CN115487258A - Traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine preparation and preparation method - Google Patents
Traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine preparation and preparation method Download PDFInfo
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- CN115487258A CN115487258A CN202211135995.3A CN202211135995A CN115487258A CN 115487258 A CN115487258 A CN 115487258A CN 202211135995 A CN202211135995 A CN 202211135995A CN 115487258 A CN115487258 A CN 115487258A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux disease, a traditional Chinese medicine preparation and a preparation method. The traditional Chinese medicine composition comprises the following components in parts by weight: 6-10 parts of radix bupleuri, 8-10 parts of rhizoma cyperi, 8-10 parts of fructus aurantii, 6-9 parts of rhizoma pinelliae preparata, 6-10 parts of fructus gardeniae preparatus, 4-6 parts of rhizoma coptidis, 3 parts of fructus evodiae, 15 parts of salvia chinensis, 20-30 parts of concha arcae, 10 parts of caulis perllae, 15 parts of ruddle, 20-30 parts of cuttle bone, 15 parts of radix paeoniae alba, 20 parts of poria cocos, 10 parts of inula flower and 6 parts of raw liquorice. The traditional Chinese medicine composition can sooth the liver, release heat, harmonize the stomach and reduce adverse qi, and has a good treatment effect on heartburn, acid regurgitation, poststernal causalgia, epigastric causalgia, abdominal fullness and distention, belching and regurgitation, vexation and irritability, gastric upset and hunger proneness and other symptoms caused by gastroesophageal reflux disease.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating gastroesophageal reflux disease, a traditional Chinese medicine preparation and a preparation method.
Background
Gastroesophageal reflux disease (GERD) refers to a disease in which stomach contents reflux into the esophagus, causing discomfort symptoms and/or complications, and is mainly classified into three clinical types, non-erosive reflux disease (NERD), reflux Esophagitis (RE) and Barrett's Esophagus (BE). The clinical manifestations include the stimulation symptoms in and out of the esophagus caused by reflux, such as heartburn, acid regurgitation, non-cardiogenic chest pain, deglutition chest pain, cough, asthma, pharyngolaryngitis, oral ulcer and the like related to reflux, and some patients have no typical symptoms. The current data show that the prevalence rate of the typical symptom GERD in China is 2.5% -7.8%. Inhibition of gastric acid secretion is currently the mainstay of treatment for GERD, using drugs including Proton Pump Inhibitors (PPI), potassium competitive acid blockers (P-CAB). The emergence of PPIs has provided a great improvement in the treatment of GERD, but it is noted that the pathological mechanisms of GERD include dysfunction and structural failure at the gastro-esophageal junction, esophageal clearance dysfunction and diminished epithelial defense function. Reflux, an aggressive factor, is associated with multiple causes of lower esophageal sphincter relaxation, delayed gastrointestinal emptying, hp infection, and the like, and acid suppression is not a true causal treatment. Not all GERD patients benefit from PPI treatment, and some patients do not have improved symptoms or relapse after withdrawal of the drug after PPI treatment. In addition, long-term acid-suppressing treatment may lead to other adverse effects, such as increased probability of intestinal infection, trace element malabsorption, gastrointestinal malignant tumor, chronic kidney disease, myocardial infarction, cognitive dysfunction, fracture, etc.
The difficulty of the gastroesophageal reflux disease lies in how to control gas or bile and other non-acid reflux, the symptom of acid suppression treatment of non-erosive gastroesophageal reflux disease is low in remission rate, the acid suppression treatment effect of refractory gastroesophageal reflux disease is poor, adverse reaction can be caused by long-term acid suppression treatment, no clear comprehensive treatment means exists when the symptoms are overlapped, and the disease condition is repeated after the acid suppression and the drug withdrawal. Modern medicine does not have a satisfactory treatment in these areas, but traditional Chinese medicine can exert its effects. For example, the adverse rising of stomach qi can be inhibited by descending qi and harmonizing stomach; relieving symptoms caused by bile reflux by soothing liver and gallbladder; improving the functions of the spleen and the stomach by strengthening the spleen and the stomach, promoting the emptying of the stomach and the like. The traditional Chinese medicine can make up the defects of the treatment schemes of refractory gastroesophageal reflux disease, symptom overlapping and the like in modern medicine and reduce the adverse reaction caused by long-term administration of western medicines due to the combination of syndrome differentiation and disease differentiation and the treatment of the whole part and the part.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating gastroesophageal reflux disease, a traditional Chinese medicine preparation and a preparation method thereof in order to solve the technical problems.
The invention is realized by adopting the following technical scheme.
A traditional Chinese medicine composition for treating gastroesophageal reflux disease comprises the following components in parts by weight: 6-10 parts of radix bupleuri, 8-10 parts of rhizoma cyperi, 8-10 parts of fructus aurantii, 6-9 parts of rhizoma pinelliae preparata, 6-10 parts of fructus gardeniae preparatus, 4-6 parts of rhizoma coptidis, 3 parts of fructus evodiae, 15 parts of salvia chinensis, 20-30 parts of concha arcae, 10 parts of caulis perllae, 15 parts of ruddle, 20-30 parts of cuttle bone, 15 parts of radix paeoniae alba, 20 parts of poria cocos, 10 parts of inula flower and 6 parts of raw liquorice.
Further, the traditional Chinese medicine composition for treating gastroesophageal reflux disease comprises the following components in parts by weight: 10 parts of radix bupleuri, 10 parts of fructus aurantii, 10 parts of rhizoma cyperi, 9 parts of rhizoma pinelliae preparata, 10 parts of fructus gardeniae preparatus, 6 parts of rhizoma coptidis, 3 parts of fructus evodiae, 15 parts of Chinese sage herb, 30 parts of concha arcae, 10 parts of caulis perllae, 15 parts of ruddle, 30 parts of cuttle bone, 15 parts of radix paeoniae alba, 20 parts of poria cocos, 10 parts of inula flower and 6 parts of raw liquorice.
The pathogenesis of the disease is characterized in that: the first is adverse, the second is heat, and the third is depression. The stomach-qi failing to descend and the adverse rising of stomach-qi are the basic pathogenesis of gastroesophageal reflux disease, and the liver and gallbladder failing to disperse and disperse, the spleen failing to transport and transform, the stomach failing to descend and the lung failing to disperse and descend, the adverse rising of stomach-qi attacking the esophagus, and a series of clinical symptoms of the disease are formed. Deficiency caused by either congenital deficiency or weakness of the spleen and stomach is the basis of gastroesophageal reflux disease, wood deficiency or wood depression and soil accumulation cause wood qi deficiency and weakness, and liver wood inhibits spleen soil and gallbladder wood inhibits stomach soil, thus liver and stomach, liver and spleen or gallbladder and stomach are not harmed; for a long time, qi stagnation transforms into fire and generates acidity, liver and gallbladder pathogenic heat invade the spleen and stomach, spleen qi rises and stomach qi falls, liver does not rise with spleen, and gallbladder does not fall with stomach, so that stomach qi is involved with fire and heat is adverse-rising; the liver fire counter-restricts the lung, and can reduce the lung metal, burn body fluid, and cause cough, adverse qi movement, phlegm-qi stagnation and chest and diaphragm; long-term disease course, qi and blood stagnation may cause blood stasis or qi stagnation and blood stasis. The pathological factors of the disease include deficiency and excess: the pathological factors of excess: phlegm, heat, dampness, depression, qi, stasis; the deficient syndrome is related to the spleen.
Acid regurgitation refers to the ascending of acid in stomach, also called pantothenic acid, which can occur alone but often combined with stomach-ache, and also has the cold-heat syndrome. This syndrome is caused by the transformation of liver depression into heat, invasion of heat into the lung and stomach, and adverse flow of qi of the lung and stomach.
Su Wen and Zhi Zhen Yao Da Lun (plain questions and essential essentials) says that vomiting of acid and violent injection are both heat, and the disease is considered to be mostly heat. Yuan-Zhu Danxi (Danxi Heart method acid regurgitation) says that the acid regurgitation refers to the condition that damp-heat stagnates in the liver and stagnates between the lung and stomach. Ming Gong Jiting (longevity preservation Yuan acid) (Gong Ji) says that the liver-wood flavor of Fu acid is also related to liver qi because liver-wood is too strong to be even wood and is sour due to its strong liver-wood flavor. In the formula, the radix bupleuri is bitter and pungent and enters liver and gallbladder, so that the effect of treating liver qi is good at dispersing stagnation, the rhizoma cyperi is pungent and enters liver, spleen and triple energizer channels, is good at soothing liver, promoting qi circulation and relieving pain, and can regulate qi and relieve epigastric distention, and the radix bupleuri and the rhizoma cyperi are monarch drugs; with the bitter and cold coptis root, one excels in clearing stomach heat, the other can purge heart fire, and the other can purge its children if it is excessive, and the combination with the pungent and hot evodia fruit can also enter liver meridian to clear liver fire; the two medicines are compatible to play the effects of clearing liver fire, harmonizing stomach and descending adverse qi, and are used as ministerial medicines. Inulae flos and Haematitum have descending property and are good at descending qi of lung and stomach, and have the actions of harmonizing stomach, checking adverse rise of qi and relieving vomiting. The ginger-pinellia tuber has the functions of lowering adverse qi and harmonizing stomach, the concha arcae and the cuttle bone are used for preparing acid and relieving pain, the bitter orange is used for promoting qi circulation and relieving pain so as to dredge liver and spleen, the charred gardenia is used for clearing heat and soothing liver, the Chinese sage is used for clearing heat and promoting diuresis and relieving pain, the perilla stem is used for regulating qi and relieving pain, the poria cocos is used for promoting diuresis and excreting dampness and tonifying spleen, the white paeony root is used for nourishing blood and softening liver and relieving spasm and pain, and the ginger-pinellia tuber is used as an adjuvant drug for matching with the radix bupleuri to nourish the body of the liver and benefiting the liver. Licorice root, radix Glycyrrhizae, in combination with Bai Shao, acts as an adjuvant and guiding drug with the actions of increasing and alleviating spasm and pain. The combination of the medicines has the effects of dispersing liver qi, clearing heat, harmonizing stomach and lowering adverse qi.
A pill for treating gastroesophageal reflux disease comprises the above traditional Chinese medicine composition.
A preparation method of the pill for treating gastroesophageal reflux disease comprises the following steps:
s1, weighing specified amounts of radix bupleuri, fructus aurantii, rhizoma cyperi, ginger processed pinellia tuber, charred gardenia jasminoides, coptis chinensis, fructus evodiae, chinese sage herb, concha arcae, ruddle, cuttle bone, radix paeoniae alba, poria cocos and raw liquorice, sterilizing, drying, crushing into fine powder, sieving with a 100-mesh sieve, and uniformly mixing;
s2, weighing a specified amount of caulis perillae and inula flower, adding 8 times of water to decoct for two times, each time for 1.5 hours, combining decoctions, filtering, and concentrating the filtrate to obtain a clear paste with the relative density of 1.10-1.15;
and S3, uniformly mixing the fine powder obtained in the step S1 with the clear paste obtained in the step S2, making pills, drying and polishing to obtain the Chinese medicinal composition.
The present application has the following advantageous effects.
The traditional Chinese medicine composition can sooth the liver, release heat, harmonize the stomach and reduce adverse rise of energy, and has a good treatment effect on heartburn, acid regurgitation, poststernal causalgia, epigastric pain, abdominal fullness and distention, belching, regurgitation, vexation, irritability, gastric upset and hunger caused by gastroesophageal reflux disease.
Drawings
FIG. 1 is a gastroscopic image of case 1 of the present invention before treatment;
FIG. 2 is a gastroscope image of the present invention after treatment of case 1;
FIG. 3 is a gastroscope image of the present invention before treatment of case 2;
FIG. 4 is a gastroscopic image of case 2 of the present invention after treatment;
FIG. 5 is a gastroscopic image of case 3 of the present invention before treatment;
FIG. 6 is a gastroscope image of the present invention after treatment of case 3;
FIG. 7 is a gastroscopic image of case 4 of the present invention before treatment;
FIG. 8 is a gastroscope image of the invention after case 4 treatment;
FIG. 9 is a gastroscopic image of case 5 of the present invention before treatment;
FIG. 10 is a gastroscopic image of the invention after case 5 treatment.
Detailed Description
The present patent application is further illustrated below with reference to the following examples.
A traditional Chinese medicine preparation pill (liver-soothing stomach-harmonizing pill) for treating gastroesophageal reflux disease comprises the following steps:
radix bupleuri, fructus Aurantii, rhizoma Cyperi, ginger processed pinellia Tuber, fructus Gardeniae preparatus, rhizoma Coptidis, fructus evodiae, herba Salviae chinensis, concha arcae, haematitum, os Sepiae, radix Paeoniae alba, poria, and radix Glycyrrhizae by wet heat sterilization at 115 deg.C for 30 min, drying at 80 deg.C, pulverizing into fine powder, sieving with 100 mesh sieve, and mixing. Decocting caulis Perillae and Inulae flos with 8 times of water for two times, each for 1.5 hr, mixing decoctions, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.10-1.15 (20 deg.C), mixing with above fine powder, making pill, drying, and polishing.
The application collects 210 patients who receive the treatment of the liver-soothing and stomach-harmonizing pills from the spleen and stomach department hospitalization and outpatient department of the second subsidiary hospital of Anhui Chinese medicine university during 2022-01-01-2022-06-30, and the total effective rate is 95%.
Inclusion criteria were:
western diagnostic criteria:
meets the diagnosis standard of gastroesophageal reflux disease in Chinese medicine diagnosis and treatment expert consensus opinion on gastroesophageal reflux disease (2017): clinically, patients have typical symptoms of heartburn and acid regurgitation, and can be preliminarily diagnosed as GERD; the upper gastrointestinal endoscopy has RE and BE expressions, and the diagnosis of the disease can BE established; for patients suspected of GERD or patients suspected of having extra-esophageal symptoms associated with reflux, PPI trial therapy can be used, and if significant results are available, a diagnosis of the condition will generally be established. For the atypical patients, diagnosis is often performed by combining endoscopy, esophageal pH impedance monitoring and PPI experimental therapy analysis.
The traditional Chinese medicine diagnosis standard is as follows: according to its main clinical manifestations, it is manifested as heartburn, acid regurgitation, burning pain after sternum, discomfort throat, bitter taste in mouth, belching and regurgitation.
The diagnosis standard of the liver-stomach stagnated heat syndrome:
the main symptoms are: (1) heartburn; (2) and (4) acid reaction.
The secondary symptoms are as follows: (1) burning pain behind the sternum; (2) burning pain in the stomach; (3) abdominal distention and fullness; (4) belching or regurgitation; (5) irritability; (6) is easy to hunger. Tongue pulse: (1) red tongue with yellow coating; (2) the pulse is wiry.
The above 2 main symptoms, plus 2 secondary symptoms, refer to the tongue pulse, and the syndrome can be diagnosed.
And (3) effective standard:
1. judgment standard of inflammation under gastroscope
The improvement of the esophagitis mucous membrane inflammation under the gastroscope before and after the treatment: the method of the los Angeles Classification (LA Classification) was defined in 1994 by the world gastroenterology Association of los Angeles. And (3) healing: esophageal mucosa was normal under the endoscope. The effect is shown: esophageal mucosal performance was improved by grade 2. The method has the following advantages: esophageal mucosal performance was improved by grade 1. And (4) invalidation: esophageal mucosal performance was not improved.
2. Reflux Disease Questionnaire (RDQ)
RDQ is the most internationally recognized and widely applied special scale for diagnosing gastroesophageal reflux disease at present, the score of symptom frequency and symptom degree is 40 points at most, and the score of RDQ is more than or equal to 12 points to be diagnosed as GERD.
RDQ scoring criteria: (1) scoring by symptom onset frequency: according to the frequency of four symptoms of heartburn, regurgitation, non-cardiogenic chest pain and acid regurgitation, the frequency of the four symptoms is respectively counted as 0, 1, 2, 3, 4 and 5 points according to the 'never-before', '1 week < 1 d', '1 week 2-3 d', '1 week 4-5 d' and 'almost every day', and the highest frequency can be 20 points; (2) scoring by symptom onset: according to the occurrence degree of the four symptoms, the score of 0 is recorded as 'never before'; the doctor can remember 1 point when the symptom is not obvious and the doctor reminds that the symptom is not obvious; "symptoms are obvious, influence daily life, take medicine occasionally" record 3 points; the 'symptoms are very obvious, influence daily life, need to take medicine for a long time to treat' remember 5 points; "symptoms between 1 point and 3 points" score 2; "symptoms ranged between 3 and 5 points" and score 4.
3. Evaluation criteria for symptom efficacy
Grading record of main symptoms: level 0: no symptoms, 0 points. Stage I: the symptoms are mild, do not affect daily life, and accumulate 1 point. And II, stage: moderate symptoms, partly affecting daily life, 2 points in volume. And (3) stage III: the symptoms are severe, affect daily life, and are difficult to persist in work, which is 3 points in volume.
Evaluation criteria:
(1) the clinical cure is as follows: the original symptoms disappear.
(2) The effect is shown: grade 2 improvement of the original symptoms.
(3) The method has the following advantages: grade 1 improvement of the original symptoms.
(4) And (4) invalidation: no improvement or aggravation of the original symptoms
4. Evaluation criteria for quality of life
SF-36 health Scale is the most common universal measuring tool and is suitable for evaluating the health-related quality of life and clinical intervention effect of patients with gastroesophageal reflux disease.
Clinical typical cases
Case 1
Schoolgirl, admission time: 2022-07-06 discharge time: 2022-07-15
Admission symptoms: discomfort after sternum, acid regurgitation, burning sensation, burning pain in the stomach, abdominal distention, belch, regurgitation, vexation, irascibility, gastric upset, hunger, red tongue with yellow coating, and wiry pulse.
Traditional Chinese medicine diagnosis: acid regurgitation (liver and stomach stagnated heat syndrome)
And (3) Western diagnosis: gastroesophageal reflux disease
The treatment scheme comprises the following steps: the traditional Chinese medicine adopts a method of soothing the liver, relieving heat, harmonizing the stomach and lowering adverse qi, and is treated by a formula of liver-soothing and stomach-harmonizing pills, wherein the formula comprises the following medicines:
the application method comprises the following steps: one dose is taken every day with warm boiled water.
Post-treatment condition: the patient has no stomach pain, basically disappears the symptoms of acid regurgitation and heart burn, does not eructate, and has good emotion.
The evaluation index of the curative effect is as follows:
(1) gastroscopy: gastroscope in the hospital at the time of admission: esophagitis (grade B); bile flows back. As shown in fig. 1, prior to treatment: the mucous membrane at the lower end of the esophagus is rough, strip-shaped erosion is seen in the directions of 12 points and 3 points above the dentate line, and the major diameter is larger than 5mm; the gastric mucus lake is yellow and turbid.
Follow-up examination gastroscope after treatment: esophagitis (grade a). As shown in fig. 2, after treatment: the mucous membrane at the lower end of the esophagus is rough, strip erosion can be seen in the direction of 12 points above the dentate line, and the major diameter is less than 5mm; no abnormality was found in the gastric mucus lake.
(2) Reflux disease questionnaire, admission time 18 points. Treatment was followed by 6 points.
(3) Symptom efficacy evaluation criteria: has obvious effect.
(4) Evaluation standard of quality of life: after treatment, the score in SF-36 health Scale was higher than at admission.
Case 2
Pengzhi, male, time of admission: 2022-07-11 discharge time: 2022-07-20
Admission symptoms: acid regurgitation, heartburn, stomach ache, fullness and distention of the upper abdomen, gastric upset, hunger, dry mouth, bitter taste, red tongue with yellow coating, and wiry pulse.
Traditional Chinese medicine diagnosis: acid regurgitation (liver-stomach stagnated heat pattern)
And (3) Western diagnosis: gastroesophageal reflux disease
The treatment scheme comprises the following steps: the traditional Chinese medicine takes 'soothing the liver and relieving heat, harmonizing the stomach and lowering adverse qi' as a big method, and is treated by a 'soothing the liver and harmonizing the stomach pill' prescription, which comprises the following medicines:
the use method comprises the following steps: one dose is taken every day with warm boiled water.
Post-treatment condition: the patient firstly has the symptoms of acid regurgitation and heartburn obviously relieved, the stomach does not swell and pain, and the mouth is not dry and bitter.
The evaluation index of the curative effect is as follows:
(1) gastroscopy: gastroscope in the hospital at the time of admission: reflux esophagitis. As shown in fig. 3, prior to treatment: the mucous membrane at the lower part of the esophagus is rough, the dentate line is unclear, and the surrounding congestion and edema are obviously accompanied with erosion.
Follow-up gastroscope after treatment: distal esophagitis. As shown in fig. 4, after treatment: the mucous membrane at the lower end of the esophagus is slightly rough, the dentate line is clear, and the vein texture is not clear.
(2) Reflux disease questionnaire 14 points at admission. 5 points after treatment.
(3) Symptom efficacy evaluation criteria: has obvious effect.
(4) Evaluation standard of quality of life: the score on the SF-36 health Scale after treatment was higher than at admission.
Case 3
Somebody, woman, admission time: 2022-06-28 discharge time: 2022-07-05
Admission symptoms: pain and discomfort after the sternum, sour regurgitation, blockage and distension of the upper abdomen, aggravation after eating, poor appetite, dry mouth, bitter taste, red tongue with yellow coating, and wiry pulse.
Traditional Chinese medicine diagnosis: acid regurgitation (liver-stomach stagnated heat pattern)
And (3) Western diagnosis: gastroesophageal reflux disease
The treatment scheme comprises the following steps: the traditional Chinese medicine takes 'soothing the liver and relieving heat, harmonizing the stomach and lowering adverse qi' as a big method, and is treated by a 'soothing the liver and harmonizing the stomach pill' prescription, which comprises the following medicines:
the application method comprises the following steps: one dose is taken every day with warm boiled water.
Post-treatment condition: the discomfort behind the sternum basically disappears, the acid is not reversed, the upper abdomen is blocked and stuffy, the obvious alleviation is realized, and the appetite is improved.
The evaluation index of the curative effect is as follows:
(1) gastroscopy: gastroscope in the hospital at the time of admission: esophagitis (grade B). As shown in fig. 5, prior to treatment: the mucous membrane of the middle lower segment of the esophagus is rough, strip-shaped erosion is respectively seen in the directions of 3 points and 5 points above the dentate line, the major diameter is larger than 5mm, and the vein texture is less clear.
Follow-up gastroscope after treatment: normal esophagus. As shown in fig. 6, after treatment: the esophageal mucosa is smooth, the dentate lines are clear, and the vascular texture is clear.
(2) Reflux disease questionnaire 16 points at admission. Treatment was followed by 3 points.
(3) Symptom efficacy evaluation criteria: the healing is complete.
(4) Evaluation standard of quality of life: the score on the SF-36 health Scale after treatment was higher than at admission.
Case 4
Zhangyi, male, admission time: discharge time 2022-06-30: 2022-07-12
Admission symptoms: regurgitation with heartburn accompanied by discomfort of the sternum, stomach distension and pain, belching with acid regurgitation, red tongue with yellow coating, and wiry pulse.
Traditional Chinese medicine diagnosis: acid regurgitation (liver-stomach stagnated heat pattern)
And (3) Western diagnosis: gastroesophageal reflux disease
The treatment scheme comprises the following steps: the traditional Chinese medicine adopts a method of soothing the liver, relieving heat, harmonizing the stomach and lowering adverse qi, and is treated by a formula of liver-soothing and stomach-harmonizing pills, wherein the formula comprises the following medicines:
the use method comprises the following steps: one dose is taken every day with warm boiled water.
Post-treatment condition: sour regurgitation and heartburn are relieved, the stomach is not distended and painful, even eructation is caused, and acid regurgitation is avoided.
The evaluation index of the curative effect is as follows:
(1) gastroscopy: gastroscope in the hospital at the time of admission: and (4) esophagitis. As shown in fig. 7, prior to treatment: the mucous membrane of the middle and lower segment of the esophagus is rough, and the veins of blood vessels are unclear.
Follow-up examination gastroscope after treatment: normal esophagus. As shown in fig. 8, after treatment: the esophageal mucosa is smooth, and the vascular texture is clear.
(2) Reflux disease questionnaire 13 points at admission. 7 points after treatment.
(3) Symptom efficacy evaluation criteria: has obvious effect.
(4) Evaluation standard of quality of life: the score on the SF-36 health Scale after treatment was higher than at admission.
Case 5
Somebody in Tang, women, admission time: 2022-07-11 discharge time: 2022-07-21
Admission symptoms: acid regurgitation and heartburn, gastric upset, abdominal distention and pain, bitter taste in the mouth, dry throat, restlessness, insomnia, low mood, red tongue with yellow coating, and wiry pulse.
Traditional Chinese medicine diagnosis: acid regurgitation (liver-stomach stagnated heat pattern)
And (3) Western diagnosis: gastroesophageal reflux disease
The treatment scheme comprises the following steps: the traditional Chinese medicine takes 'soothing the liver and relieving heat, harmonizing the stomach and lowering adverse qi' as a big method, and is treated by a 'soothing the liver and harmonizing the stomach pill' prescription, which comprises the following medicines:
the application method comprises the following steps: one dose is taken every day with warm boiled water.
Post-treatment condition: distending pain is obviously relieved, acid regurgitation is avoided, heartburn is avoided, night sleep is calm, emotion is clear, and mouth is not dry and bitter. The evaluation index of the curative effect is as follows:
(1) gastroscopy: gastroscope in the hospital at the time of admission: bile reflux gastritis. As shown in fig. 9, prior to treatment: the gastric mucus lake is yellow and turbid.
Follow-up gastroscope after treatment: active phase of chronic non-atrophic gastritis. As shown in fig. 10, after treatment: the gastric mucus lake was not abnormal.
(2) Reflux disease questionnaire 14 points at admission. 5 points after treatment.
(3) Symptom efficacy evaluation criteria: has obvious effect.
(4) Evaluation standard of quality of life: the score on the SF-36 health Scale after treatment was higher than at admission.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.
Claims (4)
1. A traditional Chinese medicine composition for treating gastroesophageal reflux disease is characterized in that: the paint comprises the following components in parts by weight: 6-10 parts of radix bupleuri, 8-10 parts of rhizoma cyperi, 8-10 parts of fructus aurantii, 6-9 parts of rhizoma pinelliae preparata, 6-10 parts of fructus gardeniae preparatus, 4-6 parts of rhizoma coptidis, 3 parts of fructus evodiae, 15 parts of salvia chinensis, 20-30 parts of concha arcae, 10 parts of caulis perllae, 15 parts of ruddle, 20-30 parts of cuttle bone, 15 parts of radix paeoniae alba, 20 parts of poria cocos, 10 parts of inula flower and 6 parts of raw liquorice.
2. The traditional Chinese medicine composition for treating gastroesophageal reflux disease according to claim 1, wherein: the paint comprises the following components in parts by weight: 10 parts of radix bupleuri, 10 parts of fructus aurantii, 10 parts of rhizoma cyperi, 9 parts of ginger processed pinellia tuber, 10 parts of charred gardenia, 6 parts of coptis chinensis, 3 parts of fructus evodiae, 15 parts of Chinese sage herb, 30 parts of concha arcae, 10 parts of caulis perllae, 15 parts of ruddle, 30 parts of cuttle bone, 15 parts of radix paeoniae alba, 20 parts of poria cocos, 10 parts of inula flower and 6 parts of raw liquorice.
3. A pill for treating gastroesophageal reflux disease, which is characterized in that: comprising the Chinese medicinal composition of claim 1 or 2.
4. A method for preparing a pill for the treatment of gastroesophageal reflux disease according to claim 3, wherein: the method comprises the following steps:
s1, weighing specified amounts of radix bupleuri, fructus aurantii, rhizoma cyperi, ginger processed pinellia tuber, charred gardenia jasminoides, coptis chinensis, fructus evodiae, chinese sage herb, concha arcae, ruddle, cuttle bone, white paeony root, poria cocos and raw liquorice, sterilizing, drying, crushing into fine powder, sieving by a 100-mesh sieve, and mixing uniformly;
s2, weighing a specified amount of caulis perillae and inula flower, adding 8 times of water to decoct for two times, each time for 1.5 hours, combining decoctions, filtering, and concentrating the filtrate to obtain a clear paste with the relative density of 1.10-1.15;
and S3, uniformly mixing the fine powder obtained in the step S1 with the clear paste obtained in the step S2, making pills, drying and polishing to obtain the Chinese medicinal composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211135995.3A CN115487258B (en) | 2022-09-19 | 2022-09-19 | Traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine preparation and preparation method |
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| CN202211135995.3A CN115487258B (en) | 2022-09-19 | 2022-09-19 | Traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine preparation and preparation method |
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| Publication Number | Publication Date |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116603023A (en) * | 2023-05-22 | 2023-08-18 | 上海市中医医院 | Traditional Chinese medicine composition for treating gastroesophageal reflux disease and application thereof |
| CN116747274A (en) * | 2023-07-31 | 2023-09-15 | 浙江省立同德医院(浙江省精神卫生研究院) | Traditional Chinese medicine composition and preparation for treating gastroesophageal reflux disease with syndrome of liver-stomach stagnation heat and application of traditional Chinese medicine composition and preparation |
| CN116832113A (en) * | 2023-07-29 | 2023-10-03 | 江西中医药大学附属医院 | Traditional Chinese medicine composition and traditional Chinese medicine decoction for treating gastroesophageal reflux disease, and preparation method and application thereof |
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| CN102430106A (en) * | 2011-12-13 | 2012-05-02 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composite for treating stomachache |
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| CN102430106A (en) * | 2011-12-13 | 2012-05-02 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composite for treating stomachache |
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| 况秀芬等: "疏肝理气法治疗反流性食管炎51例", 《现代中西医结合杂志》, vol. 10, no. 15, pages 1441 - 1442 * |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116603023A (en) * | 2023-05-22 | 2023-08-18 | 上海市中医医院 | Traditional Chinese medicine composition for treating gastroesophageal reflux disease and application thereof |
| CN116603023B (en) * | 2023-05-22 | 2024-06-18 | 上海市中医医院 | Traditional Chinese medicine composition for treating gastroesophageal reflux disease and application thereof |
| CN116832113A (en) * | 2023-07-29 | 2023-10-03 | 江西中医药大学附属医院 | Traditional Chinese medicine composition and traditional Chinese medicine decoction for treating gastroesophageal reflux disease, and preparation method and application thereof |
| CN116747274A (en) * | 2023-07-31 | 2023-09-15 | 浙江省立同德医院(浙江省精神卫生研究院) | Traditional Chinese medicine composition and preparation for treating gastroesophageal reflux disease with syndrome of liver-stomach stagnation heat and application of traditional Chinese medicine composition and preparation |
| CN116747274B (en) * | 2023-07-31 | 2024-01-30 | 浙江省立同德医院(浙江省精神卫生研究院) | Traditional Chinese medicine composition and preparation for treating gastroesophageal reflux disease with syndrome of liver-stomach stagnation heat and application of traditional Chinese medicine composition and preparation |
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