dredge stasis, it is adaptable to stagnation of QI due to dyspepsia, abdominal distention constipation
Treatment.Saltcake has purgating heat and bowels, effect of moistening for dryness and softening hard mass, it is adaptable to which real heat stagnates, the treatment of dry product of defecating.The dried immature fruit of citron orange has broken
Effect of gas disperse accumulations, it is adaptable to fullness and oppression of chest and abdomen, dyspepsia is stagnated, the treatment of constipation stomachache.Radish seed has functions that the de-swelling that helps digestion,
Suitable for stagnation of QI due to dyspepsia, the treatment of abdominal distension uncomfortable in chest.Radix Angelicae Sinensis has functions that replenishing and activating blood, relaxes bowel, it is adaptable to blood deficiency chlorosis,
The treatment of dry constipation of intestines.Fructus cannabis has functions that moisturize laxation defaecation, it is adaptable to blood deficiency and depleted fluid, the treatment of dry constipation of intestines.It is strongly fragrant
Li Ren has moisturize laxation, stagnant effect of lower gas row, it is adaptable to intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, the treatment of abdominal distention constipation.Dried orange peel has
Have functions that to whet the appetite in regulating QI and lowering the adverseness, tune, it is adaptable to full vexed, abdominal distention the treatment of taste retention of dampness due to stagnation of QI, chest diaphragm.Honey has
Qi-restoratives, the effect moisturized, it is adaptable to the treatment of dry constipation of intestines.
Chinese angelica blood supplementing promoting blood circulation in inventive formulation；The gas of dried immature fruit of citron orange benefaction stomach and intestine and relieve pain；Rheum officinale expels the heat-evil defaecation；Saltcake ease constipation
Defaecation；Bark of official magnolia promoting the circulation of qi de-swelling；Radish seed helps digestion de-swelling；Fructus cannabis moisturize laxation；Gas row is stagnant under brush-cherry seed；Dried orange peel regulating QI and lowering the adverseness；
Honey qi-restoratives is moisturized.All medicines share, tonification and purgation in combination, makes qi and blood reflex, and large intestine conducts must be taken charge of, and constipation must heal.In clinical practice,
According to patient's constitution and the actual situation of disease, rheum officinale, the consumption of Radix Angelicae Sinensis are increased and decreased as one sees fit, for excessively weak or stool without dry and hard
Person, can use rhubarb instead rhubarb, to weaken its power let out down, it is to avoid excessively consumption hinders healthy tendency；Increase the consumption of Radix Angelicae Sinensis simultaneously,
With increase its enrich blood ease constipation the effect of.
The present invention have passed through preclinical pharmacodynamics of San and clinical pharrnacokinetics experimental study.
First, preclinical pharmacodynamics of San experimental study
1st, mice with constipation experiment
Mouse 20 is taken, 2 groups are randomly divided into, every group 10, each group gives the mg/kg gavages of compound diphenoxylate 10, after 1h
Cause Constipation Model.Experimental group gavage gives the physiological saline containing 2% prepared Chinese ink after modeling, and then gavage gives and uses liquid administration group
2% prepared Chinese ink suspension being made into, administration volume is 0.02ml/g, and mouse is put into small mouse cage after administration, and per 1, cage, underlay is white
The clean filter paper of color, Continuous Observation 6h, the time of the 1st row's melena of record mouse and melena sum.Compared with experimental group, administration group
Melena efflux time first can substantially be shortened and increase 6h discharge melena points.P<0.05 is that difference is statistically significant, P<
0.01 has significant statistical significance for difference.
Influence of the Chinese medicine preparation to mouse defecation（）
2. conclusion
Preclinical pharmacodynamics of San result of study shows that Chinese medicine preparation of the invention has the effect of significant treatment constipation.
2nd, clinical pharrnacokinetics experimental study
1st, case selection:
Random selection clinic causes the patient of constipation totally 60 people, compressed fracture of thoracic vertebra and lumber vertebra 20 because of fracture surgery long-term bed
Example, pelvic fracture 20, neck of femur and intertrochanteric fracture totally 20.Wherein minimum 18 years old of age, oldest 86 years old,
Average age 52 years old.
2nd, the diagnostic criteria of disease:
It is mainly shown as that stool does not solve for 3 days or at least 3 days, not smooth during solution, amount is few, quality is normal or dry and hard such as sheep dung, very
Person just when pain with the malaise symptoms such as blood.
3rd, administrated method:
Navel patch of the invention, is affixed on umbilical region SHENQUE acupoint, twice daily.
4th, the result of determination of curative effect:
(1) it is effective:Treat stool within 1 2d to solve, abdominal pain and distension disappears, food of receiving recovers.
(2) effectively:Treat stool within 3 4d to solve, abdominal pain and distension mitigates, food of receiving improves.
(3) it is invalid:Treat and still solved without stool after 5 6d, remaining symptom is not improved.
5th, efficacy analysis:
60 constipation patients of table 5 pair are treated, (unit as a result as shown in the table:People)
After 1 course of therapy, total effective rate is 93 %, and patient has no adverse reaction.ThroughAnalysis, p<0.05
, difference has significant statistical significance, illustrates that medicine has definite therapeutic action to above-mentioned bone fracture illness.
Preclinical and clinical pharrnacokinetics described above are tested and proved, Chinese traditional medicine navel of the invention pastes easy to use, patient compliance
Property it is good, to improve constipation it is evident in efficacy, it is safe.With significant QI invigorating promoting the circulation of qi, replenishing and activating blood, the de-swelling that helps digestion, cunning is moisturized
Effect of intestines.
In sum, the characteristics of present invention has following:
1. prescription of the invention is from clinic, for illness it is definite, it is principles of formulating prescriptions science, apparent, medicinal material from reasonable,
Chinese Traditional Medicine characteristic is highlighted.
2. traditional Chinese medicine thinks that umbilical region SHENQUE acupoint is the congenital knot base of a fruit, the Qishe of the day after tomorrow, is root, the anger of twelve channels and collaterals
Source, the vital organs of the human body are originally.Stimulate the cave, can play dredging the channel, adjust and lead to up to internal organs, ease constipation by the through disease institute of channel course
Just effect, and umbilical region cortex is thin, fat-free mass, inside there is abundant blood vessel and a large amount of lymphatic vessels and nerve, permeability is strong, sensitive
Degree is high, and medicine readily penetrates through absorption.
Specific embodiment
Embodiment 1
The medicine material and consumption of Chinese traditional medicine navel patch of the present invention are constituted, by weight percentage：
Rhubarb 16%, the bark of official magnolia 16%, honey 16%, saltcake 12%, the dried immature fruit of citron orange 12%, Radix Angelicae Sinensis 12%, radish seed 4%, fructus cannabis 5%,
Brush-cherry seed 5%, dried orange peel 2%.
Preparation method:
1st, rhubarb, the bark of official magnolia, saltcake, the dried immature fruit of citron orange, Radix Angelicae Sinensis, radish seed, fructus cannabis, brush-cherry seed, dried orange peel are ground into medicinal powder, are filled
Divide well mixed.
2nd, honey and medicinal powder are pressed 1:1 ratio reconciles into pasty state.
3rd, 3g sizes are taken to spread onto on anti-anaphylaxis adhesive plaster, then is covered with waterproof membrane.
Embodiment 2
The medicine material and consumption of Chinese traditional medicine navel patch of the present invention are constituted, by weight percentage：
Rhubarb 18%, the bark of official magnolia 18%, honey 18%, saltcake 10%, the dried immature fruit of citron orange 10%, Radix Angelicae Sinensis 10%, radish seed 6%, fructus cannabis 4%,
Brush-cherry seed 4%, dried orange peel 2%.
Preparation method:
1st, rhubarb, the bark of official magnolia, saltcake, the dried immature fruit of citron orange, Radix Angelicae Sinensis, radish seed, fructus cannabis, brush-cherry seed, dried orange peel are ground into medicinal powder, are filled
Divide well mixed.
2nd, honey and medicinal powder are pressed 1:1 ratio reconciles into pasty state.
3rd, 3g sizes are taken to spread onto on anti-anaphylaxis adhesive plaster, then is covered with waterproof membrane.
Embodiment 3
The medicine material and consumption of Chinese traditional medicine navel patch of the present invention are constituted, by weight percentage：
Rhubarb 20%, the bark of official magnolia 20%, honey 20%, saltcake 8%, the dried immature fruit of citron orange 8%, Radix Angelicae Sinensis 8%, radish seed 8%, fructus cannabis 3%, Yu Li
Benevolence 3%, dried orange peel 2%.
Preparation method:
1st, rhubarb, the bark of official magnolia, saltcake, the dried immature fruit of citron orange, Radix Angelicae Sinensis, radish seed, fructus cannabis, brush-cherry seed, dried orange peel are ground into medicinal powder, are filled
Divide well mixed.
2nd, honey and medicinal powder are pressed 1:1 ratio reconciles into pasty state.
3rd, 3g sizes are taken to spread onto on anti-anaphylaxis adhesive plaster, then is covered with waterproof membrane.
Claims (5)
1. a kind of Chinese traditional medicine navel for treating constipation is pasted, for set a broken bone bed and the constipation of postoperative patient, it is characterized in that：Described
Chinese traditional medicine navel patch is made up of following Chinese medicine material by weight percentage:The rhubarb 16% 20%, bark of official magnolia 16% 20%, honey
16% 20%, the saltcake 8% 12%, dried immature fruit of citron orange 8% 12%, Radix Angelicae Sinensis 8% 12%, radish seed 4% 8%, fructus cannabis 3% 5%, brush-cherry seed
3% 5%, dried orange peel 2%.
2. the Chinese traditional medicine navel patch for the treatment of constipation according to claim 1, it is characterized in that each Chinese medicine material percentage by weight is matched somebody with somebody
Than for:Rhubarb 16%, the bark of official magnolia 16%, honey 16%, saltcake 12%, the dried immature fruit of citron orange 12%, Radix Angelicae Sinensis 12%, radish seed 4%, fructus cannabis 5%, Yu Li
Benevolence 5%, dried orange peel 2%.
3. the Chinese traditional medicine navel patch for the treatment of constipation according to claim 1, it is characterized in that each Chinese medicine material percentage by weight is matched somebody with somebody
Than for:Rhubarb 18%, the bark of official magnolia 18%, honey 18%, saltcake 10%, the dried immature fruit of citron orange 10%, it is Radix Angelicae Sinensis 10%, radish seed 6%, fructus cannabis 4%, strongly fragrant
Li Ren 4%, dried orange peel 2%.
4. the Chinese traditional medicine navel patch for the treatment of constipation according to claim 1, it is characterized in that each Chinese medicine material percentage by weight is matched somebody with somebody
Than for:Rhubarb 20%, the bark of official magnolia 20%, honey 20%, saltcake 8%, the dried immature fruit of citron orange 8%, Radix Angelicae Sinensis 8%, radish seed 8%, fructus cannabis 3%, brush-cherry seed
3%th, dried orange peel 2%.
5. the preparation method that a kind of Chinese traditional medicine navel for the treatment of constipation as claimed in claim 1 or 2 or 3 or 4 is pasted, it is characterized in that:
A, rhubarb, the bark of official magnolia, saltcake, the dried immature fruit of citron orange, Radix Angelicae Sinensis, radish seed, fructus cannabis, brush-cherry seed, dried orange peel are ground into medicinal powder, it is fully mixed
Close uniform；
B, honey and medicinal powder are pressed 1:1 ratio reconciles into pasty state；
C, take 3g sizes and spread onto on anti-anaphylaxis adhesive plaster, then covered with waterproof membrane.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687695A (en) * | 2016-01-30 | 2016-06-22 | 毛毛 | External application medicine for treating constipation caused by chemotherapy and preparation method thereof |
| CN105596622A (en) * | 2016-01-30 | 2016-05-25 | 毛毛 | External application drug for treating pleuroperitoneal fluid and preparing method thereof |
| CN106038826A (en) * | 2016-06-02 | 2016-10-26 | 首都医科大学宣武医院 | Traditional Chinese medicine formula for treating constipation of Parkinson sufferers and acupoint plaster thereof |
| CN114042134A (en) * | 2022-01-04 | 2022-02-15 | 刘相英 | Plaster for treating abdominal distension and constipation after thoracolumbar vertebral fracture operation |
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| CN101129723A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese medicine preparation for treating constipation |
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| CN1628798A (en) * | 2004-08-20 | 2005-06-22 | 康合堂 | Medicine for treating pertinacious constipation |
| CN101129723A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese medicine preparation for treating constipation |
| CN101129679A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese medicine composition for treating constipation |
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