CN106389895A - Traditional Chinese medicine composition with effects of yin nourishing, lung heat clearing, dryness-syndrome moisturizing and sore-throat relieving, preparation method and applications thereof - Google Patents
Traditional Chinese medicine composition with effects of yin nourishing, lung heat clearing, dryness-syndrome moisturizing and sore-throat relieving, preparation method and applications thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition with effects of yin nourishing, lung heat clearing, dryness-syndrome moisturizing and sore-throat relieving, a preparation method and applications thereof, wherein the active component of the traditional Chinese medicine composition is prepared from the following raw materials by weight: 44-52 parts of fructus arctii, 15-20 parts of rhizoma phragmitis, 10-15 parts of fructus canarii, 8-16 parts of rehmannia glutinosa, 8-16 parts of ophiopogon japonicus, 8-16 parts of scutellaria baicalensis, 5-13 parts of tree peony bark, 11-19 parts of radix paeoniae rubra, 5-13 parts of platycodon grandiflorus, 11-29 parts of radix scrophulariae, 8-16 parts of dendrobium, 8-16 parts of chrysanthemum, 8-16 parts of peppermint, 11-16 parts of heartleaf houttuynia herb, 10-15 parts of morus alba l, and 2-10 parts of licorice root. According to the present invention, the traditional Chinese medicine composition has effects of f yin nourishing, body fluid regeneration, qi benefiting, qi promoting, lung facilitating, sore-throat relieving, lung heat clearing, asthma relieving, heat clearing, detoxification and wind heat removing, and clinical verification results show that the traditional Chinese medicine composition does not drug dependence and further has advantages of good treatment effect, safety, and stability; the preparation process is simple, safe, and health; the massage cream produced by using the traditional Chinese medicine composition and the matrix or carrier is mild to skin without stimulation, does not have the toxic-side effect, and has the complete lung heat clearing effect.
Description
Technical field
The present invention relates to Chinese medicine external product field, the Chinese medicine group of sore-throat relieving is moisturized in more particularly to a kind of nourishing YIN and clearing away lung-heat
Compound and its preparation method and application.
Background technology
Lung governing qi department breathes, and main a surname sends out fall respectful, towards hundred arteries and veins, cures mainly section；Therefore lung have improvement adjust lung it
The gas of breathing and whole body, blood, the effect of water.But lungs are empty clearly and tender and lovely, and happiness profit is not dry, then the expiring of suctions,
That exhales is then empty, is the canopy of internal organs, and hundred feeling pulse institutes are towards meeting；It is again due to lung position highest and dirty for void clearly,
Communicate with the external world, clearly gently solemn silence, do not allow fine mustard, invading intolerant to pathogen, thus invade outside pathogenic warmth, internal injury or other
Internal organs pathological changes, all can disease and cough, pant, spitting blood in lung, the disease such as aphonia, pulmonary tuberculosis, consumptive lung disease.
And throat is one of human body vitals, account for 40% with different degrees of pharyngolaryngitis patient.With economical
High speed development, the living environment severe exacerbation of the mankind, rhythm of life quickening simultaneously, the diet of people, life
Custom and the various pressure in live and work, the body making one is chronically at the state of fatigue,
Easily pathogen invades body, cloudy liquid loss, the moon sun not processed, water failing to restrain blazing fire, hyperactivity of deficient fire, follows through above disturbing throat, sends out
Raw throat illness, such as burst laryngopharynx swelling and pain etc., pulmonary disease sickness rate is also in increase simultaneously.
At present, western medicine can only symptom management temporarily, take excessive antibiotic medicine, antibiotic or sulfonamides
Thing can lead to yin-Yang disequilibrium, immunologic hypofunction, and resistance goes down, and then makes Relapse rate difficult
More.And, the mostly oral drugs for the treatment of pulmonary and throat illness at present, medicine by oral administration afterwards can be by intestinal
The effect such as Digestive system of peptic digestion slackens the efficacy of a drug, and gastrointestinal disturbances road can be produced stimulates simultaneously, impact digestion
Function.On the contrary, topical drug have the advantages that easy to use, safe.
Content of the invention
Based on this it is necessary to for conventional oral drugs curative effect undesirable and intestines and stomach existed stimulate and
The shortcomings of less effective, a kind of nourishing YIN and clearing away lung-heat is provided to moisturize Chinese medicine composition of sore-throat relieving and preparation method thereof and answer
With.
An object of the present invention is the Chinese medicine composition providing a kind of nourishing YIN and clearing away lung-heat to moisturize sore-throat relieving.
Specific technical scheme is as follows：
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, the active component of described Chinese medicine composition be by with
Lower raw material is prepared from：Fructus Arctii 44-52 part, Rhizoma Phragmitiss 15-20 part, Fructus Canarii 10-15 part, Radix Rehmanniae
8-16 part, Radix Ophiopogonis 8-16 part, Radix Scutellariae 8-16 part, Cortex Moutan 5-13 part, Radix Paeoniae Rubra 11-19 part, Radix Platycodoniss 5-13
Part, Radix Scrophulariae 11-29 part, Herba Dendrobii 8-16 part, Flos Chrysanthemi 8-16 part, Herba Menthae 8-16 part, Herba Houttuyniae 11-16 part,
Cortex Mori 10-15 part, Radix Glycyrrhizae 2-10 part.
Wherein in an embodiment, the active component of described Chinese medicine composition is by following raw material system
Standby form：46 parts of Fructus Arctii, 16 parts of Rhizoma Phragmitiss, 12 parts of Fructus Canarii, 13 parts of Radix Rehmanniae, 11 parts of Radix Ophiopogonis, Radix Scutellariae
11 parts, 8 parts of Cortex Moutan, 13 parts of Radix Paeoniae Rubra, 8 parts of Radix Platycodoniss, 13 parts of Radix Scrophulariae, 13 parts of Herba Dendrobii, Flos Chrysanthemi 11
Part, 11 parts of Herba Menthae, 13 parts of Herba Houttuyniae, 11 parts of Cortex Mori, 6 parts of Radix Glycyrrhizae.
The Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat provided by the present invention, according to Chinese medicine " monarch "
Theory, add dry Fructus Arctii, Fructus Canarii, Rhizoma Phragmitiss, Radix Platycodoniss, Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae be monarch drug, have
Lung qi dispersing sore-throat relieving, YIN nourishing and the production of body fluid promoting, the effect of heat-clearing and toxic substances removing；Add Flos Chrysanthemi, Herba Menthae, Herba Dendrobii fish, raw meat grass, Mulberry
Rhizoma Euonymus are ministerial drug, have the effect of dispelling wind and heat pathogens, eliminating pathogen from the lung for relieving asthma, circulation of qi promoting；Add Radix Scutellariae, Cortex Moutan, red
Chinese herbaceous peony is adjuvant drug, has the effect of removing heat from blood, promoting blood circulation, blood stasis dispelling；Adding Radix Glycyrrhizae is to make medicine, has QI invigorating, is in harmonious proportion
Hypotoxic effect, drops in all medicines.
The pharmacological action of each composition is as follows respectively：
Fructus Arctii：Dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, fiber crops
Rash, rubella, laryngopharynx swelling and pain, mumps, carbuncle sore tumefacting virus.
Fructus Canarii：Heat-clearing and toxic substances removing, sore-throat relieving, promotes the production of body fluid.For laryngopharynx swelling and pain, expectorant of coughing sticks, dysphoria and thirsty.
Rhizoma Phragmitiss：Clearing away heat-fire, promoting the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis.For pyreticosis polydipsia, lung-heat is coughed
Cough, lung carbuncle pyemesis.
Radix Rehmanniae：Hot removing heat from blood, YIN nourishing and the production of body fluid promoting.For thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxiss, calentura is hindered
The moon, crimson tongue excessive thirst, Tianjin hinder constipation, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, Heat Diabetes.
Cortex Moutan：Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxiss, night
Early cool, the lossless hectic fever due to YIN-deficiency of heat.
Radix Ophiopogonis：YIN nourishing and the production of body fluid promoting, moistening lung clears away heart-fire.For dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, Tianjin is hindered
Thirsty, Heat Diabetes, vexed insomnia, dry constipation of intestines.
Radix Scutellariae：Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest,
Damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, hyperpyrexia excessive thirst, blood-head tells nosebleed, carbuncle sore tumefacting virus.
Radix Paeoniae Rubra：Clearing away heat and cooling blood, eliminating stasis to stop pain.Enter nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxiss, conjunctival congestion for heat
Swell and ache, hypochondriac pain due to stagnation of liverQI, abdominal mass is suffered from abdominal pain, carbuncle swells sore.
Radix Platycodoniss：Lung qi dispersing, sore-throat relieving, eliminating the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness,
Lung carbuncle pyemesis.
Radix Scrophulariae：Clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.For thermal man's nutrient blood, maculae caused by violent heat pathogen, calentura
Impairment of YIN, crimson tongue excessive thirst, Tianjin hinder constipation, hectic fever due to yin labor is coughed, conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
Herba Dendrobii：Stomach promotes the production of body fluid, nourishing YIN and clearing away heat.For calentura Tianjin wound, xerostomia excessive thirst, deficiency of stomach-Yin, lack of appetite is done
Vomit, deficiency-heat is not moved back after being ill, hyperactivity of fire caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, poor vision, muscles and bones impotence.
Flos Chrysanthemi：Scattered wind heat clearing away, flat liver improving eyesight, heat-clearing and toxic substances removing.For anemopyretic cold, dizziness of having a headache, conjunctival congestion
Swell and ache, eyes is dim-sighted, sore and toxic.
Herba Menthae：Dispelling wind and heat pathogens, the sharp clearly head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.For anemopyretic cold, wind
Temperature from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, Breast bilges frowsty about.
Herba Houttuyniae：Pungent, it is slightly cold.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus.Spit for lung abscess, expectorant dyspnea of heat type is coughed, swelling
Swollen sore.
Cortex Mori：Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, oedema turgor oliguria, appearance skin
Edema.
Radix Glycyrrhizae：Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For taste
Weakness, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
It is a further object of the present invention to provide the preparation side of the Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat
Method.
Specific technical scheme is as follows：
The preparation method of the Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, comprises the following steps：Weigh institute
State raw material, the water of the described raw material weight 3-10 times amount of addition or the ethanol solution that mass fraction is 10-70% are carried out
Extract 1-2 time, filter or be centrifuged, after concentrating filter liquor, obtain described Chinese medicine composition；The method of described extraction
For decocting extraction method or reflux extraction or ultrasonic extraction or permeating extraction.
Wherein in an embodiment, comprise the following steps：Weigh described raw material, add described raw material weight 6
The mass fraction of times amount is 50% ethanol solution supersound extraction, filters, and filtering residue continues to adopt raw material weight 6
The mass fraction of times amount is 10% ethanol solution supersound extraction, filters, merging filtrate, is concentrated into medical material：
The weight of concentrated solution is than for 1:0.6, that is, obtain the Chinese medicine composition that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat.
It is a further object of the present invention to provide a kind of nourishing YIN and clearing away lung-heat moisturizes the Chinese medicine composition of sore-throat relieving in preparation yin nourishing
Application in the topical drug of clearing away lung-heat and moistening for dryness sore-throat relieving.
Specific technical scheme is as follows：
The topical drug that the Chinese medicine composition of sore-throat relieving moisturizes sore-throat relieving in preparation nourishing YIN and clearing away lung-heat is moisturized in a kind of nourishing YIN and clearing away lung-heat
In application.
It is a further object of the present invention to provide the massage cream of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat.
Specific technical scheme is as follows：
The massage cream of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and described massage cream is to moisturize profit by above-mentioned nourishing YIN and clearing away lung-heat
The Chinese medicine composition of pharynx and the conventional substrate of massage cream or carrier are prepared from；Described carrier include water, wetting agent,
Emulsifying agent, excipient, covering agent, isostearyl glyceryl pentaerythrityl ether, conditioner, suspending agent, chelating agen, preservative and spice.
Wherein in an embodiment, described nourishing YIN and clearing away lung-heat moisturizes the Chinese medicine composition of sore-throat relieving in described massage cream
In percetage by weight be 10.0-30.0%；Relative density at 55 DEG C -65 DEG C for the described Chinese medicine composition is
1.05-1.25.
Wherein in an embodiment, described massage cream is to be prepared from by the raw material of following percetage by weight：
Chinese medicine composition described in 15.0-23.0%, 43.0-46.0% water, 3.5-5.5% emulsifying agent, 2.5-4.5% excipient,
11.5-13.5% isostearyl glyceryl pentaerythrityl ether, 0.05-0.09% conditioner, 11.0-13.0% wetting agent, 0.4-0.6% suspending agent,
0.1-0.2% chelating agen, 0.4-0.8% covering agent, 0-1.0% preservative, 0-0.3% essence.
Wherein in an embodiment, described massage cream is to be prepared from by the raw material of following percetage by weight：
Chinese medicine composition described in 20%, 46.00% water, 4.3% emulsifying agent, 3.3% excipient, 10.5% isostearyl glyceryl pentaerythrityl ether, 0.07%
Conditioner, 14% wetting agent, 0.43% suspending agent, 0.1% chelating agen, 0.6% covering agent, 0.6% preservative,
0.1% essence.
Wherein in an embodiment, described massage cream is to be prepared from by the raw material of following percetage by weight：
Chinese medicine composition described in 20.0%, 1.2% stereth -2,1.5% stereth -21,3.3% spermaceti is hard
Lipidol, 4.0% carbonic acid dibutyl ester, 1.6% glyceryl stearate, 5.0% isopropyl myristate, 1.5% octanoic acid/
Tricaprin, 2.0% polydimethylsiloxane, 0.05% bisabolol, 46.00% water, 8.0% butanediol,
2.0% glycerol, 0.23% xanthan gum, 0.2% sodium alginate, 0.1%EDTA disodium, 1.0% glycine betaine, 0.6% 2
Titanium oxide, 0.02% tetrahydrochysene piperine, 1.0%1,3 propylene glycol, 0.6% phenoxyethanol, 0.1% essence.
The Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat provided by the present invention, is raw material using pure Chinese medicine, presses
Tcm theory compatibility according to " monarch " forms, and has a YIN nourishing and the production of body fluid promoting, QI invigorating circulation of qi promoting, lung qi dispersing sore-throat relieving,
Eliminating pathogen from the lung for relieving asthma, heat-clearing and toxic substances removing, the effect of dispelling wind and heat pathogens, according to clinical verification, drug dependence will not be produced, also
There is good effect, safety and stability.
The preparation method of the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat provided by the present invention, has technique letter
The single, advantage of safety and sanitation.
The Chinese medicine composition of sore-throat relieving is moisturized in above-mentioned nourishing YIN and clearing away lung-heat provided by the present invention and massage cream commonly uses substrate
Or the external massage cream that carrier is prepared from, gently non-stimulated to skin, have no toxic side effect, YIN nourishing and the production of body fluid promoting,
Lung qi dispersing sore-throat relieving, eliminating pathogen from the lung for relieving asthma, heat-clearing and toxic substances removing, reach comprehensive lung heat clearing effect.Further, since above-mentioned yin nourishing is clear
The raw material that lung moisturizes used by the Chinese medicine composition of sore-throat relieving is pure Chinese medicine, without antibiotic and hormone, so will not
Produce drug dependence.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The Chinese medicine composition of sore-throat relieving is moisturized in embodiment 1 nourishing YIN and clearing away lung-heat
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and the active component of described Chinese medicine composition is by following
Raw material is prepared from：44 parts of Fructus Arctii, 15 parts of Rhizoma Phragmitiss, 10 parts of Fructus Canarii, 8 parts of Radix Rehmanniae, Radix Ophiopogonis
8 parts, 8 parts of Radix Scutellariae, 5 parts of Cortex Moutan, 11 parts of Radix Paeoniae Rubra, 5 parts of Radix Platycodoniss, 11 parts of Radix Scrophulariae, 8 parts of Herba Dendrobii,
8 parts of Flos Chrysanthemi, 8 parts of Herba Menthae, 11 parts of Herba Houttuyniae, 10 parts of Cortex Mori, 2 parts of Radix Glycyrrhizae.
The preparation method that the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is：
Weigh the raw material of above-mentioned weight portion, be sufficiently mixed, pulverize, put in supersound extraction tank, add above-mentioned former
The mass fraction of material weight 6 times amount is 70% ethanol solution, and supersound extraction 30min filters (400 mesh sieve),
Filtering residue continues to be 30% ethanol solution supersound extraction 30min using the mass fraction of raw material weight 6 times amount, mistake
Filter (400 mesh sieve), merges filtrate twice, is concentrated into medical material：The weight of concentrated solution is than for 1:0.6, obtain final product
Moisturize the Chinese medicine composition of sore-throat relieving to nourishing YIN and clearing away lung-heat.
The Chinese medicine composition of sore-throat relieving is moisturized in embodiment 2 nourishing YIN and clearing away lung-heat
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and the active component of described Chinese medicine composition is by following
Raw material is prepared from：46 parts of Fructus Arctii, 16 parts of Rhizoma Phragmitiss, 12 parts of Fructus Canarii, 13 parts of Radix Rehmanniae, wheat
11 parts of winter, 11 parts of Radix Scutellariae, 8 parts of Cortex Moutan, 13 parts of Radix Paeoniae Rubra, 8 parts of Radix Platycodoniss, 13 parts of Radix Scrophulariae, Herba Dendrobii
13 parts, 11 parts of Flos Chrysanthemi, 11 parts of Herba Menthae, 13 parts of Herba Houttuyniae, 11 parts of Cortex Mori, 6 parts of Radix Glycyrrhizae.
The preparation method that the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is：
Weigh the raw material of above-mentioned weight portion, be sufficiently mixed, pulverize, put in supersound extraction tank, add above-mentioned former
The mass fraction of material weight 6 times amount is 50% ethanol solution, and supersound extraction 30min filters (400 mesh sieve),
Filtering residue continues to be 10% ethanol solution supersound extraction 30min using the mass fraction of raw material weight 6 times amount, mistake
Filter (400 mesh sieve), merges filtrate twice, is concentrated into medical material：The weight of concentrated solution is than for 1:0.6, obtain final product
Moisturize the Chinese medicine composition of sore-throat relieving to nourishing YIN and clearing away lung-heat.
The Chinese medicine composition of sore-throat relieving is moisturized in embodiment 3 nourishing YIN and clearing away lung-heat
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and the active component of described Chinese medicine composition is by following
Raw material is prepared from：52 parts of Fructus Arctii, 20 parts of Rhizoma Phragmitiss, 15 parts of Fructus Canarii, 16 parts of Radix Rehmanniae, wheat
16 parts of winter, 16 parts of Radix Scutellariae, 13 parts of Cortex Moutan, 19 parts of Radix Paeoniae Rubra, 13 parts of Radix Platycodoniss, 29 parts of Radix Scrophulariae, stone
16 parts of dry measure used in former times, 16 parts of Flos Chrysanthemi, 16 parts of Herba Menthae, 16 parts of Herba Houttuyniae, 15 parts of Cortex Mori, 10 parts of Radix Glycyrrhizae.
The preparation method that the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is：
Weigh the raw material of above-mentioned each weight portion, be ground into middle powder, be placed in reflux, extract, tank, add above-mentioned former
The mass fraction of material weight 6 times amount is 65% ethanol solution reflux, extract, 1 time, and extracting solution filters, filtering residue
The mass fraction adding above-mentioned raw materials weight 3 times amount is 45% ethanol solution reflux, extract, 1 time, extracts
Liquid filters, and merges filtrate twice, reclaims ethanol and is concentrated into medical material：The weight of concentrated solution is than for 1:0.6, that is,
Obtain the Chinese medicine composition that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat.
The Chinese medicine composition of sore-throat relieving is moisturized in embodiment 4 nourishing YIN and clearing away lung-heat
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and the active component of described Chinese medicine composition is by following
Raw material is prepared from：46 parts of Fructus Arctii, 16 parts of Rhizoma Phragmitiss, 12 parts of Fructus Canarii, 13 parts of Radix Rehmanniae, wheat
11 parts of winter, 11 parts of Radix Scutellariae, 8 parts of Cortex Moutan, 13 parts of Radix Paeoniae Rubra, 8 parts of Radix Platycodoniss, 13 parts of Radix Scrophulariae, Herba Dendrobii
13 parts, 11 parts of Flos Chrysanthemi, 11 parts of Herba Menthae, 13 parts of Herba Houttuyniae, 11 parts of Cortex Mori, 6 parts of Radix Glycyrrhizae.
The preparation method that the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is：
Weigh the raw material of above-mentioned weight portion, be sufficiently mixed, smash into coarse powder, add 6 times of above-mentioned raw materials weight
The water boiling and extraction of amount 2 times, collects volatile oil and extracting solution, and extracting solution filters, and filtrate is concentrated into medical material：
Concentrated solution weight is than for 1:0.6, that is, obtain the Chinese medicine composition that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat.
The Chinese medicine composition of sore-throat relieving is moisturized in embodiment 5 nourishing YIN and clearing away lung-heat
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and the active component of described Chinese medicine composition is by following
Raw material is prepared from：46 parts of Fructus Arctii, 16 parts of Rhizoma Phragmitiss, 12 parts of Fructus Canarii, 13 parts of Radix Rehmanniae, wheat
11 parts of winter, 11 parts of Radix Scutellariae, 8 parts of Cortex Moutan, 13 parts of Radix Paeoniae Rubra, 8 parts of Radix Platycodoniss, 13 parts of Radix Scrophulariae, Herba Dendrobii
13 parts, 11 parts of Flos Chrysanthemi, 11 parts of Herba Menthae, 13 parts of Herba Houttuyniae, 11 parts of Cortex Mori, 6 parts of Radix Glycyrrhizae.
The preparation method that the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is：
Weigh the raw material of above-mentioned each weight portion, pulverizing is sufficiently mixed, and medicated powder is placed in extraction pot, in addition
The mass fraction stating medical material weight 6 times amount is 55% ethanol solution supersound extraction 1 time, extracting solution low speed from
The heart, obtains centrifugal liquid 1 and medicinal residues 1, centrifugal liquid 1 high speed centrifugation again, obtains centrifugal liquid 2；Medicinal residues 1 add again
The mass fraction entering raw material weight 4 times amount is 35% ethanol solution supersound extraction 1 time, extracting solution low speed from
The heart, obtains centrifugal liquid 3 and medicinal residues 2, and it is abandoned by medicinal residues 2, centrifugal liquid 3 high speed centrifugation again, obtains centrifugal liquid 1,
Merge centrifugal liquid 2 and centrifugal liquid 4, concentrating under reduced pressure (70 DEG C -75 DEG C, -0.08Mpa～-0.1Mpa), reclaim second
Alcohol, is concentrated into medical material：Concentrated solution weight is than for 1:0.6, that is, obtain the Chinese medicine composition that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat
Thing.
The Chinese medicine composition of sore-throat relieving is moisturized in embodiment 6 nourishing YIN and clearing away lung-heat
The Chinese medicine composition of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, and the active component of described Chinese medicine composition is by following
Raw material is prepared from：46 parts of Fructus Arctii, 16 parts of Rhizoma Phragmitiss, 12 parts of Fructus Canarii, 13 parts of Radix Rehmanniae, wheat
11 parts of winter, 11 parts of Radix Scutellariae, 8 parts of Cortex Moutan, 13 parts of Radix Paeoniae Rubra, 8 parts of Radix Platycodoniss, 13 parts of Radix Scrophulariae, Herba Dendrobii
13 parts, 11 parts of Flos Chrysanthemi, 11 parts of Herba Menthae, 13 parts of Herba Houttuyniae, 11 parts of Cortex Mori, 6 parts of Radix Glycyrrhizae.
The preparation method that the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is：
Weigh the raw material of above-mentioned each weight portion, be ground into middle powder, add the quality of above-mentioned raw materials weight 8 times amount
Fraction is 65% ethanol solution, stirs, and places 5 hours, transfers in percolation filtration extraction pot, plus
The mass fraction entering raw material weight 10 times amount is that 45% ethanol solution carries out seepage pressure effects, and percolation speed is pressed every
1 liter of percolate collected per hour by kilogram medical material, after the completion of extraction, reclaims ethanol and be concentrated into from percolate
Medical material：The weight of concentrated solution is than for 1:0.6, that is, obtain the Chinese medicine composition that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat.
Massage cream of sore-throat relieving and preparation method thereof is moisturized in embodiment 7 nourishing YIN and clearing away lung-heat
The massage cream of sore-throat relieving is moisturized in a kind of nourishing YIN and clearing away lung-heat, is prepared from by the raw material of following percetage by weight：
Chinese medicine composition described in 20.0%, 1.2% stereth -2,1.5% stereth -21,3.3% spermaceti is hard
Lipidol, 4.0% carbonic acid dibutyl ester, 1.6% glyceryl stearate, 5.0% isopropyl myristate, 1.5% octanoic acid/
Tricaprin, 2.0% polydimethylsiloxane, 0.05% bisabolol, 46.00% water, 8.0% butanediol,
2.0% glycerol, 0.23% xanthan gum, 0.2% sodium alginate, 0.1%EDTA disodium, 1.0% glycine betaine, 0.6% 2
Titanium oxide, 0.02% tetrahydrochysene piperine, 1.0%1,3 propylene glycol, 0.6% phenoxyethanol, 0.1% essence, such as table
Shown in 1.
Massage cream raw material components and its percentage by weight of sore-throat relieving is moisturized in table 1 nourishing YIN and clearing away lung-heat
The preparation method that the massage cream of sore-throat relieving is moisturized in this nourishing YIN and clearing away lung-heat comprises the following steps：
First, preposition process
(1) prepare the Chinese medicine composition that yin and clearing lung-heat moisturizes sore-throat relieving, step is with embodiment 2；
(2) pretreatment D phase, accurate weighing D phase raw material, after being slowly stirred moistening, cross colloid mill circulation
Be milled to fine and smooth pulpous state, heating in water bath to 85-90 DEG C, insulated sterilizing 10min, standby (electromagnetic oven or other
Mode of heating, notes stirring at any time, it is to avoid burnt)；
(3) pretreatment E phase, accurate weighing E phase raw material, after mixing, stir to being completely dissolved, can be
Less than 50 DEG C heating auxiliary dissolvings, standby；
(4) pretreatment C phase, accurate weighing C phase raw material, add aqueous phase pot, after stirring, be heated to
85-90 DEG C, insulation 30min sterilizing, standby；
2nd, production technology
(1) accurate weighing A phase raw material, adds oil phase pot, is heated to 85-90 DEG C under stirring, maintains
This temperature 10min sterilizes；
(2) accurate weighing B phase raw material, adds emulsion tank, after stirring five minutes, continuously stirred (20-25r/min)
Begin to warm up, be heated to 85-90 DEG C, insulation 10min sterilizing, then C phase is passed through 200 mesh filter-cloth filterings,
In suction emulsion tank, it is sufficiently stirred for mixing；
(3) A phase is passed through under 200 mesh filter-cloth filtering states, in suction emulsion tank, suction process is opened all
Matter device, high speed homogenization, after exhausting, evacuation simultaneously maintains 0.02-0.03Mpa, continues high speed homogenization 12-15min；
(4) pretreatment D phase is poured in emulsion tank, evacuation simultaneously maintains 0.02-0.03Mpa, high speed homogenization
8-10min；
(5) start to be lowered the temperature mastic with frozen water, temperature-fall period continuously stirred (20-25r/min)；
(6) it is cooled to 60 DEG C, pour pretreatment E phase, continuously stirred 5-10min into；
(7) it is cooled to 50 DEG C, sequentially adds F phase raw material, evacuation simultaneously maintains 0.04-0.05Mpa, at a high speed
After homogenizing 2-4min, continue cooling mastic；
(8) stop stirring, discharging after mastic is cooled to 40 DEG C, sample censorship, and seal mastic, move to half
Between finished stock storage.
The stability test of the massage cream of sore-throat relieving is moisturized in embodiment 8 nourishing YIN and clearing away lung-heat
Nourishing YIN and clearing away lung-heat prepared by embodiment 7 moisturizes the massage cream of sore-throat relieving respectively in 40 DEG C (heat-resisting) and -10 DEG C
(resisting cold) deposits 15 days, and observed result shows, the massage cream that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is no layered and coarse
Etc. phenomenon, illustrate that the nourishing YIN and clearing away lung-heat of embodiment 7 preparation is moisturized the massage cream of sore-throat relieving and had good stability.
The heavy metal analysis test of the massage cream of sore-throat relieving is moisturized in embodiment 9 nourishing YIN and clearing away lung-heat
Entrust China Guangzhou Analysis ＆. Test Center, sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat that embodiment 7 is prepared
In massage cream, the content of heavy metal is detected, testing result is as shown in table 2.
The content of heavy metal in the massage cream of sore-throat relieving is moisturized in table 2 nourishing YIN and clearing away lung-heat
| Analysis project | Inspection result | Measurement unit |
| Hydrargyrum | <1 (qualified) | mg/kg |
| Lead | <10 (qualified) | mg/kg |
| Arsenic | <1 (qualified) | mg/kg |
| Cadmium | <2 (qualified) | mg/kg |
Moisturize the massage cream weight of sore-throat relieving by the nourishing YIN and clearing away lung-heat that test data in table 2 can be seen that present invention offer
Metal detection result is qualified, has the advantages that safe and free of toxic and side effects.
The irritation test of the massage cream of sore-throat relieving is moisturized in embodiment 10 nourishing YIN and clearing away lung-heat
Skin irritation examination is carried out to rabbit using the massage cream that sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat of embodiment 7 preparation
Test.
First, Experimental agents
Test side：The massage cream of sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat of embodiment 7 preparation.
Control sides：Normal saline
2nd, laboratory animal
Health white experiment rabbit 4, body weight 2.0～3.0kg, animal credit number：
SCXK (Guangdong) 2014-0023.
3rd, method and result
Skin irritation test method and step according to《Cosmetics health specification 2007 editions》In skin irritation
Property test method is carried out with step.Wherein, contrast using about consubstantiality itself, left side goes to hair-fields to smear enforcement
The massage cream of sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat of example 7 preparation, and right side unhairing smears normal saline.Repeatedly skin thorn
Sharp property result of the test is as shown in table 3.
Table 3 nourishing YIN and clearing away lung-heat moisturizes the massage cream of sore-throat relieving to rabbit multiple irritation test result
As can be seen from Table 3, the massage cream that sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat that prepared by embodiment 7 is multiple to rabbit
In irritation test, every animal average integral is 0.46 daily, and stimulus intensity evaluation is respectively less than 0.5,
For non-stimulated, illustrate that the massage cream nonirritant of sore-throat relieving, safety are moisturized in the nourishing YIN and clearing away lung-heat of embodiment 7 preparation
High.
The clinical trial of the massage cream of sore-throat relieving is moisturized in embodiment 11 nourishing YIN and clearing away lung-heat
The massage cream that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat prepared by embodiment 7 carries out clinical effect trial.
First, subject enrollment standard：
(1) men and women does not limit, and cooperation product beta test requires；
(2) dry laryngopharynx pain, dry cough, coughs or no expectorant less；
(3) energy compatibility test well, can keep good daily life system time and dietary habit in the trial employment period.
2nd, given the test agent, sample using method and the time
Test group：
Given the test agent：The massage cream of sore-throat relieving, every 3mL are moisturized in the nourishing YIN and clearing away lung-heat of embodiment 7 preparation；
Using method：The appropriate massage of given the test agent is taken to be applied in back DAZHUI acupoint, FEIYU acupoint and neighbouring position；
Use time：Two weeks, each 1 time of daily morning, noon and afternoon.
Matched group：
Given the test agent：Nourishing YIN and clearing away lung-heat oral liquid；
Using method：Oral；
Use time：Two weeks.One time 1,2-3 time on the one.
3rd, test the course for the treatment of
Time on probation is 2 weeks.
4th, evaluation of clinical curative effect standard
Dry laryngopharynx pain disappears, and cough disappears for recovery from illness；Dry laryngopharynx pain substantially mitigates, cough
Substantially disappear for effective；Dry laryngopharynx pain, cough unchanged for invalid.
5th, result on trial analysis
The massage cream that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat is tried out two weeks by a definite date.
Person on probation must not be less than 50 people.
The on probation of the massage cream of sore-throat relieving is moisturized in a total of 56 people's participation nourishing YIN and clearing away lung-heat.It is randomly divided into two groups, every group
28 people.During subject's Evaluation product, the allergic phenomenas such as skin pruritus, twinge, redness all do not occur.
Test group, after test terminates, 19 people's dry laryngopharynx pains are wholly absent, and cough disappears, for recovery from illness；3
People's dry laryngopharynx pain substantially mitigates, and cough is basic to disappear, and is effective；6 people's dry laryngopharynx pain, cough
Unchanged, it is invalid.Matched group, after test terminates, 12 people's dry laryngopharynx pains are wholly absent, cough
Disappear, for recovery from illness；7 people's dry laryngopharynx pains substantially mitigate, and cough is basic to disappear, and is effective；9 people's pharynxs
Laryngoxerosis pain, cough are unchanged, are invalid.Concrete outcome is such as shown in Table 4.
The massage cream clinical test results of sore-throat relieving are moisturized in table 4 nourishing YIN and clearing away lung-heat
| The course for the treatment of | Matched group | Test group |
| Recovery from illness | 19 | 12 |
| Effective | 3 | 7 |
| Invalid | 6 | 9 |
| Effective percentage | 78.57% | 67.86% |
Be can be seen that on probation through by a definite date 2 weeks by test data in table 4, sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat
The effective percentage of massage cream has reached 78.57%, illustrates that the massage cream of sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat that the present invention provides
Not only easy to use, and gently non-stimulated to skin, have no toxic side effect, YIN nourishing and the production of body fluid promoting, lung qi dispersing sore-throat relieving,
Eliminating pathogen from the lung for relieving asthma, heat-clearing and toxic substances removing, reach comprehensive lung heat clearing effect, there is good effect, safety and stability.
Each technical characteristic of embodiment described above can arbitrarily be combined, for making description succinct, not right
The all possible combination of each technical characteristic in above-described embodiment is all described, as long as however, these skills
There is not contradiction in the combination of art feature, be all considered to be the scope of this specification record.
Embodiment described above only have expressed the several embodiments of the present invention, and its description is more concrete and detailed,
But can not therefore be construed as limiting the scope of the patent.It should be pointed out that for this area
For those of ordinary skill, without departing from the inventive concept of the premise, can also make and some deform and change
Enter, these broadly fall into protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be with appended power
Profit requires to be defined.
Claims (10)
1. a kind of nourishing YIN and clearing away lung-heat moisturizes the Chinese medicine composition of sore-throat relieving it is characterised in that described Chinese medicine composition
Active component is to be prepared from by following raw material：Fructus Arctii 44-52 part, Rhizoma Phragmitiss 15-20 part, Fructus Canarii
10-15 part, Radix Rehmanniae 8-16 part, Radix Ophiopogonis 8-16 part, Radix Scutellariae 8-16 part, Cortex Moutan 5-13 part, Radix Paeoniae Rubra 11-19
Part, Radix Platycodoniss 5-13 part, Radix Scrophulariae 11-29 part, Herba Dendrobii 8-16 part, Flos Chrysanthemi 8-16 part, Herba Menthae 8-16 part,
Herba Houttuyniae 11-16 part, Cortex Mori 10-15 part, Radix Glycyrrhizae 2-10 part.
2. nourishing YIN and clearing away lung-heat according to claim 1 moisturize sore-throat relieving Chinese medicine composition it is characterised in that
The active component of described Chinese medicine composition is to be prepared from by following raw material：46 parts of Fructus Arctii, Rhizoma Phragmitiss
16 parts, 12 parts of Fructus Canarii, 13 parts of Radix Rehmanniae, 11 parts of Radix Ophiopogonis, 11 parts of Radix Scutellariae, 8 parts of Cortex Moutan, Radix Paeoniae Rubra 13
Part, 8 parts of Radix Platycodoniss, 13 parts of Radix Scrophulariae, 13 parts of Herba Dendrobii, 11 parts of Flos Chrysanthemi, 11 parts of Herba Menthae, 13 parts of Herba Houttuyniae,
11 parts of Cortex Mori, 6 parts of Radix Glycyrrhizae.
3. the preparation method of the Chinese medicine composition of sore-throat relieving is moisturized in the nourishing YIN and clearing away lung-heat described in any one of claim 1-2,
It is characterized in that, comprise the following steps：Weigh described raw material, add the water of described raw material weight 3-10 times amount
Or the ethanol solution that mass fraction is 10-70% carries out extracting 1-2 time, filter or be centrifuged, after concentrating filter liquor
Obtain described Chinese medicine composition；The method of described extraction is to decoct extraction method or reflux extraction or supersound extraction
Method or permeating extraction.
4. the preparation method of the Chinese medicine composition of sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat according to claim 3, its
It is characterised by, comprise the following steps：Weigh described raw material, add the quality of described raw material weight 6 times amount to divide
The ethanol solution supersound extraction for 50% for the number, filters, and filtering residue continues to divide using the quality of raw material weight 6 times amount
The ethanol solution supersound extraction for 10% for the number, filters, merging filtrate, is concentrated into medical material：The weight of concentrated solution
Than for 1:0.6, that is, obtain the Chinese medicine composition that sore-throat relieving is moisturized in nourishing YIN and clearing away lung-heat.
5. the nourishing YIN and clearing away lung-heat described in any one of claim 1-2 moisturizes the Chinese medicine composition of sore-throat relieving in preparation yin nourishing
Application in the Chinese medicine external product of clearing away lung-heat and moistening for dryness sore-throat relieving.
6. a kind of nourishing YIN and clearing away lung-heat moisturizes the massage cream of sore-throat relieving it is characterised in that described massage cream is will by right
Ask that the Chinese medicine composition of sore-throat relieving and substrate are moisturized in the nourishing YIN and clearing away lung-heat described in any one of 1-2 or carrier is prepared from.
7. nourishing YIN and clearing away lung-heat according to claim 6 moisturizes the massage cream of sore-throat relieving it is characterised in that described
It is 10.0-30.0% that the Chinese medicine composition of the sore-throat relieving percetage by weight in described massage cream is moisturized in nourishing YIN and clearing away lung-heat；Institute
Stating relative density at 55 DEG C -65 DEG C for the Chinese medicine composition is 1.05-1.25.
8. nourishing YIN and clearing away lung-heat according to claim 7 moisturizes the massage cream of sore-throat relieving it is characterised in that described
Massage cream is to be prepared from by the raw material of following percetage by weight：Chinese medicine composition described in 15.0-23.0%,
43.0-46.0% water, 3.5-5.5% emulsifying agent, 2.5-4.5% excipient, 11.5-13.5% isostearyl glyceryl pentaerythrityl ether, 0.05-0.09%
Conditioner, 11.0-13.0% wetting agent, 0.4-0.6% suspending agent, 0.1-0.2% chelating agen, 0.4-0.8% covering agent,
0-1.0% preservative, 0-0.3% essence.
9. nourishing YIN and clearing away lung-heat according to claim 8 moisturizes the massage cream of sore-throat relieving it is characterised in that described
Massage cream is to be prepared from by the raw material of following percetage by weight：Chinese medicine composition described in 20%, 46.00% water,
4.3% emulsifying agent, 3.3% excipient, 10.5% isostearyl glyceryl pentaerythrityl ether, 0.07% conditioner, 14% wetting agent, 0.43% hangs
Floating agent, 0.1% chelating agen, 0.6% covering agent, 0.6% preservative, 0.1% essence.
10. nourishing YIN and clearing away lung-heat according to claim 9 moisturizes the massage cream of sore-throat relieving it is characterised in that institute
Stating massage cream is to be prepared from by the raw material of following percetage by weight：Chinese medicine composition described in 20.0%, 1.2% is hard
Lipidol polyethers -2,1.5% stereth -21,3.3% cetearyl alcohol, 4.0% carbonic acid dibutyl ester, 1.6% is sweet
Oleostearin acid esters, 5.0% isopropyl myristate, 1.5% caprylic/capric triglyceride, 2.0% poly dimethyl silicon
Oxygen alkane, 0.05% bisabolol, 46.00% water, 8.0% butanediol, 2.0% glycerol, 0.23% xanthan gum, 0.2%
Sodium alginate, 0.1%EDTA disodium, 1.0% glycine betaine, 0.6% titanium dioxide, 0.02% tetrahydrochysene piperine, 1.0%1,3
Propylene glycol, 0.6% phenoxyethanol, 0.1% essence.
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| CN201510439367.8A CN106389895B (en) | 2015-07-22 | 2015-07-22 | Chinese medicine composition of relieving sore-throat and its preparation method and application is moisturized in nourishiing yin to clear away the lung-heat |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301408A (en) * | 2013-06-28 | 2013-09-18 | 珠海圣原生物科技有限公司 | Traditional Chinese medicine extract and massage cream prepared from extract |
| CN103861018A (en) * | 2012-12-10 | 2014-06-18 | 马建民 | Traditional Chinese medicine for treating sore throat |
| CN104083709A (en) * | 2014-06-16 | 2014-10-08 | 范健身 | Traditional Chinese medicinal composition for treating cold pharyngalgia, and preparation method thereof |
| CN104587249A (en) * | 2015-01-12 | 2015-05-06 | 曹成瑞 | Traditional Chinese medicine composition with effects of clearing lung, moistening dryness and relieving sore throat as well as preparation method and application thereof |
-
2015
- 2015-07-22 CN CN201510439367.8A patent/CN106389895B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861018A (en) * | 2012-12-10 | 2014-06-18 | 马建民 | Traditional Chinese medicine for treating sore throat |
| CN103301408A (en) * | 2013-06-28 | 2013-09-18 | 珠海圣原生物科技有限公司 | Traditional Chinese medicine extract and massage cream prepared from extract |
| CN104083709A (en) * | 2014-06-16 | 2014-10-08 | 范健身 | Traditional Chinese medicinal composition for treating cold pharyngalgia, and preparation method thereof |
| CN104587249A (en) * | 2015-01-12 | 2015-05-06 | 曹成瑞 | Traditional Chinese medicine composition with effects of clearing lung, moistening dryness and relieving sore throat as well as preparation method and application thereof |
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