CN103961632A - Traditional Chinese medicinal composition for treating gastric ulcer and duodenal ulcer - Google Patents

Abstract

The invention provides a traditional Chinese medicinal composition for treating gastric ulcer and duodenal ulcer. The traditional Chinese medicinal composition for treating the gastric ulcer and duodenal ulcer is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of caltrop, 5-15 parts of rhizoma cyperi, 5-15 parts of fried rhizoma atractylodis, 5-10 parts of szechwan lovage rhizome, 15-30 parts of thunberg fritillary bulb, 5-15 parts of rhizoma bletillae, 5-15 parts of cuttle bone, 10-25 parts of codonopsis pilosula, 10-25 parts of raw white atractylodes rhizome, 20-40 parts of poria cocos, 15-30 parts of fructus evodiae, 5-15 parts of inula flower, 5-15 parts of fructus amomi and 10-20 parts of liquorice. The traditional Chinese medicinal composition for treating the gastric ulcer and the duodenal ulcer adopts natural traditional Chinese medicines as raw materials, can be used for treating the gastric ulcer and the duodenal ulcer by utilizing combined action of the natural traditional Chinese medicines, produces no toxic or side effects to a human body and is low in cost and definite in curative effect.

Description

A kind of Chinese medicine composition for the treatment of gastric and duodenal ulcers

Technical field:

The present invention relates to Chinese medicine technical field, particularly a kind of Chinese medicine composition for the treatment of gastric and duodenal ulcers.

Background technology:

Gastric and duodenal ulcers is a kind of multi-factor disease, cause of disease complexity, completely unclear so far, the clearer and more definite cause of disease is helicobacter pylori infections, take non-steroid antiinflammatory drug, gastroxia and heredodiathesis, stress with the composite factor such as psychological factor, smoking due to.Common clinical manifestation has the stomachache of the epigastrium of being confined to, how to occur half an hour after the meal, continue 1-2 hour, fade away, also often have other gastrointestinal symptoms concurrently, as belch, acid regurgitation, heartburn, nauseating, vomiting etc., how slow onset is, and the course of disease reaches several years or many decades, is periodical attack, having a strong impact on Health and Living, can there is canceration in multiple epimegetic ulcer.In recent years clinical onset rate has the trend of continuous rising.

Be main for the treatment of gastric and duodenal ulcers mainly with oral western medicine at present, Western medicine side effect is large, easily impairing the liver, easily recurrence.Occurred in the market the Chinese medicine of many treatment stomaches, duodenal ulcer, although these medicines have the ailing effect of good alleviation, but still it is long to have treatment cycle, and price is high, the not obvious deficiency that waits of therapeutic effect.

Summary of the invention:

Object of the present invention is exactly in order to overcome deficiency of the prior art, and the Chinese medicine composition of the treatment gastric and duodenal ulcers that a kind of therapeutic effect is good, effective percentage is high, human body is had no side effect is provided.

The invention provides following technical scheme:

Treat a Chinese medicine composition for gastric and duodenal ulcers, it is characterized in that being made by the raw material of Chinese medicine of following weight proportion: Fructus Tribuli 10-20 part, Rhizoma Cyperi 5-15 part, Rhizoma Atractylodis (parched) 5-15 part, Rhizoma Chuanxiong 5-10 part, Bulbus Fritillariae Thunbergii 15-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Os Sepiae 5-15 part, Radix Codonopsis 10-25 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Poria 20-40 part, Fructus Evodiae 15-30 part, Flos Inulae 5-15 part, Fructus Amomi 5-15 part, Radix Glycyrrhizae 10-20 part.

Formula optimization is:

15 parts of Fructus Tribulis, 10 parts of Rhizoma Cyperis, 10 parts of Rhizoma Atractylodis (parched), 7 parts of Rhizoma Chuanxiongs, 20 parts of Bulbus Fritillariae Thunbergiis, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Os Sepiae, 15 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 30 parts, Poria, 20 parts of Fructus Evodiaes, 10 parts of Flos Inulaes, 10 parts of Fructus Amomis, 15 parts, Radix Glycyrrhizae.

Preparation method: get by weight ratio above-mentioned raw material of Chinese medicine, concoct qualified after, decoct 3 times, merge 3 times decoction liquor, be condensed into dry extract, be ground into 600 order fine powders, fill capsule after mycete, 1 gram of crude drug of fill in every capsules.

Instructions of taking:

3 times on the one, each oral 2-4 grain, taking medicine continuously 15 days is a course for the treatment of.

Form being described as follows of each raw material of Chinese medicine of the present invention:

Fructus Tribuli: slightly warm in nature, acrid in the mouth, hardship.There is suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, the effect such as antipruritic.Be usually used in for having a headache dizzy, distending pain in the chest and hypochondrium, breast closes acute mastitis, conjunctival congestion cataracta, the diseases such as rubella pruritus.Research shows: this product has Antiageing effect, strong effect, Fructus Tribuli total saponins has protective effect, Fructus Tribuli to have the effects such as micronutrient levels in the blood fat of adjusting, control agent, antibacterial analgesia, protection retinal neuronal cell to hypoxia/reoxygenation, Myocardial Ischemia-reperfusion.

Rhizoma Cyperi: acrid in the mouth, micro-hardship, micro-sweet, property is flat.Return liver, spleen, tri-jiao channel.There are promoting QI circulation for relieving depression, the effects such as menstruction regulating and pain relieving.Be usually used in for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, colic of cold type stomachache, distending pain of the breast, menoxenia, the diseases such as amenorrhea dysmenorrhea.Research shows: this product have calmness, analgesia, antipyretic, heart tonifying, decreased heart rate, also, blood pressure lowering, antiinflammatory, inhibition intestinal tube shrink and the effect such as antibacterial.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.There is the effects such as drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Be usually used in distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, the diseases such as nyctalopia.Research shows: this product has the function of adjusting gastrointestinal motility, Rhizoma Atractylodis decoct, atractylol extract can obviously be alleviated isolated small intestines of rabbits spasm due to acetylcholine in range of doses, and intestinal motility due to epinephrine is suppressed, there is certain antagonism.In addition, also there is gastric acid secretion inhibiting, strengthen gastric mucosal protection, the effect such as protect the liver.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.There is blood-activating and qi-promoting, the effects such as wind-expelling pain-stopping.Be usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches.Blood circulation promoting and blood stasis dispelling effect is extensive, the various diseases of suitable stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, nearly says the functions such as pungent loose, the resolving depression of its residence, sensible, pain relieving.In vitro tests shows: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.

Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature.Return lung, heart channel.In tool " book on Chinese herbal medicine is just ", record this product: " great order lung abscess lung withers, and cough with asthma is spitted blood, and mental disorder, falls most in epistaxis, kind relieving stagnation, and the pain that relieves the pain, relieving distension is full, clearing away liver-fire, improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, the hematuria of having blood in stool; Relieving heat toxin, kills parasites and treats sore throat, scrofula, and acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain, than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times ".

Pseudobulbus Bletillae (Rhizoma Bletillae): the i.e. Pseudobulbus Bletillae (Rhizoma Bletillae), bitter in the mouth, sweet, puckery, cold in nature, returns lung, stomach.Liver Channel.Have astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc.Research shows: local exchange has the effects such as good hemostasis, antibacterial, antifungal, also has protection gastric mucosa, repairs the effects such as gastric mucosa.

Os Sepiae: salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.There is astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, the effects such as sore.Be usually used in the acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the diseases such as the many pus of skin ulcer.This product and Bulbus Fritillariae Thunbergii, Pseudobulbus Bletillae (Rhizoma Bletillae) compatibility use Peptic Ulcers and hemorrhage, the perforation that cause, all have good therapeutic effect.

Radix Codonopsis: sweet in the mouth, property is flat.Return spleen, lung meridian.There is invigorating the spleen and replenishing QI, the effects such as spleen invigorating lung benefiting.Be usually used in deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, the interior-heat disease such as quench one's thirst.Experiment shows: this product, to having protective effect by type gastric ulcer, can suppress the variation of above-mentioned stomach electricity stomach function regulating motion simultaneously; Rat Pylorus Ligated Gastric Ulcer is all had to obvious preventive effect; To the protective effect of dehydrated alcohol injury rats gastric mucosa; Radix Codonopsis and effective ingredient thereof damage and have protective effect damage gastric mucosa.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive disease such as grade.Be usually used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, the diseases such as loose stool, frequent fetal movement of having loose bowels.This product has obvious inhibitory action to platelet aggregation; To animal water-immersion restraint stress ulcer, have and showing inhibition; Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus etc. are all had to bacteriostasis in various degree, also there is promotion hemopoietic function, promote protein synthesis, promote the effects such as list secretion.

Poria: sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, the effects such as spleen invigorating mind calming.Be usually used in edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia waits disease.Research shows: Poria has direct relexation to family's rabbits infestines, and the ulcer that rat pylorus ligation is formed has preventive effect, and can reduce gastric acid.

Fructus Evodiae: acrid in the mouth, hardship, hot in nature; Slightly poisonous.Return liver, spleen, stomach, kidney channel.There is dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, the effects such as supporing yang antidiarrheal.Be usually used in headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; The diseases such as hypertension.This product also has anti-gastric-ulcer, reduces gastric acidity, improves Stomach residue rate, preventing or arresting vomiting, antidiarrheal, protects the liver, the effect such as anti-hypoxia.

Flos Inulae: bitter in the mouth, pungent, salty, slightly warm in nature.Return lung, spleen, stomach, large intestine channel.There is sending down the abnormal ascending QI, expectorant, row water, the effects such as preventing or arresting vomiting.Be usually used in cough due to wind and cold, phlegm retention is held knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, the diseases such as epigastric oppression and rigidity.Research shows: the caffeic acid in Flos Inulae and chlorogenic acid have bacteriostasis more widely; Can increase the secretory volume of hydrochloric acid in people's stomach; Also have the effect that increases rat bile secretion, Flos Inulae decoct has obvious inhibitory action to staphylococcus aureus, anthrax bacillus and shigella flexneri II a strain.

Radix Glycyrrhizae: sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effects such as coordinating the actions of various ingredients in a prescription.Be usually used in weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, the disease such as strong.The aqueous extract of Radix Glycyrrhizae has the effect of protection gastric mucosa.

The invention has the beneficial effects as follows:

The present invention, taking natural Chinese medicine as raw material, utilizes the comprehensive function treatment gastric and duodenal ulcers of each taste medicine, human body had no side effect, and cheap, determined curative effect.

Detailed description of the invention:

Embodiment 1:

Treat a Chinese medicine composition for gastric and duodenal ulcers, it is characterized in that being made by the raw material of Chinese medicine of following weight proportion: 15 parts of Fructus Tribulis, 10 parts of Rhizoma Cyperis, 10 parts of Rhizoma Atractylodis (parched), 7 parts of Rhizoma Chuanxiongs, 20 parts of Bulbus Fritillariae Thunbergiis, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Os Sepiae, 15 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 30 parts, Poria, 20 parts of Fructus Evodiaes, 10 parts of Flos Inulaes, 10 parts of Fructus Amomis, 15 parts, Radix Glycyrrhizae.

Preparation method: get by weight ratio above-mentioned raw material of Chinese medicine, concoct qualified after, decoct 3 times, merge 3 times decoction liquor, be condensed into dry extract, be ground into 600 order fine powders, fill capsule after mycete, 1 gram of crude drug of fill in every capsules.

Embodiment 2:

Treat a Chinese medicine composition for gastric and duodenal ulcers, it is characterized in that being made by the raw material of Chinese medicine of following weight proportion: 10 parts of Fructus Tribulis, 5 parts of Rhizoma Cyperis, 5 parts of Rhizoma Atractylodis (parched), 5 parts of Rhizoma Chuanxiongs, 15 parts of Bulbus Fritillariae Thunbergiis, 5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 5 parts of Os Sepiae, 10 parts of Radix Codonopsis, 10 parts of Rhizoma Atractylodis Macrocephalae, 20 parts, Poria, 15 parts of Fructus Evodiaes, 5 parts of Flos Inulaes, 5 parts of Fructus Amomis, 10 parts, Radix Glycyrrhizae.

Preparation method: get by weight ratio above-mentioned raw material of Chinese medicine, concoct qualified after, decoct 3 times, merge 3 times decoction liquor, be condensed into dry extract, be ground into 600 order fine powders, fill capsule after mycete, 1 gram of crude drug of fill in every capsules.

Embodiment 3:

Treat a Chinese medicine composition for gastric and duodenal ulcers, it is characterized in that being made by the raw material of Chinese medicine of following weight proportion: 20 parts of Fructus Tribulis, 15 parts of Rhizoma Cyperis, 15 parts of Rhizoma Atractylodis (parched), 10 parts of Rhizoma Chuanxiongs, 30 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 15 parts of Os Sepiae, 25 parts of Radix Codonopsis, 25 parts of Rhizoma Atractylodis Macrocephalae, 40 parts, Poria, 30 parts of Fructus Evodiaes, 15 parts of Flos Inulaes, 15 parts of Fructus Amomis, 20 parts, Radix Glycyrrhizae.

Preparation method: get by weight ratio above-mentioned raw material of Chinese medicine, concoct qualified after, decoct 3 times, merge 3 times decoction liquor, be condensed into dry extract, be ground into 600 order fine powders, fill capsule after mycete, 1 gram of crude drug of fill in every capsules.

The clinical observation on the therapeutic effect experiment of a kind of Chinese medicine for the treatment of gastric ulcer and duodenal ulcer of the present invention:

The physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat altogether 52 routine patients, wherein male 39 examples, female's 13 examples; The oldest person 77 years old, age reckling 21 years old.

Therapeutic Method:

Adopt the prepared medicament of the embodiment of the present invention 1, its usage and consumption are as follows: in after meal early, and before supper, the capsule that before sleeping, each clothes contain four grams of crude drugs.Warm water takes.The course for the treatment of: 15 days be a course for the treatment of, treat altogether 4～8 courses for the treatment of.

The standard of curative effect evaluation

Cure: sign and symptom are improved completely, diet digestion is normal, in high spirits.

Effective: sign and symptom are improved completely, diet digestion normal, in high spirits.

Effective: sign and symptom change, random thoughts are slightly uncomfortable, but can accept.

Invalid: symptom is front without taking a turn for the better with treatment.

Therapeutic outcome:

In 52 routine cases, through treatment in 2 to 4 months, wherein cure 20 examples, account for 38.49% of total number of persons, effective 21 examples, account for 40.38% of total number of persons, and effective 9 examples, account for 17.3% of total number of persons, and invalid 2 examples, account for 3.84% of total number of persons, and total effective rate reaches 96.15%.Result shows, Chinese medicine composition of the present invention has extremely significant curative effect to treatment gastric ulcer and duodenal ulcer patients.

Model case:

1, patient Lee so-and-so, suffer from chronic gastric ulcer duodenal ulcer more than 6 years, cure of various big hospital do not have medicine to cure more, can not control institute's treatment because of busy, start to take this Chinese medicine composition April in this year, after two months, disease takes a favorable turn, and stomachache disappears, stool is normal, continue to take a month ulcerate disease condition and disappear completely, appetite increases, and people's mental attitude takes a favorable turn, after consolidate again the drug withdrawal in January of taking medicine, follow up a case by regular visits to one year over and do not occur repeatedly.

2, grandson patient so-and-so, female, 45 years old.Gastric abscess shows effect repeatedly for many years, scorching hot pain, and acid regurgitation, increases the weight of when hungry, must eat alleviation, and scorching being difficult to resolve of defecating, though remission after western medicine repeatly, soon recurrence again.Within nearly 2 days, increase the weight of red tongue, white and thin fur, stringy and rolling pulse, electronic gastroscopy result: duodenal ulcer.Take medicine of the present invention, treat 2 courses for the treatment of, symptom obviously alleviates, and conscious gastral cavilty is comfortable, and appetite takes a turn for the better, and continues to take 2 courses for the treatment of, and gastroscopy ulcer disappears completely, and recovery from illness is followed up a case by regular visits to after 1 year without recurrence.

3, patient is in so-and-so, man, 23 years old, often diet was irregular, hungry after a full meal, causes stomach dull pain, and with abdominal distention, have the hiccups, inappetence, lose weight, the symptom such as the gloomy and dyspepsia of complexion.Be diagnosed as duodenal ulcer by examination in hospital, after take after 2 courses for the treatment of of Chinese medicine composition of the present invention, the symptoms such as abdominal pain disappear substantially, complexion takes a turn for the better to some extent, takes medicine after 4 courses for the treatment of, above-mentioned symptom disappears, and detects through B is super, ulcer disappears.

Claims (2)

1. treat a Chinese medicine composition for gastric and duodenal ulcers, it is characterized in that being made by the raw material of Chinese medicine of following weight proportion: Fructus Tribuli 10-20 part, Rhizoma Cyperi 5-15 part, Rhizoma Atractylodis (parched) 5-15 part, Rhizoma Chuanxiong 5-10 part, Bulbus Fritillariae Thunbergii 15-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Os Sepiae 5-15 part, Radix Codonopsis 10-25 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Poria 20-40 part, Fructus Evodiae 15-30 part, Flos Inulae 5-15 part, Fructus Amomi 5-15 part, Radix Glycyrrhizae 10-20 part.

2. according to a kind of Chinese medicine composition for the treatment of gastric and duodenal ulcers described in claim 1, it is characterized in that being made by the raw material of Chinese medicine of following weight proportion: 15 parts of Fructus Tribulis, 10 parts of Rhizoma Cyperis, 10 parts of Rhizoma Atractylodis (parched), 7 parts of Rhizoma Chuanxiongs, 20 parts of Bulbus Fritillariae Thunbergiis, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Os Sepiae, 15 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 30 parts, Poria, 20 parts of Fructus Evodiaes, 10 parts of Flos Inulaes, 10 parts of Fructus Amomis, 15 parts, Radix Glycyrrhizae.