CN106389967A - Medicine for treating neurasthenia and preparation method thereof - Google Patents
Medicine for treating neurasthenia and preparation method thereof Download PDFInfo
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses medicine for treating neurasthenia and a preparation method thereof. The medicine is prepared by placenta hominis, radix codonopsis, radix astragali, pericarpium citri reticulatae and malt according to certain weight. The medicine has functions of tonifying middle-jiao and qi, drying dampness and resolving phlegm, regulating qi and tonifying the spleen, tonifying qi and nourishing blood and tonifying the stomach and securing the exterior and is quick in action, good in curative effect and free of relapse when being used for treating the neurasthenia.
Description
Technical field
The present invention relates to one kind treats neurasthenic medicine and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Neurasthenia is due to being chronically under anxiety and pressure, the easily excited and mental easily tired phenomenon of spirit.In
Doctor is then considered depression of liver-QI, the hepatic and renal YIN deficiency, deficiency of both the heart and spleen, caused by disturbing in phlegm-fire.Due to western medicine neurasthenia's side effect
Greatly, therefore people to effectively treatment there is great demand in neurasthenic Chinese medicine, up to now, also do not find with regard to
The relevant report of the present invention.
Content of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, have found effectively treatment nerve finally
Weak medicine, thus complete the present invention.
It is an object of the invention to provide a kind of neurasthenic Chinese medicine composition of effectively treatment.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention is to select Placenta Hominiss, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus medicine to be combined preparing, by these medicines
Thing combination makes each efficacy of drugs produce synergism such that it is able to effectively treatment neurasthenia.Wherein from Placenta Hominiss be because
For its property sweet-salty, temperature, enter lung, liver and kidney channel, have QI invigorating, blood-nourishing, the function of benefit essence, governance wasting, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough
Breathe heavily, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, infertile or newborn few.It is because that its nature and flavor is sweet from Radix Codonopsis, put down, enter
Handss, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, and control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty,
Chronic diarrhea, proctoptosis.Be because that its nature and flavor is sweet from the Radix Astragali, tepor, enter lung, spleen channel, raw defend consolidating superficial resistance with beneficial, inducing diuresis to remove edema, poison holding,
The function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or burst and holds back long；Process the function with there being invigorating middle warmer benefit, control internal injury labor
Tired, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.It is because that its nature and flavor is bitter, pungent from Pericarpium Citri Reticulatae,
Temperature, return lung, spleen channel, there are regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, control fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.From Fructus Hordei Germinatus
It is because that its nature and flavor is sweet, tepor, enter spleen, stomach, have and help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, control dyspepsia, swollen distention and fullness in the abdomen, appetite
Depressed, vomiting is had loose bowels, mammary swelling does not disappear.
Specific embodiment
The drug dose of instant component is also that inventor draws through groping in a large number to summarize, and the consumption of each component is following heavy
All there is in the range of amount preferable curative effect：
25-35 gram of Placenta Hominiss, 15-25 gram of Radix Codonopsis, 10-20 gram of the Radix Astragali, 15-25 gram of Pericarpium Citri Reticulatae, 15-25 gram of Fructus Hordei Germinatus.
It is preferably：
30 grams of Placenta Hominiss, 20 grams of Radix Codonopsis, 15 grams of the Radix Astragali, 20 grams of Pericarpium Citri Reticulatae, 20 grams of Fructus Hordei Germinatus.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Placenta Hominiss：With fresh Placenta Hominiss, anyhow cut open blood vessel, repeatedly wash drift totally with water, Placenta Hominiss：With fresh purple river
Car, cuts open blood vessel anyhow, repeatedly washes drift totally with water, separately takes the decoct soup that adds water in Pericarpium Zanthoxyli loading cloth bag, removes slag, by clean Placenta Hominiss
Put and in pepper soup, boil 2-3 minute, pull out in time, drip water purification, mixed thoroughly with yellow wine, take out, dry, every Placenta Hominiss 100, use Pericarpium Zanthoxyli
4 liang, 3 jin of yellow wine；
2nd, Radix Codonopsis：Run through reed, section or cutting after clean silt, dry；
3rd, the Radix Astragali：Pick net impurity, remove the root head of residual and hollow larger root, be soaked in water, pull out, cut in time after running through
Piece, dries；
4th, Pericarpium Citri Reticulatae：Take crude drug, remove the peel of impurity and blackening, wash quickly is net, softens, shredding, dries or cold drying, sieve
Dedusting is considered to be worth doing；
5th, Fructus Hordei Germinatus：Take Fructus Hordei Germinatus put micro- in pot fry to yellow, taking-up cools.
2nd, prepare
1. the Placenta Hominiss cooking, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus are put into add water to cook in decocting container secondary, for the first time plus
Water 8 times amount, decocts 1.5 hours, and 6 times amount that add water for the second time decoct 1 hour, merge decoction liquor twice, filter to get filtrate；
2. filtrate is condensed into the extractum that proportion is 1.35, plus 90%-95% ethanol carries out precipitate with ethanol, reclaims ethanol and concentrates, in 45-
It is dried at 50 DEG C, prepared dry extract；
3. dry extract is broken into fine powder, adds adjuvant to make granule, tabletted, every 0.5 gram.
Placenta Hominiss QI invigorating in prescription, blood-nourishing, benefit essence is monarch drug；Radix Codonopsis invigorating the spleen and replenishing QI, promotes the production of body fluid, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, dampness
Resolving sputum, the two is ministerial drug, and three taste medicines play benefiting qi and nourishing blood, Mi Gu granule, regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm, treatment jointly
Neurasthenia's effect comprehensively, and with benefiting qi and nourishing blood, regulating qi-flowing for strengthening spleen, can effect a permanent cure based on drying dampness to eliminate phlegm, the Radix Astragali is beneficial to defend consolidating superficial resistance, diuretic
Detumescence, poison holding, granulation promoting, the function of invigorating middle warmer benefit is adjuvant drug, and Fructus Hordei Germinatus help digestion, and in, the therapeutic method to keep the adverse QI flowing downwards is to make medicine, and all medicines are to take stopgap measures with being left.
Medicine of the present invention has invigorating the spleen and replenishing QI, drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen, benefiting qi and nourishing blood, the function of stomach reinforcing consolidating superficial resistance, is used for
Treatment neurasthenia, short treating period, instant effect, non-relapse after healing.
Specific embodiment：
The beneficial effect of of the present invention medicine is expanded on further below by way of test example, these test examples include medicine of the present invention
The animal toxicity test report of thing and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Take rabbit 30, male and female dual-purpose, body weight 2.0 2.5kg, divide two groups, every group 15, one of which is that overdose is tested
Group, another group is normal amount test group.Super quantity group oral tablet 0.1g/kg, normal amount is 0.05g/kg, and administering mode is dilute
Release administration by gavage administration, twice daily, serve on 7 days, daily observation is administered reaction, result shows that two groups of rabbit activities, diet are normal,
The no bad toxic and side effects of medicine.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept neurasthenia out-patient totally 21 for medical treatment.
2nd, diagnostic criteria
Neurasthenic symptom is to be nervous, insomnia and dreamful sleep, and muscle tone is had a headache, dizziness and blurred vision, abdominal distention uncomfortable in chest, and digestion is not
Good etc..
3rd, Therapeutic Method
From above-mentioned medicament, take to patient, each take 2 grams of tablet, early, middle and late daily respectively take 1 time, be within 7 days a treatment
Journey, continuously takes 3 courses for the treatment of.
4th, efficacy assessment standard
Effective：Neurasthenia symptom disappears, and body constitution gradually recovers normal, recovery from illness；
Take a turn for the better：Patient's insomnia and dreamful sleep, dizziness and blurred vision, the general malaise phenomenon such as be nervous mitigates；
Invalid：Do not reach improvement standard person.
5th, therapeutic outcome（See table）
In above-mentioned treatment, with Drug therapy neurastheniac of the present invention 21, effective 15 of result, obvious effective rate is
71.43%, take a turn for the better 5, improvement rate is 23.8%, invalid 1, total effective rate is 95.24%.
Claims (3)
1. one kind treat neurasthenic medicine it is characterised in that：It is made up of the crude drug in following weight range：
25-35 gram of Placenta Hominiss, 15-25 gram of Radix Codonopsis, 10-20 gram of the Radix Astragali, 15-25 gram of Pericarpium Citri Reticulatae, 15-25 gram of Fructus Hordei Germinatus.
2. medicine according to claim 1, the consumption of wherein each crude drug is：
30 grams of Placenta Hominiss, 20 grams of Radix Codonopsis, 15 grams of the Radix Astragali, 20 grams of Pericarpium Citri Reticulatae, 20 grams of Fructus Hordei Germinatus.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Placenta Hominiss：With fresh Placenta Hominiss, anyhow cut open blood vessel, repeatedly wash drift totally with water, separately take Pericarpium Zanthoxyli to load in cloth bag
Add water decoct soup, removes slag, and clean Placenta Hominiss is put and boils 2-3 minute in pepper soup, pull out in time, drips water purification, is mixed thoroughly with yellow wine, take
Go out, dry, every Placenta Hominiss 100, with 4 liang of Pericarpium Zanthoxyli, 3 jin of yellow wine；
（2）Radix Codonopsis：Run through reed, section or cutting after clean silt, dry；
（3）The Radix Astragali：Pick net impurity, remove the root head of residual and hollow larger root, be soaked in water, pull out, cut in time after running through
Piece, dries；
（4）Pericarpium Citri Reticulatae：Take crude drug, remove the peel of impurity and blackening, wash quickly is net, softens, shredding, dries or cold drying,
Weed out ash bits；
（5）Fructus Hordei Germinatus：Take Fructus Hordei Germinatus put micro- in pot fry to yellow, taking-up cools；
（Two）Preparation
1. the Placenta Hominiss cooking, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus are put into add water to cook in decocting container secondary, for the first time plus
Water 8 times amount, decocts 1.5 hours, and 6 times amount that add water for the second time decoct 1 hour, merge decoction liquor twice, filter to get filtrate；
2. filtrate is condensed into the extractum that proportion is 1.35, plus 90%-95% ethanol carries out precipitate with ethanol, reclaims ethanol and concentrates, in 45-
It is dried at 50 DEG C, prepared dry extract；
3. dry extract is broken into fine powder, adds adjuvant to make granule, tabletted, every 0.5 gram.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611145050.4A CN106389967A (en) | 2016-12-13 | 2016-12-13 | Medicine for treating neurasthenia and preparation method thereof |
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| CN201611145050.4A CN106389967A (en) | 2016-12-13 | 2016-12-13 | Medicine for treating neurasthenia and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116785345A (en) * | 2021-07-13 | 2023-09-22 | 山西中医药大学 | Astragalus mongholicus strengthening tea with immunity regulating function and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549085A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine for treating neurasthenia and preparation method thereof |
| CN105267518A (en) * | 2015-10-29 | 2016-01-27 | 赵卫国 | Traditional Chinese medicine for treating panasthenia and preparation method thereof |
| CN106075311A (en) * | 2016-08-09 | 2016-11-09 | 王中杰 | One is used for treating neurasthenic Chinese medicine composition |
-
2016
- 2016-12-13 CN CN201611145050.4A patent/CN106389967A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549085A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine for treating neurasthenia and preparation method thereof |
| CN105267518A (en) * | 2015-10-29 | 2016-01-27 | 赵卫国 | Traditional Chinese medicine for treating panasthenia and preparation method thereof |
| CN106075311A (en) * | 2016-08-09 | 2016-11-09 | 王中杰 | One is used for treating neurasthenic Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 王寿亭著: "《王寿亭中医临床80种》", 31 December 2015, 河南科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116785345A (en) * | 2021-07-13 | 2023-09-22 | 山西中医药大学 | Astragalus mongholicus strengthening tea with immunity regulating function and preparation method thereof |
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