CN106421612A - Pharmaceutical composition for resisting helicobator pylori gastric disease - Google Patents

Pharmaceutical composition for resisting helicobator pylori gastric disease Download PDF

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Publication number
CN106421612A
CN106421612A CN201611010957.XA CN201611010957A CN106421612A CN 106421612 A CN106421612 A CN 106421612A CN 201611010957 A CN201611010957 A CN 201611010957A CN 106421612 A CN106421612 A CN 106421612A
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pharmaceutical composition
radix
helicobator
resisting
helicobacter pylori
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CN201611010957.XA
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袁晓燕
王明义
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention relates to the field of medicine formulas, in particular to a pharmaceutical composition for resisting helicobator pylori gastric disease. The pharmaceutical composition is characterized by being prepared by, by weight, 30g of taraxacum mongolicum, 12g of Lonicera japonica, 10g of radix bupleuri, 15g of stir-fried radix paeoniae alba, 10g of radix tinosporae, 15g of poria cocos, 3g of rhizoma coptidis, 15g of rhizoma bletillae, 10g of fructus amomi, 15g of stir-fried malt, 12g of fritillary bulb, 20g of ossa sepiae and 10g of prepared radix glycyrrhizae. A preparation method of the pharmaceutical composition includes: soaking the medicinal raw materials above with water, decocting, and removing dregs to obtain filtrate. The pharmaceutical composition is definite in curative effect, quick in action, high in cure rate, free of toxic and side effects and low in cost.

Description

The pharmaceutical composition of helicobacter pylori resistant gastropathy
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of drug regimen of helicobacter pylori resistant gastropathy Thing.
Background technology
It is known that helicobacter pylori colonizes in mucosa tissue, the gastric ulcer of 67%-80% and 95% 12 finger Intestinal ulcer is caused by helicobacter pylori.The universal symptom of chronic gastritiss and digestive tract ulcer patient is：Epigastrium after food Glutted, uncomfortable or pain, is often accompanied by other ill symptomses, such as belch, abdominal distention, acid regurgitation and loss of appetite etc..Some patients also may be used Repeated relapsing tormina, a small amount of bleeding of upper digestive tract etc. occur.Helicobacter pylori infection can be cured, general Therapeutic Principle is based on antibiotic, additional acid inhibitor（Bismuth）, common antibiotics amoxicillin, gentamycin, carat Mycin and amoxicillin etc., but side effect is also more apparent.
Content of the invention
The technical problem to be solved is to overcome the deficiencies in the prior art, providing a kind of anti-H. pylori The pharmaceutical composition of bacterium gastropathy, determined curative effect, instant effect, cure rate is high, has no toxic side effect, low cost.
The present invention solves above-mentioned technical problem and employed technical scheme comprise that：A kind of medicine group of helicobacter pylori resistant gastropathy Compound is it is characterised in that be made up of the crude drug of following weight：Herba Taraxaci 30g, Flos Lonicerae 12g, Radix Bupleuri 10g, Radix Paeoniae Alba (parched) 15g, Radix Tinosporae 10g, Poria 15g, Rhizoma Coptidis 3g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Fructus Amomi 10g, Fructus Hordei Germinatus (parched) 15g, Bulbus Fritillariae Thunbergii 12g, Endoconcha Sepiae 20g, Radix Glycyrrhizae Preparata 10g, above-mentioned raw materials medicine is soaked in water, filtrate of removing slag after decocting to obtain.
The invention has the beneficial effects as follows, determined curative effect, instant effect, cure rate is high, has no toxic side effect, low cost.
Specific embodiment
With reference to embodiment, the invention will be further described：
Embodiment：
Its component（Weight %）Every pair is Herba Taraxaci 30g, Flos Lonicerae 12g, Radix Bupleuri 10g, Radix Paeoniae Alba (parched) 15g, Radix Tinosporae 10g, Poria 15g, Rhizoma Coptidis 3g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Fructus Amomi 10g, Fructus Hordei Germinatus (parched) 15g, Bulbus Fritillariae Thunbergii 12g, Endoconcha Sepiae 20g, Radix Glycyrrhizae Preparata 10g, add water 1000ml Left and right, soaks 3～4 hours, boils rear slow fire and decocts the filtrate 200ml that removes slag to obtain, medicinal residues add water 200, remove slag after decocting Filtrate 100ml, there are 300ml about medicine juice, that is, decoction is obtained.Daily 1 dose point is administered orally for 2 times, each (medicine) being taken before meal 150ml Left and right.
Rhizoma Coptidis antimicrobial and protozoacide effect in side of the present invention, by agar plate dilution method to conventional Chinese medicine 100 taste Carry out the research of vitro inhibition helicobacter pylori, found that Rhizoma Coptidis etc. have height inhibitory action to helicobacter pylori, can also resist Ulcer, can suppress gastric injury to be formed.The effect that Radix Tinosporae extract has preventing and treating peptic ulcer and promotes ulcer healing, its Mechanism may be damaged with antioxidant radical, promotes nitric oxide synthesis, improves gastric mucosa endogenouss PGE2Level thus adjusting The effect of Mucosal blood flow amount, and anti-Hp infection is relevant.Fructus Amomi volatile oil treats acetic acid ulcer, can make aminohexose and phospholipid Content significantly raise, so that the hydrophobicity of gastric mucosa is strengthened further, prevent ulcer produce with recurrence.Herba Taraxaci, Radix Glycyrrhizae have suppression Gastric ulcer effect processed, Herba Taraxaci, Flos Lonicerae, the Radix Paeoniae Alba have resisting pathogenic microbes to act on.Radix Glycyrrhizae has anti-microbial effect, can suppress general Lead to and Drug resistance Helicobacter pylori.Radix Bupleuri acts on to gastrointestinal, the acidic polysaccharose portion of separation and purification in the hot water extract of Radix Bupleuri Divide BR-2 coloclysis, alcohol repellency ulcer, harness water logging stress ulcer and rat pylorus ligation ulcer all significantly inhibit to mice Effect.Poria energy preventing gastric ulcer：Poria aqueous extract, to Oral Administration in Rats, can prevent the generation of slight gastric ulcer, mice is also had Pre- waterproof attacks the effect of caused stress gastric ulcer.Pseudobulbus Bletillae (Rhizoma Bletillae) has the protective effect to mucosa.Fructus Hordei Germinatus (parched) has the work of promoting digestion and removing stagnation With.Bulbus Fritillariae Thunbergii has stronger anti-helicobacter pylori activity, antiulcer and analgesic and anti-inflammatory effects.Endoconcha Sepiae has astringing to arrest bleeding, antacid The effect of pain relieving.
With reference to clinical trial the present invention is made further, describe in detail：
Model case：
King so-and-so, female, 42 years old, vague epigastralgia was uncomfortable, distension after food, belch, acid regurgitation, anorexia.
Gastroscope finding：Antrum is rough, antetheca visible lamellar ulcer, adheres to white fur.
Gastroscope Diagnosis：Gastric ulcer.
Pathological diagnosis:Gastric antrum：Mucosa severe chronic is scorching to be formed with acute inflammation and lymph follicle it is seen that seldom being permitted inflammatory exudation Thing.Helicobacter pylori.
Give we treatment, one month is a course for the treatment of, after taking a course for the treatment of, vague epigastralgia is uncomfortable to disappear, no acid regurgitation, Appetite is good, stomach distension, belch after sometimes eating, and after one course for the treatment of of following the service, all cards disappear.Take the 3rd course for the treatment of and consolidate curative effect, half After year, check gastroscope is normal, Helicobacter pylori-Negative.
Song, man, 50 years old, vague epigastralgia, eat postemphasis, anorexia, belching of gas frequency is made.
Gastroscope finding：Antrum congestion and edema, erosion.
Gastroscope Diagnosis：Non- atrophic gastritis accompanied is rotten to the corn.
Pathological diagnosis：Gastric antrum：Mucosa severe chronic scorching companion acute inflammation and erosion.Helicobacter pylori.
Give we treatment, serve on two courses for the treatment of, remission, interruption takes the 3rd course for the treatment of, after half a year, check gastroscope Normally, Helicobacter pylori-Negative.

Claims (1)

1. a kind of pharmaceutical composition of helicobacter pylori resistant gastropathy is it is characterised in that be made up of the crude drug of following weight：Pu Herba Taraxaci 30g, Flos Lonicerae 12g, Radix Bupleuri 10g, Radix Paeoniae Alba (parched) 15g, Radix Tinosporae 10g, Poria 15g, Rhizoma Coptidis 3g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Fructus Amomi 10g, Fructus Hordei Germinatus (parched) 15g, Bulbus Fritillariae Thunbergii 12g, Endoconcha Sepiae 20g, Radix Glycyrrhizae Preparata 10g, above-mentioned raw materials medicine is soaked in water, and removes slag and must filter after decocting Liquid.
CN201611010957.XA 2016-11-17 2016-11-17 Pharmaceutical composition for resisting helicobator pylori gastric disease Pending CN106421612A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3892287A4 (en) * 2018-12-06 2022-08-24 Green Cross Wellbeing Corporation Lonicera japonica flower water extract-containing pharmaceutical composition for preventing or treating helicobacter pylori infection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102764403A (en) * 2012-07-18 2012-11-07 刘晓云 Traditional Chinese medicine for treating chronic gastritis and gastroduodenal ulcer
CN103212032A (en) * 2013-04-11 2013-07-24 闫忠英 Traditional Chinese medicine composition for treating gastric diseases
CN104474441A (en) * 2014-11-27 2015-04-01 张雷 Drug for treating gastropathy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102764403A (en) * 2012-07-18 2012-11-07 刘晓云 Traditional Chinese medicine for treating chronic gastritis and gastroduodenal ulcer
CN103212032A (en) * 2013-04-11 2013-07-24 闫忠英 Traditional Chinese medicine composition for treating gastric diseases
CN104474441A (en) * 2014-11-27 2015-04-01 张雷 Drug for treating gastropathy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3892287A4 (en) * 2018-12-06 2022-08-24 Green Cross Wellbeing Corporation Lonicera japonica flower water extract-containing pharmaceutical composition for preventing or treating helicobacter pylori infection

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Application publication date: 20170222