CN106389687A - Preparation method of Li medical callicarpa nudiflora scald ointment - Google Patents
Preparation method of Li medical callicarpa nudiflora scald ointment Download PDFInfo
- Publication number
- CN106389687A CN106389687A CN201610971201.5A CN201610971201A CN106389687A CN 106389687 A CN106389687 A CN 106389687A CN 201610971201 A CN201610971201 A CN 201610971201A CN 106389687 A CN106389687 A CN 106389687A
- Authority
- CN
- China
- Prior art keywords
- callicarpa nudiflora
- ointment
- preparation
- scald
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a Li medical callicarpa nudiflora scald ointment. The preparation method comprises the following steps of taking callicarpa nudiflora medicine, respectively adding 12 and 10 times of water into the medicine, soaking for 2h, refluxing and extracting, extracting for 1h each time, filtering, combining three times of water extraction liquid, and concentrating, so as to obtain a callicarpa nudiflora medicine ointment; using an emulsion method to prepare a w/o callicarpa nudiflora scald ointment; firstly, heating oil-phase raw materials to 70 to 80 DEG C, such as polysorbate-80, glycerin monostearate and glycerin; then, slowly adding into water-phase raw materials which are heated to 70 to 80 DEG C, such as liquid paraffin, sorbitan oleate, solid paraffin and Vaseline; stirring, adding the callicarpa nudiflora flowing ointment, emulsifying, and condensing for 20 to 30min, so as to obtain the Li medical callicarpa nudiflora scald ointment. The preparation method has the advantage that the raw materials are preferably selected through massive experiments. The prepared Li medical callicarpa nudiflora scald ointment has the advantages that the proportion ratio of components is scientific and reasonable, the property is stable, the effect of promoting wound healing is good, the treatment effect is reliable, and the safety is good.
Description
Technical field
The invention belongs to pharmaceutical technology field is and in particular to a kind of preparation method of the callicarpa nudiflora ointment for treating scald of multitude's medicine.
Technical background
Callicarpa nudiflora (Callicarpa nudiflora Hook.ex Arn.) is that Verenaceae Callicarpa is perennial small-sized
Arbor, calls big blade, is distributed in more than Hainan middle and south height above sea level 300m, the vast mountain area of annual rainfall 1 000～1 800mm
By hill path, valley floor, in small stream side or shrub grove, good in the larger ambient growth of 15～25 DEG C of temperature of year-round average temperature, be one
Plant Hainan large property authentic medicinal herbs, be also one of Nationality in Hainan Province doctor's medicinal herbs most in use simultaneously.Modern pharmacology research multitude's medicine nakedflower
Japanses beauty-berry active component includes terpene, flavones and volatile oil component, has the effects such as good anti-inflammatory, hemostasis.
There is presently no callicarpa nudiflora for the multitude's medicine report being prepared into ointment for treating scald.
Content of the invention
Goal of the invention：Present invention aim to address the deficiencies in the prior art, provide a kind of component proportioning scientific and reasonable, property
Can be stable, there is good promotion wound healing, curative effect is reliable, the preparation method of the callicarpa nudiflora ointment for treating scald of multitude's medicine of safety.
Technical scheme：In order to realize object above, the technical scheme that the present invention takes is：
A kind of preparation method of multitude's medicine is callicarpa nudiflora ointment for treating scald, it is made up of the raw material of following percentage by weight:
(1) extraction of callicarpa nudiflora medicinal material：
Take callicarpa nudiflora medicinal material, respectively the water of dosing material weight 12,10,10 times amount, soak 2h, be then refluxed for extracting, often
Secondary extraction 1h, filters, and merges 3 aqueous extracts, is concentrated to give callicarpa nudiflora medicinal material medicinal extract；
(2) preparation of ointment for treating scald
Using emulsion process, prepared w/o is callicarpa nudiflora scald paste, first take oil phase raw material polyoxyethylene sorbitan monoleate, monostearate
Glyceride and glycerine are heated to 70～80 DEG C, are then added slowly to be heated to the Aqueous Phase Raw Material liquid stone of 70～80 DEG C of temperature
In wax, Sorbitan Oleate, solid paraffin and vaseline, then stir lower add callicarpa nudiflora medicinal material liquid extract, ethyl hydroxy benzoate and
Dimethyl sulfoxide (DMSO), stirring and emulsifying condensation 20～40 minutes, obtains the callicarpa nudiflora ointment for treating scald of multitude's medicine in the same direction.
The preparation method of above-described multitude's medicine is callicarpa nudiflora ointment for treating scald, the dosage of each component is as follows：Oil phase raw material forms
For polyoxyethylene sorbitan monoleate 0.8～1.4g, glycerin monostearate 4.2～5.5g and glycerine 0.6～1.2g；
Aqueous Phase Raw Material consist of atoleine 9～12g, Sorbitan Oleate 0.6～1.8g, solid paraffin 0.6～1.8g and
Vaseline 0.7～1.3g；
The consumption of callicarpa nudiflora medicinal material medicinal extract is 2～5g；Ethyl hydroxy benzoate 0.037～0.15g, dimethyl sulfoxide (DMSO) 0.0187～
0.03g；
Preferably, the preparation method of the callicarpa nudiflora ointment for treating scald of above-described multitude's medicine, the dosage of each component is as follows：
Oil phase raw material consists of polyoxyethylene sorbitan monoleate 1.2g, glycerin monostearate 4.7g and glycerine 0.9g；
Aqueous Phase Raw Material consists of atoleine 10.8g, Sorbitan Oleate 1.4g, solid paraffin 1.4g and vaseline 0.9g；
The consumption of callicarpa nudiflora medicinal material medicinal extract is 3g；Ethyl hydroxy benzoate 0.0729g, dimethyl sulfoxide (DMSO) 0.0243g；
Preferably, the preparation method of the callicarpa nudiflora ointment for treating scald of above-described multitude's medicine, step (2) emulsifying temperature is
70 DEG C, emulsification times are 25 minutes.
Craft screening is tested：
First, the optimization experiment # of callicarpa nudiflora water extraction process
1st, experiment purpose
The optimised process that preferably callicarpa nudiflora water extracts
2nd, experimental technique
Using distilled water refluxing extraction, select medicinal material soak time, the consumption of water, extraction time, extraction time four factor,
Every three levels of selecting factors, by orthogonal arrage experiment arrangement, as shown in table 1, table 2.
Table 1 is callicarpa nudiflora, and water extraction takes horizontal factor meter
Table 2 is callicarpa nudiflora, and water extracts orthogonal design table
3rd, experimental result
To sum up, callicarpa nudiflora medicinal material optimum extraction process is A2B3C2D3, i.e. soak time 2h, the times amount that adds water be 12,10,
10, extraction time 3 times, each extraction time is 1h；Factor impact primary and secondary is D>C>B>A, that is, extraction time is to yield of extract shadow
Ring maximum, next to that extraction time, be followed by the times amount that adds water, what impact was minimum is soak time, by optimised process, through repeating
Property experiment extract callicarpa nudiflora medicinal material medicinal extract rate be 19.9%.
2nd, the development of callicarpa nudiflora paste
1st, experiment purpose
Screen the prescription of callicarpa nudiflora paste.
2nd, experimentation
Using emulsion process, prepared w/o is callicarpa nudiflora paste, take oil phase to heat, be slowly added into and be heated to synthermal water
Phase, the more callicarpa nudiflora medicinal extract having concentrated is slowly added to, side edged stirs in the same direction and condenses to emulsification.
3rd, experimental result
1. adopt orthogonal experiment method, as index, preferably gone out with emulsifying effectiveness (for analysis score directly perceived, 40 points of full marks)
Good prescription, emulsifying temperature, emulsification times.Prescription one experiment orthogonal arrage is shown in Table 3, table 4；Prescription two experiment orthogonal arrage is shown in Table 5, table 6.
Table 3 is callicarpa nudiflora ointment prescription one horizontal factor table
Table 4 is callicarpa nudiflora ointment prescription one quadrature analysis table
Callicarpa nudiflora ointment prescription one orthogonal arrage result shows：Filter out in callicarpa nudiflora ointment prescription one effect
Good for A1B1C2D2.
Table 5 is callicarpa nudiflora ointment prescription two horizontal factor table
Table 6 is callicarpa nudiflora ointment prescription two quadrature analysis table
Callicarpa nudiflora ointment prescription two quadrature analysis result shows：Filter out effect in callicarpa nudiflora ointment prescription two
Most preferably A3B3C2D1.
3rd, experimental result
1st, experimental result comparative analysis shows：The A of prescription two3B3C2D1Outward appearance and on probation after than prescription one result more more preferably,
To A3B3C2D1Carry out experiment is repeated several times, meet the requirements, therefore select the A of prescription two3B3C2D1, that is, oil phase raw material consist of poly-
Sorb ester 80 1.2g, glycerin monostearate 4.7g and glycerine 0.9g；Aqueous Phase Raw Material consists of atoleine 10.8g, oleic acid
The smooth 1.4g of sorb, solid paraffin 1.4g and vaseline 0.9g；Emulsify as 70 DEG C, emulsification times are 25 minutes.
2nd, ointment for treating scald stability checks：Take the callicarpa nudiflora ointment for treating scald of 10ml to be placed in centrifuge tube, be cooled to room temperature after from
4000r/min centrifugation 1h in scheming.Stable in properties after the display ointment for treating scald centrifugation of stability inspection result, not stratified it was demonstrated that nakedflower
The stability of Japanses beauty-berry ointment for treating scald meets the requirements.
Beneficial effect：The present invention provide the callicarpa nudiflora ointment for treating scald of multitude's medicine preparation method compared to the prior art have with
Lower advantage：
The present invention passes through many experiments preferred feedstock, preferably goes out optimal callicarpa nudiflora water extraction especially by many experiments
Taking technique, prescription composition of callicarpa nudiflora paste etc., the callicarpa nudiflora ointment for treating scald of multitude's medicine preparing, component proportioning science is closed
Reason, stable performance, there is good promotion wound healing, curative effect is reliable, and security is good.Multitude's medicine that the present invention provides is callicarpa nudiflora
The preparation method of ointment for treating scald, industrial design is rationally, workable, beneficial to popularization, low production cost.
Specific embodiment
Be further elucidated with the present invention with reference to specific embodiment it should be understood that these embodiments be merely to illustrate the present invention and
It is not used in restriction the scope of the present invention, after having read the present invention, the various equivalence shapes to the present invention for the those skilled in the art
The modification of formula all falls within the application claims limited range.
Embodiment 1
A kind of preparation method of multitude's medicine is callicarpa nudiflora ointment for treating scald is it is characterised in that it comprises the following steps：
(1) extraction of callicarpa nudiflora medicinal material：
Take callicarpa nudiflora medicinal material, respectively the water of dosing material weight 12,10,10 times amount, soak 2h, be then refluxed for extracting, often
Secondary extraction 1h, filters, and merges 3 aqueous extracts, is concentrated to give callicarpa nudiflora medicinal material medicinal extract；
(2) preparation of ointment for treating scald
Using emulsion process, prepared w/o is callicarpa nudiflora scald paste, first take oil phase raw material oil phase raw material to consist of poly- sorb
Ester 801.2g, glycerin monostearate 4.7g and glycerine 0.9g are heated to 70 DEG C, are then added slowly to be heated to 70 DEG C
In the Aqueous Phase Raw Material atoleine 10.8g of temperature, Sorbitan Oleate 1.4g, solid paraffin 1.4g and vaseline 0.9g, then stir
Mix lower addition callicarpa nudiflora medicinal material liquid extract 3g, ethyl hydroxy benzoate 0.12g and dimethyl sulfoxide (DMSO) 0.022g, stirring and emulsifying condenses in the same direction
30 minutes, obtain the callicarpa nudiflora ointment for treating scald of multitude's medicine.
Embodiment 2 is callicarpa nudiflora ointment for treating scald pharmacodynamic experiment
1st, experimental principle
1. scald wound can be acted on by medicine, degree or the speed of wound healing can be changed, heal process
In can produce macroscopic change (such as：Wound area size, color, soft or hard degree, incrustation situation etc.).
2. scald wound during healing, the content of internal some cell factors (TNF, IL, TGF, VEGF etc.)
Can change.Situation according to its changes of contents and then the mechanism of action of exploration medicine.
2nd, experimental technique
1. SD burned rats modeling：Take SD rat 30 (240 ± 10g), be randomly divided into 3 groups, every group 10, i.e. depthⅡ°
Scald experimental group (the callicarpa nudiflora ointment for treating scald group that embodiment 1 prepares), depthⅡ° scalds blank control group (without nakedflower purple
The matrix group of pearl medicinal extract), depthⅡ° scald negative control group (blank group).Coat vulcanized sodium hair remover, several minutes in rat back
Gently scrape off afterwards.24h after depilation, with 20% urethane 1000mg/kg intraperitoneal injection of anesthesia rat.Rat is fixed on by dorsal position
On modeling plank, (modeling hole size is about 6cm2), make the skin of back of rat be exposed to template in the hole, template is inserted electric heating
80 DEG C of boiling hot 12s in thermostat water bath, cause depthⅡ° to scald.
2. the administration of SD rat is processed：After scalding modeling 24h, to experimental group rat, daily will quantitative (0.3mL/ in right amount
Callicarpa nudiflora ointment for treating scald (embodiment 1 prepares, and callicarpa nudiflora liquid extract content is 19.9%) only) is applied to it and is burned
Position, makes uniformly one layer；To blank control group rat, daily by matrix (0.3mL/ is only) uniform application in being burned position；
Negative control group is not administered.Every rat single cage is raised, and food and water are enough.
3. data and sample are taken：After scald, every film recording wound situation of change on the 3rd.Every 5 days to every mouse
Take blood after carrying out eye socket, be centrifuged (8000r/40min) after the static 30min of blood sample, take upper serum, preserve in -70 DEG C.
4. pathological section is processed：Scald latter 21 days, intradermal has a large amount of sweat glands to generate, and has a large amount of collagenous fibres simultaneously, and
Fibroblast and capillary quantity seldom, are scalded paste group epithelialization and are basically completed, healing is basically completed, and matrix group with
Not exclusively, appendages of skin generation is inconspicuous, has a large amount of fibroblasts and capillary simultaneously, is in meat for blank group epithelialization
Bud organizes a large amount of proliferation periods.
5. wound macroscopic view areal analysis：Areal calculation is carried out to photo using Image J software, its wound area size is
Initially wound size.
Computing formula is：Wound size * of the wound size of the wound percentage area of which day=which day/initial
100%, average for every group, with SPSS, data is analyzed.Analysis result is shown in Table 7, table 8.
Ointment wound macroscopic view area (square measure cm that table 7 is callicarpa nudiflora2) change table
Table 8 is callicarpa nudiflora ointment pharmacodynamic experiment Multiple range test
4th, experimental result
Above test result indicate that：The wound area of the callicarpa nudiflora scald paste group that the present invention prepares is substantially little
In remaining two groups of (P<0.05) it is worth mentioning at this point that, callicarpa nudiflora scald paste group wound size started to be always from the 8th day
Minimum, show that the callicarpa nudiflora ointment for treating scald that the present invention prepares has obvious therapeutic effect to scald.
The above is only the preferred embodiment of the present invention it is noted that ordinary skill people for the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (4)
1. a kind of preparation method of the callicarpa nudiflora ointment for treating scald of multitude's medicine is it is characterised in that it comprises the following steps：
(1) extraction of callicarpa nudiflora medicinal material：
Take callicarpa nudiflora medicinal material, respectively the water of 12,10,10 times of volumes of dosing material weight, soak 2h, be then refluxed for extracting, often
Secondary extraction 1h, filters, and merges 3 aqueous extracts, is concentrated to give callicarpa nudiflora medicinal material medicinal extract；
(2) preparation of ointment for treating scald
Using emulsion process, prepared w/o is callicarpa nudiflora scald paste, first take oil phase raw material polyoxyethylene sorbitan monoleate, glycerol monostearate
Ester and glycerine are heated to 70～80 DEG C, be then added slowly to be heated to 70～80 DEG C of temperature Aqueous Phase Raw Material atoleine,
In Sorbitan Oleate, solid paraffin and vaseline, then stir lower addition ethyl hydroxy benzoate, dimethyl sulfoxide (DMSO) and step (1) preparation
The callicarpa nudiflora medicinal material liquid extract obtaining, stirring and emulsifying condensation 20～40 minutes, obtains the callicarpa nudiflora ointment for treating scald of multitude's medicine in the same direction.
2. the preparation method of the callicarpa nudiflora ointment for treating scald of multitude's medicine according to claim 1 is it is characterised in that the dosage of each component
As follows：Oil phase raw material consist of polyoxyethylene sorbitan monoleate 0.8～1.4g, glycerin monostearate 4.2～5.5g and glycerine 0.6～
1.2g；
Aqueous Phase Raw Material consists of atoleine 9～12g, Sorbitan Oleate 0.6～1.8g, solid paraffin 0.6～1.8g and Fan Shi
Woods 0.7～1.3g；
The consumption of callicarpa nudiflora medicinal material medicinal extract is 2～5g；Ethyl hydroxy benzoate 0.037～0.15g, dimethyl sulfoxide (DMSO) 0.0187～
0.03g.
3. the preparation method of the callicarpa nudiflora ointment for treating scald of multitude's medicine according to claim 1 is it is characterised in that the dosage of each component
As follows：Oil phase raw material consists of polyoxyethylene sorbitan monoleate 1.2g, glycerin monostearate 4.7g and glycerine 0.9g；
Aqueous Phase Raw Material consists of atoleine 10.8g, Sorbitan Oleate 1.4g, solid paraffin 1.4g and vaseline 0.9g；
The consumption of callicarpa nudiflora medicinal material medicinal extract is 3g；Ethyl hydroxy benzoate 0.0729g, dimethyl sulfoxide (DMSO) 0.0243g.
4. the preparation method of the callicarpa nudiflora ointment for treating scald of multitude's medicine according to claim 1 is it is characterised in that step (2) emulsification
Temperature is 70 DEG C, and emulsification times are 25 minutes.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110640642.8A CN113318162A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medicine Callicarpa nudiflora scald ointment |
| CN201610971201.5A CN106389687A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medical callicarpa nudiflora scald ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610971201.5A CN106389687A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medical callicarpa nudiflora scald ointment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110640642.8A Division CN113318162A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medicine Callicarpa nudiflora scald ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389687A true CN106389687A (en) | 2017-02-15 |
Family
ID=58015010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110640642.8A Pending CN113318162A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medicine Callicarpa nudiflora scald ointment |
| CN201610971201.5A Pending CN106389687A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medical callicarpa nudiflora scald ointment |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110640642.8A Pending CN113318162A (en) | 2016-11-07 | 2016-11-07 | Preparation method of Li medicine Callicarpa nudiflora scald ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN113318162A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669757A (en) * | 2017-09-28 | 2018-02-09 | 禹华刚 | Promote dressing of wound healing and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559451A (en) * | 2004-02-17 | 2005-01-05 | 海南国瑞堂制药有限公司 | Medicine compound having synergistic action |
| CN102258637A (en) * | 2011-07-19 | 2011-11-30 | 九芝堂股份有限公司 | Callicarpa nudiflora extract, and preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623394B (en) * | 2009-01-22 | 2011-12-28 | 九芝堂股份有限公司 | Nakedflower beautyberry extract as well as preparation method, preparation and application thereof |
| CN102048909A (en) * | 2009-10-28 | 2011-05-11 | 江西省药物研究所 | Callicarpa nudiflora effective part with hemostatic effect and pharmaceutical preparation thereof |
-
2016
- 2016-11-07 CN CN202110640642.8A patent/CN113318162A/en active Pending
- 2016-11-07 CN CN201610971201.5A patent/CN106389687A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559451A (en) * | 2004-02-17 | 2005-01-05 | 海南国瑞堂制药有限公司 | Medicine compound having synergistic action |
| CN102258637A (en) * | 2011-07-19 | 2011-11-30 | 九芝堂股份有限公司 | Callicarpa nudiflora extract, and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| "裸花紫珠软膏剂的制备及质量评定": "霍煜，等。", 《海南医学》 * |
| 王云云: "《药物制剂技术》", 31 August 2016 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669757A (en) * | 2017-09-28 | 2018-02-09 | 禹华刚 | Promote dressing of wound healing and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113318162A (en) | 2021-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103315356B (en) | Preparation method of plant-enzyme-containing functional drink capable of alleviating hangover | |
| CN109512760A (en) | A kind of preparation method of compound plant Shu Min maintenance essence | |
| CN104083317B (en) | A kind of white young tea leaves eye-care frost and preparation method thereof | |
| CN107224522A (en) | A kind of Preparation process method of stir-baked RHIZOMA POLYGONATI with yellow rice wine | |
| CN102580033A (en) | Medicinal composition for treating skin injury and quality detection method | |
| CN106074238A (en) | A kind of golden flower certain herbaceous plants with big flowers whitening and spot eliminating cream and preparation method thereof | |
| CN101461763A (en) | Method for producing cosmetics containing notoginseng polysaccharide and use | |
| CN105998093A (en) | Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof | |
| CN105853287A (en) | Hibiseu Smanihot L. moisturizing essence and preparation method thereof | |
| CN107875196A (en) | Complex enzyme, extract solution system, medicament, extract and preparation method thereof, application | |
| CN106389687A (en) | Preparation method of Li medical callicarpa nudiflora scald ointment | |
| CN109453073A (en) | Dendrobium candidum flower essential oil perfume and preparation method thereof | |
| CN108670933A (en) | Have both moisturizing, the skin care compositions of whitening and anti-aging and its application | |
| CN101085181B (en) | Plaster for treating bony spur and osteoproliferation and preparation method thereof | |
| CN106729444A (en) | A kind of gel breast of repairing skin wound surfaces and preparation method thereof | |
| CN103893714B (en) | Health care moxibustion liquid and preparation method thereof | |
| CN101322698A (en) | Applications of betaine in preparing medicament for preventing and treating alimentary obesity | |
| CN110237012A (en) | A kind of bletilla striata hand lotion and preparation method thereof for preventing and treating chapped skin | |
| CN105920130A (en) | Preparation method and externally used ointment of traditional Chinese medicine for treating talalgia | |
| CN102755276B (en) | Dalbergia wood perfume | |
| CN106074691A (en) | The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method | |
| CN109125375B (en) | Preparation method of Chuzhou chrysanthemum eye patch liquid for protecting eyes and improving eyesight | |
| CN108186821A (en) | A kind of Chinese medicine composition for treating nervous headache and its preparation method and application | |
| CN107648397A (en) | It is a kind of to be used to treat Chinese medicine composition of liver-kidney yin deficiency and its preparation method and application | |
| CN107875057A (en) | Cosmetic composition and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170215 |