CN104984206B - Pediatric spleen-reinforcing digestion-promoting Chinese medicine composition and its preparation method and application and its creme - Google Patents
Pediatric spleen-reinforcing digestion-promoting Chinese medicine composition and its preparation method and application and its creme Download PDFInfo
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Abstract
The present invention relates to a kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition and its preparation method and application and its cremes.The active constituent of the Chinese medicine composition is prepared by the raw material of following parts by weight：38 48 parts of galangal, 17 27 parts of radix pseudostellariae, 7 17 parts of rhizoma atractylodis macrocephalae, 7 17 parts of Poria cocos, 7 17 parts of hawthorn, 7 17 parts of Radix Glycyrrhizae, 1 11 parts of the coptis, 7 17 parts of Chinese honey locust (fruit), 1 11 parts of cloves.The creme is prepared by common matrix in the Chinese medicine composition and creme and carrier.The effect of Chinese medicine composition of the present invention helps digestion with warming middle-JIAO and strengthening the spleen, tonifying qi and harmonizing stomach, dredging the channel, be made creme to skin it is mild it is non-stimulated, have no toxic side effect, there is pediatric spleen-reinforcing digestion-promoting.
Description
Technical field
The present invention relates to Chinese medicine external product field, more particularly to a kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition and its preparation
Methods and applications and using this Chinese medicine composition as the creme of functional component.
Background technology
" asthenic susceptibility of spleen " is one of the physilogical characteristics in children's period, Chang Yiwei injury due to diet；Clinical common taste illness, such as
Stagnant, infantile malnutrition, vomiting, diarrhea etc..So intemperance of taking food, particular about food, the fragrant and sweet raw food of addiction, easily cause taste to be damaged, cause having indigestion
Change heat, consumption stomach-Yin, it is incoordination between the spleen and the stomach, receive fortune and disturbance in ascending and descending, therefore there is receiving poor apocleisis, abdominal distension or pain, urine such as rice swill；And then then
Cause it is weakness of the spleen and the stomach, essence of water and grain be unable to compress skin and ensure whole body development needs, therefore appearance it is lean and haggard, body development is slow
Slow, disease resistance weakens；Incoordination between the spleen and the stomach, night sleeps uneasy." the liver being liable to excess " is another physilogical characteristics in children's period, and taste are empty
It is weak to be easier that edema with the liver involved ash is caused to multiply, form the weak liver-yang hyperactivity of spleen, therefore occur disposition it is irritated, it is active it is uneasy, easily fly into a rage, rub eyebrow digging nose,
Prostrate grinding tooth.Doctor trained in Western medicine is diagnosed as " the mild malnutrition " more to this at present, is only to supplement drug according to clinical symptoms, such as injects same
Change hormone and promote protein adsorption, supplement a variety of micro-elements and trace element, zinc preparation, amino acid etc.；Also to some polyzyme tablets,
The drug of alctasin etc improves digestion and absorption function.But effect is unsatisfactory, mainly palliative, not fundamentally
Improve the digestion and absorption function of children, it is impossible to reach the effect of satisfactory, and child administration drug is more difficult, therefore to this disease
It is necessary that shape researches and develops the external-application cream that a kind of convenient for children uses.
Invention content
Based on this, the purpose of the present invention is to provide a kind of safety and stability, eutherapeutic pediatric spleen-reinforcing digestion-promoting Chinese traditional medicine compositions
Object.
Realize that the specific technical solution of foregoing invention purpose is as follows：
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition by following parts by weight raw material
It is prepared：38-48 parts of galangal, 17-27 parts of radix pseudostellariae, 7-17 parts of rhizoma atractylodis macrocephalae, 7-17 parts of Poria cocos, 7-17 parts of hawthorn, Radix Glycyrrhizae
7-17 parts, 1-11 parts of the coptis, 7-17 parts of Chinese honey locust (fruit), 1-11 parts of cloves.
In wherein some embodiments, the active constituent of the Chinese medicine composition prepared by the raw material of following parts by weight and
Into：40-45 parts of galangal, 20-25 parts of radix pseudostellariae, 10-15 parts of rhizoma atractylodis macrocephalae, 10-15 parts of Poria cocos, 10-15 parts of hawthorn, Radix Glycyrrhizae 10-
15 parts, 4-8 parts of the coptis, 10-15 parts of Chinese honey locust (fruit), 4-8 parts of cloves.
In wherein some embodiments, the active constituent of the Chinese medicine composition prepared by the raw material of following parts by weight and
Into：43 parts of galangal, 22 parts of radix pseudostellariae, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 12 parts of hawthorn, 12 parts of Radix Glycyrrhizae, 6 parts of the coptis, Chinese honey locust (fruit)
12 parts, 6 parts of cloves.
Above-mentioned Chinese medicine composition according to Chinese medicine " monarch " theory, addition radix pseudostellariae, galangal, cloves be monarch drug in a prescription,
It helps digestion with warming middle-JIAO and strengthening the spleen, tonifying qi and harmonizing stomach, warm stomach preventing or arresting vomiting, the effect of eliminating cold to stop pain.It is ministerial drug to add Rhizoma Atractylodis Macrocephalae, Poria cocos, hawthorn, is had
There are food digesting stomach fortifying, reinforcing spleen to promote digestion promoting the circulation of qi, eliminate dampness and have diuretic effect effect.Addition radix scutellariae, Chinese honey locust (fruit) are adjutant, have dredging the channel, clear away heart-fire
The effect of fire.For addition Radix Glycyrrhizae to make medicine, having increases pharmacological property, reduces the effect of toxicity.
The pharmacology of traditional Chinese medicine ingredients used is as follows：
Galangal：It is pungent, heat.Returns spleen, stomach.Warm stomach preventing or arresting vomiting, eliminating cold to stop pain.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch gulps down
Acid.
Radix pseudostellariae：Sweet, slight bitter is put down.Returns spleen, lung channel.It replenishes qi to invigorate the spleen and helps digestion, it is promoting production of body fluid and nourishing the lung.Tired for spleen deficiency body, appetite is not
It shakes, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Hawthorn：It is sour, sweet, tepor.Returns spleen, stomach, Liver Channel.Food digesting stomach fortifying, scattered stasis change turbid lipid-loweringing.For meat stagnation,
Gastral cavilty turgor, diarrhea dysentery abdominal pain, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia.
Rhizoma atractylodis macrocephalae：Bitter, sweet, warm.Returns spleen, stomach.Reinforcing spleen to promote digestion QI invigorating, eliminate dampness and have diuretic effect.For spleen eating less, abdominal distension is let out
It rushes down, phlegm retention anti-dazzle nervous, oedema.
Poria cocos：It is sweet, light, it puts down.The thoughts of returning home, lung, spleen, kidney channel.Clearing damp and promoting diuresis, reinforcing spleen to promote digestion, calming heart.For oedema oliguria, spleen
Empty deficiency of food, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Radix Glycyrrhizae：Sweet and neutral.The thoughts of returning home, lung, spleen, stomach.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain reconciles all
Medicine.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, abirritant
It is object toxicity, strong.
The coptis：Hardship is trembled with fear.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, vomit
Spit acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache quenches one's thirst,
Carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.
Chinese honey locust (fruit)：It is pungent, salty, temperature；It is slightly poisonous.Return lung, large intestine channel.Eliminating the phlegm is had one's ideas straightened out, mass dissipating and swelling eliminating.For apoplexy lockjaw, dusk
Fan does not wake up, and epilepsy phlegm is contained, and pass key is obstructed, and the resistance of larynx numbness phlegm, stupid phlegm asthma cough, expectoration is not well, dry feces；Controlling outward carbuncle swells.
Cloves：It is acrid in flavour and warm in nature.Returns spleen, stomach, lung, kidney channel.Middle benefit gas drop is inverse, tonifies the kidney and support yang.For deficiency-cold in spleen and stomach, hiccup vomiting, food
It is few to vomit and diarrhoea, trusted subordinate's crymodynia, impotence due to deficiency of the kidney.
Another object of the present invention is to provide a kind of preparation method of above-mentioned Chinese medicine composition.
It is as follows to realize that above-mentioned purpose tool stops technical solution：
A kind of preparation method of above-mentioned pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, includes the following steps：The raw material is weighed, is filled
It is extracted after dividing co-grinding with water or ethanol solution, filters or be sieved after centrifuging, obtained after obtained concentrating filter liquor small
Youngster's reinforcing spleen to promote digestion Chinese medicine composition.
In wherein some embodiments, the volume fraction of ethyl alcohol is 25%-75% in the ethanol solution；The water or second
The quality of alcoholic solution is 5-10 times of material quality；The method of the extraction is described dense to decoct extraction method or ultrasonic extraction
It is 1.05-1.45 to be condensed to concentrate the filtrate to the relative density at 55 DEG C -65 DEG C.
Another object of the present invention is to provide a kind of application of above-mentioned Chinese medicine composition.
Specific technical solution is as follows：
Application of the above-mentioned Chinese medicine composition in the Chinese medicine external product with pediatric spleen-reinforcing digestion-promoting effect is prepared.
The pediatric spleen-reinforcing digestion-promoting external-application cream used another object of the present invention is to provide a kind of convenient for children.
Specific technical solution is as follows：
A kind of pediatric spleen-reinforcing digestion-promoting creme, the creme in above-mentioned pediatric spleen-reinforcing digestion-promoting Chinese medicine composition and creme by commonly using
Matrix or carrier be prepared.
In wherein some embodiments, the creme is prepared by the raw material of following weight percent：The Chinese medicine group
Close object 12-19%, conditioner 0.4-0.5%, moisturizer 24.0-26.0%, suspending agent 0.5-1.2%, emulsifier 8.0-
10.0%th, water 46.0-48.0%, chelating agent 0.05-0.2%, covering agent 0.5-1.0%, pH adjusting agent 0.1-0.3%, anti-corrosion
Agent 0.5-0.8%；The relative density of the Chinese medicine composition is 1.05-1.45 at 55 DEG C -65 DEG C.
In wherein some embodiments, the creme is prepared by the raw material of following weight percent：Described in 15.0%
Chinese medicine composition, 47.13% water, 0.15% disodium ethylene diamine tetraacetate, 0.1% allantoin, 0.2% xanthans, 0.5% beet
Alkali, 3.0% glycerine, 0.2% panthenol, 0.8% hydroxypropyl starch phosphate, 0.2% arginine, 0.3% stearoyl-glutamic acid sodium,
0.8% titanium dioxide, 7.0% butanediol, 1.8% stereth -2,2.0% stereth -21,5.0% glyceryl stearate
Acid esters, 4.0% cetostearyl alcohol, 4.0% isopropyl myristate, 3.0% carbonic acid dibutyl ester, 2.0% dimethyl silicone polymer,
0.03% bisabolol, 2.0% propylene glycol, 0.1% borneol, 0.6% Phenoxyethanol, 0.09% methylisothiazolinone/ethyl
Hexyl glycerine.
Above-mentioned pediatric spleen-reinforcing digestion-promoting Chinese medicine composition uses pure Chinese medicine to match for raw material according to the tcm theory of monarch
5 form, and the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition helps digestion with warming middle-JIAO and strengthening the spleen, and tonifying qi and harmonizing stomach, dredging the channel, help digestion Li Shui,
The effect of eliminating cold to stop pain, according to clinical verification, also has the advantages that good effect, safety and stability.Using in above-mentioned pediatric spleen-reinforcing digestion-promoting
Creme made of common carrier or matrix in drug composition and creme, to skin it is mild it is non-stimulated, have no toxic side effect, there are children
Reinforcing spleen to promote digestion effect.Further, since the raw material used in above-mentioned pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is pure Chinese medicine, without antibiotic
And hormone, drug dependence will not be generated.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The preparation method of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of the present invention is：Chinese medicine is weighed, is sufficiently mixed powder
Suitable water is added in after broken or the ethyl alcohol of different quality containing is extracted according to general extraction methods in industry, obtained filtrate
Pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is obtained after concentrated.
1 pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of embodiment
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition is by the original of following parts by weight
Material is prepared：38 parts of galangal, 1 part of cloves, 17 parts of radix pseudostellariae, 7 parts of rhizoma atractylodis macrocephalae, 7 parts of Poria cocos, 7 parts of hawthorn, 7 parts of Radix Glycyrrhizae, Huang
Even 1 part, 7 parts of Chinese honey locust (fruit).
The preparation method of the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is as follows：
Galangal, cloves, radix pseudostellariae, rhizoma atractylodis macrocephalae, Poria cocos, hawthorn, Radix Glycyrrhizae, the coptis, the Chinese honey locust (fruit) of above-mentioned parts by weight are weighed,
Crushing is sufficiently mixed, is placed in ultrasonic extraction tank, the ethyl alcohol that the mass fraction for adding in 7 times of amounts of above-mentioned raw materials weight is 70% surpasses
Sound extracts, extracting solution low-speed centrifugal, crosses 400 mesh sieve, and filtrate is concentrated into relative density as 1.05-1.45 (55 DEG C -65 DEG C)；Filter residue
Continue to use 7 times of mass fractions measured of raw material weight to be extracted for 30% EtOH Sonicate, extracting solution low-speed centrifugal crosses 400 mesh
Sieve, filtrate are concentrated into relative density as 1.05-1.45 (55 DEG C -65 DEG C).Merge concentrate twice to obtain in pediatric spleen-reinforcing digestion-promoting
Drug composition.
2 pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of embodiment
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition is by the original of following parts by weight
Material is prepared：43 parts of galangal, 6 parts of cloves, 22 parts of radix pseudostellariae, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 12 parts of hawthorn, Radix Glycyrrhizae 12
Part, 6 parts of the coptis, 12 parts of Chinese honey locust (fruit).
The preparation method of the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is as follows：
Galangal, cloves, radix pseudostellariae, rhizoma atractylodis macrocephalae, Poria cocos, hawthorn, Radix Glycyrrhizae, the coptis, the Chinese honey locust (fruit) of above-mentioned parts by weight are weighed,
Crushing is sufficiently mixed, is placed in ultrasonic extraction tank, the ethyl alcohol that the mass fraction for adding in 7 times of amounts of above-mentioned raw materials weight is 70% surpasses
Sound extracts, extracting solution low-speed centrifugal, crosses 400 mesh sieve, and filtrate is concentrated into relative density as 1.05-1.45 (55 DEG C -65 DEG C)；Filter residue
Continue to use the mass fraction of 7 times of amounts of raw material weight to be extracted for 30% EtOH Sonicate, extracting solution low-speed centrifugal crosses 400 mesh sieve,
Filtrate is concentrated into relative density as 1.05-1.45 (55 DEG C -65 DEG C).Merge concentrate twice and obtain pediatric spleen-reinforcing digestion-promoting Chinese medicine group
Close object.
3 pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of embodiment
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition is by the original of following parts by weight
Material is prepared：48 parts of galangal, 11 parts of cloves, 27 parts of radix pseudostellariae, 17 parts of rhizoma atractylodis macrocephalae, 17 parts of Poria cocos, 17 parts of hawthorn, Radix Glycyrrhizae 17
Part, 11 parts of the coptis, 17 parts of Chinese honey locust (fruit).
The preparation method of the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is as follows：
Galangal, cloves, radix pseudostellariae, rhizoma atractylodis macrocephalae, Poria cocos, hawthorn, Radix Glycyrrhizae, the coptis, the Chinese honey locust (fruit) of above-mentioned parts by weight are weighed,
Crushing is sufficiently mixed, is placed in ultrasonic extraction tank, the mass fraction for adding in 7 times of amounts of above-mentioned raw materials weight is 70% EtOH Sonicate
Extraction, extracting solution low-speed centrifugal cross 400 mesh sieve, and filtrate is concentrated into relative density as 1.05-1.45 (55 DEG C -65 DEG C)；Filter residue after
The continuous mass fraction for using 7 times of amounts of raw material weight is extracted for 30% EtOH Sonicate, and extracting solution low-speed centrifugal crosses 400 mesh sieve, filter
Liquid is concentrated into relative density as 1.05-1.45 (55 DEG C -65 DEG C).Merge concentrate twice and obtain pediatric spleen-reinforcing digestion-promoting Chinese traditional medicine composition
Object.
4 pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of embodiment
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition is by the original of following parts by weight
Material is prepared：43 parts of galangal, 6 parts of cloves, 22 parts of radix pseudostellariae, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 12 parts of hawthorn, Radix Glycyrrhizae 12
Part, 6 parts of the coptis, 12 parts of Chinese honey locust (fruit).
The preparation method of the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is as follows：
Galangal, cloves, radix pseudostellariae, rhizoma atractylodis macrocephalae, Poria cocos, hawthorn, Radix Glycyrrhizae, the coptis, the Chinese honey locust (fruit) of above-mentioned parts by weight are weighed,
It is sufficiently mixed, smashes into coarse powder, add in the water of 7 times of amounts of above-mentioned raw materials weight, decoct extraction 2 times, each 1.5h, filter, merge
Filtrate, filtrate be concentrated into relative density for 1.05-1.45 (55 DEG C -65 DEG C) to get pediatric spleen-reinforcing digestion-promoting Chinese medicine composition.
5 pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of embodiment
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition is by the original of following parts by weight
Material is prepared：43 parts of galangal, 6 parts of cloves, 22 parts of radix pseudostellariae, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 12 parts of hawthorn, Radix Glycyrrhizae 12
Part, 6 parts of the coptis, 12 parts of Chinese honey locust (fruit).
The preparation method of the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is as follows：
Galangal, cloves, radix pseudostellariae, rhizoma atractylodis macrocephalae, Poria cocos, hawthorn, Radix Glycyrrhizae, the coptis, the Chinese honey locust (fruit) of above-mentioned parts by weight are weighed,
It is sufficiently mixed, is placed in supersonic extractors, the water ultrasonic extraction for adding in 7 times of amounts of above-mentioned raw materials weight twice, filters, and merges filter
Liquid, filtrate be concentrated into relative density for 1.05-1.45 (55 DEG C -65 DEG C) to get pediatric spleen-reinforcing digestion-promoting Chinese medicine composition.
6 pediatric spleen-reinforcing digestion-promoting Chinese medicine composition of embodiment
A kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, the active constituent of the Chinese medicine composition is by the original of following parts by weight
Material is prepared：43 parts of galangal, 6 parts of cloves, 22 parts of radix pseudostellariae, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 12 parts of hawthorn, Radix Glycyrrhizae 12
Part, 6 parts of the coptis, 12 parts of Chinese honey locust (fruit).
The preparation method of the pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is as follows：
Galangal, cloves, radix pseudostellariae, rhizoma atractylodis macrocephalae, Poria cocos, hawthorn, Radix Glycyrrhizae, the coptis, the Chinese honey locust (fruit) of above-mentioned parts by weight are weighed,
It is sufficiently mixed, is placed in supersonic extractors, the ethanol solution ultrasound that the mass fraction for adding in 7 times of amounts of above-mentioned raw materials weight is 45%
Extraction twice, filtering, merging filtrate, recycle ethyl alcohol and be concentrated into relative density for 1.05-1.45 (55 DEG C -65 DEG C) to get small
Youngster's reinforcing spleen to promote digestion Chinese medicine composition.
7 pediatric spleen-reinforcing digestion-promoting creme of embodiment and preparation method thereof
A kind of pediatric spleen-reinforcing digestion-promoting creme, raw material composition and its weight percent are as shown in table 1, wherein methyl-isothiazol
Quinoline ketone/Sensiva SC50 is novel built preservative, trade nameK220。
The raw material and its weight percent of 1 pediatric spleen-reinforcing digestion-promoting creme of table
The preparation method of above-mentioned pediatric spleen-reinforcing digestion-promoting creme includes the following steps：
(1) it is spare by C phase components stirring and dissolving to clear；
(2) D phase component heating stirrings are dissolved to no particle clear shape, temperature is spare no more than 50 DEG C；
(3) A1 phase components are sequentially added into emulsification pot, opens stirring (40r/min), be heated to 85 DEG C, be stirred well to
It is swollen and confirms entirely；
(4) A2 phase components are added in into water phase pot, is heated with stirring to 90 DEG C, kept the temperature 20 minutes and sterilize；
(5) B phase components are sequentially added into oil phase agitated kettle, stirring (30r/min) state is heated to 85 DEG C, and stirring and dissolving is simultaneously
Confirm, keep the temperature 10 minutes and sterilize；
(6) the A2 components filtering (200 mesh) in step (4) the water phase pot is first pumped into the emulsification pot described in step (3)
In, it is dispersed with stirring uniformly and confirms, continue the B phase components in the oil phase pot described in step (5) slowly under stirring (40r/min)
It filters (200 mesh) to be pumped into emulsification pot, pre-emulsification 5 minutes keeps vacuum -0.02~-0.04MPa, high speed homogenization 15 minutes, dimension
Stirring (40r/min) is held, and opens cooling water and starts to cool down；
(7) 60 DEG C are persistently cooled to, C phase components are slowly added in the emulsification pot described in step (6), stirs (40r/
Min), vacuum -0.04~-0.06MPa is kept, continues stirring cooling；
(8) 50 DEG C are cooled to, the D phase components pre-processed filtering (200 mesh) is added in into the emulsification pot described in step (7)
In, it stirs (30r/min), high speed homogenization 2 minutes, keeps vacuum -0.04~-0.06MPa, continue stirring cooling；
(9) 45 DEG C are cooled to, successively adds in E phases each component in the emulsification pot described in step (8), is stirred (30r/min)
It is uniformly dispersed, keeps vacuum -0.04~-0.06MPa, be cooled to 37 DEG C of stopping stirrings, sampling detection pH value is is after 4.0-6.0
It can discharge.Up to pediatric spleen-reinforcing digestion-promoting creme.
The stability test of 8 pediatric spleen-reinforcing digestion-promoting creme of embodiment
The pediatric spleen-reinforcing digestion-promoting creme of embodiment 7 under 40 DEG C (heat-resisting) and -10 DEG C (cold-resistant) is stored 30 days respectively, is seen
It examines the results show that pediatric spleen-reinforcing digestion-promoting creme illustrates the pediatric spleen-reinforcing digestion-promoting creme of embodiment 7 without layering and thinning trend phenomenon
Stability is good.
The heavy metal analysis experiment of 9 pediatric spleen-reinforcing digestion-promoting creme of embodiment
Entrust China Guangzhou Analysis ＆. Test Center, to the content of heavy metal in the pediatric spleen-reinforcing digestion-promoting creme of embodiment 7 into
Detection is gone, testing result is as shown in table 2：
The content table of heavy metal in 2 pediatric spleen-reinforcing digestion-promoting creme of table
| Analysis project | Inspection result | Measurement unit |
| Mercury | <1 (qualification) | mg/kg |
| Lead | <10 (qualifications) | mg/kg |
| Arsenic | <1 (qualification) | mg/kg |
| Cadmium | <2 (qualifications) | mg/kg |
By table 2 it is known that the pediatric spleen-reinforcing digestion-promoting creme heavy metal analysis result of embodiment 7 is qualified.
The skin irritation test of 10 pediatric spleen-reinforcing digestion-promoting creme of embodiment
Skin irritation test is carried out to rabbit using the pediatric spleen-reinforcing digestion-promoting creme of embodiment 7.
First, experimental drug：The pediatric spleen-reinforcing digestion-promoting creme of embodiment 7.
2nd, experimental animal：Healthy white experiment rabbit 4,2.0~3.0kg of weight, animal credit number：SCXK (Guangdong)
2014-0023。
3rd, method and result：
Multiple skin irritation test method and step according to《Cosmetics health specification 2007 editions》In skin irritation
Test method is carried out with step.Wherein, the pediatric spleen-reinforcing digestion-promoting creme of the present embodiment 7 is smeared in every rabbit body both sides, side,
For experimental group；Side does not smear any sample, is blank control group.The results are shown in Table 3 for multiple skin irritation test.
3 pediatric spleen-reinforcing digestion-promoting creme of table multiple skin irritation test result to rabbit
As can be seen from Table 3, the pediatric spleen-reinforcing digestion-promoting creme of embodiment 7 is to rabbit in multiple skin irritation test, often
It every animal average integral is 0.46, and stimulus intensity evaluation is less than 0.5, is non-stimulated, illustrates that the infant spleen-tonifying of embodiment 7 disappears
It is nonirritant to eat creme, it is safe.
The clinical test of 11 pediatric spleen-reinforcing digestion-promoting creme of embodiment
Clinical effect trial is carried out to the pediatric spleen-reinforcing digestion-promoting creme of embodiment 7.
First, diagnostic criteria and subject
Diagnostic criteria：
1st, tcm diagnosis standard foundation《Disease of tcm Standardization of diagnosis and curative effect》The diagnosis of middle malnutrition：
(1) diet is abnormal, there is apparent dysfunction of spleen and stomach person；
(2) body is become thin；
(3) lassitude, irritable are had concurrently, happiness rubs eyebrows and eyes, and fair finger such as is ground one's teeth in sleep at the symptoms；
(4) there is improper feeding, lack of proper care after being ill, history of becoming thin for a long time；
(5) anemic patient is reduced with hemoglobin, red blood cell；
2nd, the dialectical foundation of spleen-deficient
Reference《New Chinese medicine guideline of clinical investigations》
(1) primary symptom：Long loss of appetite, eats without digesting, abdominal distention after meal, and stool is dry dilute uncomfortable；
(2) minor symptom：Deficiency of QI with disinclination to talk, continuous and dull pain in the abdomen, body is partially thin, lustreless complexion；
2 primary symptoms of tool or 1 primary symptom add 2 minor symptoms, you can diagnosis.
Subject：
Meet 1-5 Sui infant of malnutrition diagnostic criteria and the dialectical foundation of traditional Chinese medical science spleen-deficient simultaneously, and through parent or subject
Guardian's informed consent.
2nd, given the test agent, sample application method and time
Test group：Given the test agent：The pediatric spleen-reinforcing digestion-promoting creme of embodiment 7, specification are every 3g；
Usage time：Time on probation is 5 days, once in the morning and once at night；
Application method：Given the test agent is taken to massage in right amount and is applied to navel and neighbouring position, with warm water erasing or not after 3-5 minutes
Give processing.
Control group：Given the test agent：Stomach strengthening and digestion promoting pastes；
Usage time and application method：It replaces within eight hours primary.
3rd, the course for the treatment of is tested
Test the course for the treatment of:5 days.
4th, evaluation of clinical curative effect standard
(1) it fully recovers：After testing the course for the treatment of, appetite is restored to normal level with appetite, and abdominal distention after meal completely disappears, stool
It is dry dilute uncomfortable to significantly improve.
(2) it is effective：After testing the course for the treatment of, appetite substantially or is restored with appetite, and abdominal distention after meal disappears substantially, stool
It is dry dilute uncomfortable to make moderate progress.
(3) it is invalid：After testing the course for the treatment of, appetite and appetite are unchanged, and abdominal distention after meal does not disappear, defecate and do dilute uncomfortable nothing
Improve.
5th, result on trial is analyzed
Pediatric spleen-reinforcing digestion-promoting creme is tried out 5 days by a definite date, and person on probation must not be less than 50 people.
A total of 80 people of the present embodiment participates in the on probation of pediatric spleen-reinforcing digestion-promoting creme.It is randomly divided into test group and control group.
During subject's Evaluation product, do not occur pruitus, shouting pain, redness etc..After testing the course for the treatment of, test group：29
People's appetite and appetite are all restored to normal level, and abdominal distention after meal completely disappears, stool it is dry it is dilute it is uncomfortable significantly improve, for recovery from illness, 9 people
Appetite is restored with appetite, and abdominal distention after meal does not completely disappear, stool it is dry it is dilute it is uncomfortable make moderate progress, be effective；2 people's appetite and food
Measure unchanged, abdominal distention after meal does not disappear, defecates and does dilute uncomfortable no improvement, is invalid；Control group：21 people's appetite and appetite are all restored
To normal level, abdominal distention after meal completely disappears, stool it is dry it is dilute it is uncomfortable significantly improve, for recovery from illness；5 people's appetite and appetite are extensive
Multiple, abdominal distention after meal does not completely disappear, stool it is dry it is dilute it is uncomfortable make moderate progress, be effective；14 people's appetite and appetite are unchanged, abdomen after food
It is swollen not disappear, it defecates and does dilute uncomfortable no improvement, be invalid.Concrete outcome is shown in Table 4：
4 pediatric spleen-reinforcing digestion-promoting creme clinical test results of table
| The course for the treatment of | Test group | Control group |
| Number | 40 | 40 |
| Recovery from illness | 29 | 21 |
| It is effective | 9 | 5 |
| In vain | 2 | 14 |
| Total effective rate | 95.0% | 65.0% |
As can be seen from Table 4, it is on probation by 5 days, pediatric spleen-reinforcing digestion-promoting creme treat the spleen and stomach in children it is weak it is total effectively
Rate has reached 95.0%, is significantly better than control group.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that those of ordinary skill in the art are come
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (7)
1. a kind of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, which is characterized in that the active constituent of the Chinese medicine composition is by following heavy
The raw material of amount part is prepared：40-45 parts of galangal, 20-25 parts of radix pseudostellariae, 10-15 parts of rhizoma atractylodis macrocephalae, 10-15 parts of Poria cocos, hawthorn
10-15 parts, 10-15 parts of Radix Glycyrrhizae, 4-8 parts of the coptis, 10-15 parts of Chinese honey locust (fruit), 4-8 parts of cloves.
2. pediatric spleen-reinforcing digestion-promoting Chinese medicine composition according to claim 1, which is characterized in that the work of the Chinese medicine composition
Property ingredient is prepared by the raw material of following parts by weight：43 parts of galangal, 22 parts of radix pseudostellariae, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, mountain
12 parts of short, bristly hair or beard, 12 parts of Radix Glycyrrhizae, 6 parts of the coptis, 12 parts of Chinese honey locust (fruit), 6 parts of cloves.
3. a kind of preparation method of claim 1-2 any one of them pediatric spleen-reinforcing digestion-promoting Chinese medicine composition, which is characterized in that
Include the following steps：The raw material is weighed, is extracted after being sufficiently mixed crushing with water or ethanol water, after filtering or centrifuging
It is sieved, pediatric spleen-reinforcing digestion-promoting Chinese medicine composition is obtained after obtained concentrating filter liquor.
4. the preparation method of pediatric spleen-reinforcing digestion-promoting Chinese medicine composition according to claim 3, which is characterized in that the ethyl alcohol
The mass fraction of ethyl alcohol is 25%-75% in solution；The quality of the water or ethanol water is 5-10 times of material quality；It is described
The method of extraction is decocts extraction method or ultrasonic extraction；The concentration is opposite at 55 DEG C -65 DEG C to concentrate the filtrate to
Density is 1.05-1.45.
5. claim 1-2 any one of them Chinese medicine composition is preparing the production of the Chinese medicine external with pediatric spleen-reinforcing digestion-promoting effect
Application in product.
6. a kind of pediatric spleen-reinforcing digestion-promoting creme, which is characterized in that the creme is good for by claim 1-2 any one of them children
Spleen helps digestion Chinese medicine composition and matrix or carrier is prepared.
7. pediatric spleen-reinforcing digestion-promoting creme according to claim 6, which is characterized in that the creme is by following weight percent
Raw material be prepared：Pediatric spleen-reinforcing digestion-promoting Chinese medicine composition 12-19%, conditioner 0.4-0.5%, moisturizer 24.0-26.0%,
Suspending agent 0.5-1.2%, emulsifier 8.0-10.0%, water 46.0-48.0%, chelating agent 0.05-0.2%, covering agent 0.5-1.0%, pH
Conditioning agent 0.1-0.3%, preservative 0.5-0.8%；The relative density of the Chinese medicine composition is 1.05- at 55 DEG C -65 DEG C
1.45。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223885A (en) * | 1998-12-01 | 1999-07-28 | 王自润 | Digestive appetitive assimilation-promoting Chinese medicine preparation |
| CN102247569A (en) * | 2011-08-22 | 2011-11-23 | 丁文田 | Method for preparing spleen tonifying and antidiarrheic paste |
| CN103977338A (en) * | 2014-06-04 | 2014-08-13 | 天津太平洋制药有限公司 | Traditional Chinese medicine for strengthening spleen and stomach |
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2015
- 2015-07-16 CN CN201510419555.4A patent/CN104984206B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223885A (en) * | 1998-12-01 | 1999-07-28 | 王自润 | Digestive appetitive assimilation-promoting Chinese medicine preparation |
| CN102247569A (en) * | 2011-08-22 | 2011-11-23 | 丁文田 | Method for preparing spleen tonifying and antidiarrheic paste |
| CN103977338A (en) * | 2014-06-04 | 2014-08-13 | 天津太平洋制药有限公司 | Traditional Chinese medicine for strengthening spleen and stomach |
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