CN106018773A - Disposable blood cell counting and analyzing integrated reagent sensing unit and novel blood analyzer - Google Patents
Disposable blood cell counting and analyzing integrated reagent sensing unit and novel blood analyzer Download PDFInfo
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- CN106018773A CN106018773A CN201610472207.8A CN201610472207A CN106018773A CN 106018773 A CN106018773 A CN 106018773A CN 201610472207 A CN201610472207 A CN 201610472207A CN 106018773 A CN106018773 A CN 106018773A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4915—Blood using flow cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N2015/137—Cleaning
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Abstract
The invention relates to a disposable blood cell counting and analyzing integrated reagent sensing unit and a novel blood analyzer. The sensing unit comprises a casing, wherein a first accommodating cavity, a second accommodating cavity and a first waste liquid cavity are formed in the casing, the first accommodating cavity and the second accommodating cavity are used for accommodating to-be-analyzed blood, and first opening parts allowing addition of a reagent and the to-be-analyzed blood are formed in the first accommodating cavity and the second accommodating cavity; the first accommodating cavity is communicated with the first waste liquid cavity, and a first sensing device is arranged at a communication part; a second sensing device is arranged in the first waste liquid cavity. The novel blood analyzer matched with the reagent sensing unit is in communication connection with the sensing devices through a sensing inserting part, so that related data can be uploaded to the analyzer for analysis and interpretation. The sensing unit and the analyzer are not needed to be cleaned after blood analysis and detection, the sensing unit can be abandoned, the structure and the size of the blood analyzer are simplified greatly, and the integrated reagent sensing unit and the blood analyzer have great significance for application of blood detection in mobile health care and rapid diagnosis.
Description
Technical field
The present invention relates to belong to clinical laboratory medicine instrument class, especially blood testing analytical equipment field.
Background technology
Blood cell analyzer, is commonly called as routine analysis of blood instrument, to the erythrocyte in blood, leukocyte, platelet and blood red
Albumen carries out Clinical Laboratory analysis, and routine blood test is one of important disease detection means, and blood cell analyzer is also clinically
One of most widely used testing instruments.Existing blood cell analyzer is to develop based on Coulter principle, in instrument
Portion include master control set, liquid-way system, sensing detection device, blood parameters analytical equipment (Circuits System), display device and
Cleaning device etc., a normal blood is measured process and is formed by sampling, dilute, measure, calculate, show, cleaning, blood analyser
Blood sample to be detected is sucked in the liquid-way system of analyser, liquid-way system completes blood quantitatively (sampling), blood
Cell suspension after mixing with diluting of various reagent, mix is by detecting the micro channel position in sensing device to measure
(hemoglobin parameters passes through light source and photoelectronic analyzer to go out the signal of telecommunication of blood cell therein and hemoglobin photosignal
Obtain), above-mentioned signal is uploaded to the blood parameters analytical equipment (Circuits System) of analyser and calculates, and then test result shows
Showing in the display device of analyser, ultimate analysis instrument is by this detection of residual in whole liquid-way system and detection sensor
Blood cell, cell debris, tissue liquid clean comprehensively, just can carry out next blood sample after having cleaned
Detection.
But, after system one obvious problem of existence that this set is continued to use more than 60 year is exactly detection every time, it is right to be required for
The whole liquid-way system of analyser cleans comprehensively, and the most special parts detection is cleaned the cleanest, if meet
Carrying out the condition of blood testing next time, this cleans index the most thoroughly and is referred to as residual contamination rate, and this is to weigh a blood
The one of which important indicator of liquid cytoanalyze quality.Ironically, cleaning is not the complete of blood analyser
Become the central principle accurately detecting hemocyte, but the parts being used for cleaning procedure account for the institute of whole blood cell analyzer
Have more than the 60% of parts, and this program cleaned not only consume whole detection 80% time, also make to have used up whole
The reagent of detection 80%, this is the waste of great cost and resource.And the analyser structure continuing to use purging system is complicated, body
Long-pending huge, external several flushing liquors and cleanout fluid reagent barrel, complex operation, instrument failure rate is high, and the result of portioned product is stable
Property is poor, brings inconvenience to the Clinical Laboratory of medical institutions at different levels.
Summary of the invention
The technical problem to be solved in the present invention is, it is provided that a kind of disposable blood cell counting without cleaning and analysis
The New Blood analyser that integrated reagent sensing part and structure simplify.
The technical solution adopted for the present invention to solve the technical problems is: disposable blood cell counting and analyze integrated examination
Agent sensing part, sensing part includes that housing, described housing are provided with the first receiving chamber for placing blood to be analyzed, the second receiving
Chamber and the first waste liquid chamber, described first accommodate chamber, second accommodate and be equipped with on chamber for adding reagent and blood to be detected
First inlet portion；It is interconnected between described first receiving chamber and the first waste liquid chamber, and is provided with for examining in place of both connections
Survey the first sensing device of blood parameters to be analyzed；Described first waste liquid intracavity be provided with for sense its internal liquid level position
Two sensing devices.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described sensing part is additionally provided with
Second the second waste liquid chamber accommodating chamber connection, described second accommodate chamber and the connection in the second waste liquid chamber in place of be provided with and treat for detecting
Analyze the 3rd sensing device of blood parameters；Described second waste liquid intracavity is provided with the 4th biography for sensing its internal liquid level position
Induction device.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described first sensing device, the
Three sensing devices include micropore portion and two induction electrodes respectively, micropore portion connection first receiving of described first sensing device
Chamber and the first waste liquid chamber, and first accommodate chamber and be respectively equipped with induction electrode with the first waste liquid chamber；Described 3rd sensing device micro-
Hole portion connection second accommodates chamber and the second waste liquid chamber, and the second receiving chamber is respectively equipped with induction electrode with the second waste liquid chamber.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described first waste liquid chamber, second
The air pressure port for being connected it is equipped with outside negative pressure source of the gas on waste liquid chamber.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described sensing part is additionally provided with the
Three accommodate chamber, and the described 3rd accommodates chamber is provided with the second inlet portion for adding reagent and blood to be detected.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described first inlet portion, second
Inlet portion includes the inlet for adding reagent respectively and adds the interpolation mouth of blood to be detected；The note in each described receiving chamber
Entrance is arranged at bottom, adds mouth and is arranged at top.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described sensing part also include for
Accommodating the flexible bottle of reagent, described flexible bottle is provided with and the delivery outlet of inlet Corresponding matching.
Foregoing disposable blood cell counting and analyze integrated reagent sensing part, described second accommodates the sidewall in chamber
Be provided with wall thickness relatively thin be easy to the detection window that light shines through.
A kind of New Blood analyser, including apparatus subject, described apparatus subject is provided with for laying disposable blood
Cell counting and analyze the fixed structure of integrated reagent sensing part, be provided with in described apparatus subject master control set, for biography
Feel the negative pressure device of air pressure port connection on part, for the sensing Plug Division being connected with sensing device on sensing part, described sensing
The outfan of Plug Division connects blood parameters analytical equipment, and the outfan connection of described blood analysis parameters analytical equipment has aobvious
Showing device, described sensing Plug Division, blood parameters analytical equipment, display device are all connected with master control set.
Foregoing a kind of New Blood analyser, described apparatus subject is additionally provided with light supply apparatus and corresponding therewith
Photoelectronic analyzer, and be formed between the two and lay disposable blood cell counting and analyze the sky of integrated reagent sensing part
Between；Described light supply apparatus is all connected with master control set with photoelectronic analyzer.
Foregoing a kind of New Blood analyser, described fixed structure is the cavity being formed on apparatus subject, institute
The sidewall stating cavity is provided with on described sensing Plug Division and described negative pressure device for the spliced eye being connected with air pressure port.
Foregoing a kind of New Blood analyser, the bottom of described cavity is additionally provided with for promoting and stretching described in stretching
The push rod of contracting bottle, described push rod can move up and down.
Implement technical scheme, at least there is following beneficial effect: blood sample is added integrated examination by user
After agent sensing part, the overall process dilute, measured all completes at this set disposable blood cell counting and analyzing in integrated sensing part,
Measuring the signal of telecommunication to be uploaded to carry out on analyser to calculate by the built-in sensitive electrode on sensing device, show, printed, measurement is tied
Change integrated reagent sensing part after bundle and can carry out the detection of next blood sample.Use and disposably sense integration member, will
The part operation step originally carried out inside blood analyser proposes to carry out to instrument, simplifies the interior of blood analyser
Portion's structure, as saved liquid-way system, cleaning structure etc., makes instrument cost be substantially reduced and the lightest portable.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described, in accompanying drawing:
Fig. 1 is the schematic diagram inventing integrated reagent sensing part；
Fig. 2 is that the present invention lays the blood analyser schematic diagram being provided with integrated reagent sensing part；
In figure, mark is described as follows:
1, first accommodates chamber；2, second accommodates chamber；3, the first waste liquid chamber；4, the first sensing device；5, the second sensing device；6, gas
Pressure side mouth；7, the 3rd sensing device；8, the second waste liquid chamber；9, the 4th sensing device；10, detection window；11, inlet；12, flexible
Bottle；13, delivery outlet；14, apparatus subject；15, display device；16, cavity；17, capping；100, sensing part.
Detailed description of the invention
In order to be more clearly understood from the technical characteristic of the present invention, purpose and effect, now comparison accompanying drawing describes in detail
The detailed description of the invention of the present invention.
Disposable blood cell counting as shown in Figure 1 and analyze integrated reagent sensing part, sensing part 100 includes housing,
Described housing is provided with and accommodates chamber 2 and the first waste liquid chamber 3 for the first receiving chamber 1, second placing blood to be analyzed, described
It is equipped with the first inlet portion for adding reagent and blood to be detected on first the 1, second receiving chamber 2, receiving chamber；Described first
Accommodate and be interconnected between chamber 1 and the first waste liquid chamber 3, and be provided with in place of both connections for detecting blood parameters to be analyzed
First sensing device 4；The second sensing device 5 for sensing its internal liquid level position it is provided with in described first waste liquid chamber 3.
A kind of New Blood analyser as shown in Figure 2, including apparatus subject 14, described apparatus subject 14 be provided with for
Lay disposable blood cell counting and analyze the fixed structure of integrated reagent sensing part 100, installing in described apparatus subject 14
Have master control set, for the negative pressure device being connected with air pressure port 6 on sensing part 100, for sensing device on sensing part 100
The sensing Plug Division connected, the outfan of described sensing Plug Division connects blood parameters analytical equipment, and described hemanalysis is joined
The outfan of number analytical equipment connects display device 15, described sensing Plug Division, blood parameters analytical equipment, display device 15
All it is connected with master control set.
Being placed on analyser by sensing part 100, fixed structure can be a cavity 16 mated with sensing part 100,
Cavity arrange one can the capping 17 of folding, the installation utilizing Embedded connected mode to realize both is fixed, it is also possible to utilize
Buckle, screw element installation etc..Sensing part 100 installs, and its each sensing device is connected with the sensing Plug Division on analyser, in order to
Each sensing device being sensed the signal data detected be uploaded on analyser calculate, two induction electrodes set respectively
Putting and accommodate on chamber and the first waste liquid chamber first, one end of each induction electrode is at corresponding intracavity, when intracavity has liquid, and sense
The one end answering electrode can contact conduction with liquid, and the other end of induction electrode, outside corresponding chamber, is inserted with the sensing on analyser
The portion that connects connects, and is transmitted on analyser by the signal of telecommunication in corresponding cavity；Being linked and packed between induction electrode and corresponding chamber is
Seal, liquid can be avoided to flow out.Finally can obtain which type of blood parameters and depend on that the first receiving chamber 1, second accommodates
The type of added reagent in chamber 2.
Add dilution reagent and blood to be detected in accommodating chamber 1 toward first, jiggle and both are mixed, be arranged on analysis
After on instrument, external force (such as tilt) is utilized to promote blood to accommodate chamber 1 to the first waste liquid chamber 3 diffluence from first, because both
Being provided with sensing device in place of connection, when blood flows through, corresponding parameter values is detected, and is uploaded by sensing Plug Division
Carrying out understanding to analyser and calculate, final result is shown by display device 15.
Successively add hemolyzing reagent and blood to be detected in accommodating chamber 2 toward second, jiggle and both are mixed, be arranged on
Have on the analyser of photoanalysis function and detect.Such analyser apparatus subject 14 is provided with light supply apparatus and therewith
Corresponding photoelectronic analyzer, and be formed between the two and lay disposable blood cell counting and analyze integrated reagent sensing part
The space of 100；Light supply apparatus is all connected with master control set with photoelectronic analyzer.Light source shines to another from sensing part 100 side
Side, the light penetrated is received understanding, and the data interpreted are sent to blood parameters divide by photoelectronic analyzer
Analysis apparatus to draw accordingly result, this operation getable be the parameter of hemoglobin in blood.
In certain embodiments, sensing part 100 is additionally provided with and accommodates the second waste liquid chamber 8 of connecting, chamber 2 with second, described the
It is provided with the 3rd sensing device 7 for detecting blood parameters to be analyzed in place of two connections accommodating chamber 2 and the second waste liquid chamber 8；Institute
The 4th sensing device 9 for sensing its internal liquid level position, first, second, third and fourth sensing dress it is provided with in stating the second waste liquid chamber 8
The signal data put is all that the Plug Division on instrument carries out uploading by analysis.
In certain embodiments, described first sensing device the 4, the 3rd sensing device 7 includes micropore portion and two respectively
Induction electrode, micropore portion connection first receiving chamber 1 and the first waste liquid chamber 3 of described first sensing device 4, and the first receiving chamber 1
It is respectively equipped with induction electrode with the first waste liquid chamber 3；Micropore portion connection the second receiving chamber 2 and second of described 3rd sensing device 7
Waste liquid chamber 8, and second accommodate chamber 2 and the second waste liquid chamber 8 and be respectively equipped with induction electrode.
Energy its relevant parameter of analyzed deciphering when blood to be detected is circulated by micropore portion, this deciphering principle is with existing
Blood analyser on sensing device consistent, all utilize Coulter principle to realize, this principle is pointed out to be suspended in electrolyte
In granule with electrolyte by micropore time, replace same volume electrolyte, constant current design circuit in cause micropore
Inside and outside two faradism electrode resistance generation transient change, produce potential pulse, the size of pulse signal and number of times and granule
Size and number are directly proportional.Existing blood analyser also be use this principle sensing device to realize the acquisition of parameter, but
Need to be realized by internal liquid-way system and the isostructural cooperation of sensor, and have loaded down with trivial details cleaning structure, cause
Instrument is huge the most portable, and detection program is loaded down with trivial details and cost is high.
The second, four sensing devices are effects quantitative after to the sensing of waste liquid intracavity liquid level position, when to be checked
Survey blood from accommodate chamber flow into waste liquid intracavity to time a certain amount of by detected by the induction electrode of the two sensing device, the most quantitatively
Principle as follows: the cell suspension after the reagent accommodated in chamber mixes with blood flows into waste liquid chamber, and cell suspension is slowly full of
Waste liquid chamber, when cell suspension overflows the induction electrode position to second, four sensing devices, owing to the dilution in cell suspension mixes
Liquid or haemolysis mixing liquid are all conductions, and first and third sensing device of the induction electrode sum respectively of second, four sensing devices is positioned at
The induction electrode of waste liquid intracavity will turn on, and this Continuity signal is the most also detection end signal, thus may determine that
At the end of detection, the cell suspension of how many liquid measures is had to enter waste liquid chamber, in order to blood parameters analysis module draws to be counted accurately
Calculate result.
In certain embodiments, the 3, second waste liquid chamber 8, described first waste liquid chamber is equipped with for outside negative pressure source of the gas
The air pressure port 6 connected.If the mode utilizing external force to tilt promotes blood to be detected to flow into waste liquid chamber from accommodating chamber, exist
Shortcomings: operate the most convenient, blood circulation speed is slow, the bad control in direction, and utilizes negative pressure device (generally negative pressure gas
Pump) cooperation can these problems of extraordinary solution, by master control set start negative pressure device, by blood to be detected from accordingly
Receiving chamber suck waste liquid chamber, operate intelligent, convenient, liquid flow to accurately, speed.
In certain embodiments, described sensing part 100 being additionally provided with the 3rd receiving chamber, the described 3rd accommodates chamber is provided with use
In adding reagent and the second inlet portion of blood to be detected.In hemanalysis, relating to the interpolation of two kinds of reagent, one is haemolysis
Reagent, another is dilution reagent, sometimes for the needs of blood testing, must increase the extension rate of blood sample, to be detected
Blood need to mix through the interpolation of dilute twice reagent.Therefore, when sensing part 100 is provided simultaneously with three receiving chambeies, can synchronize real
Existing three of the above operation, usually first and second accommodates chamber is used for adding hemolyzing reagent, dilution reagent, and the 3rd accommodates chamber adds dilute
Release reagent and blood to be detected is carried out pre-dilution, place into first or two after pre-dilution and accommodate in chamber and carry out second time and dilute examination
The interpolation of agent is analyzed to carry out detection.
In certain embodiments, described first inlet portion, the second inlet portion include the injection for adding reagent respectively
Mouth 11 and the interpolation mouth of interpolation blood to be detected；The inlet 11 in each described receiving chamber is arranged at bottom, adds mouth and is arranged at top
Portion.
In certain embodiments, described sensing part 100 also includes the flexible bottle 12 for accommodating reagent, described flexible bottle 12
It is provided with and the delivery outlet 13 of inlet 11 Corresponding matching.Flexible bottle 12 is that a kind of bottle can be by outer force compresses, after external force is cancelled
Or can reply again the container of former state under gas pressure when external force becomes tensile force, accommodating reagent with flexible bottle 12 can fill
Divide the mixing utilizing its this architectural characteristic to realize blood to be detected and reagent.Flexible bottle 12 is enclosed within the note accommodating lower end, chamber
Entrance 11, can arrange O-ring seal in order to avoid liquid flows out in inlet 11, and the body of the flexible bottle 12 of extruding is by inside
Reagent extrusion mix to accommodating intracavity and blood to be detected (adding afterwards), external force is cancelled rear or stretches time external force becomes tensile force
Bottle 12 body resets and two kinds of liquid is again served to mixing effect, and this circulation turbulent flow repeatedly at flexible bottle 12 mixes liquid
Under mode, blood and reagent can play extraordinary Blending Efficiency of Blending.And the built-in complicated structure of existing hemanalysis is used for
Control both Blending Efficiency of Blendings, generally comprise malleation air pump, plemum, control air valve, control circuit etc..
In certain embodiments second accommodate chamber 2 sidewall be provided with wall thickness relatively thin be easy to the detection window that light shines through
10, on the relatively thin wall ratio sidewall referring to detection window 10 position of wall thickness, the thickness of other parts is little.
The principle of blood parameters is as follows to utilize photoanalysis to draw: the erythrocyte accommodated in intracavity cell suspension is tried by haemolysis
Agent is dissolved into fragment, discharges hemoglobin, and then other composition in hemolyzing reagent reacts with hemoglobin, and generation has
Color substance, content of hemoglobin is the highest, and the color of liquid is the deepest, light transmission the poorest (or light absorptive is the strongest).Generally, release
Go out hemoglobin, be combined formation cyanohemoglobin (having cyanogen hemolyzing reagent) or particular complex with hemolyzing reagent (without cyanogen haemolysis
Reagent).The way of detection light transmission is the most such, uses the light source on corollary new blood analyser, this light source one
As with the monochromatic light of wavelength 525nm, by light, through the hemoglobin detection window 10 mouthfuls accommodated on chamber, (meaning of window is one
Individual wall ratio accommodates thinner region, other position, chamber, more conducively transmitted light, such wall thickness 0.5 millimeter to 2 millimeter it
Between proper, simultaneously can use more transparent material, the light transmittance of material preferably more than 90% and homogeneous,
Stability of characteristics), and accommodating the opposite side in chamber, detect transmitted intensity with photoelectric device on corollary new blood analyser, and
Compared with the Hemoglobin Value calibrated, content of hemoglobin can be drawn.
Ordinary circumstance, in order to reduce each disposable blood cell counting and analyze the material transmittance, molten of sensing part 100
The transmittance of blood reagent, the sensor random error that the trickle difference of placement location is brought in analyser, hemolyzing reagent can quilt
First inject and accommodate chamber, when reagent is already at resting state, can first detect transmitted intensity the most at this moment, as background
Value, namely blank through light intensity, by this blank light intensity that passes through divided by the transmitted intensity having hemoglobin recorded afterwards,
Again compared with the Hemoglobin Value calibrated, content of hemoglobin more accurately can be drawn.The most conventional light path system
Unite to prevent light scattering and ambient light interference, double-wavelength method can be used to measure.
Drawn by light supply apparatus and photoelectronic analyzer is the parameter of hemoglobin in blood, and this is in hemanalysis
Modal parameter value, the principle of existing blood analyser detection hemoglobin is identical with this programme, is all to use optical telecommunications
Number analysis method, but it needs to utilize internal liquid-way system to be sucked by blood to be detected, adds reagent again in inside mixed
Even, then utilize photoelectronic analyzer that blood carries out detect analysis and draw hemoglobin parameters, terminate to need afterwards in analysis
Whole liquid-way system is cleaned for detecting by the cleaning procedure started in instrument next time.
For sensing part 100 is placed on analyser have a lot of in different fixed structure, the most common buckle-type
Structure, damascene structures and be similar to threaded connector structure connect mode can.
In certain embodiments, the fixed structure on blood analyser is the cavity 16 being formed on apparatus subject 14, institute
The sidewall stating cavity 16 is provided with on described sensing Plug Division and described negative pressure device for the grafting being connected with air pressure port 6
Hole.The connection of the connection of induction electrode on Plug Division and each sensing device, air pressure port 6 and spliced eye is the most by sensing part
100 are fixed on analyser, cavity 16 be one for the space accommodating sensing part 100, the nesting that both can mate completely
Live, it is also possible to be that cavity 16 is more than sensing part 100.
In certain embodiments, in order to make reagent and blood to be detected mixing, can realize with the manual compression bottle 12 that stretches,
Frame for movement can also be utilized.Be additionally provided with the push rod for bottle 12 flexible described in push-and-pull in the bottom of cavity 16, described push rod can
Moving up and down, the up and down motion of push rod is driven by cylinder or motor.If relying on merely user manually to flexible bottle
12 operate, and compare waste of manpower, and Blending Efficiency of Blending is difficult to keep stable, so using frame for movement to promote flexible bottle
12.When push rod up promotes, flexible bottle 12 compresses；Push rod down time, flexible bottle 12 resets, and final flexible bottle 12 is in by external force
The state of compression, it is to avoid blood to be detected stays impact analysis result in flexible bottle 12.Produced during flexible bottle 12 mixing operation
Dynamics is less, and liquid will not overflow by the interpolation mouth from top.
Below for accommodating the blood parameters that can draw when intracavity adds different reagent:
Sensing part possesses the first receiving chamber, the second receiving chamber, and first accommodates intracavity has sensing device, accommodates intracavity toward first and adds
Add dilution reagent, the second receiving intracavity adds hemolyzing reagent, can detect following 15 in conjunction with supporting New Blood analyser
Parameter:
Erythrocyte class parameter includes: mean constant of red blood cell, packed cell volume, mean corpuscular volume (MCV), Erythrocyte hemoglobin distribution width make a variation
Coefficient, Erythrocyte hemoglobin distribution width standard deviation, HRD of RBC showed；
Platelet class parameter includes: number of platelets, thrombocytocrit, mean platelet volume, MPW make a variation
Coefficient, MPW standard deviation, platelet rectangular histogram；
Hemoglobin parameter includes: hemoglobin, mean corpusular hemoglobin, mean corpuscular hemoglobin are dense
Degree.
Sensing part possesses the first receiving chamber, the second receiving chamber, and first accommodates intracavity has sensing device, first by blood to be detected
Liquid is put into the second receiving chamber and is carried out pre-dilution with dilution reagent, then puts into the first receiving intracavity again the by instruments such as pipettors
Secondary adds dilution reagent and is diluted, and can detect following 12 parameters in conjunction with supporting New Blood analyser:
Erythrocyte class parameter includes: mean constant of red blood cell, packed cell volume, mean corpuscular volume (MCV), Erythrocyte hemoglobin distribution width make a variation
Coefficient, Erythrocyte hemoglobin distribution width standard deviation, HRD of RBC showed；
Platelet class parameter includes: number of platelets, thrombocytocrit, mean platelet volume, MPW make a variation
Coefficient, MPW standard deviation, platelet rectangular histogram.
Sensing part possesses the first receiving chamber, the second receiving chamber, and first and second accommodates intracavity is respectively provided with sensing device, in conjunction with joining
The New Blood analyser of set can detect whole 23 parameters:
Erythrocyte class parameter includes: mean constant of red blood cell, packed cell volume, mean corpuscular volume (MCV), Erythrocyte hemoglobin distribution width make a variation
Coefficient, Erythrocyte hemoglobin distribution width standard deviation, HRD of RBC showed；
Platelet class parameter includes: number of platelets, thrombocytocrit, mean platelet volume, MPW make a variation
Coefficient, MPW standard deviation, platelet rectangular histogram；
Leukocyte class parameter includes: number of white blood cells, lymphocyte number, intermediate cell number, neutrophil numbers, lymph
Cell percentages, intermediate cell percentage ratio, neutrophilic granulocyte percentage ratio, WBC curves；
Hemoglobin parameter includes: hemoglobin, mean corpusular hemoglobin, mean corpuscular hemoglobin are dense
Degree.
The preferred scheme of sensing part is to be provided simultaneously with first, second and third to accommodate chamber, and first and second accommodates intracavity is respectively provided with biography
Induction device, first accommodates intracavity injects dilution reagent, and second accommodates intracavity and inject hemolyzing reagent, and the 3rd accommodates chamber for right
First blood to be detected accommodating intracavity carries out pre-dilution (adding dilution reagent).
First accommodates in chamber in the cell suspension of dilution erythrocyte and platelet passes sequentially through micropore portion along with cell suspension
Flowing into waste liquid chamber, the diluent in cell suspension is conduction, and erythrocyte and platelet are non-conductive medias, when erythrocyte and
When platelet flows through micropore, the first sensing device produces impedance variation, by this erythrocyte and hematoblastic bio-impedance electricity
Pressure pulse information is uploaded in the blood parameters analytical equipment of measurement main frame be analyzed and process, and just can obtain fixing liquid measure
Each erythrocyte by micropore portion and hematoblastic volume and total quantity in cell suspension.Dilution mixing chamber is only detected red
Cell and platelet, and leukocyte also with cell suspension one piece by micropore, but because the volume of leukocyte be significantly greater than red carefully
Born of the same parents and platelet, quantity only has erythrocytic 1/1000, so being easy to remove the signal of leukocyte in signal analysis.
In cell suspension in second receiving chamber, erythrocyte is dissolved into fragment by hemolyzing reagent, and special hemolyzing reagent will not
Dissolve leukocyte, so the micropore portion staying leukocyte to pass sequentially through the 3rd sensing device along with cell suspension flows into waste liquid chamber.
Diluent in cell suspension is conduction, and leukocyte is also non-conductive media, when leukocyte flows through micropore portion, the 3rd
Produce impedance variation on sensing device, the bio-impedance potential pulse information of this leukocyte is uploaded to measure the blood ginseng of main frame
Number analytical equipment it is analyzed and processes, just can obtain each leukocyte by micropore in the cell suspension of fixing liquid measure
Volume and total quantity, and judge which kind of leukocyte the leukocyte flowing through micropore belongs to, and what volume was minimum is lymph by volume
Cell, what volume was maximum is neutrophilic granulocyte, and what volume was moderate is intermediate cell.In haemolysis mixing chamber only detection leukocyte and
Hemoglobin, and dissolve fragmented bib and platelet also with cell suspension one piece by micropore, but because red carefully
Born of the same parents' fragment and hematoblastic volume are significantly less than leukocyte, thus be easy in signal analysis remove bib and blood little
The signal of plate.
Use disposable blood cell counting and analyze integrated reagent sensing part, blood testing convenient to operation, survey
After amount terminates, it is carried out abandoning without to integrated sensing part, i.e. saves the time cleaned spent by fluid path, save again
Saved clean used by 80% amount of reagent, save time economical.Sensing part replaces in analyser whole liquid-way system and external
Reagent barrel, waste liquid barrel etc. so that coordinate the structure of the New Blood analyser of integrated reagent sensing part and the volume also can letter significantly
Changing, New Blood analyser has good portability and ease for use, for blood testing on portable medical and quick diagnosis
Application value great.Sensing part main body uses macromolecular material manufacture, is suitable for batch production, with low cost, and abandon
Sensing part can reclaim circulation and again be shaped processing, environment friendly and pollution-free while can producing huge economic benefit, is suitable for
Spread.
The acquisition of blood cell analysis parameter and computational methods:
Blood cell analysis parameter one has 23, and a part is by directly obtaining transducing signal analysis, and another part is
By secondhand to the calculating again of front portion parametric results.Parameter, by classification, is segmented into four big classes, erythrocyte class
Parameter, platelet class parameter, leukocyte class parameter and hemoglobin parameter.
Erythrocyte class parameter includes: mean constant of red blood cell RBC, mean corpuscular volume (MCV) MCV, packed cell volume HCT, erythrocyte
Dispersion of distribution coefficient of variation RDW-CV, Erythrocyte hemoglobin distribution width standard deviation RDW-SD, HRD of RBC showed；
(erythrocyte pulse number is passed [mean constant of red blood cell RBC]=thinner ratio × erythrocyte pulse number × volume × coefficient by first
Induction device obtains)
[mean corpuscular volume (MCV) MCV]
The electrical pulse height counting that each erythrocyte is produced by instrument by the first sensing device, electrical pulse height and erythrocyte
Volume is directly proportional, and then collects according to volume size, eventually passes microprocessor correction, calculates all erythrocytic average body
Long-pending MCV.Unit fL.
[packed cell volume HCT]
[Erythrocyte hemoglobin distribution width coefficient of variation RDW-CV]
Erythrocyte hemoglobin distribution width coefficient of variation RDW-CV=(difference of mean corpuscular volume/mean corpuscular volume (MCV) MCV) ×
100%, whether mainly reaction erythrocyte size is the same, and different dispersion degree has how many, and unit is %.
[Erythrocyte hemoglobin distribution width standard deviation RDW-SD]
RDW-SD is obtained by RBC rectangular histogram, and RDW-SD is the dispersion of distribution of HRD of RBC showed baseline 20%, unit be fL or
um3
[HRD of RBC showed]
It is the histogram of reflection RBC volume size, the electricity that each erythrocyte is produced by instrument by the first sensing device
Pulse height counts, and electrical pulse height is directly proportional to erythrocyte volume, then collects according to volume size and classifies, eventually passing
Microprocessor corrects, and draws HRD of RBC showed.General histogrammic Y-axis represents that cell volume, X-axis represent the thin of same volume
The frequency of occurrences of the number of born of the same parents, i.e. this volume cells.
Platelet class parameter includes: number of platelets PLT, mean platelet volume MPV, thrombocytocrit PCT, platelet
Dispersion of distribution coefficient of variation PDW-CV, MPW standard deviation PDW-SD, platelet rectangular histogram；
(platelet pulse number is passed [number of platelets PLT]=thinner ratio × platelet pulse number × volume × coefficient by first
Induction device obtains)
[mean platelet volume MPV]
The electrical pulse height counting that each platelet is produced by instrument by the first sensing device, electrical pulse height and platelet
Volume is directly proportional, and then collects according to volume size, eventually passes microprocessor correction, calculates all hematoblastic average body
Long-pending MPV.Unit fL or um3.
[thrombocytocrit PCT]
Calculated by formula below and obtain, unit %:
[MPW coefficient of variation PDW-CV]
MPW coefficient of variation PDW-CV=(difference of mean platelet volume/mean platelet volume MPV) ×
100%, whether mainly reaction Platelet Size is the same, and different dispersion degree has how many, and unit is %.
[MPW standard deviation PDW-SD]
PDW-SD is obtained by PLT rectangular histogram, and PDW-SD is the dispersion of distribution of platelet baseline for histograms 20%, unit be fL or
um3
[platelet rectangular histogram]
It is the histogram of reflection PLT volume size, the electricity that each erythrocyte is produced by instrument by the first sensing device
Pulse height counts, and electrical pulse height is directly proportional to volume of platelets, then collects according to volume size and classifies, eventually passing
Microprocessor corrects, and draws HRD of RBC showed.General histogrammic Y-axis represents that cell volume, X-axis represent the thin of same volume
The frequency of occurrences of the number of born of the same parents, i.e. this volume cells.
Leukocyte class parameter includes: number of white blood cells WBC, lymphocyte number Lymph#, intermediate cell number Mid#, in
Property granulocyte number Gran#, cent lymphocytes Lymph%, intermediate cell percentage ratio Mid%, neutrophilic granulocyte percentage ratio
Gran%, WBC curves；
[number of white blood cells WBC]=thinner ratio × leukocyte pulse number × (leukocyte pulse number is by the 3rd for volume × coefficient
Sensing device obtains)
[lymphocyte number Lymph#]=thinner ratio × lymphocyte pulse number × volume × coefficient (lymphocyte umber of pulse
Mesh is obtained by the 3rd sensing device)
[intermediate cell number Mid#]=thinner ratio × intermediate cell pulse number × volume × coefficient (intermediate cell pulse number
Obtained by the 3rd sensing device)
[neutrophil numbers Gran#]=thinner ratio × neutrophilic granulocyte pulse number × volume × coefficient (neutrophilic granulocyte
Pulse number is obtained by the 3rd sensing device)
[cent lymphocytes Lymph%]=(lymphocyte number Lymph#/number of white blood cells WBC) × 100%
[intermediate cell percentage ratio Mid%]=(intermediate cell number Mid#/number of white blood cells WBC) × 100%
[neutrophilic granulocyte percentage ratio Gran%]=(neutrophil numbers Gran#/number of white blood cells WBC) × 100%
[WBC curves]
It is the histogram of reflection WBC volume size, the electricity that each erythrocyte is produced by instrument by the 3rd sensing device
Pulse height counts, and electrical pulse height is directly proportional to leukocyte volume, then collects according to volume size and classifies, eventually passing
Microprocessor corrects, and draws HRD of RBC showed.General histogrammic Y-axis represents that cell volume, X-axis represent the thin of same volume
The frequency of occurrences of the number of born of the same parents, i.e. this volume cells.
Hemoglobin parameter includes: Hb H GB, mean corpusular hemoglobin MCH, mean corpuscular blood
Hemoglobin concentration MCHC；
[hemoglobin]
[mean corpusular hemoglobin MCH]
[mean corpuscular hemoglobin concentration (MCHC) MCHC]
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for those skilled in the art
For Yuan, the present invention can have various change, combines and change.All within the spirit and principles in the present invention, that is made is any
Amendment, equivalent, improvement etc., within should be included in scope of the presently claimed invention.
Claims (12)
1. disposable blood cell counting and analyze integrated reagent sensing part, it is characterised in that: sensing part includes housing, described shell
Body is provided with the first receiving chamber for placing blood to be analyzed, the second receiving chamber and the first waste liquid chamber, and described first accommodates
It is equipped with the first inlet portion for adding reagent and blood to be detected on chamber, the second receiving chamber；Described first accommodates chamber and the
It is interconnected between one waste liquid chamber, and in place of both connections, is provided with the first sensing dress for detecting blood parameters to be analyzed
Put；Described first waste liquid intracavity is provided with the second sensing device for sensing its internal liquid level position.
2. disposable blood cell counting as claimed in claim 1 and analyze integrated reagent sensing part, it is characterised in that: described
Be additionally provided with on sensing part and accommodate the second waste liquid chamber of connect, chamber with second, described second accommodate chamber and the second waste liquid chamber connection it
Place is provided with the 3rd sensing device for detecting blood parameters to be analyzed；Described second waste liquid intracavity is provided with for sensing inside it
4th sensing device of liquid level position.
3. disposable blood cell counting as claimed in claim 2 and analyze integrated reagent sensing part, it is characterised in that: described
First sensing device, the 3rd sensing device include micropore portion and two induction electrodes respectively, described first sensing device micro-
Hole portion connection first accommodates chamber and the first waste liquid chamber, and the first receiving chamber is respectively equipped with induction electrode with the first waste liquid chamber；Described
The micropore portion connection second of the 3rd sensing device accommodates chamber and the second waste liquid chamber, and the second receiving chamber sets respectively with the second waste liquid chamber
There is induction electrode.
4. disposable blood cell counting as claimed in claim 2 and analyze integrated reagent sensing part, it is characterised in that: described
The air pressure port for being connected it is equipped with outside negative pressure source of the gas on first waste liquid chamber, the second waste liquid chamber.
5. disposable blood cell counting as claimed in claim 2 and analyze integrated reagent sensing part, it is characterised in that: described
Being additionally provided with the 3rd receiving chamber on sensing part, the described 3rd accommodates chamber is provided with second to enter for add reagent and blood to be detected
Oral area.
6. disposable blood cell counting as claimed in claim 5 and analyze integrated reagent sensing part, it is characterised in that: described
First inlet portion, the second inlet portion include the inlet for adding reagent respectively and add the interpolation mouth of blood to be detected；
The inlet in each described receiving chamber is arranged at bottom, adds mouth and is arranged at top.
7. disposable blood cell counting as claimed in claim 6 and analyze integrated reagent sensing part, it is characterised in that: described
Sensing part also includes the flexible bottle for accommodating reagent, and described flexible bottle is provided with and the delivery outlet of inlet Corresponding matching.
8. disposable blood cell counting as claimed in claim 1 and analyze integrated reagent sensing part, it is characterised in that: described
Second accommodate chamber sidewall be provided with wall thickness relatively thin be easy to the detection window that light shines through.
9. a New Blood analyser, including apparatus subject, it is characterised in that: described apparatus subject is provided with for laying one
Secondary property blood cell counting and analyze the fixed structure of integrated reagent sensing part, be provided with in described apparatus subject master control set,
For the negative pressure device being connected with air pressure port on sensing part, for the sensing Plug Division being connected with sensing device on sensing part,
The outfan of described sensing Plug Division connects blood parameters analytical equipment, the outfan of described blood analysis parameters analytical equipment
Connecting has display device, described sensing Plug Division, blood parameters analytical equipment, display device to be all connected with master control set.
10. a kind of New Blood analyser as claimed in claim 9, it is characterised in that: it is additionally provided with light on described apparatus subject
Source apparatus and corresponding photoelectronic analyzer, and be formed between the two and lay disposable blood cell counting and analysis
The space of integrated reagent sensing part；Described light supply apparatus is all connected with master control set with photoelectronic analyzer.
11. a kind of New Blood analysers as claimed in claim 9, it is characterised in that: described fixed structure is for being formed at instrument
Cavity in device main body, the sidewall of described cavity be provided with on described sensing Plug Division and described negative pressure device for air pressure
The spliced eye that port connects.
12. a kind of New Blood analysers as claimed in claim 11, it is characterised in that: the bottom of described cavity is additionally provided with use
In promoting and stretch the push rod of described flexible bottle, described push rod can move up and down.
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| CN201610472207.8A CN106018773A (en) | 2016-06-24 | 2016-06-24 | Disposable blood cell counting and analyzing integrated reagent sensing unit and novel blood analyzer |
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| CN106525696A (en) * | 2016-11-24 | 2017-03-22 | 张雪 | Portable blood cell analyzer |
| CN111239027A (en) * | 2020-01-22 | 2020-06-05 | 深圳市锦瑞生物科技有限公司 | Blood particle detection method and blood analyzer |
| CN113686759A (en) * | 2021-02-03 | 2021-11-23 | 深圳市帝迈生物技术有限公司 | Kit and POCT blood cell analyzer |
| WO2022165682A1 (en) * | 2021-02-03 | 2022-08-11 | 深圳市帝迈生物技术有限公司 | Kit and sample test apparatus |
| WO2022226746A1 (en) * | 2021-04-26 | 2022-11-03 | 深圳市帝迈生物技术有限公司 | Poct blood cell analyzer and using method therefor |
| CN118067591A (en) * | 2024-04-17 | 2024-05-24 | 南京佰抗生物科技有限公司 | Consumable for blood analysis |
| CN118067591B (en) * | 2024-04-17 | 2024-07-12 | 南京佰抗生物科技有限公司 | Consumable for blood analysis |
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