CN106418549A - 一种含有甘草甜素的肠内营养乳剂及其制备方法 - Google Patents
一种含有甘草甜素的肠内营养乳剂及其制备方法 Download PDFInfo
- Publication number
- CN106418549A CN106418549A CN201510476089.3A CN201510476089A CN106418549A CN 106418549 A CN106418549 A CN 106418549A CN 201510476089 A CN201510476089 A CN 201510476089A CN 106418549 A CN106418549 A CN 106418549A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- glycyrrhizin
- enteral nutrition
- nutrition emulsion
- emulsion containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 229960004949 glycyrrhizic acid Drugs 0.000 title claims abstract description 32
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 235000019410 glycyrrhizin Nutrition 0.000 title claims abstract description 32
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 title claims abstract description 32
- 239000004378 Glycyrrhizin Substances 0.000 title claims abstract description 27
- 239000000839 emulsion Substances 0.000 title claims abstract description 27
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 22
- 230000035764 nutrition Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000004945 emulsification Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000013325 dietary fiber Nutrition 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 24
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 18
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 18
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 16
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 15
- 239000003921 oil Substances 0.000 claims description 12
- 235000019198 oils Nutrition 0.000 claims description 12
- 229920001542 oligosaccharide Polymers 0.000 claims description 11
- 150000002482 oligosaccharides Chemical class 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 11
- 239000008158 vegetable oil Substances 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 239000004368 Modified starch Substances 0.000 claims description 10
- 229920000881 Modified starch Polymers 0.000 claims description 10
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 10
- 238000004090 dissolution Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 235000019426 modified starch Nutrition 0.000 claims description 10
- 239000012071 phase Substances 0.000 claims description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 9
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 9
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 claims description 9
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 9
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 9
- 108010073771 Soybean Proteins Proteins 0.000 claims description 9
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 9
- 229930003779 Vitamin B12 Natural products 0.000 claims description 9
- 229930003471 Vitamin B2 Natural products 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 9
- 229960002685 biotin Drugs 0.000 claims description 9
- 239000011616 biotin Substances 0.000 claims description 9
- 235000020958 biotin Nutrition 0.000 claims description 9
- 229910052804 chromium Inorganic materials 0.000 claims description 9
- 239000011651 chromium Substances 0.000 claims description 9
- 235000012721 chromium Nutrition 0.000 claims description 9
- 229960000304 folic acid Drugs 0.000 claims description 9
- 235000019152 folic acid Nutrition 0.000 claims description 9
- 239000011724 folic acid Substances 0.000 claims description 9
- 235000019175 phylloquinone Nutrition 0.000 claims description 9
- 239000011772 phylloquinone Substances 0.000 claims description 9
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 9
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims description 9
- 229960001898 phytomenadione Drugs 0.000 claims description 9
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 9
- 229960002477 riboflavin Drugs 0.000 claims description 9
- 235000019710 soybean protein Nutrition 0.000 claims description 9
- 235000019155 vitamin A Nutrition 0.000 claims description 9
- 239000011719 vitamin A Substances 0.000 claims description 9
- 235000019163 vitamin B12 Nutrition 0.000 claims description 9
- 239000011715 vitamin B12 Substances 0.000 claims description 9
- 235000019164 vitamin B2 Nutrition 0.000 claims description 9
- 239000011716 vitamin B2 Substances 0.000 claims description 9
- 235000019158 vitamin B6 Nutrition 0.000 claims description 9
- 239000011726 vitamin B6 Substances 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 9
- 235000005282 vitamin D3 Nutrition 0.000 claims description 9
- 239000011647 vitamin D3 Substances 0.000 claims description 9
- 229940045997 vitamin a Drugs 0.000 claims description 9
- 229940011671 vitamin b6 Drugs 0.000 claims description 9
- 229940021056 vitamin d3 Drugs 0.000 claims description 9
- 229910021380 Manganese Chloride Inorganic materials 0.000 claims description 8
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 claims description 8
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 8
- 235000010216 calcium carbonate Nutrition 0.000 claims description 8
- 229960002079 calcium pantothenate Drugs 0.000 claims description 8
- 229960004874 choline bitartrate Drugs 0.000 claims description 8
- QWJSAWXRUVVRLH-UHFFFAOYSA-M choline bitartrate Chemical compound C[N+](C)(C)CCO.OC(=O)C(O)C(O)C([O-])=O QWJSAWXRUVVRLH-UHFFFAOYSA-M 0.000 claims description 8
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 8
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 8
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 8
- 239000000395 magnesium oxide Substances 0.000 claims description 8
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 8
- 235000012245 magnesium oxide Nutrition 0.000 claims description 8
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 8
- 239000011565 manganese chloride Substances 0.000 claims description 8
- 235000002867 manganese chloride Nutrition 0.000 claims description 8
- 229940099607 manganese chloride Drugs 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 239000001103 potassium chloride Substances 0.000 claims description 8
- 235000011164 potassium chloride Nutrition 0.000 claims description 8
- 235000007715 potassium iodide Nutrition 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 235000002639 sodium chloride Nutrition 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- 235000013024 sodium fluoride Nutrition 0.000 claims description 8
- 239000011684 sodium molybdate Substances 0.000 claims description 8
- 235000015393 sodium molybdate Nutrition 0.000 claims description 8
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 claims description 8
- 239000011781 sodium selenite Substances 0.000 claims description 8
- 235000015921 sodium selenite Nutrition 0.000 claims description 8
- 229960001471 sodium selenite Drugs 0.000 claims description 8
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 8
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 8
- 229960001763 zinc sulfate Drugs 0.000 claims description 8
- 238000009928 pasteurization Methods 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 5
- 229930003451 Vitamin B1 Natural products 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 229960000355 copper sulfate Drugs 0.000 claims description 5
- 239000012043 crude product Substances 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 5
- 244000000010 microbial pathogen Species 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229960004839 potassium iodide Drugs 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 229960000414 sodium fluoride Drugs 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229960003495 thiamine Drugs 0.000 claims description 5
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 235000010374 vitamin B1 Nutrition 0.000 claims description 5
- 239000011691 vitamin B1 Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 235000013601 eggs Nutrition 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical group CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 108010058846 Ovalbumin Proteins 0.000 claims description 2
- 241000286209 Phasianidae Species 0.000 claims description 2
- 235000014103 egg white Nutrition 0.000 claims description 2
- 210000000969 egg white Anatomy 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229940010454 licorice Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 abstract description 6
- 229930003231 vitamin Natural products 0.000 abstract description 6
- 235000013343 vitamin Nutrition 0.000 abstract description 6
- 239000011782 vitamin Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 3
- 150000001720 carbohydrates Chemical class 0.000 abstract description 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 3
- 239000008103 glucose Substances 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 235000014633 carbohydrates Nutrition 0.000 abstract description 2
- 235000019197 fats Nutrition 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 235000018102 proteins Nutrition 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 230000002155 anti-virotic effect Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000011573 trace mineral Substances 0.000 abstract 1
- 235000013619 trace mineral Nutrition 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 description 9
- 150000002338 glycosides Chemical class 0.000 description 9
- 235000010980 cellulose Nutrition 0.000 description 8
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 8
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- -1 nicotiamide Chemical compound 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000036541 health Effects 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000002443 hepatoprotective effect Effects 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
本发明涉及一种含有甘草甜素的肠内营养乳剂及其制备方法，属于营养食品制剂的技术领域。该产品由甘草甜素、蛋白质、脂肪、碳水化合物、维生素、微量元素、膳食纤维和水经过一定的生产工艺加工而成。本发明提供的肠内营养乳剂作为一种全营养乳剂，易于消化吸收，可直接用于病人食用。同时，较之于其他的营养制剂，本产品添加了甘草甜素这种有效的活性成分，既能消炎抗病毒，又能保肝护肝，还能在不影响血糖水平的同时，增加该营养品的甜度，尤其适用于糖尿病人和高血糖病人食用，增强机体免疫力。
Description
技术领域
本发明涉及一种含有甘草甜素的肠内营养乳剂及其制备方法，属于营养食品制剂的技术领域。
背景技术
甘草甜素又称甘草酸苷，从甘草根中提取，由一分子的甘草次酸和两分子的葡萄糖醛酸组成，是甘草的主要成分。具有抗炎、抗变态反应、抗惊厥、抗肿瘤、镇痛、利尿，能够调节免疫、抑制病毒增殖及灭活病毒,降低转氨酶、修复肝组织损伤等多种作用。有文献报道甘草酸苷对慢性乙肝患者的血糖没有升高作用，反而在一定剂量下有降低作用。
另外，甘草甜素的甜度是蔗糖的200-300倍，在食品添加剂方面具有低热能、安全无毒和较强的医疗保健功效，是高血压、肥胖症、糖尿病、心脏病患者使用的最理想甜味剂，有浓郁的甘草 特殊香味，具有保健、解毒、护肝、消炎、增香等功效，是非常理想的纯天然甜味剂原料。
发明内容
本发明的目的是提供一种含有甘草酸苷的食用方便、口感极佳、在提供全面营养的同时保持机体血糖稳定的肠内营养乳剂及其制备方法。
本发明所述的含甘草酸苷的肠内营养乳剂的配方如下：以质量计，由蛋清蛋白粉22-38 g，大豆蛋白粉25-40 g，植物油27-39 g，甘油10-17 g，甘草甜素3．0-5．6 g，膳食纤维19.2-29.8 g，低聚糖15-26 g，钾1.22-1.54g，氯0.66-1.48g，氟1.2-2.0 mg，碘0.10-0.19mg，钠0.67-1.05mg，钙480-1045 mg，镁176-372mg，磷400-708mg，铁8.4-15.6mg，锌8.42-15.96mg，铜0.88-1.79mg，锰0.9-4.1mg，铬225-376μg，钼80-110μg ，硒56-84μg，生物素78-105μg，维生素K149-133μg，维生素B61.18-2.89mg，泛酸3.58-7.96mg，叶酸0.24-4.76mg，维生素A0.62-1.26mg，维生素E19.6-59.2 mg，维生素C90-804mg，维生素B11.03-2.50 mg，维生素B21.3-3.2mg，胆碱214-398mg，烟酰胺9.1-17.3mg，维生素B122.1-4.9μg，维生素D34.2-8.8μg和水1000ml组成。
甘草甜素提取方法如下：将甘草粉碎后与10%的乙醇溶剂以1：10的量投放到水浴锅中进行回流提取2-3小时，然后过滤，将滤液进行真空浓缩得到甘草提取浸膏，干燥后得到棕红色粉末状粗品。将浸膏用水溶解，用稀盐酸调节PH值至5.8-6.3后，过滤得到甘草酸溶液，然后利用大孔树脂分离，采用乙醇水溶液进行梯度洗脱，所得溶液用活性炭在65℃下脱色30分钟，趁热抽滤，静置析晶，抽滤，真空干燥即得甘草酸成品。
所述的蛋清蛋白粉是鸡蛋蛋清蛋白粉和鹌鹑蛋蛋清蛋白粉混合而成。
所述的植物油是大豆油、玉米油、菜籽油和花生油中的一种或几种混合物。
所述的低聚糖是低聚麦芽糖和低聚果糖中的一种或两种混合物。
所述的膳食纤维由纤维素和变性淀粉组成。
所述的营养乳剂具体制备步骤如下：
（1）物料混合：将配方量的蛋清蛋白粉，大豆蛋白粉，甘草甜素，低聚糖，碳水化合物，氯化钠，氯化钾，碳酸钙，氧化镁，焦磷酸铁，硫酸锌，硫酸铜，氯化锰，碘化钾， 氟化钠，氯化铬，钼酸钠，亚硒酸钠，纤维素，变性淀粉，酒石酸氢胆碱，维生素A，维生素D3，维生素E，维生素K1，维生素B1，维生素B2，维生素B6，维生素B12，维生素C，烟酰胺，生物素，泛酸钙和叶酸在氮气保护下混合溶解或分散在配方量的50-65℃水中得到水相；将配方量的甘油、植物油在60-70℃条件下混合均匀得到油相；将水相和油相进行加热微波搅拌混合得到稳定均匀的乳状液。
（2）巴氏灭菌：将混合好的乳状液在巴氏灭菌机中，于90-120℃下杀菌5-10分钟，杀死病原微生物后立即冷却至45-50℃，缓慢冷却至室温后，于1-4℃冷藏。
本发明的优点在于：本产品含有糖类、脂肪、蛋白质、维生素、无机盐和膳食纤维七大营养元素，是一种全营养乳剂，而且所用物料均来自天然，绿色健康。同时，相比其他营养制剂，本产品添加了甘草酸苷，不仅能够稳定血糖水平，保肝护肝；而且能改善口感，抗菌消炎，即便是糖尿病人、高血糖病人或者肝病患者都能放心食用。
本发明中用到的g、mg、μg、ml分别表示克、毫克、微克、毫升。
附图说明
图1为甘草酸苷的结构示意图；图2为各实施例保存一个月时的理化性能指标。
具体实施方式
实施例1
提取甘草酸苷：将甘草粉碎后与10%的乙醇溶剂以1：10的量投放到水浴锅中进行回流提取2.5小时，然后过滤，将滤液进行真空浓缩得到甘草提取浸膏，干燥后得到棕红色粉末状粗品。将浸膏用水溶解，用稀盐酸调节PH值为5.9，过滤得到甘草酸溶液，然后利用大孔树脂分离，采用乙醇水溶液进行梯度洗脱，所得溶液用活性炭在65℃下脱色30分钟，趁热抽滤，静置析晶，抽滤，真空干燥即得甘草酸成品。
以质量克数计，取蛋清蛋白粉25.8g，大豆蛋白粉36.2g，甘草甜素3.7g，低聚糖18.3，氯化钠0.4g，氯化钾1.8g，碳酸钙0.7g，氧化镁0.4g，焦磷酸铁53.4mg，硫酸锌37.5mg，硫酸铜3.6mg，氯化锰9.3mg，碘化钾0.2mg， 氟化钠3.7mg，氯化铬1.3mg，钼酸钠0.2mg，亚硒酸钠0.2mg，酒石酸氢胆碱0.9g，维生素A0.98mg，维生素D35.5μg，维生素E23.7mg，维生素K179μg，维生素B11.6mg，维生素B21.8mg，维生素B61.87mg，维生素B122.6μg，维生素C580mg，烟酰胺10.6mg，生物素99μg，泛酸钙5.7mg，叶酸2.9mg，纤维素9.8g，变性淀粉12.1g，植物油28.4g，甘油14.2g和水1000ml。
生产过程如下：将配方量的蛋清蛋白粉，大豆蛋白粉，甘草甜素，低聚糖，氯化钠，氯化钾，碳酸钙，氧化镁，焦磷酸铁，硫酸锌，硫酸铜，氯化锰，碘化钾， 氟化钠，氯化铬，钼酸钠，亚硒酸钠，纤维素、变性淀粉，酒石酸氢胆碱，维生素A，维生素D3，维生素E，维生素K1，维生素B1，维生素B2，维生素B6，维生素B12，维生素C，烟酰胺，生物素，泛酸钙和叶酸在氮气保护下混合溶解或分散在配方量的60℃水中得到水相；将配方量的甘油、植物油在60℃温度下混合均匀得到油相；将水相和油相在87℃进行微波搅拌混合得到稳定均匀的乳状液。将混合好的乳状液罐装后，在巴氏灭菌机中，于120℃下杀菌5分钟，杀死病原微生物后再氮气环境下立即冷却至室温后，于4℃冷藏。产品在该条件下保存一个月后的理化性能指标见图2。
实施例2
提取甘草酸苷：将甘草粉碎后与10%的乙醇溶剂以1：10的量投放到水浴锅中进行回流提取2小时，然后过滤，将滤液进行真空浓缩得到甘草提取浸膏，干燥后得到棕红色粉末状粗品。将浸膏用水溶解，用稀盐酸调节PH值至6.1后，过滤得到甘草酸溶液，然后利用大孔树脂分离，采用乙醇水溶液进行梯度洗脱，所得溶液用活性炭在65℃下脱色30分钟，趁热抽滤，静置析晶，抽滤，真空干燥即得甘草酸成品。
以质量克数计，取蛋清蛋白粉29.8g，大豆蛋白粉33.2g，甘草甜素4.2g，低聚糖18.3，氯化钠0.4g，氯化钾1.8g，碳酸钙0.7g，氧化镁0.4g，焦磷酸铁53.4mg，硫酸锌37.5mg，硫酸铜3.6mg，氯化锰9.3mg，碘化钾0.2mg， 氟化钠3.7mg，氯化铬1.3mg，钼酸钠0.2mg，亚硒酸钠0.2mg，酒石酸氢胆碱0.9g，维生素A0.98mg，维生素D35.5μg，维生素E23.7mg，维生素K179μg，维生素B11.6mg，维生素B21.8mg，维生素B61.87mg，维生素B122.6μg，维生素C580mg，烟酰胺10.6mg，生物素99μg，泛酸钙5.7mg，叶酸2.9mg，纤维素8.7g，变性淀粉11.3g，植物油29.7g，甘油16.8g和水1000ml。
生产过程如下：将配方量的蛋清蛋白粉，大豆蛋白粉，甘草甜素，低聚糖，氯化钠，氯化钾，碳酸钙，氧化镁，焦磷酸铁，硫酸锌，硫酸铜，氯化锰，碘化钾， 氟化钠，氯化铬，钼酸钠，亚硒酸钠，纤维素、变性淀粉，酒石酸氢胆碱，维生素A，维生素D3，维生素E，维生素K1，维生素B1，维生素B2，维生素B6，维生素B12，维生素C，烟酰胺，生物素，泛酸钙和叶酸在氮气保护下混合溶解或分散在配方量的60℃水中得到水相；将配方量的甘油、植物油在60℃温度下混合均匀得到油相；将水相和油相在83℃进行微波搅拌混合得到稳定均匀的乳状液。将混合好的乳状液罐装后，在巴氏灭菌机中，于120℃下杀菌5分钟，杀死病原微生物后再氮气环境下立即冷却至室温后，于4℃冷藏。产品在该条件下保存一个月后的理化性能指标见图2。
实施例3
提取甘草酸苷：将甘草粉碎后与10%的乙醇溶剂以1：10的量投放到水浴锅中进行回流提取3小时，然后过滤，将滤液进行真空浓缩得到甘草提取浸膏，干燥后得到棕红色粉末状粗品。将浸膏用水溶解，用稀盐酸调节PH值至6.3后，过滤得到甘草酸溶液，然后利用大孔树脂分离，采用乙醇水溶液进行梯度洗脱，所得溶液用活性炭在65℃下脱色30分钟，趁热抽滤，静置析晶，抽滤，真空干燥即得甘草酸成品。
以质量克数计，取蛋清蛋白粉36.5g，大豆蛋白粉31.2g，甘草甜素5.3g，低聚糖20.7，氯化钠0.4g，氯化钾1.8g，碳酸钙0.7g，氧化镁0.4g，焦磷酸铁53.4mg，硫酸锌37.5mg，硫酸铜3.6mg，氯化锰9.3mg，碘化钾0.2mg， 氟化钠3.7mg，氯化铬1.3mg，钼酸钠0.2mg，亚硒酸钠0.2mg，酒石酸氢胆碱0.9g，维生素A0.98mg，维生素D35.5μg，维生素E23.7mg，维生素K179μg，维生素B11.6mg，维生素B21.8mg，维生素B61.87mg，维生素B122.6μg，维生素C580mg，烟酰胺10.6mg，生物素99μg，泛酸钙5.7mg，叶酸2.9mg，纤维素11.2g，变性淀粉8.5g，植物油29.7g，甘油15.2g和水1000ml。
生产过程如下：将配方量的蛋清蛋白粉，大豆蛋白粉，甘草甜素，低聚糖，氯化钠，氯化钾，碳酸钙，氧化镁，焦磷酸铁，硫酸锌，硫酸铜，氯化锰，碘化钾， 氟化钠，氯化铬，钼酸钠，亚硒酸钠，纤维素、变性淀粉，酒石酸氢胆碱，维生素A，维生素D3，维生素E，维生素K1，维生素B1，维生素B2，维生素B6，维生素B12，维生素C，烟酰胺，生物素，泛酸钙和叶酸在氮气保护下混合溶解或分散在配方量的60℃水中得到水相；将配方量的甘油、植物油在60℃温度下混合均匀得到油相；将水相和油相在83℃进行微波搅拌混合得到稳定均匀的乳状液。将混合好的乳状液罐装后，在巴氏灭菌机中，于110℃下杀菌8分钟，杀死病原微生物后再氮气环境下立即冷却至室温后，于4℃冷藏。产品在该条件下保存一个月后的理化性能指标见图2。
Claims (7)
1.一种含有甘草甜素的肠内营养乳剂，其特征在于：1000ml该产品中，以质量计，包含以下营养成分：
。
2.如权利要求1所述的一种含有甘草甜素的肠内营养乳剂，其特征在于：蛋清蛋白粉是鸡蛋蛋清蛋白粉和鹌鹑蛋蛋清蛋白粉混合而成。
3.如权利要求1所述的一种含有甘草甜素的肠内营养乳剂，其特征在于：植物油是大豆油、玉米油、菜籽油和花生油中的一种或几种混合物。
4.如权利要求1所述的一种含有甘草甜素的肠内营养乳剂，其特征在于：低聚糖是低聚麦芽糖和低聚果糖中的一种或两种混合物。
5.如权利要求1所述的一种含有甘草甜素的肠内营养乳剂，其特征在于：甘草甜素是从甘草根中提取后进行纯化而制得的；提取方法如下：将甘草粉碎后与10%的乙醇溶剂以1：10的量投放到水浴锅中进行回流提取2-3小时，然后过滤，将滤液进行真空浓缩得到甘草提取浸膏，干燥后得到棕红色粉末状粗品；将浸膏用水溶解，用稀盐酸调节PH值至5.8-6.3后，过滤得到甘草酸溶液，然后利用大孔树脂分离，采用乙醇水溶液进行梯度洗脱，所得溶液用活性炭在65℃下脱色30分钟，趁热抽滤，静置析晶，抽滤，真空干燥即得甘草酸成品。
6.如权利要求1所述的一种含有甘草甜素的肠内营养乳剂及其制备方法，其特征在于：膳食纤维由纤维素和变性淀粉组成。
7.如权利要求1所述的一种含有甘草甜素的肠内营养乳剂及其制备方法，其特征在于：具体制备步骤如下：
（1）物料混合：将配方量的蛋清蛋白粉，大豆蛋白粉，甘草甜素，低聚糖，氯化钠，氯化钾，碳酸钙，氧化镁，焦磷酸铁，硫酸锌，硫酸铜，氯化锰，碘化钾，
氟化钠，氯化铬，钼酸钠，亚硒酸钠，纤维素，变性淀粉，酒石酸氢胆碱，维生素A，维生素D3，维生素E，维生素K1，维生素B1，维生素B2，维生素B6，维生素B12，维生素C，烟酰胺，生物素，泛酸钙和叶酸在氮气保护下混合溶解或分散在配方量的50-65℃水中得到水相；将配方量的甘油、植物油在60-70℃条件下混合均匀得到油相；将水相和油相进行加热微波搅拌混合得到稳定均匀的乳状液；
（2）巴氏灭菌：将混合好的乳状液在巴氏灭菌机中，于90-120℃下杀菌5-10分钟，杀死病原微生物后立即冷却至45-50℃，缓慢冷却至室温后，于1-4℃冷藏。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510476089.3A CN106418549A (zh) | 2015-08-06 | 2015-08-06 | 一种含有甘草甜素的肠内营养乳剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510476089.3A CN106418549A (zh) | 2015-08-06 | 2015-08-06 | 一种含有甘草甜素的肠内营养乳剂及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106418549A true CN106418549A (zh) | 2017-02-22 |
Family
ID=58092517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510476089.3A Pending CN106418549A (zh) | 2015-08-06 | 2015-08-06 | 一种含有甘草甜素的肠内营养乳剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106418549A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200121585A1 (en) * | 2018-10-23 | 2020-04-23 | Capsum | Unit for the manufacture of an extract of interest of at least one plant, microorganism and/or fungus |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278736A (zh) * | 2008-03-28 | 2008-10-08 | 西安力邦制药有限公司 | 一种适合亚洲人群营养支持的均衡肠内全营养制剂 |
| CN101889669A (zh) * | 2010-06-24 | 2010-11-24 | 华瑞制药有限公司 | 肠内营养乳剂及其制备方法 |
| CN101928325A (zh) * | 2010-08-27 | 2010-12-29 | 江苏天晟药业有限公司 | 一种制备天然18-α甘草酸的方法 |
| CN102453075A (zh) * | 2010-10-26 | 2012-05-16 | 曾科 | 一种甘草酸的分离纯化工艺 |
| CN103392969A (zh) * | 2013-07-28 | 2013-11-20 | 吉林大学 | 一种含卵磷脂的肠内营养乳剂及其制备方法 |
-
2015
- 2015-08-06 CN CN201510476089.3A patent/CN106418549A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278736A (zh) * | 2008-03-28 | 2008-10-08 | 西安力邦制药有限公司 | 一种适合亚洲人群营养支持的均衡肠内全营养制剂 |
| CN101889669A (zh) * | 2010-06-24 | 2010-11-24 | 华瑞制药有限公司 | 肠内营养乳剂及其制备方法 |
| CN101928325A (zh) * | 2010-08-27 | 2010-12-29 | 江苏天晟药业有限公司 | 一种制备天然18-α甘草酸的方法 |
| CN102453075A (zh) * | 2010-10-26 | 2012-05-16 | 曾科 | 一种甘草酸的分离纯化工艺 |
| CN103392969A (zh) * | 2013-07-28 | 2013-11-20 | 吉林大学 | 一种含卵磷脂的肠内营养乳剂及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 上海钾盐工程技术研究中心: "《中国钾盐工业概况》", 31 July 2009, 上海交通大学出版社 * |
| 冯福盛等: ""吸附树脂AB-8对甘草酸的吸附性能及其在提取纯化中的应用"", 《天然产物研究与开发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200121585A1 (en) * | 2018-10-23 | 2020-04-23 | Capsum | Unit for the manufacture of an extract of interest of at least one plant, microorganism and/or fungus |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007535576A (ja) | 迅速な体重減少を促進し、カロリーを燃焼させ、熱発生を増大させ、エネルギー代謝を補助し、且つ／または食欲を抑制する栄養組成物 | |
| CN107822040A (zh) | 一种干姜肉桂保健果冻的制备方法 | |
| CN112205559A (zh) | 含有杜仲和桑叶的组合物及应用 | |
| AU2003226923A1 (en) | Iron dextrin compounds for the treatment of iron deficiency anaemia | |
| CN101711858A (zh) | 一种治疗癌症的药 | |
| CN106418485A (zh) | 一种含有硫辛酸的肠内营养乳剂 | |
| CN106072614A (zh) | 假酸浆子‑海藻酸钠复合凝胶球及其制备方法 | |
| CN102406032B (zh) | 一种含中药提取物的润喉糖 | |
| CN108740620A (zh) | 一种西梅澄清饮料及其制备方法 | |
| CN106418549A (zh) | 一种含有甘草甜素的肠内营养乳剂及其制备方法 | |
| JP2021159063A (ja) | コンニャク機能性食品及びその製造方法 | |
| CN102836254A (zh) | 一种用于治疗鸡传染性法氏囊炎的药物组合物及其制备方法 | |
| JP2000189109A (ja) | 液状食品 | |
| CN106234896A (zh) | 一种治疗肾病的保健饮品及其制备方法 | |
| CN106924581A (zh) | 一种治疗腹痛的药酒及其制备方法 | |
| CN102784230A (zh) | 一种治疗营养性贫血的药物组合物制剂 | |
| CN107854575B (zh) | 一种具有降血糖功能的红葱饮料及其制备方法 | |
| CN105963330A (zh) | 神秘果制剂及其应用 | |
| CN110771894A (zh) | 一种鹿茸口服液及制备方法 | |
| KR20150031373A (ko) | 비타민나무 잎 추출물을 유효성분으로 함유하는 비만 예방 또는 치료용 약학 조성물 및 식품 조성물 | |
| Fixsen | The effect of desiccation upon the nutritive properties of egg-white. II | |
| CN108477359A (zh) | 一种葫芦茶饮及其制备方法 | |
| CN108541941A (zh) | 一种复方桑叶糖调节受损制品及其制备方法 | |
| CN106581499A (zh) | 一种治疗鳖白底板病的中药药方 | |
| CN104263597A (zh) | 一种山药菊花酒及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170222 |
|
| RJ01 | Rejection of invention patent application after publication |