CN106404640A - System for detecting and analyzing blood cells - Google Patents
System for detecting and analyzing blood cells Download PDFInfo
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- CN106404640A CN106404640A CN201610966965.5A CN201610966965A CN106404640A CN 106404640 A CN106404640 A CN 106404640A CN 201610966965 A CN201610966965 A CN 201610966965A CN 106404640 A CN106404640 A CN 106404640A
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- fluid path
- path chip
- analyser
- impedance
- main frame
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- 210000000601 blood cell Anatomy 0.000 title abstract description 5
- 238000001514 detection method Methods 0.000 claims abstract description 21
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 210000001772 blood platelet Anatomy 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims abstract description 4
- 239000012530 fluid Substances 0.000 claims description 34
- 238000004458 analytical method Methods 0.000 claims description 19
- 210000003677 hemocyte Anatomy 0.000 claims description 15
- 229940000351 hemocyte Drugs 0.000 claims description 15
- 230000003287 optical effect Effects 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 210000000265 leukocyte Anatomy 0.000 claims description 8
- 230000005540 biological transmission Effects 0.000 claims description 6
- 230000006698 induction Effects 0.000 claims description 4
- 206010018910 Haemolysis Diseases 0.000 claims description 3
- 230000008588 hemolysis Effects 0.000 claims description 2
- 238000005286 illumination Methods 0.000 claims 1
- 238000013461 design Methods 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 239000000376 reactant Substances 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 102000010445 Lactoferrin Human genes 0.000 description 2
- 108010063045 Lactoferrin Proteins 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000003219 hemolytic agent Substances 0.000 description 2
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 2
- 229940078795 lactoferrin Drugs 0.000 description 2
- 235000021242 lactoferrin Nutrition 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a system for detecting and analyzing blood cells. The system comprises an analyzer host machine and a first impedance sensor, wherein the analyzer host machine is used for controlling a detection process; the analyzer host machine is in functional connection with and is used for controlling a liquid path chip; the liquid path chip at least comprises a sample channel used for quantitatively adding samples; the first impedance sensor is arranged at the downstream side the sample channel and is used for counting the erythrocytes and the platelets. The system for detecting and analyzing blood cells, provided by the invention, adopts the liquid path chip for detecting and analyzing blood cells, the liquid path chip is separated from the analyzer host machine and the liquid path chip can be used at one time, so that the simple design of the volume is realized and the system can be conveniently taken and used.
Description
Technical field
The present invention relates to a kind of vitro detection device, more particularly, to a kind of system improvement of hemocyte detection and analysis.
Background technology
At present for the mensure of hemocyte typing and routine blood test, due to erythrocyte and hematoblastic small volume, it is difficult to such as
Leukocyte is accurately measured using optics like that.It is diluted typically by being added to blood preparation in the reaction tank of instrument,
Then adopt impedance principle（Kurt method）Erythrocyte and platelet are counted, and a certain amount of dilution specimen is added molten
Blood reagent, by erythrocytolysis, then carries out white blood count and differential using impedance principle again, and is carried out blood red with colorimetry
Protein determination, outside finally the solution after measuring being discharged instrument, and the path that all specimen are passed through is carried out to keep
Cleaning, prepares next test.
In this scheme above-mentioned of prior art, sampling apparatuses, reaction tank, metering pool, proportioning device, fluid circuit etc.
It is provided entirely in instrument internal, instrument is huge, composition is complicated, especially relate to the part of fluid and liquid chemical challenges are all connected in
So that instrument cost is high, volume is big, weight is big, be not easy to movement on instrument, use typically can only be pinpointed in laboratory.And
And all these process, including sampling-point sample-dilution-mixing-haemolysis-measurement-cleaning, need mechanism to be automatically performed, wherein appoint
What step goes wrong and all can lead to break down, thus directly improves the fault rate of equipment.
Therefore, prior art has yet to be improved and developed.
Content of the invention
It is an object of the invention to provide a kind of system of hemocyte detection and analysis, provide volume to simplify, facilitate portable making
Erythrocyte testing and analysis system and implementation method.
Technical scheme is as follows：
A kind of system of hemocyte detection and analysis, it includes analyser main frame, for controlling detection process；Wherein, described analysis
Instrument host function connects and controls a fluid path chip, and described fluid path chip setting is separated with described analyser main frame, and at least wraps
Include：One sample channel, for the addition of quantitative sample；First impedance transducer, is arranged on described sample channel downstream, for right
Erythrocyte and enumeration of thrombocytes.
Described system, wherein, described fluid path chip also includes a hemoglobinometry unit, is arranged on described first resistance
The downstream position of anti-sensor, and it is additionally provided with one first air entry above described hemoglobinometry unit, this first suction
QI KOU connects and is controlled by described analyser main frame.
Described system, wherein, described fluid path chip is additionally provided with one second impedance transducer, is arranged on described blood red egg
The downstream of white measuring unit, for counting to leukocyte.
Described system, wherein, described first impedance transducer setting includes：One inlet, connects described sample channel；
One liquid outlet, connects follow-up measuring unit；One metering orifice, is arranged on the passage between described inlet and described liquid outlet
On, and described metering orifice both sides are provided with impedance induction electrode；Described impedance induction electrode is with described analyser main frame even
Connect and counted.
Described system, wherein, described metering orifice arranges a size of 40-100 μm of aperture.
Described system, wherein, described hemoglobinometry unit setting includes solution after a receiving erythrocyte haemolysis
Chamber portion, and, one be subject to described analyser host computer control light path；Described light path includes an incident optical channel, and a transmission
Optical channel, described incidence optical channel forms described transmission optical channel after solution in the portion of described chamber；Arrange above the portion of described chamber
Have by the first air entry of described analyser host computer control.
Described system, wherein, described fluid path chip is single use part.
A kind of system of hemocyte detection and analysis provided by the present invention, the mode due to employing fluid path chip enters promoting the circulation of blood
Erythrocyte detection and analyze, fluid path is separated with analyser main frame, and fluid path chip can with single use it is achieved that
The simplification design of volume, and facilitate portable use.
Brief description
Fig. 1 is that the system of hemocyte detection and analysis of the present invention realizes structural representation.
Fig. 2 realizes structural representation for impedance transducer of the present invention.
Fig. 3 is the structural representation of hemoglobinometry unit of the present invention.
Specific embodiment
Hereinafter presently preferred embodiments of the present invention is described in detail.
The system of hemocyte detection and analysis of the present invention, its technical scheme adopting is as shown in figure 1, be by all fluids
Partly all concentrate on disposable fluid path chip 100, in this fluid path chip 100, encapsulate quantitative reagent and impedance
Sensor, the circuit of fluid path chip 100 and analyser main frame, gas circuit and light path are connected（Its nuclear interface standardizing can be designed,
Ensure the connection of each passage after the insertion of fluid path chip）, setting is separated with described analyser main frame it is possible to conduct disposably makes
Consumptive material, using once can abandoning afterwards；Directly specimen to be detected is added after fluid path chip 100 of the present invention（Also may be used
To be set to be automatically injected quantitative sample to be detected）, it is driven with the Pneumatic pressure power of analyser host instrument, drive fluid path core
Reactant liquor flowing to be detected in piece 100, reactant liquor passes sequentially through each sensor, is entered with the equipment circuit of described analyser main frame
Row analysis, you can complete the mensure of leukocyte, erythrocyte, platelet count and hemoglobin.
As shown in figure 1, in the system of hemocyte detection and analysis of the present invention, described fluid path chip 100 includes being loaded position
200, the sample channel 201 of sample-adding position 200 lower section connection, then communicating downstream successively：First impedance transducer 300, is used for
Count erythrocyte and platelet counts；Hemoglobinometry unit 400, for measuring to hemoglobin；Second impedance
Sensor 500, for counting to quantity of leucocyte；First air entry 600 and the second air entry 700, respectively as blood red
Protein measurement unit 400 and the driving pressure channel of the second impedance transducer 500.Hemocyte of the present invention detection and analysis be
In system, the counting mode to leukocyte is different to erythrocyte and enumeration of thrombocytes mode, due to the former cell volume
And substantial amounts little far beyond the latter, therefore, the present invention realizes first against to the counting of erythrocyte, can pass through fluid path chip
Implementation, simplify detection and analysis equipment, to leukocyte analysis detection can adopt prior art conventional optical metrology
Mode.
Wherein sample-adding position 200 can be used for the amount of reordering sample manually, and described first impedance transducer 300 is used for erythrocyte
Counted with platelet；Described hemoglobinometry position 400 is used for measuring hemoglobin concentration, and seals in advance in its chamber portion
The hemolytic agent of the amount of setting；Described first air entry 600 is used for the gas circuit of linking parsing instrument main frame, by host computer control air-breathing, makes
At sample-adding position 200, the sample that adds can pass through the first impedance transducer 300, and flows to hemoglobinometry unit 400, and wherein
Hemolytic agent mixing so that the erythrocytolysis in sample.Described second impedance transducer 500 is used for leukocyte is counted
And classify, described second air entry 700 is used for the gas circuit of linking parsing instrument main frame, by host computer control air-breathing, makes hemoglobin
Reactant liquor in measuring unit cavity flows through the second impedance transducer 500.
The electrode system of described first impedance transducer 300 and described second impedance transducer 500 is all connected to analyser
The Circuits System of main frame, to carry out data acquisition by described analyser main frame.According to impedance counting principle, when passing through in aperture
During cell, the electric conductivity between electrode can change, and that is, resistance value changes, and the peak value such that it is able to be changed by electrode pair is united
Meter is realized counting.Certainly, for realizing the accuracy counting, being counted cell needs to dilute enough, so as to distinguishing and detecting
Change and peak number to conductive current.The small aperture that spacing between electrode and cell are passed through is also more crucial,
Suitable aperture guarantee cell is more accurate through out-of-date detection data, and minimizing is misread.
First impedance transducer 300 of the present invention is similar with the structure of the second impedance transducer 500, can all such as
Shown in Fig. 2, but should be noted that the second impedance transducer can be realized by other counting circuit, reason is the volume of leukocyte
Larger, counting in the prior art is realized being easier more than erythrocyte.First impedance transducer 300 reference picture of the present invention
With the second impedance transducer 500 for exemplifying its structure shown in 2, Fig. 2, it includes an inlet 501, connects the unit of upstream,
For example described hemoglobinometry unit 400；One metering orifice 502, a liquid outlet 503, a first electrode 504, one second electricity
Pole 505, and, holding wire 506, described holding wire 506 electrically connects described first electrode 504 and second electrode 505 arrives described analysis
Instrument main frame.
With reference to the second impedance transducer 500, in the first impedance transducer 300, for metering erythrocyte and platelet, institute
State the hole that metering orifice 502 is set to 40-100um aperture size, so so that the hemocyte in sample passes through in order
Aperture, described first electrode 504 and described second electrode 505 are located at the both sides of metering orifice 502 respectively, when hemocyte is through meter
During amount aperture, two interelectrode impedances change therewith, and changing value is relevant with cell volume, and two electrodes are all by holding wire
The Circuits System of 506 linking parsing instrument main frames, can be to the erythrocyte in sample and blood by the impedance variation measuring two electrodes
Platelet is counted and is counted size（Described second impedance transducer is used for counting quantity of leucocyte）.
The structure of described hemoglobinometry unit 400 is as shown in figure 3, include incident optical channel 401, transmission optical channel
402, inlet 404, air entry 405, photo measure passage 406.Described incidence optical channel 401 and transmission optical channel 402 exist respectively
The both sides of hemoglobinometry unit 400（Specifically as shown in figure 3,400 label pointed location are cavity）, both can be light
Fibre, by the light path system of optical fiber linking parsing instrument main frame it is also possible to directly hemoglobinometry unit 400 is placed on analyser
In the light path of main frame.Photo measure passage 406 is parallel with the top surface plane of fluid path chip 100 as shown in Figure 3, specifically real
Apply in mode and perpendicular to the top surface plane of fluid path chip 100 or other directions can also be set to.By described analyser
Main frame measurement incident intensity and transmitted intensity, are computed the absorbance of reactant liquor to be measured, you can measure blood in reactant liquor
Lactoferrin content.Such that it is able to realize to erythrocyte and hematoblastic measurement.
In the system of hemocyte detection and analysis of the present invention, by arranging the implementation of fluid path chip, analyser master
Machine can not contact fluid, and the part of contact fluid is disposably droppable fluid path chip, and this fluid path chip product is little
Ingeniously, portable and be not required to carrying of liquids reagent, there is no bio-safety risk, can use in various complex conditions.
The system of hemocyte detection and analysis of the present invention carries out blood cell analysis, chip using disposable fluid path chip
Fluid path is not had to be connected with analyser main frame, such that it is able to extend the service life of analyser main frame, and conveniently to dress to be detected
The structure design put, is also convenient for the portable use to functional part to be detected.By being integrated with two in described fluid path chip
Impedance transducer and a hemoglobinometry unit, can realize the basic demand to routine blood test detection comprehensively.By in blood
Encapsulated reaction reagent in advance in Lactoferrin measuring unit, and, it is placed directly in analyser light path in hemoglobinometry unit
Measure, its measurement realization is more simple, and accuracy of measurement is higher.
It should be appreciated that for those of ordinary skills, can be improved according to the above description or be converted,
And all these modifications and variations all should belong to the protection domain of claims of the present invention.
Claims (7)
1. a kind of system of hemocyte detection and analysis, it includes analyser main frame, for controlling detection process；It is characterized in that,
Described analyser host function connects and controls a fluid path chip, and described fluid path chip setting is separated with described analyser main frame,
And at least include：One sample channel, for the addition of quantitative sample；First impedance transducer, is arranged under described sample channel
Trip, for erythrocyte and enumeration of thrombocytes.
2. system according to claim 1 is it is characterised in that described fluid path chip also includes a hemoglobinometry list
Unit, is arranged on the downstream position of described first impedance transducer, and is additionally provided with one above described hemoglobinometry unit
First air entry, this first air entry connects and is controlled by described analyser main frame.
3. system according to claim 2 is it is characterised in that described fluid path chip is additionally provided with one second impedance sensing
Device, is arranged on the downstream of described hemoglobinometry unit, for counting to leukocyte.
4. system according to claim 1 is it is characterised in that described first impedance transducer setting includes：One inlet,
Connect described sample channel；One liquid outlet, connects follow-up measuring unit；One metering orifice, be arranged on described inlet with described
On passage between liquid outlet, and described metering orifice both sides are provided with impedance induction electrode；Described impedance induction electrode with
Described analyser main frame connects and is counted.
5. system according to claim 4 is it is characterised in that described metering orifice arranges a size of 40-100 μm of aperture.
6. system according to claim 2 is it is characterised in that the setting of described hemoglobinometry unit includes a receiving blood
The chamber portion of solution after erythrocyte hemolysis, and, one is subject to the light path of described analyser host computer control；Described light path includes an incident illumination
Passage, and a transmission optical channel, described incidence optical channel forms described transmission optical channel after solution in the portion of described chamber；Institute
State and be provided with above the portion of chamber by the first air entry of described analyser host computer control.
7. system according to claim 1 is it is characterised in that described fluid path chip is single use part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610966965.5A CN106404640A (en) | 2016-10-28 | 2016-10-28 | System for detecting and analyzing blood cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610966965.5A CN106404640A (en) | 2016-10-28 | 2016-10-28 | System for detecting and analyzing blood cells |
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| Publication Number | Publication Date |
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| CN106404640A true CN106404640A (en) | 2017-02-15 |
Family
ID=58014244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610966965.5A Pending CN106404640A (en) | 2016-10-28 | 2016-10-28 | System for detecting and analyzing blood cells |
Country Status (1)
| Country | Link |
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| CN (1) | CN106404640A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108362615A (en) * | 2018-04-28 | 2018-08-03 | 东莞德益生物医疗科技有限公司 | A kind of analysis detection device and cell or particle detection technique |
| CN111239027A (en) * | 2020-01-22 | 2020-06-05 | 深圳市锦瑞生物科技有限公司 | Blood particle detection method and blood analyzer |
| CN111707601A (en) * | 2020-06-23 | 2020-09-25 | 合肥安为康医学检验有限公司 | Whole blood biochemical detection method and device |
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| US20050118705A1 (en) * | 2003-11-07 | 2005-06-02 | Rabbitt Richard D. | Electrical detectors for microanalysis |
| CN102564977A (en) * | 2010-09-27 | 2012-07-11 | 东洋纺织株式会社 | Measuring device and measuring method |
| CN102600918A (en) * | 2012-03-09 | 2012-07-25 | 深圳联合医学科技有限公司 | Microfluidic chip for blood analysis and method for using microfluidic chip |
| US20130345989A1 (en) * | 2012-06-26 | 2013-12-26 | Horiba, Ltd. | Method and device for counting particles in liquid |
| CN105728069A (en) * | 2016-01-30 | 2016-07-06 | 深圳市贝沃德克生物技术研究院有限公司 | Multi-channel micro-fluidic chip for rapid blood self-inspection |
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2016
- 2016-10-28 CN CN201610966965.5A patent/CN106404640A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050118705A1 (en) * | 2003-11-07 | 2005-06-02 | Rabbitt Richard D. | Electrical detectors for microanalysis |
| CN102564977A (en) * | 2010-09-27 | 2012-07-11 | 东洋纺织株式会社 | Measuring device and measuring method |
| CN102600918A (en) * | 2012-03-09 | 2012-07-25 | 深圳联合医学科技有限公司 | Microfluidic chip for blood analysis and method for using microfluidic chip |
| US20130345989A1 (en) * | 2012-06-26 | 2013-12-26 | Horiba, Ltd. | Method and device for counting particles in liquid |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108362615A (en) * | 2018-04-28 | 2018-08-03 | 东莞德益生物医疗科技有限公司 | A kind of analysis detection device and cell or particle detection technique |
| CN108362615B (en) * | 2018-04-28 | 2023-06-27 | 东莞德益生物医疗科技有限公司 | Device for analysis and detection and cell or particle detection method |
| CN111239027A (en) * | 2020-01-22 | 2020-06-05 | 深圳市锦瑞生物科技有限公司 | Blood particle detection method and blood analyzer |
| CN111707601A (en) * | 2020-06-23 | 2020-09-25 | 合肥安为康医学检验有限公司 | Whole blood biochemical detection method and device |
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Effective date of registration: 20170904 Address after: 518000 Guangdong city of Shenzhen province Nanshan District Xili Xili Street Industrial Park District Baiwang letter a 4B Applicant after: Shenzhen Ward Life Technology Co., Ltd. Address before: 114002, No. 5, No. 5, No. 101, Shengli South Road, MTR Eastern, Liaoning, Anshan Province, 60 Applicant before: Xu Tingkuan |
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Address after: 518000 Building 1, Shenzhen Biomedical Innovation Industrial Park, 14 Jinhui Road, Kengzi Street, Pingshan New District, Shenzhen City, Guangdong Province Applicant after: Shenzhen Ward Life Technology Co., Ltd. Address before: 518000 4B, Xili street, Xili, Nanshan District, Shenzhen, Guangdong. Applicant before: Shenzhen Ward Life Technology Co., Ltd. |
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Application publication date: 20170215 |